...Bohao Liu; Zhong Wang; Ruyuan He; Rui Xiong; Guorui Li; Lin Zhang; Tinglv Fu; Chenyuan Li; Ning Li; Qing Geng Background : NOD-like receptor family pyrin domain containing 3 (NLRP3)-mediated macrophage pyroptosis plays an important role in sepsis-induced acute lung injury (ALI). Inhibition...

...Zibin Lu; Huayi Yang; Huihui Cao; Chuying Huo; Yuyao Chen; Dongyi Liu; Pei Xie; Hongling Zhou; Junshan Liu; Linzhong Yu Acute lung injury (ALI) is a life-threatening disease without effective pharmacotherapies, so far. Forsythia suspensa is frequently used in the treatment of lung infection...

... was neutralized by 2.0 M Tris and subsequently centrifuged again at 12400 g for 10 min. Eventually, the neutralized supernatant was transferred and injected on to an HPLC column. Sulphite–bimane adduct was detected by excitation at 392 nm and emission at 479 nm. acute lung injury inflammatory response...

...)-induced lung injury and down-regulates several signalling pathways including PI3K-Akt-NF-κB, Src-NF-κB, E-cadherin and mTOR. Targeting EphA2 receptor may be a novel strategy in LPS-induced lung injury. acute lung injury EphA2 EphrinA1 lipopolysaccharide The antibodies used in the present...

... protect against HAE (high-altitude exposure)-induced acute lung injury and oedema via promoting the expression of HSP70 in lungs prior to the onset of HAE. At 2 weeks after the start of HHP, animals were exposed to a simulated HAE of 6000 m in a hypobaric chamber for 24 h. Immediately after being returned...

...Rafal Fudala; Agnieszka Krupa; Dorota Stankowska; Timothy C. Allen; Anna K. Kurdowska ALI (acute lung injury) and its more severe form ARDS (acute respiratory distress syndrome) are inflammatory diseases of the lung characterized by hypoxaemia and diffuse bilateral infiltrates. Disruption...

...Aimalohi Esechie; Levente Kiss; Gabor Olah; Eszter M. Horváth; Hal Hawkins; Csaba Szabo; Daniel L. Traber Acute lung injury results in a severe inflammatory response, which leads to priming and activation of leucocytes, release of reactive oxygen and reactive nitrogen species, destruction...

... in the plasma concentration of antithrombin. Therefore the aim of the present study was to test the hypothesis that intravenous administration of recombinant human antithrombin in combination with aerosolized heparin will ameliorate acute lung injury in sheep exposed to cutaneous burn and smoke inhalation...

... of the prone position, but also to the management of patients with ARDS in general. Correspondence: Dr David F. Treacher (email David.Treacher@gstt.nhs.uk ). 24 3 2006 10 4 2006 10 4 2006 The Biochemical Society 2006 acute lung injury acute respiratory distress syndrome...

... (email joerg.reutershan@med.uni-tuebingen.de ). 8 11 2005 5 1 2006 23 1 2006 23 1 2006 The Biochemical Society 2006 acute lung injury acute respiratory distress syndrome (ARDS) alveolar recruitment end-expiratory lung volume prone position ARDS (acute...

... after injury and reduced the degree of bronchiolar obstruction in sheep with S+B; however, treated sheep showed higher levels of NOx and increased lung lymph flow. Tezosentan treatment was ineffective in protecting against acute lung injury in this model. Correspondence: Dr Robert A. Cox, Shriners...

... the pathophysiological aspects of acute lung injury induced by combined burn and smoke inhalation and examine various therapeutic approaches. acute lung injury burn and smoke inhalation cytokine nitric oxide (NO) pathophysiology poly(ADP-ribose) polymerase (PARP) Figure 4 Airway obstruction-related...

...) in an experimental model of acute lung injury (ALI), in a prospective, randomized, controlled animal study. A total of 30 anaesthetized, tracheotomized and mechanically ventilated pigs underwent induction of ALI by repeated saline washout of surfactant. The animals were then randomly assigned to receive...

... for severe pneumonia aimed at circumventing mechanical ventilation in future studies. 24 6 1997 30 6 1997 © 1997 The Biochemical Society and the Medical Research Society 1997 acute lung injury adult respiratory distress syndrome 67 gallium pneumonia pulmonary leak index...