... receptor angiotensin II type 1 receptor aldosterone adrenal gland Compound 21 Renin-angiotensin system The biosynthesis of aldosterone, the main mineralocorticoid hormone in the adrenocortical zona glomerulosa [ 1 , 2 ] is tightly controlled by multiple factors, as angiotensin II (Ang II...

... in any medium, provided the original work is properly cited. adrenal gland β-fragment of activated Factor XIIa (β-FXIIa) blood pressure bradykinin haemodynamics vasoconstriction For decades after its initial discovery in 1955, FXIIa (activated Factor XII) was considered exclusively...

...Kenji Mizuno; Motoko Ojima; Shigeatsu Hashimoto; Makio Tani; Susumu Niimura; Nobuyasu Kunii; Ryuji Yabe; Hiroaki Watari; Tadashi Inagami; Soitsu Fukuchi 1. There is increasing evidence which suggests that the adrenal gland contains the renin–angiotensin cycle. The localization of renin has been...

... suggest that the responsiveness to ANG II in these two target tissues is determined by the circulating ANG II level. 3. In the adrenal gland the aldosterone responses to ANG II also were significantly greater after ( P < 0.01) than before captopril (increment at 3 pmol kg −1 min −1 : 660 ± 88 vs 381...

... with controls. 6. The possibility that a reduction in extracellular fluid volume (due to a natriuresis) and/or a peripheral vasodilatation contributed to the antihypertensive effect of KCl loading is discussed. adrenal gland aldosterone corticosterone hypertension plasma volume potassium chloride ©...

... involvement of adrenal and vascular renin in the pathogenesis of hypertension in SHR. © 1982 The Biochemical Society and the Medical Research Society 1982 adrenal gland mesenteric vessels renin spontaneously hypertensive rats ClinicalScience (1982) 63,187s-189s 187s Antibody-sensitive renin...

... slices stimulated by isoprenaline. © 1976 The Biochemical Society and the Medical Research Society 1976 adrenal gland catecholamines electron microscopy juxtaglomerular apparatus kidney radioimmunoassay of angiotensin I vincristine Clinical Science and Molecular Medicine (1976) 51, 93s...

..., the free deoxycorticosterone pool 21 days post-operatively was significantly lower than that in sham-operated control rats and returned to control values at 60 days. © 1976 The Biochemical Society and the Medical Research Society 1976 adrenal gland adrenal regeneration hypertension...

... of kidney renin and of extrarenal tissue iso-renin are similar. 2. Results indicate that tissue iso-renins are part of a complex enzyme system with mainly local function. A possible biological role has been demonstrated in brain, adrenal gland and tissue culture. © 1976 The Biochemical Society...