... mechanisms, where metabolic deregulation of adipokines can modulate multiple oncogenic molecular pathways. Leptin and adiponectin are the most well-studied adipokines, and their imbalance can trigger different tumorigenic responses. Both epidemiologic and experimental studies have associated leptin...

... the established association between obesity/excess adiposity and hypertension, whether and how adiponectin, one of the adipokines, contributes to impaired sodium excretion in hypertension has not been previously investigated. The current study tested the hypothesis that adiponectin promotes natriuresis...

..., and makes crucial contributions to tumour lymphangiogenesis and lymphatic metastasis. Adiponectin is a protein hormone secreted predominantly by differentiated adipocytes. In recent years, adiponectin has also been indicated as facilitating tumorigenesis, angiogenesis and metastasis. However, the effect...

... was quantified via M30 (caspase-cleaved cytokeratin-18 fragments). Plasma concentrations of adiponectin and fetuin-A were determined by ELISA. Serum-derived parameters were additionally taken at 4 weeks and 6 months post-operatively. In addition, primary human hepatocytes were treated with NEFA (non-esterified...

...) at baseline, and pre- and post-PPAR agonist treatment. Obese individuals had significantly increased adipocyte cell surface, percentage CD14 + /CD16 + monocyte numbers and ATM number (all P =0.0001). Additionally, serum TNF-α levels were significantly elevated ( P =0.017) and adiponectin levels reduced (total...

... on adipose tissue metabolism in the offspring. Postnatal changes in serum adiponectin, leptin and TAG [triacylglycerol (triglyceride)] levels, adipose tissue TAGs, fatty acids and enzyme activities were determined in offspring of cafeteria-diet-fed dams during gestation and lactation, weaned on to standard...

...Maria Luisa Balmer; Jeannine Joneli; Alain Schoepfer; Felix Stickel; Wolfgang Thormann; Jean-François Dufour Adiponectin, which plays a pivotal role in metabolic liver diseases, is reduced in concentration in patients with NASH (non-alcoholic steatohepatitis). The aim of the present study...

... for the measurement of fasting glucose, HbA 1c , fasting insulin, intact proinsulin, adiponectin and Hct (haematocrit). In addition, the erythrocyte EI (elongation index) was measured using laser diffractoscopy. Both treatments significantly improved HbA 1c levels (PIO, −0.9±1.1%; GLIM, −0.6±0.4%; both P <0.05...

...An M. Van Berendoncks; Paul Beckers; Vicky Y. Hoymans; Nadine Possemiers; Floris L. Wuyts; Christiaan J. Vrints; Viviane M. Conraads High adiponectin concentrations have emerged as an independent risk factor of outcome in patients with CHF (chronic heart failure); however, modification...

...Donald S. C. Ang; Paul Welsh; Pauline Watt; Scott M. Nelson; Allan Struthers; Naveed Sattar Plasma adiponectin is inversely associated with the risk of coronary heart disease in healthy people. However, adiponectin and BNP (B-type natriuretic peptide) are both known to be positively associated...

... or antidiabetic/anti-obesity drugs, should be explored. Correspondence: Dr Jan Kopecky (email [email protected] ). 19 12 2007 19 2 2008 10 3 2008 adiponectin diabetes docosahexaenoic acid (DHA) eicosapentaenoic acid (EPA) insulin obesity Obesity represents...

...Makrina D. Savvidou; Alexandros Sotiriadis; Christine Kaihura; Kypros H. Nicolaides; Naveed Sattar Adiponectin and leptin, two adipose-tissue-derived proteins, have been reported to be elevated in women with established PE (pre-eclampsia). The aim of the present study was to investigate whether...

...Saima Qurashi; Dennis C. Mynarcik; Margaret A. McNurlan; Hongshik Ahn; Robert Ferris; Marie C. Gelato The present study was designed to investigate the relationship of isoforms of adiponectin to insulin sensitivity in subjects with HIV-associated insulin resistance in response to treatment...

...Weidong Zhu; Kenneth K. Y. Cheng; Paul M. Vanhoutte; Karen S. L. Lam; Aimin Xu Adiponectin is a major adipocyte-secreted adipokine abundantly present in the circulation as three distinct oligomeric complexes. In addition to its role as an insulin sensitizer, mounting evidence suggests...

...Herbert Tilg; Alexander R. Moschen Obesity and obesity-related disorders play an important role in clinical medicine. Adipose tissue, with its soluble mediators called adipocytokines, has emerged as a major endocrine organ. These adipocytokines comprise many mediators such as adiponectin, PBEF (pre...

... larger increase in waist circumference than those eating carbohydrates rich in fibre and whole grains [ 9 ]. Furthermore, fat-rich diets can acutely induce insulin resistance, especially in subjects with already low adiponectin levels [ 10 ]. Thus it is possible that the restriction of dietary fat...

... index; +13 and +10% respectively; P <0.05) and abdominal fat (+70% in both HFD1 and HFD2; P <0.05), higher plasma leptin (+130 and +135% respectively; P <0.05), lower plasma adiponectin levels (−23 and −30% respectively; P <0.05) and impaired glucose tolerance. Only the HFD1 group had...

...Jan Polak; Zuzana Kovacova; Martin Jacek; Eva Klimcakova; Michaela Kovacikova; Michaela Vitkova; Ondrej Kuda; Marek Sebela; Eva Samcova; Vladimir Stich Adiponectin is involved in the regulation of glucose and fatty acid metabolism, influences whole-body insulin sensitivity and protects arterial...

... (determined by ultrasound), S I (insulin sensitivity index; determined by isoglycaemic–hyperinsulinaemic clamp) and serum levels of CRP (C-reactive protein), TNF-α (tumour necrosis factor-α), IL-6 (interleukin 6), resistin and adiponectin (determined by ELISA) were measured. Associations between FMD/NTG and S...

... excess body energy, but also secretes a variety of bioactive adipocytokines. Obese patients, particularly those with visceral fat accumulation, have reduced plasma levels of adiponectin, the most abundant and adipose-specific adipocytokine. Although the association of adiponectin with several diseases...

... physiological processes and participates in disease. Adipose tissue secretes factors that exert local and systemic effects. Leptin, pro-inflammatory cytokines, resistin and proteins involved in haemodynamic regulation and coagulation are increased in obesity while adiponectin is reduced. The production...

...) and chylomicrons] determined by a novel HPLC method, with adiponectin, which is decreased in Type II diabetes and assumed to be involved in dysregulated metabolism and atherogenesis. Type II diabetic patients who were not treated with insulin, statins and fibrates were enrolled. Study subjects included Type II...

...-diabetic patients, which may only partly be explained by traditional risk factors. Our purpose was to compare non-traditional risk factors, such as endothelial function, C-reactive protein (CRP) and adiponectin, in Type II diabetic and non-diabetic patients following AMI (acute myocardial infarction...

...Yukihiro YAMAMOTO; Hiroshi HIROSE; Ikuo SAITO; Motowo TOMITA; Matsuo TANIYAMA; Koichi MATSUBARA; Yasunori OKAZAKI; Tatsuya ISHII; Kanako NISHIKAI; Takao SARUTA Adiponectin, which is secreted specifically by adipose tissue, has been shown to act as an anti-atherosclerotic protein by direct effects...