...Shin-Ei Cheng; I-Ta Lee; Chih-Chung Lin; Li-Der Hsiao; Chuen-Mao Yang Up-regulation of ICAM-1 (intercellular adhesion molecule-1) is frequently implicated in lung inflammation and lung diseases, such as IPF (idiopathic pulmonary fibrosis). Thrombin has been shown to play a key role in inflammation...

... to the inflammation pathways in diabetic nephropathy include transcription factors, pro-inflammatory cytokines, chemokines, adhesion molecules, Toll-like receptors, adipokines and nuclear receptors, which are candidates for the new molecular targets for the treatment of diabetic nephropathy. Understanding...

... of inflammatory mediators that lead to endothelial dysfunction and vascular injury. Inflammatory markers (e.g. C-reactive protein, chemokines and adhesion molecules) are increased in patients with hypertension and metabolic disorders, and predict the development of cardiovascular disease. Lifestyle modification...

..., at Kidney Research Centre and Molecular Medicine Program, Ottawa Health Research Institute, Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada K1H 8M5 (email ckennedy@uottawa.ca ). 8 6 2006 7 9 2006 10 10 2006 The Biochemical Society 2007 adhesion molecule...

... fraction of 23.7±1.8% were studied. Controls comprised age-matched healthy volunteers ( n =15; 54.1±3.2 years). Plasma levels of cytokines [IL (interleukin)-6 and IL-18], chemokines [MCP-1 (monocyte chemotactic protein-1)], adhesion molecules [sICAM (soluble intercellular adhesion molecule), sE-selectin...

... of the hypertensive patients had diabetes, renal impairment or overt vascular diseases. Plasma VEGF and adhesion molecules were measured using ELISAs. Endothelial function was measured by FMD (flow-mediated vasodilation) of the brachial artery. Plasma levels of VEGF, excluding adhesion molecules, were significantly...

... mg daily. Levels of C-reactive protein (CRP), soluble intercellular cell-adhesion molecule (s-ICAM) and soluble E-selectin (s-E-selectin) were determined at baseline and again after 6 weeks and 12 months of therapy. A total of 35 subjects participated in the study (mean age 42 years; 60% male). When...

...Hiroyuki HASHIMOTO; Kazuo KITAGAWA; Keisuke KUWABARA; Hidetaka HOUGAKU; Toshiho OHTSUKI; Masayasu MATSUMOTO; Masatsugu HORI The relationship between levels of circulating intercellular cell-adhesion molecule-1 (cICAM-1) or P-selectin (cP-selectin) and the severity of carotid atherosclerosis...

... for any cell type. Analysis of subgroups of patients according to disease type, severity or treatment also showed no difference compared with control subjects. 4. We conclude that failure to identify a population of circulating leucocytes whose adhesion molecules or complement receptors are upregulated...