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Clin Sci (Lond) (2008) 115 (2): 69–77.
Published: 12 June 2008
... investigate whether PPC (pharmacological preconditioning) by transient activation of A 1 R (adenosine A 1 receptor) protects against long-term HI/R and whether the protective effects of IPC depend on A 1 R activation and whether both preconditionings affect remote organs. Wistar rats underwent IPC and long...
Niels P. Riksen, Marlies Bosselaar, Stephan J.L. Bakker, Robert J. Heine, Gerard A. Rongen, Cees J. Tack, Paul Smits
Clin Sci (Lond) (2007) 113 (1): 33–40.
Published: 01 June 2007
... of elevated plasma NEFAs by the simultaneous assessment of blood pressure, pulse wave velocity, FBF (forearm blood flow) and sympathetic nervous system activity during acute elevation of NEFAs. Secondly, we hypothesized that NEFA-induced vasodilation is mediated by adenosine receptor stimulation...
Clin Sci (Lond) (2004) 107 (5): 467–475.
Published: 26 October 2004
... receptor blockade). To avoid vasoconstrictor effects induced by ET A receptor stimulation, additional experiments were performed in the presence of the vasodilator adenosine (2.0 mg·kg −1 of body weight·min −1 ). Myocardial function was also examined during aortic clamping so as to circumvent the effect...
Henri J. L. M. TIMMERS, Gerard A. RONGEN, John M. KAREMAKER, Wouter WIELING, Henri A. M. MARRES, Jacques W. M. LENDERS
Clin Sci (Lond) (2004) 106 (1): 75–82.
Published: 01 January 2004
...Henri J. L. M. TIMMERS; Gerard A. RONGEN; John M. KAREMAKER; Wouter WIELING; Henri A. M. MARRES; Jacques W. M. LENDERS The direct vasodilatory and negative chronotropic effects of adenosine in humans are counterbalanced by a reflex increase in sympathetic nerve traffic. A suggested mechanism...
Endre ZIMA, Violetta KÉKESI, Andrea NAGY, László LOSONCZI, Ildikó TOMA, Pál SOÓS, Erzsébet Barát, Éva HUSZÁR, Béla MERKELY, Ferenc HORKAY, Alexander Juhász-Nagy
Clin Sci (Lond) (2002) 103 (s2002): 202S–205S.
Published: 01 September 2002
...). The aim of the present study was to characterize the pericardial concentrations of the purine metabolites adenosine, inosine and hypoxanthine before and after intrapericardial administration of ET-1 to the in situ heart. The closed pericardial sac of anaesthetized dogs ( n = 9) was cannulated for ET-1...
Clin Sci (Lond) (2000) 98 (3): 303–311.
Published: 09 February 2000
... examined the role of adenosine in mediating these effects using the isolated perfused rat kidney. Kidneys were perfused with a 6.7%-(w/v)-albumin-based perfusate supplemented with glucose and amino acids ( n = 6 per group). They were exposed to diatrizoate [20 mg of iodine (mgI)/ml; osmolality 1650 mOsm/kg...
Clin Sci (Lond) (2000) 98 (1): 15–20.
Published: 19 November 1999
...Björn E. ERIKSSON; Bita SADIGH; Jan SVEDENHAG; Christer SYLVÉN It has been proposed that adenosine mediates ischaemic pain in humans. Patients with cardiac Syndrome X are hypersensitive to potential pain stimuli, including adenosine. On the other hand, recent findings suggest that low-dose...
Gerard A. RONGEN, Steven C. BROOKS, Michael J. POLLARD, Shin-ichi ANDO, Hilmi R. DAJANI, Catherine F. NOTARIUS, John S. FLORAS
Clin Sci (Lond) (1999) 96 (6): 597–604.
Published: 07 May 1999
...Gerard A. RONGEN; Steven C. BROOKS; Michael J. POLLARD; Shin-ichi ANDO; Hilmi R. DAJANI; Catherine F. NOTARIUS; John S. FLORAS By stimulating afferent nerve endings in skeletal muscle, heart, kidney and the carotid body, adenosine infusion evokes a receptor-specific sympatho-excitatory reflex...
Clin Sci (Lond) (1999) 96 (4): 349–355.
Published: 01 April 1999
...P. FORSYTHE; L. P. A. MCGARVEY; L. G. HEANEY; J. MACMAHON; M. ENNIS Previous studies have shown that in vitro adenosine enhances histamine release from activated human lung mast cells obtained by enzymic dispersion of lung parenchyma. However, adenosine alone has no effect on histamine release from...
Clin Sci (Lond) (1995) 89 (3): 227–232.
Published: 01 September 1995
...Samuel S. Lee; Jung-Min Pak; Shaun M. Medlicott; Arieh Bomzon 1. There is currently considerable interest in the role of locally produced vasodilators such as nitric oxide and adenosine in the pathogenesis of the peripheral vasodilatation of cirrhosis. However, the signal transduction pathways...
Clin Sci (Lond) (1992) 83 (5): 511–518.
Published: 01 November 1992
... of myocytes which might have regained normal function, or does reperfusion merely hasten Key words adenosine, adhesion molecules, complement, endothelium, inflammation, leukotrienes, myocardial ischaemia, neutrophils, oxygen free radicals, reperfusion injury. Abbreviations: ICAM-I, intercellular adhesion...
Jorma J. Ohisalo, Johanna M. Kaartinen, Susanna Ranta, Pertti Mustajoki, Stanely P. Hreniuk, Kathryn F. LaNoue, Louis F. Martin
Clin Sci (Lond) (1992) 83 (5): 589–592.
Published: 01 November 1992
... or gastroplasty (post-bypass patients) and from control subjects of a stable normal body weight. 2. The inhibition of isoprenaline-stimulated lipolysis by N 6 -(phenylisopropyl)adenosine in the presence of adenosine deaminase was much attenuated in cells from the massively obese patients as compared with those...
Clin Sci (Lond) (1991) 81 (5): 691–694.
Published: 01 November 1991
...U. Söderbäck; A. Sollevi; N. H. Wallen; P. T. Larsson; P. Hjemdahl 1. The anti-aggregatory effect of adenosine (0.3–10 μmol/l), alone or in combination with the adenosine-uptake inhibitor dipyridamole (2 μmol/l), was studied in vitro in whole blood from 11 healthy subjects by filtragometry. 2. ADP...
Clin Sci (Lond) (1991) 80 (2): 107–112.
Published: 01 February 1991
...S. T. Parsons; T. L. Griffiths; J. M. L. Christie; S. T. Holgate 1. Twelve healthy young men took part in this investigation of the effect of oral theophylline and dipyridamole (two drugs known to affect the pharmacological effects of the purine nucleoside adenosine) on the respiratory response...
Clin Sci (Lond) (1990) 79 (2): 131–138.
Published: 01 August 1990
...Anders Edlund; Alf Sollevi; Birgitta Linde 1. Haemodynamic and metabolic effects of intravenous infusion of adenosine, an endogenous vasodilator, were studied in healthy humans. 2. Catheters were inserted into pulmonary and brachial arteries and into the hepatic and subclavian veins. Cardiac output...
Clin Sci (Lond) (1990) 78 (1): 25–31.
Published: 01 January 1990
...T. L. Griffiths; S. J. Warren; A. D. B. Chant; S. T. Holgate 1. We have studied the carotid body contribution to hypoxic respiratory drive, using a hypoxic/hyperoxic switching technique, and the ventilatory response to intravenous infusion of adenosine, a recently described respiratory stimulant...
Clin Sci (Lond) (1988) 75 (4): 429–436.
Published: 01 October 1988
...G. D. Phillips; S. T. Holgate 1. Adenosine 5′-monophosphate (AMP) causes bronchoconstriction in atopic and non-atopic asthma by a mechanism believed to involve histamine release from airway mast cells. To determine whether preformed mast cell mediators, principally histamine, can initiate a late...
Clin Sci (Lond) (1986) 71 (4): 385–392.
Published: 01 October 1986
... agonists were chosen for study: adenosine with methacholine and PGD 2 with histamine. For each agonist, concentration–s G aw response curves were constructed, from which were derived the provocation concentrations of agonist causing a 25% fall in sGaw from baseline (PC 25 ) and required to further...
Clin Sci (Lond) (1986) 70 (5): 461–468.
Published: 01 May 1986
...Jonathan S. Mann; Andrew G. Renwick; Stephen T. Holgate 1. Human leucocytes whose adenine nucleotide pool was prelabelled with [ 3 H]adenine were investigated for their capacity to release adenosine and its metabolites and histamine when activated with the calcium ionophore A23187...
Clin Sci (Lond) (1986) 70 (4): 353–357.
Published: 01 April 1986
...Elizabeth A. Woodcock; Edward Leung; Colin I. Johnston 1. Adenylate cyclase activity in homogenates of human papillae was stimulated by adenosine agonist compounds. 2. The rank order of agonist potencies for stimulation was 5′- N -ethylcarboxamidoadenosine > l - N 6 -phenylisopropyladenosine...
Clin Sci (Lond) (1981) 60 (5): 565–569.
Published: 01 May 1981
...Z. Bereznowski; A. Stankiewicz; W. Makarewicz 1. The liberation of ammonia from adenosine 5′-phosphate (AMP) and adenosine and the release of inorganic phosphate from AMP were investigated in homogenates of bovine and human parotid glands. 2. Adenosine phosphate deaminase (AMP deaminase...
Clin Sci Mol Med (1978) 55 (4): 407–412.
Published: 01 October 1978
...B. M. Dean; D. Perrett; H. Anne Simmonds; A. Sahota; K. J. Van Acker 1. We have studied the metabolism of adenine and adenosine in intact erythrocytes from three children and four adults of two separate families. The children were homozygotes for a deficiency of AMP-pyrophosphate...