... -adrenoreceptors. To investigate the mechanism of such cross-talk between G s -coupled receptors, we have measured the mRNA expression of the cardiac adenylate cyclases (types IV, V, VI and VII) and of β-adrenoceptor kinase 1 in human atria using TaqMan quantitative PCR, and compared expression between patients...

...Carmen W. Dessauer; Bruce A. Posner; Alfred G. Gilman 1. The first glimpses of heterotrimeric G-proteins came with the discoveries of the ubiquitous adenylate cyclase activator, G s , and the specialized retinal cGMP phosphodiesterase activator, G t or transducin. The model that evolved...

...M. NoGami; D. J. Romberger; S. I. Rennard; M. L. Toews 1. Cultured bovine bronchial epithelial cells express a large number of β-adrenoceptors of the β 2 subtype which are coupled to activation of adenylate cyclase and synthesis of cyclic AMP. The mechanisms involved in agonist-induced...

... observed in the inhibitory regulation of lipolysis in obesity are secondary. © 1992 The Biochemical Society and the Medical Research Society 1992 adenosine adenylate cyclase cell size gastric bypass hormone regulation metabolism obesity Clinical Science (1992) 83, 589-592 (Printed in Great...

... and ambulatory and six were decompensated, hospitalized) as compared with 12 normal controls. 2. Lymphocyte β-receptor mediated adenylate cyclase activity (EC 4.6.1.1) was not decreased in the ambulatory cystic fibrosis patients as compared with controls. In contrast, decompensated hospitalized cystic fibrosis...

...Serge Adnot; Nicolas Ferry; Jacques Hanoune; Marie-Use Lacombe 1. Plasmin was recently reported to inhibit platelet aggregation [1]. We report here on the interaction of plasmin with the adenylate cyclase system of human platelets. Human plasmin caused a dose-and time-dependent increase...

...M. S. Seshadri; R. S. Mason; C. J. Cornish; A. M. Pryke; S. Posen 1. Tumour extracts from two patients with humoral hypercalcaemia of malignancy contained material which stimulated adenylate cyclase in chick renal membranes and in rat osteosarcoma cells. 2. Adenylate cyclase-stimulating activity...

... a direct action of PGE, enhancement of prostaglandin synthetase by cyclic GMP and stimulation of guanylate cyclase by mecholyl and bradykinin. Isoprenaline presumably stimulates adenylate cyclase directly. 6. This complex chain of events, from cholinergic stimulation to an enhancement of adenylate cyclase...

...M. S. Seshadri; Y. L. Chan; M. R. Wilkinson; R. S. Mason; S. Posen 1. A renal adenylate cyclase system was assessed for its suitability in the performance of parathyroid hormone (PTH) bioassays. Membrane preparations from 1 week old chicks were found to be more sensitive to PTH than material from...

...M. S. Seshadri; Y. L. Chan; M. R. Wilkinson; R. S. Mason; S. Posen 1. An adenylate cyclase bioassay for parathyroid hormone (PTH) was evaluated in peripheral sera of ten normal subjects, 15 patients with various types of hypoparathyroidism, nine patients with malignancy-associated hypercalcaemia...

...Zvi Farfel; Adrian Iaina; Haskel Eliahou; Zohara Cohen 1. In order to define the alteration of the function of the adrenergic system in hypertension, we studied directly the receptor-cyclase coupling protein (N protein), which is one of the components of the enzyme adenylate cyclase. 2. N protein...

...-stimulated adenylate cyclase activities were measured in membranes in the presence of several vitamin D 3 metabolites. 2. 24,25-Dihydroxycholecalciferol (10 and 1000 pmol/l) decreased isoproterenol- and sodium fluoride-stimulated adenylate cyclase activities in membranes prepared from parathyroid glands...

...F. Pecker; P. Duvaldestin; P. Berthelot; J. Hanoune 1. Adenylate cyclase (EC 4.6.1.1) activity was characterized in human liver, and its subcellular distribution compared with that of three other potential enzyme markers of the pericellular membrane: leucine aminopeptidase (EC 3.4.11.1), γ...

...T. J. Martin; S. R. Nahorski; N. H. Hunt; J. K. Dawborn; R. S. Loomes; J. C. E. Underwood 1. A human cancer cell line (COLO 16) derived originally from an epidermal squamous cell carcinoma was found to possess adenylate cyclase responsiveness to β-adrenergic agonists. 2. The adenylate cyclase...

...N. S. Dhalla; J. N. Singh; E. Bajusz; G. Jasmin 1. The activities of some membrane-bound enzymes such as adenylate cyclase, Na + +K + -stimulated adenosine triphosphatase (Na + +K + -ATPase), Ca 2+ -stimulated ATPase and Mg 2+ -stimulated ATPase were examined in heart sarcolemmal fractions from...

... significantly contribute to the total intestinal secretion in cholera. 6 8 1975 © 1976 The Biochemical Society and the Medical Research Society 1976 adenylate cyclase biliary tract cholera toxin intestinal hormones pancreas Clinical Science and Molecular Medicine (1976) Sf, 81-85...