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Articles

Serpina3c Deficiency Promotes Obesity-related Hypertriglyceridemia and Inflammation through Activation of the Hif1α - glycolysis Axis in Adipose Tissue

Jiaqi Guo, Zhenjun Ji, Yu Jiang, Ya Wu, Shaofan Wang, Peng Zheng, Mengchen Yang, Yongjun Li, Genshan Ma, Yuyu Yao

Clin Sci (Lond) (2024) CS20242610.

https://doi.org/10.1042/CS20242610

Published: 18 December 2024

...Jiaqi Guo; Zhenjun Ji; Yu Jiang; Ya Wu; Shaofan Wang; Peng Zheng; Mengchen Yang; Yongjun Li; Genshan Ma; Yuyu Yao Adipose tissue dysfunction leads to abnormal lipid metabolism and high inflammation levels. This research aims to explore the role of Serpina3c, which is highly expressed in adipocytes...

View articletitled, Serpina3c Deficiency Promotes Obesity-related Hypertriglyceridemia and Inflammation through Activation of the Hif1α - glycolysis Axis in Adipose Tissue

Articles

Interruption of perivascular and perirenal adipose tissue thromboinflammation rescues prediabetic cardioautonomic and renovascular deterioration

Aya Al-Saidi, Ibrahim F. Alzaim, Safaa H. Hammoud, Ghida Al Arab, Samaya Abdalla, Nahed Mougharbil, Ali H. Eid, Ahmed F. El-Yazbi

Clin Sci (Lond) (2024) 138 (5): 289–308.

https://doi.org/10.1042/CS20231186

Published: 05 March 2024

...Aya Al-Saidi; Ibrahim F. Alzaim; Safaa H. Hammoud; Ghida Al Arab; Samaya Abdalla; Nahed Mougharbil; Ali H. Eid; Ahmed F. El-Yazbi The cardiovascular and renovascular complications of metabolic deterioration are associated with localized adipose tissue dysfunction. We have previously demonstrated...

View articletitled, Interruption of perivascular and perirenal adipose tissue thromboinflammation rescues prediabetic cardioautonomic and renovascular deterioration

Articles

Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease

Nour-Mounira Z. Bakkar, Ibrahim AlZaim, Ahmed F. El-Yazbi

Clin Sci (Lond) (2022) 136 (22): 1631–1651.

https://doi.org/10.1042/CS20220404

Published: 16 November 2022

... agonists therapy might be driven by their ameliorative impact on adipose tissue inflammation. adipose tissue cardiovascular benefit GLP1 agonists SGLT2 Inhibitors One of the main challenges in the treatment of diabetic patients is the management of the associated cardiovascular diseases (CVDs...

View articletitled, Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease

Articles

Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids

Helena L. Fisk, Caroline E. Childs, Elizabeth A. Miles, Robert Ayres, Paul S. Noakes, Carolina Paras-Chavez, Ondrej Kuda, Jan Kopecký, Elie Antoun, Karen A. Lillycrop, Philip C. Calder

Clin Sci (Lond) (2021) 135 (1): 185–200.

https://doi.org/10.1042/CS20201060

Published: 08 January 2021

... inflammation. However, reports of this in human white adipose tissue (WAT) are limited and inconclusive. Marine long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) have anti-inflammatory actions and therefore may improve obesity-associated adipose tissue inflammation. Therefore, fatty acid (FA...

View articletitled, Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids

Includes: Supplementary data

Articles

GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension

Yan Zhang, Shaoxiong Wang, Hefei Huang, Andi Zeng, Yu Han, Cindy Zeng, Shuo Zheng, Hongmei Ren, Yajing Wang, Yu Huang, Pedro A. Jose, Xin-Liang Ma, Chunyu Zeng, Ken Chen

Clin Sci (Lond) (2020) 134 (18): 2453–2467.

https://doi.org/10.1042/CS20200671

Published: 25 September 2020

... year and 92 million disability-adjusted life years, in the world, are attributed to high blood pressure [ 1 ]. However, the mechanisms of the pathogenesis of hypertension are still not clear. The interactions among blood pressure-regulating tissues/organs and adipose tissue have received considerable...

View articletitled, GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension

Includes: Supplementary data

Articles

The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue

Anissa Viveiros, Gavin Y. Oudit

Clin Sci (Lond) (2020) 134 (18): 2447–2451.

https://doi.org/10.1042/CS20201028

Published: 25 September 2020

... signaling pathways involved in the differential phenotype of adipose tissue between males and females. Delineating the distinction between metabolically healthy and unhealthy obesity is a topic of emerging interest, and the precise nature of adipocytes are key to pathogenesis, independent of adipose tissue...

View articletitled, The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue

Articles

Adipose biology, cardiovascular, and cardiometabolic disease: novel insights and new targets for intervention

Ahmed F. El-Yazbi, Gavin Y. Oudit

Clin Sci (Lond) (2020) 134 (12): 1473–1474.

https://doi.org/10.1042/CS20200816

Published: 24 June 2020

.... We highlight the state of the art on adipose tissue function/dysfunction in the context of cardiovascular and metabolic pathologies. In this Thematic Collection of Clinical Science, we brought together a number of comprehensive articles highlighting the state of the art on the interaction between...

View articletitled, Adipose biology, cardiovascular, and cardiometabolic disease: novel insights and new targets for intervention

Articles

Latest advances in STAT signaling and function in adipocytes

In Collection

Adipose biology, cardiovascular and cardiometabolic disease

Jasmine A. Burrell, Anik Boudreau, Jacqueline M. Stephens

Clin Sci (Lond) (2020) 134 (6): 629–639.

https://doi.org/10.1042/CS20190522

Published: 27 March 2020

...Jasmine A. Burrell; Anik Boudreau; Jacqueline M. Stephens Adipocytes and adipose tissue are not inert and make substantial contributions to systemic metabolism by influencing energy homeostasis, insulin sensitivity, and lipid storage. In addition to well-studied hormones such as insulin...

View articletitled, Latest advances in STAT signaling and function in adipocytes

Articles

Adipocytes initiate an adipose-cerebral-peripheral sympathetic reflex to induce insulin resistance during high-fat feeding

Wei Cao, Meng Shi, Liling Wu, Jiaxin Li, Zhichen Yang, Youhua Liu, Christopher S. Wilcox, Fan Fan Hou

Clin Sci (Lond) (2019) 133 (17): 1883–1899.

https://doi.org/10.1042/CS20190412

Published: 10 September 2019

...Wei Cao; Meng Shi; Liling Wu; Jiaxin Li; Zhichen Yang; Youhua Liu; Christopher S. Wilcox; Fan Fan Hou The underlying mechanism by which amassing of white adipose tissue in obesity regulates sympathetic nerve system (SNS) drive to the tissues responsible for glucose disposal, and causes insulin...

View articletitled, Adipocytes initiate an adipose-cerebral-peripheral sympathetic reflex to induce insulin resistance during high-fat feeding

Includes: Supplementary data

Articles

Adipose-specific inactivation of JNK alleviates atherosclerosis in apoE-deficient mice

Kelvin H.M. Kwok, Kenneth K.Y. Cheng, Ruby L.C. Hoo, Dewei Ye, Aimin Xu, Karen S.L. Lam

Clin Sci (Lond) (2016) 130 (22): 2087–2100.

https://doi.org/10.1042/CS20160465

Published: 11 October 2016

...Kelvin H.M. Kwok; Kenneth K.Y. Cheng; Ruby L.C. Hoo; Dewei Ye; Aimin Xu; Karen S.L. Lam Both atherosclerosis and obesity, an independent atherosclerotic risk factor, are associated with enhanced systemic inflammation. Obesity is also characterized by increased adipose tissue inflammation. However...

View articletitled, Adipose-specific inactivation of JNK alleviates atherosclerosis in apoE-deficient mice

Includes: Supplementary data

Articles

Attenuated atrial natriuretic peptide-mediated lipolysis in subcutaneous adipocytes of obese type 2 diabetic men

Kenneth Verboven, Dominique Hansen, Cedric Moro, Bert O. Eijnde, Nicole Hoebers, Joep Knol, Wim Bouckaert, Anne Dams, Ellen E. Blaak, Johan W.E. Jocken

Clin Sci (Lond) (2016) 130 (13): 1105–1114.

https://doi.org/10.1042/CS20160220

Published: 23 May 2016

... resistance in subcutaneous adipose tissue (SCAT), data on ANP lipolytic response and sensitivity in different adipose tissue (AT) depots of metabolically distinct humans are scarce. Ex vivo catecholamine- and ANP-induced lipolysis was investigated in adipocytes derived from SCAT and visceral AT (VAT) depot...

View articletitled, Attenuated atrial natriuretic peptide-mediated lipolysis in subcutaneous adipocytes of obese type 2 diabetic men

Includes: Supplementary data

Articles

PAFR in adipose tissue macrophages is associated with anti-inflammatory phenotype and metabolic homoeostasis

Luciano Ribeiro Filgueiras, Marianna Mainardi Koga, Paula G. Quaresma, Edson Kiyotaka Ishizuka, Marlise B.A. Montes, Patricia O. Prada, Mario J. Saad, Sonia Jancar, Francisco J. Rios

Clin Sci (Lond) (2016) 130 (8): 601–612.

https://doi.org/10.1042/CS20150538

Published: 08 March 2016

...Luciano Ribeiro Filgueiras; Marianna Mainardi Koga; Paula G. Quaresma; Edson Kiyotaka Ishizuka; Marlise B.A. Montes; Patricia O. Prada; Mario J. Saad; Sonia Jancar; Francisco J. Rios Metabolic dysfunction is associated with adipose tissue inflammation and macrophage infiltration. PAFR (platelet...

View articletitled, PAFR in adipose tissue macrophages is associated with anti-inflammatory phenotype and metabolic homoeostasis

Includes: Supplementary data

Articles

Altered adipose tissue metabolism in offspring of dietary obese rat dams

Nassira Batoul Benkalfat, Hafida Merzouk, Samira Bouanane, Sid-Ahmed Merzouk, Jérôme Bellenger, Joseph Gresti, Christian Tessier, Michel Narce

Clin Sci (Lond) (2011) 121 (1): 19–28.

https://doi.org/10.1042/CS20100534

Published: 18 March 2011

... on adipose tissue metabolism in the offspring. Postnatal changes in serum adiponectin, leptin and TAG [triacylglycerol (triglyceride)] levels, adipose tissue TAGs, fatty acids and enzyme activities were determined in offspring of cafeteria-diet-fed dams during gestation and lactation, weaned on to standard...

View articletitled, Altered adipose tissue metabolism in offspring of dietary obese rat dams

Articles

Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytes

Silvia Lorente-Cebrián, Matilde Bustos, Amelia Marti, J. Alfredo Martinez, Maria J. MORENO-ALIAGA

Clin Sci (Lond) (2009) 117 (6): 243–249.

https://doi.org/10.1042/CS20090020

Published: 14 August 2009

...Silvia Lorente-Cebrián; Matilde Bustos; Amelia Marti; J. Alfredo Martinez; Maria J. MORENO-ALIAGA Visfatin is an adipokine highly expressed in visceral AT (adipose tissue) of humans and rodents, the production of which seems to be dysregulated in excessive fat accumulation and conditions of insulin...

View articletitled, Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytes

Articles

Basal adipose tissue and hepatic lipid kinetics are not affected by a single exercise bout of moderate duration and intensity in sedentary women

Faidon Magkos, Bruce W. Patterson, B. Selma Mohammed, Bettina Mittendorfer

Clin Sci (Lond) (2009) 116 (4): 327–334.

https://doi.org/10.1042/CS20080220

Published: 15 January 2009

... adipose tissue apolipoprotein exercise fatty acid tracer triacylglycerol very-low-density lipoprotein (VLDL) High plasma TAG [triacylglycerol (triglyceride)] concentrations are an important risk factor for CVD (cardiovascular disease), particularly in women, who have a 2–3-fold greater...

View articletitled, Basal adipose tissue and hepatic lipid kinetics are not affected by a single exercise bout of moderate duration and intensity in sedentary women

Articles

An increase in plasma adiponectin multimeric complexes follows hypocaloric diet-induced weight loss in obese and overweight pre-menopausal women

Jan Polak, Zuzana Kovacova, Martin Jacek, Eva Klimcakova, Michaela Kovacikova, Michaela Vitkova, Ondrej Kuda, Marek Sebela, Eva Samcova, Vladimir Stich

Clin Sci (Lond) (2007) 112 (11): 557–565.

https://doi.org/10.1042/CS20060296

Published: 01 May 2007

... disturbances included in the metabolic syndrome. In the search for the mechanisms that explain the link between obesity and metabolic syndrome, it has been suggested that endocrine substances produced by adipose tissue (adipocytokines) might play a role [ 1 , 2 ]. Adiponectin is a 30 kDa plasma protein...

View articletitled, An increase in plasma adiponectin multimeric complexes follows hypocaloric diet-induced weight loss in obese and overweight pre-menopausal women

Articles

Effect of aging and obesity on the expression of dyslipidaemia in children from families with familial combined hyperlipidaemia

Ewoud ter Avest, Allan D. Sniderman, Sebastian J. H. Bredie, Albert Wiegman, Anton F. H. Stalenhoef, Jacqueline de Graaf

Clin Sci (Lond) (2007) 112 (2): 131–139.

https://doi.org/10.1042/CS20060234

Published: 11 December 2006

...-related post-maturation increases in adipose tissue mass also appear to contribute to an aggravation and/or modulation of this genetically determined apoB overproduction. Correspondence: Dr Ewoud ter Avest (email [email protected] ). Figure 2 Association of apoB with age in 194 young...

View articletitled, Effect of aging and obesity on the expression of dyslipidaemia in children from families with familial combined hyperlipidaemia

Articles

Neuroendocrine and metabolic effects of adipocyte-derived hormones

Malaka B. Jackson, Rexford S. Ahima

Clin Sci (Lond) (2006) 110 (2): 143–152.

https://doi.org/10.1042/CS20050243

Published: 17 January 2006

...Malaka B. Jackson; Rexford S. Ahima Obesity is characterized by an increase in adipose tissue mass. Contrary to the previous view of adipose tissue as simply an inert tissue devoted to energy storage, studies over the past decade have shown that adipose tissue is actively involved in regulating...

View articletitled, Neuroendocrine and metabolic effects of adipocyte-derived hormones

Articles

The adipocyte life cycle hypothesis

Jessica Smith, Maha Al-Amri, Prabhakaran Dorairaj, Allan Sniderman

Clin Sci (Lond) (2006) 110 (1): 1–9.

https://doi.org/10.1042/CS20050110

Published: 12 December 2005

... and the position within the life cycle of the organism at which proliferation occurs. The adipocyte life cycle hypothesis posits that the metabolic consequences of obesity depend on whether expansion of adipose tissue is achieved primarily by an increase in adipocyte number or adipocyte size. This hypothesis may...

View articletitled, The adipocyte life cycle hypothesis

Articles

Change in β 1 -adrenergic receptor protein concentration in adipose tissue correlates with diet-induced weight loss

Mads RASMUSSEN, Anita BELZA, Thomas ALMDAL, Søren TOUBRO, Palle BRATHOLM, Arne ASTRUP, Niels J. CHRISTENSEN

Clin Sci (Lond) (2005) 108 (4): 323–329.

https://doi.org/10.1042/CS20040238

Published: 22 March 2005

...Mads RASMUSSEN; Anita BELZA; Thomas ALMDAL; Søren TOUBRO; Palle BRATHOLM; Arne ASTRUP; Niels J. CHRISTENSEN The aim of the present study was to examine gene expression and protein concentrations of β 1 - and β 2 -adrenergic receptors in subcutaneous adipose tissue in obese subjects in response...

View articletitled, Change in β 1 -adrenergic receptor protein concentration in adipose tissue correlates with diet-induced weight loss

Articles

Elevated β2-adrenoceptor protein concentration in adipose tissue from obese subjects is closely related to the body mass index and waist/hip ratio

Mads RASMUSSEN, Thomas ALMDAL, Palle BRATHOLM, Niels Juel CHRISTENSEN

Clin Sci (Lond) (2003) 104 (2): 93–102.

https://doi.org/10.1042/cs1040093

Published: 09 January 2003

...Mads RASMUSSEN; Thomas ALMDAL; Palle BRATHOLM; Niels Juel CHRISTENSEN The aim of the present study was to quantify β 2 -adrenoceptor protein content in adipose tissue during fasting, and to study the relationships between β 2 -adrenoceptor protein and mRNA levels and changes in metabolites related...

View articletitled, Elevated β2-adrenoceptor protein concentration in adipose tissue from obese subjects is closely related to the body mass index and waist/hip ratio

Articles

Predicting composition of leg sections with anthropometry and bioelectrical impedance analysis, using magnetic resonance imaging as reference

N. J. FULLER, C. R. HARDINGHAM, M. GRAVES, N. SCREATON, A. K. DIXON, L. C. WARD, M. ELIA

Clin Sci (Lond) (1999) 96 (6): 647–657.

https://doi.org/10.1042/cs0960647

Published: 11 May 1999

...N. J. FULLER; C. R. HARDINGHAM; M. GRAVES; N. SCREATON; A. K. DIXON; L. C. WARD; M. ELIA Magnetic resonance imaging (MRI) was used to evaluate and compare with anthropometry a fundamental bioelectrical impedance analysis (BIA) method for predicting muscle and adipose tissue composition in the lower...

View articletitled, Predicting composition of leg sections with anthropometry and bioelectrical impedance analysis, using magnetic resonance imaging as reference

Articles

Glucocorticoids and insulin resistance: old hormones, new targets

Robert C. ANDREWS, Brian R. WALKER

Clin Sci (Lond) (1999) 96 (5): 513–523.

https://doi.org/10.1042/cs0960513

Published: 16 April 1999

... human studies that glucocorticoids make an important contribution to the pathophysiology of insulin resistance in the population. Correspondence : Dr Brian R. Walker. The Biochemical Society and the Medical Research Society © 1999 1999 adipose tissue glucocorticoid hormones...

View articletitled, Glucocorticoids and insulin resistance: old hormones, new targets

Articles

Microdialysis of Human Breast Tissue during the Menstrual Cycle

Charlotta Dabrosin, Åse Hallström, Urban Ungerstedt, Mats Hammar

Clin Sci (Lond) (1997) 92 (5): 493–496.

https://doi.org/10.1042/cs0920493

Published: 01 May 1997

... and/or apoptotic activity during this period. However, the data we have obtained cannot yet be fully explained. adipose tissue amino acids breast tissue lactate menstrual cycle microdialysis pyruvate Clinical Science ( I 997) 92,493-496 (Printed in Great Britain) 493 Microdialysis of human breast...

View articletitled, Microdialysis of Human Breast Tissue during the Menstrual Cycle

Articles

Effects of Adrenaline Infusion on the Interstitial Environment of Subcutaneous Adipose Tissue as Studied by Microdialysis

J. S. Samra, E. J. Simpson, M. L. Clark, C. D. Forster, S. M. Humphreys, I. A. MacDonald, K. N. Frayn

Clin Sci (Lond) (1996) 91 (4): 425–430.

https://doi.org/10.1042/cs0910425

Published: 01 October 1996

...J. S. Samra; E. J. Simpson; M. L. Clark; C. D. Forster; S. M. Humphreys; I. A. MacDonald; K. N. Frayn 1. Adrenaline was infused at a rate of 25 ng min −1 kg −1 into seven healthy volunteers and its effects on adipose tissue were studied by microdialysis. 2. Adrenaline infusion led to a rapid rise...

View articletitled, Effects of Adrenaline Infusion on the Interstitial Environment of Subcutaneous Adipose Tissue as Studied by Microdialysis

Articles

Interstitial Glycerol Concentration in Human Skeletal Muscle and Adipose Tissue is Close to the Concentration in Blood

Jaswinder S. Samra, Cate L. Ravell, Sarah L. Giles, Peter Arner, Keith N. Frayn

Clin Sci (Lond) (1996) 90 (6): 453–456.

https://doi.org/10.1042/cs0900453

Published: 01 June 1996

...Jaswinder S. Samra; Cate L. Ravell; Sarah L. Giles; Peter Arner; Keith N. Frayn 1. The suggestion that the interstitial glycerol concentration in both adipose tissue and skeletal muscle is around 3 mmol/l (Maggs DG, Jacob R, Rife F, et al. J Clin Invest 1995; 96: 370–7), rather than close...

View articletitled, Interstitial Glycerol Concentration in Human Skeletal Muscle and Adipose Tissue is Close to the Concentration in Blood

Articles

Total Forearm Blood Flow as an Indicator of Skeletal Muscle Blood Flow: Effect of Subcutaneous Adipose Tissue Blood Flow

E. E. Blaak, M. A. van Baak, G. J. Kemerink, M. T. W. Pakbiers, G. A. K. Heidendal, W. H. M. Saris

Clin Sci (Lond) (1994) 87 (5): 559–566.

https://doi.org/10.1042/cs0870559

Published: 01 November 1994

... is that it only measures total blood flow through a segment of forearm and not the flow through the individual parts such as skin, adipose tissue and muscle. 2. In the present study the contribution of forearm subcutaneous adipose tissue blood flow to total forearm blood flow was evaluated in lean (% body fat...

View articletitled, Total Forearm Blood Flow as an Indicator of Skeletal Muscle Blood Flow: Effect of Subcutaneous Adipose Tissue Blood Flow

Articles

Anti-Tumour Necrosis Factor-α Treatment Interferes with Changes in Lipid Metabolism in a Tumour Cachexia Model

Neus Carbó, Paola Costelli, Luciana Tessitore, Gregory J. Bagby, Francisco J. López-Soriano, Francesco M. Baccino, Josep M. Argilés

Clin Sci (Lond) (1994) 87 (3): 349–355.

https://doi.org/10.1042/cs0870349

Published: 01 September 1994

...Neus Carbó; Paola Costelli; Luciana Tessitore; Gregory J. Bagby; Francisco J. López-Soriano; Francesco M. Baccino; Josep M. Argilés 1. Rats bearing the Yoshida ascites hepatoma AH-130 showed an important decrease in white adipose tissue lipoprotein lipase activity as compared with non-tumour...

View articletitled, Anti-Tumour Necrosis Factor-α Treatment Interferes with Changes in Lipid Metabolism in a Tumour Cachexia Model

Articles

Metabolic Effects of Acute Hyperketonaemia in Man before and during An Hyperinsulinaemic Euglycaemic Clamp

J. Webber, E. Simpson, H. Parkin, I. A. MacDonald

Clin Sci (Lond) (1994) 86 (6): 677–687.

https://doi.org/10.1042/cs0860677

Published: 01 June 1994

... and during an insulin—glucose clamp. Arteriovenous differences were measured across forearm and subcutaneous abdominal adipose tissue. 2. In response to the clamp the respiratory exchange ratio rose from 0.82 to 0.83 during 3-hydroxybutyrate infusion and from 0.83 to 0.94 during control (saline) infusion ( P...

View articletitled, Metabolic Effects of Acute Hyperketonaemia in Man before and during An Hyperinsulinaemic Euglycaemic Clamp

Articles

Interpretation of Oxygen and Carbon Dioxide Exchange across Tissue Beds in vivo

Keith N. Frayn, Patricia Lund, Mark Walker

Clin Sci (Lond) (1993) 85 (4): 373–384.

https://doi.org/10.1042/cs0850373

Published: 01 October 1993

...Keith N. Frayn; Patricia Lund; Mark Walker © 1993 The Biochemical Society and the Medical Research Society 1993 adipose tissue arteriovenous differences carbon dioxide indirect calorimetry muscle oxygen respiratory quotient substrate oxidation Clinical S c i i e (1993) 85, 373...

View articletitled, Interpretation of Oxygen and Carbon Dioxide Exchange across Tissue Beds in vivo

Articles

Effect of Glucocorticosteroid Treatment on β -Adrenoceptor Subtype Function in Adipocytes from Patients with Asthma

Signy Reynisdottir, Hans Wahrenberg, Gunnar Bylin, Peter Arner

Clin Sci (Lond) (1993) 85 (2): 237–244.

https://doi.org/10.1042/cs0850237

Published: 01 August 1993

... and the Medical Research Society 1993 adipose tissue β-adrenoceptors asthma fat cells glucocorticoids lipolysis Clinical Science (1993) 85, 237-244 (Printed in Great Britain) Effect of glucocorticosteroid treatment on p-adrenoceptor subtype function in adipocytes from patients with asthma Signy...

View articletitled, Effect of Glucocorticosteroid Treatment on β -Adrenoceptor Subtype Function in Adipocytes from Patients with Asthma

Articles

Insulin resistance, adipose tissue and coronary heart disease

Keith N. Frayn, Simon W. Coppack

Clin Sci (Lond) (1992) 82 (1): 1–8.

https://doi.org/10.1042/cs0820001

Published: 01 January 1992

...Keith N. Frayn; Simon W. Coppack © 1992 The Biochemical Society and the Medical Research Society 1992 adipose tissue coronary heart disease insulin insulin resistance lipoproteins non-esterified fatty acids triacylglycerol Clinical Science (1992) 82, 1-8 (Printed in Great Britain...

View articletitled, Insulin resistance, adipose tissue and coronary heart disease

Articles

Fat-cell heat production, adipose tissue fatty acids, lipoprotein lipase activity and plasma lipoproteins in adiposis dolorosa

Birger Fagher, Mario Monti, Peter Nilsson-Ehle, Björn Åukesson

Clin Sci (Lond) (1991) 81 (6): 793–798.

https://doi.org/10.1042/cs0810793

Published: 01 December 1991

...Birger Fagher; Mario Monti; Peter Nilsson-Ehle; Björn Åukesson 1. Gluteal adipose tissue was examined in 13 patients with generalized adiposis dolorosa, a clinical condition characterized by painful adiposity with a chronic intractable course. The total metabolic activity of fat cells, isolated...

View articletitled, Fat-cell heat production, adipose tissue fatty acids, lipoprotein lipase activity and plasma lipoproteins in adiposis dolorosa

Articles

Peripheral triacylglycerol extraction in the fasting and post-prandial states

Jennifer L. Potts, Rachel M. Fisher, Sandy M. Humphreys, Simon W. Coppack, Geoffrey F. Gibbons, Keith N. Frayn

Clin Sci (Lond) (1991) 81 (5): 621–626.

https://doi.org/10.1042/cs0810621

Published: 01 November 1991

...Jennifer L. Potts; Rachel M. Fisher; Sandy M. Humphreys; Simon W. Coppack; Geoffrey F. Gibbons; Keith N. Frayn 1. Triacylglycerol extraction by subcutaneous adipose tissue and forearm muscle was studied in nine normal subjects after an overnight fast and after the consumption of a mixed meal. 2...

View articletitled, Peripheral triacylglycerol extraction in the fasting and post-prandial states

Articles

Noradrenaline release in skeletal muscle and in adipose tissue studied by microdialysis

Bo Grønlund, Arne Astrup, Peter Bie, Niels Juel Christensen

Clin Sci (Lond) (1991) 80 (6): 595–598.

https://doi.org/10.1042/cs0800595

Published: 01 June 1991

...Bo Grønlund; Arne Astrup; Peter Bie; Niels Juel Christensen 1. In adipose tissue and in skeletal muscle the extracellular noradrenaline levels were studied by microdialysis in the conscious dog and compared with the noradrenaline concentration in arterial plasma. 2. The experiments were performed...

View articletitled, Noradrenaline release in skeletal muscle and in adipose tissue studied by microdialysis

Articles

Amino acid metabolism in human subcutaneous adipose tissue in vivo

K. N. Frayn, K. Khan, S. W. Coppack, M. Elia

Clin Sci (Lond) (1991) 80 (5): 471–474.

https://doi.org/10.1042/cs0800471

Published: 01 May 1991

...K. N. Frayn; K. Khan; S. W. Coppack; M. Elia 1. Arteriovenous differences for alanine, glutamate and glutamine were measured across subcutaneous adipose tissue and forearm muscle in normal subjects. 2. After an overnight fast, adipose tissue showed net production of alanine and glutamine and uptake...

View articletitled, Amino acid metabolism in human subcutaneous adipose tissue in vivo

Articles

Postprandial Substrate Deposition in Human Forearm and Adipose Tissues in Vivo

S. W. Coppack, R. M. Fisher, G. F. Gibbons, S. M. Humphreys, M. J. McDonough, J. L. Potts, K. N. Frayn

Clin Sci (Lond) (1990) 79 (4): 339–348.

https://doi.org/10.1042/cs0790339

Published: 01 October 1990

...S. W. Coppack; R. M. Fisher; G. F. Gibbons; S. M. Humphreys; M. J. McDonough; J. L. Potts; K. N. Frayn 1. Substrate movements in forearm muscle and subcutaneous adipose tissue were studied, by measurement of arteriovenous differences and blood flow, in seven normal subjects after an overnight fast...

View articletitled, Postprandial Substrate Deposition in Human Forearm and Adipose Tissues in Vivo

Articles

Effects of Insulin on Human Adipose Tissue Metabolism in Vivo

S. W. Coppack, K. N. Frayn, S. M. Humphreys, H. Dhar, T. D. R. Hockaday

Clin Sci (Lond) (1989) 77 (6): 663–670.

https://doi.org/10.1042/cs0770663

Published: 01 December 1989

...S. W. Coppack; K. N. Frayn; S. M. Humphreys; H. Dhar; T. D. R. Hockaday 1. The metabolic effects of insulin on human adipose tissue were studied by combining the euglycaemic clamp technique with measurement of arteriovenous differences across the subcutaneous adipose tissue of the anterior...

View articletitled, Effects of Insulin on Human Adipose Tissue Metabolism in Vivo

Articles

Metabolic characteristics of human adipose tissue in vivo

K. N. Frayn, S. W. Coppack, S. M. Humphreys, P. L. Whyte

Clin Sci (Lond) (1989) 76 (5): 509–516.

https://doi.org/10.1042/cs0760509

Published: 01 May 1989

...K. N. Frayn; S. W. Coppack; S. M. Humphreys; P. L. Whyte 1. A method was developed for sampling the venous drainage from the subcutaneous adipose tissue of the anterior abdominal wall. This is a large depot in many subjects, and seems well suited to such studies as it is completely separated from...

View articletitled, Metabolic characteristics of human adipose tissue in vivo

Articles

Cardiovascular and metabolic responses to low dose adrenaline infusion: an invasive study in humans

U. Freyschuss, P. Hjemdahl, A. Juhlin-Dannfelt, B. Linde

Clin Sci (Lond) (1986) 70 (2): 199–206.

https://doi.org/10.1042/cs0700199

Published: 01 February 1986

... and concentration-dependent increases in stroke volume and cardiac output (thermodilution), as well as decreases in the vascular resistances of the systemic circulation, calf and adipose tissue. These changes were significant from 1.3 nmol/l ADR. Less marked effects were found on blood pressure and heart rate. 3...

View articletitled, Cardiovascular and metabolic responses to low dose adrenaline infusion: an invasive study in humans

Articles

Effects of Acipimox, a Nicotinic Acid Derivative, on Lipolysis in Human Adipose Tissue and on Cholesterol Synthesis in Human Jejunal Mucosa

C. Stirling, M. McAleer, J. P. D. Reckless, R. R. Campbell, D. Mundy, D. J. Betteridge, K. Foster

Clin Sci (Lond) (1985) 68 (1): 83–88.

https://doi.org/10.1042/cs0680083

Published: 01 January 1985

...C. Stirling; M. McAleer; J. P. D. Reckless; R. R. Campbell; D. Mundy; D. J. Betteridge; K. Foster 1. The mode of action of acipimox (5-methyl-pyrazine carboxylic acid 4-oxide), an hypotriglyceridaemic agent, was examined in human adipose tissue and intestinal mucosa. 2. The rates of release...

View articletitled, Effects of Acipimox, a Nicotinic Acid Derivative, on Lipolysis in Human Adipose Tissue and on Cholesterol Synthesis in Human Jejunal Mucosa

Articles

Ephedrine-Induced Thermogenesis in Man: No Role for Interscapular Brown Adipose Tissue

A. Astrup, J. Bülow, N. J. Christensen, J. Madsen

Clin Sci (Lond) (1984) 66 (2): 179–186.

https://doi.org/10.1042/cs0660179

Published: 01 February 1984

... and adipose tissue blood flow were measured before and during ephedrine-induced thermogenesis. 3. The skin and subcutaneous temperatures increased in the interscapular area as well as in the lumbar area, by about 0.7-1.2°C. The interscapular skin temperature remained about 1°C higher than the lumbar...

View articletitled, Ephedrine-Induced Thermogenesis in Man: No Role for Interscapular Brown Adipose Tissue

Articles

Effect of Nicotinic Acid on Acylglycerol Metabolism in Human Adipose Tissue

Peter Arner, Jan östman

Clin Sci (Lond) (1983) 64 (2): 235–237.

https://doi.org/10.1042/cs0640235

Published: 01 February 1983

...Peter Arner; Jan östman 1. The effect of nicotinic acid on the metabolism of acylglycerols was investigated in human adipose tissue incubated with [U- 14 C]-glucose. 2. Nicotinic acid caused a 25% inhibition of the conversion of [U- 14 C]glucose into total lipids of adipose tissue, which was solely...

View articletitled, Effect of Nicotinic Acid on Acylglycerol Metabolism in Human Adipose Tissue

Articles

Importance of the Cyclic AMP Concentration for the Rate of Lipolysis in Human Adipose Tissue

P. Arner, J. Östman

Clin Sci (Lond) (1980) 59 (3): 199–201.

https://doi.org/10.1042/cs0590199

Published: 01 September 1980

...P. Arner; J. Östman 1. The activation of lipolysis on incubation of human subcutaneous adipose tissue was examined in terms of the relationship between the release of glycerol and the concentration of tissue cyclic AMP. 2. A strong positive correlation was obtained between the maximum concentration...

View articletitled, Importance of the Cyclic AMP Concentration for the Rate of Lipolysis in Human Adipose Tissue

Articles

The Esterification of Exogenous Fatty Acids by Adipose Tissue of Hypertriglyceridaemic Subjects with or without Diabetes Mellitus

P. Clifton-Bligh, D. J. Galton

Clin Sci Mol Med (1976) 51 (3): 257–265.

https://doi.org/10.1042/cs0510257

Published: 01 September 1976

... insulin levels were greater in the hypertriglyceridaemic group than in the normotriglyceridaemic group. The difference in esterification rates could have been due to differences in adipocyte size. 4. The esterification of fatty acid in adipose tissue of diabetic patients was lower than in non-diabetic...

View articletitled, The Esterification of Exogenous Fatty Acids by Adipose Tissue of Hypertriglyceridaemic Subjects with or without Diabetes Mellitus

Articles

Lipoprotein Lipase and Hormone-Sensitive Lipase Activities in Human Subcutaneous Lipomas: Comparison with Normal Subcutaneous Adipose Tissue

Y. Giudicelli, R. Pecquery, B. Agli, C. Jamin, J. Quevauvilliers

Clin Sci Mol Med (1976) 50 (4): 315–318.

https://doi.org/10.1042/cs0500315

Published: 01 April 1976

...Y. Giudicelli; R. Pecquery; B. Agli; C. Jamin; J. Quevauvilliers 1. Lipoprotein lipase activity and hormone-sensitive lipase activity were investigated in subcutaneous lipomas removed from two patients and compared with the enzyme activities in subcutaneous adipose tissue from two normal subjects...

View articletitled, Lipoprotein Lipase and Hormone-Sensitive Lipase Activities in Human Subcutaneous Lipomas: Comparison with Normal Subcutaneous Adipose Tissue

Articles

Effect of Nutritional Status on Rat Adipose Tissue, Muscle and Post-Heparin Plasma Clearing Factor Lipase Activities: Their Relationship to Triglyceride Fatty Acid Uptake by Fat-Cells and to Plasma Insulin Concentrations

A. Cryer, Susan E. Riley, E. R. Williams, D. S. Robinson

Clin Sci Mol Med (1976) 50 (3): 213–221.

https://doi.org/10.1042/cs0500213

Published: 01 March 1976

...A. Cryer; Susan E. Riley; E. R. Williams; D. S. Robinson 1. In rats in a variety of nutritional states, the adipose tissue clearing factor lipase activity is strongly, positively correlated with fat-cell triglyceride fatty acid uptake. 2. In the same animals, muscle clearing factor lipase activity...

View articletitled, Effect of Nutritional Status on Rat Adipose Tissue, Muscle and Post-Heparin Plasma Clearing Factor Lipase Activities: Their Relationship to Triglyceride Fatty Acid Uptake by Fat-Cells and to Plasma Insulin Concentrations

Articles

The Effect of Age on Deoxyribonucleic Acid Synthesis in Rat Adipose Tissue

B. M. Lewis, T. M. Hayes

Clin Sci Mol Med (1975) 48 (4): 323–325.

https://doi.org/10.1042/cs0480323

Published: 01 April 1975

... into the deoxyribonucleic acid (DNA) of both fractions was greatest in the 6-week-old animals. Uptake was significantly decreased in 12- and 15-week-old animals and was lowest in 22-week-old rats. 19 11 1974 © 1975 The Biochemical Society and the Medical Research Society 1975 adipose tissue...

View articletitled, The Effect of Age on Deoxyribonucleic Acid Synthesis in Rat Adipose Tissue

Articles

Seasonal Variation of Lipoprotein Lipase Activity in Human Subcutaneous Adipose Tissue

B. Persson

Clin Sci Mol Med (1974) 47 (6): 631–634.

https://doi.org/10.1042/cs0470631

Published: 01 December 1974

...B. Persson 1. In 126 normotriglyceridaemic and in seventy-three hypertriglyceridaemic subjects there was a similar seasonal variation of adipose tissue lipoprotein lipase activity, the lowest activity being noted during the summer months. 2. There was no seasonal variation of the serum triglyceride...

View articletitled, Seasonal Variation of Lipoprotein Lipase Activity in Human Subcutaneous Adipose Tissue

Articles

Fatty Acid Synthesis De Novo in Human Adipose Tissue

R. B. Goldrick, D. J. Galton

Clin Sci Mol Med (1974) 46 (4): 469–479.

https://doi.org/10.1042/cs0460469

Published: 01 April 1974

...R. B. Goldrick; D. J. Galton 1. Homogenates of subcutaneous adipose tissue from obese subjects contained sufficient citrate cleavage enzyme (EC 4.1.3.8: ATP—citrate oxaloacetate lyase), acetyl-CoA carboxylase (EC 6.4.1.2: acetyl-CoA—carbon dioxide ligase) and fatty acid synthetase to account...

View articletitled, Fatty Acid Synthesis De Novo in Human Adipose Tissue

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