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Keyword: adrenaline
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Articles
Clin Sci (Lond) (2015) 129 (4): 375-384.
Published: 27 May 2015
... in humans and to characterize the response to an exogenous adrenaline challenge. Repeated blood samples from artery and femoral vein together with blood flow measurements and muscle biopsies were obtained from healthy male volunteers ( n =8) at baseline and during an adrenaline infusion...
Articles
Clin Sci (Lond) (2006) 111 (3): 189-191.
Published: 15 August 2006
... preventing syncope in a double-blind cross-over trial in eight subjects with a diagnosis based on tilt table testing and elevated plasma adrenaline levels during syncope. Of these, seven did not respond and the authors therefore suggest that this drug has no role in the management of vasovagal syncope. Their...
Articles
Clin Sci (Lond) (2006) 111 (3): 209-216.
Published: 15 August 2006
...Basil A. Eldadah; Sandra L. Pechnik; Courtney S. Holmes; Jeffrey P. Moak; Ahmed M. Saleem; David S. Goldstein In patients with neurocardiogenic syncope, head-up tilt often evokes acute loss of consciousness accompanied by vasodilatation, increased plasma adrenaline and systemic hypotension. Since...
Articles
Clin Sci (Lond) (2006) 111 (2): 163-169.
Published: 13 July 2006
... and during both exercise work bouts for measurements of WBC count, leucocyte subset counts, cortisol, adrenaline (epinephrine) and noradrenaline (norepinephrine). WBC, neutrophil and lymphocyte counts increased significantly ( P <0.05) during rest and exercise from SL to PreIAE and decreased ( P...
Articles
Clin Sci (Lond) (2005) 108 (2): 113-119.
Published: 21 January 2005
... monitoring and repeated measurements of FBF (forearm blood flow), arterial and venous concentrations of glucose, catecholamines [EPI (adrenaline) and NE (noradrenaline)], renin, ANG II and aldosterone. EPRO induced an 8–10-fold increase in plasma renin and ANG II concentrations compared with placebo. Plasma...
Articles
Clin Sci (Lond) (2003) 105 (3): 315-322.
Published: 01 September 2003
... adrenaline concentration (from 0.19±0.03 to 1.68±0.32 nmol/l; P <0.001), and a modest 1.3-fold increase in the plasma noradrenaline concentration (from 1.74±0.22 to 2.02±0.19 nmol/l; P <0.05) compared with baseline. Furthermore, we observed significant decreases in diastolic blood pressure (from 68±3...
Articles
Clin Sci (Lond) (2003) 104 (5): 509-520.
Published: 01 May 2003
... insertion/deletion (I/D), β 1 -AR R389G, β 2 -AR G16R and β 2 -AR Q27E] and are associated with modified in vivo and in vitro functionality. We tested their possible effects on the haemodynamic responses to intravenous adrenaline (20, 40, 80 and 160ng/kg of body weight per min; 5min for each infusion rate...
Articles
Clin Sci (Lond) (2001) 100 (3): 283-290.
Published: 30 January 2001
... on the surface of muscle detect changes in muscle capillary (nutritive) flow. With this as background, we examined the effects of insulin and adrenaline (epinephrine), which are both known to increase total leg blood flow, on the LDF signals from scanning and stationary probes on the muscle surface...
Articles
Clin Sci (Lond) (1999) 96 (6): 589-595.
Published: 07 May 1999
... and the Medical Research Society © 1999 1999 adrenaline catecholamines cortisol glucose infarct size myocardial infarction noradrenaline unstable angina 589Clinical Science (1999) 96, 589ñ595 (Printed in Great Britain) Circulating stress hormone and insulin concentrations in acute...
Articles
Clin Sci (Lond) (1999) 96 (6): 549-555.
Published: 28 April 1999
...Carolina GARCIA; Tania C. PITHON-CURI; Maria DE LOURDES FIRMANO; Mariza PIRES DE MELO; Philip NEWSHOLME; Rui CURI Despite the large body of information on the role of corticosteroids in regulating lymphocyte and phagocyte function, the role of the hormone adrenaline in immunoregulation is an under...
Articles
Clin Sci (Lond) (1998) 95 (3): 377-383.
Published: 01 September 1998
... close correlation was also obtained in the present study between lymphocyte noradrenaline and adrenaline and cAMP both in the basal state and after stimulation with isoproterenol ( P < 0.05 to 0.007). 2. Although 99% of the thrombocytes were removed from the LP during the washing procedure, LP...
Articles
Clin Sci (Lond) (1998) 94 (4): 383-393.
Published: 01 April 1998
...Jane M. Thompson; B. Gunnar Wallin; Gavin W. Lambert; Garry L. Jennings; Murray D. Esler 1. Evidence from animal studies indicates that circulating adrenaline may be taken up into sympathetic nerves, facilitating the release of noradrenaline. To test whether adrenaline acts as a co-transmitter in...
Articles
Clin Sci (Lond) (1996) 91 (5): 621-626.
Published: 01 November 1996
... did not differ between young and elderly non-smokers, whereas plasma noradrenaline increased slightly but significantly with age. Physical training did not influence either plasma noradrenaline or adrenaline at rest or cAMP in lymphocytes. 4. In seven elderly long-term smokers cAMP production and the...
Articles
Clin Sci (Lond) (1996) 90 (5): 337-343.
Published: 01 May 1996
... catecholaminergic responses to lower body negative pressure depends on the intensity of the stimulus (−15 versus −40 mmHg). 2. In 14 healthy subjects, responses of forearm blood flow and noradrenaline spillover and of total body noradrenaline and adrenaline spillover were assessed during infusion of [ 3 H...
Articles
Clin Sci (Lond) (1995) 89 (4): 349-357.
Published: 01 October 1995
...Mario Vaz; Andrea Turner; Bronwyn Kingwell; Jaye Chin; Elizabeth Koff; Helen Cox; Garry Jennings; Murray Esler 1. Sympatho-adrenal activity was measured after the consumption of a 3.15 MJ mixed meal. Whole-body noradrenaline spillover rates, forearm plasma noradrenaline spillover and adrenaline...
Articles
Clin Sci (Lond) (1995) 88 (5): 533-542.
Published: 01 May 1995
... from plasma measurements of these metabolites in a number of clinical conditions (hypertension, cardiac failure, bilateral adrenalectomy and X-chromosomal deletions of the gene for monoamine oxidase), and before and during activation of sympathetic outflow or infusions of noradrenaline and adrenaline...
Articles
Clin Sci (Lond) (1995) 88 (4): 439-446.
Published: 01 April 1995
...Kjell Larsson; Per Carlens; Sture Bevegård; Paul Hjemdahl 1. Bronchoconstriction does not seem to be a stimulus for sympathoadrenal activation, as judged by venous plasma concentrations of noradrenaline, adrenaline or neuropeptide Y-like immunoreactivity. However, venous measurements have...
Articles
Clin Sci (Lond) (1995) 88 (3): 269-275.
Published: 01 March 1995
...Valentine C. Menys; Philip R. Belcher; Mark I. M. Noble; George E. Drossos; Ravi Pillai; Steve Westaby 1. We tested the effect of intravenous adrenaline at 0.55–1.10 nmol min −1 kg −1 (for 3–8 min, at 7–10 min post bypass; n = 7) on both microaggregation in hirudinized whole blood, using platelet...
Articles
Clin Sci (Lond) (1994) 87 (1): 69-74.
Published: 01 July 1994
... between the groups either during fasting (post-obese women 0.08 ± 0.01 ng/ml versus control women 0.10 ± 0.01 ng/ml) or in the significant postprandial increase ( P < 0.001). The plasma adrenaline concentration increased significantly during sham-feeding in the control group from 0.024 ± 0.004 ng/ml to...
Articles
Clin Sci (Lond) (1994) 86 (1): 35-41.
Published: 01 January 1994
... stress. 2. To assess the biological variability within individuals, ten subjects were sampled on five occasions over 8–30 h. The intra-individual coefficients of variation for plasma and platelet noradrenaline levels were 193 +10% and 9.5 +4.2%, respectively, and for plasma and platelet adrenaline levels...
Articles
Clin Sci (Lond) (1993) 85 (5): 577-583.
Published: 01 November 1993
...N. Håkan Wallén; Claes Held; Nina Rehnqvist; Paul Hjemdahl 1. The impact of oral acetylsalicylic acid treatment on the enhancing effect of adrenaline on platelet aggregation in vitro was investigated in patients with stable angina pectoris. In addition, the influence of different anticoagulants...
Articles
Clin Sci (Lond) (1993) 84 (2): 201-207.
Published: 01 February 1993
...G. D. Braatvedt; M. D. Flynn; A. Stanners; M. Halliwell; R. J. M. Corrall 1. Superior mesenteric artery blood flow was examined by Doppler ultrasound in six male subjects aged 19–23 years during the infusion of saline (control), 10 and 40 ng of adrenaline min −1 kg −1 for 30 min, or propranolol and...
Articles
Clin Sci (Lond) (1992) 83 (2): 191-198.
Published: 01 August 1992
...Manfred J. Müller; Olaf Willmann; Andrea Fenk; Annette Rieger; Oliver Selberg; Helmut Canzler; Alexander von zur Mühlen; Friedrich W. Schmidt 1. Resting energy expenditure and the metabolic responses to adrenaline (infusion rate: 0.03 μg min −1 kg −1 fat-free mass for 1 h) were investigated in 25...
Articles
Clin Sci (Lond) (1992) 82 (4): 369-376.
Published: 01 April 1992
...P. T. Larsson; N. H. Wallén; N. Egberg; P. Hjemdahl 1. The effects of phentolamine (500 μg/min) on platelet aggregability in vivo at rest and during adrenaline infusion were assessed by ex vivo filtragometry and measurements of plasma β-thromboglobulin levels in 10 healthy male subjects. Plasma...
Articles
Clin Sci (Lond) (1992) 82 (1): 113-116.
Published: 01 January 1992
... higher in both treated and untreated hypercholesterolaemic patients than in normal subjects. Adrenaline concentrations did not differ. 3. Platelet noradrenaline levels were higher in untreated hypercholesterolaemic patients than in normal subjects. 4. Positive correlations between the plasma...
Articles
Clin Sci (Lond) (1992) 82 (1): 77-83.
Published: 01 January 1992
... 1991 © 1992 The Biochemical Society and the Medical Research Society 1992 adrenaline dobutamine infusion energy expenditure free fatty acids glucose glycerol noradrenaline respiratory exchange ratio Clinical Science (1992) 82,77-83 (Printed in Great Britain) 77 Metabolic effects...
Articles
Clin Sci (Lond) (1991) 80 (3): 227-233.
Published: 01 March 1991
...Alastair J. McCance; J. Colin Forfar 1. To investigate the possible role of adrenaline as a modulator of noradrenaline release from the sympathetic nervous system, the responses of cardiac and whole-body noradrenaline kinetics to intravenous infusions of adrenaline (30 ng min −1 kg −1 ) and...
Articles
Clin Sci (Lond) (1990) 79 (2): 155-159.
Published: 01 August 1990
... long-term oxygen therapy, although the mechanism of this response is unknown. 2. To evaluate the effects of transient hypoxaemia on plasma adrenaline and noradrenaline levels, we studied eight oxygen-dependent patients who underwent either a 4 h period of oxygen withdrawal or their routine therapy, in...
Articles
Clin Sci (Lond) (1989) 77 (6): 611-616.
Published: 01 December 1989
... skeletal muscle was investigated. Healthy volunteers were given a 6 h infusion of adrenaline ( n = 8), Cortisol ( n = 8), a triple-hormone combination of adrenaline, Cortisol and glucagon ( n = 8), or saline ( n = 8) 2. The total ribosome concentration declined by 30.4 ± 7.2% in the triple-hormone group...
Articles
Clin Sci (Lond) (1989) 77 (2): 149-155.
Published: 01 August 1989
...J. Hilsted; N. J. Christensen; S. Larsen 1. The effect of intravenous catecholamine infusions and of intravenous insulin on plasma volume and intravascular mass of albumin was investigated in healthy males. 2. Physiological doses of adrenaline (0.5 μg/min and 3 μg/min) increased peripheral venous...
Articles
Clin Sci (Lond) (1989) 76 (6): 625-630.
Published: 01 June 1989
... naloxone. We have therefore investigated the actions of saline placebo and increasing bolus doses of intravenous naloxone (25, 100 and 250 μg/kg) on the plasma noradrenaline, adrenaline, adrenocorticotrophin (ACTH) and cortisol responses to a cold-pressor test in six males and two females in a double-blind...
Articles
Clin Sci (Lond) (1989) 76 (3): 255-260.
Published: 01 March 1989
...Å. Wennmalm; E. Karwatowska-Prokopczuk; M. Wennmalm 1. Methylxanthines have been shown to elevate the basal plasma level and/or urinary excretion of noradrenaline (NA) and adrenaline (ADR) in healthy subjects. The present study addressed the hypothesis that the methylxanthine aminophylline also...
Articles
Clin Sci (Lond) (1988) 75 (4): 389-394.
Published: 01 October 1988
...I. W. Fellows; I. A. MacDonald; T. Bennett; D. P. O'Donoghue 1. On two separate occasions, at least 1 week apart, seven young healthy male subjects received intravenous infusions of either adrenaline [0.27 nmol (50 ng) min −1 kg −1 ] or saline (154 mmol/l NaCl), plus ascorbic acid (5.68 mmol/l...
Articles
Clin Sci (Lond) (1988) 75 (3): 285-291.
Published: 01 September 1988
... sustained effects after the termination of the isoprenaline infusions, as has been observed previously after the infusion of adrenaline. 2. The isoprenaline infusions produced dose-dependent increases in heart rate, systolic blood pressure and metabolic rate, but similar increases in calf blood flow and...
Articles
Clin Sci (Lond) (1988) 74 (4): 397-401.
Published: 01 April 1988
... increased skeletal muscle blood flow and/or intracellular acidosis. 15 9 1987 1 10 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 adrenaline arrhythmia noradrenaline potassium Clinical Science (1988) 74, 397-401 397 Rapid changes in plasma potassium...
Articles
Clin Sci (Lond) (1988) 74 (4): 347-350.
Published: 01 April 1988
...B. J. Robinson; R. H. Johnson 1. Syncopal or near syncopal episodes have been observed in five subjects who stood or were tilted and in whom blood samples were being taken. 2. In all subjects bradycardia and hypotension developed before the onset of symptoms. Increases in plasma adrenaline...
Articles
Clin Sci (Lond) (1987) 73 (4): 411-416.
Published: 01 October 1987
... control drink there was no evidence from measurements of circulating adrenaline, noradrenaline, Cortisol, aldosterone or renin of activation of the sympathoadrenal axis, adrenal cortex or renin–angiotensin systems after alcohol. 31 3 1987 21 4 1987 © 1970 The Biochemical Society and the...
Articles
Clin Sci (Lond) (1987) 73 (2): 135-141.
Published: 01 August 1987
... I showed a greater increase in plasma noradrenaline and adrenaline ( P < 0.05). On multivariate analysis, those with lower systolic blood pressure, better renal function and more reactive sympathetic nervous system were discriminated as group I. 5. These data suggest that group I patients have...
Articles
Clin Sci (Lond) (1987) 73 (1): 99-103.
Published: 01 July 1987
... aggregation in response to adenosine 5′-pyrophosphate, thrombin, adrenaline and collagen. Platelet sensitivity to prostacyclin was also examined. 3. Platelet noradrenaline showed a positive correlation with extent of aggregation induced by ‘low-dose’ collagen (1 μg/ml). No correlation was seen at the higher...
Articles
Clin Sci (Lond) (1987) 72 (1): 135-138.
Published: 01 January 1987
... insulin-induced hypoglycaemia stress tests. 2. The effects of l -adrenaline infusions, sufficient to achieve pathophysiological levels of adrenaline, and of therapeutic intravenous infusions of salbutamol, a β 2 -agonist, on plasma magnesium, plasma potassium, plasma glucose and plasma insulin levels were...
Articles
Clin Sci (Lond) (1986) 71 (5): 621-624.
Published: 01 November 1986
...), vasopressin (aVP) and adrenaline. 3. During nausea plasma aVP concentrations rose from median values of 0.4 pg/ml (at time 0) to 76 pg/ml at peak nausea and fell to 32 pg/ml 20 min later. Adrenaline rose from 0.36 to 0.91 nmol/l ( P < 0.05) before falling to 0.55 nmol/l. 4. During nausea, FVIIIC rose from...
Articles
Clin Sci (Lond) (1986) 71 (1): 31-39.
Published: 01 July 1986
... supplied, then only 9% (31–22%) of the glucose can be accounted for by adaptive thermogenesis. 19 9 1986 3 2 1986 © 1986 The Biochemical Society and the Medical Research Society 1986 adrenaline glucose intravenous nutrition thermogenesis ClinicalScience(1986) 71,31-39 31...
Articles
Clin Sci (Lond) (1986) 71 (1): 111-115.
Published: 01 July 1986
... hypertension in the human. We describe the results of two studies involving women who developed hypertension during pregnancy. 2. In the first study, plasma concentrations of noradrenaline and adrenaline were measured in 17 women with pregnancy induced hypertension (PIH) and 17 normotensive pregnant control...
Articles
Clin Sci (Lond) (1986) 70 (5): 495-500.
Published: 01 May 1986
... irreversible aggregation with 10 μmol/l ADP and 0.3 unit of thrombin/ml, extents of aggregation being 27% and 76% respectively. 3. ADP (10μmol/l) increased noradrenaline release to the medium by 20% and adrenaline by 28%. As observed with aggregation, 0.3 unit of thrombin/ml produced a more marked effect on...
Articles
Clin Sci (Lond) (1986) 70 (4): 347-352.
Published: 01 April 1986
...K. E. Berkin; G. C. Inglis; S. G. Ball; N. C. Thomson 1. Airway, cardiovascular and metabolic responses were measured in six asthmatic patients with stable asthma during separate adrenaline, noradrenaline and control infusions. Four incremental infusion rates (4, 10, 25 and 62.5 ng min −1 kg −1...
Articles
Clin Sci (Lond) (1986) 70 (2): 199-206.
Published: 01 February 1986
...U. Freyschuss; P. Hjemdahl; A. Juhlin-Dannfelt; B. Linde 1. Cardiovascular and metabolic responses to intravenous infusions of adrenaline (ADR), which raised arterial plasma ADR in a stepwise fashion from 0.3 to 1.3, 2.3 and 6.0 nmol/l, were studied in 11 healthy volunteers. 2. ADR evoked marked...
Articles
Clin Sci (Lond) (1985) 69 (4): 483-492.
Published: 01 October 1985
... to β-adrenoceptor stimulation was also determined in each subject by measurement of heart rate responses to bolus injections of isoprenaline. 2. Both periods of mental stress were associated with significant increases in systolic and diastolic blood pressures, heart rate and plasma adrenaline, but...
Articles
Clin Sci (Lond) (1985) 69 (3): 365-368.
Published: 01 September 1985
... performance liquid chromatography coupled to electrochemical detection. 2. Cold stimulation induced significant elevations in plasma noradrenaline and adrenaline to reach mean peak levels 61% and 108% above their respective basal levels ( P < 0.05). Systolic blood pressure increased by 23 ± 6.5 mmHg ( P...
Articles
Clin Sci (Lond) (1985) 69 (2): 215-222.
Published: 01 August 1985
...I. W. Fellows; T. Bennett; I. A. Macdonald 1. On three separate occasions, at least 1 week apart, seven young healthy male subjects received intravenous infusions of either adrenaline, 50 ng min −1 kg −1 (high A), adrenaline, 10 ng min −1 kg −1 (low A) or sodium chloride solution (saline :154 mmol...
Articles
Clin Sci (Lond) (1985) 68 (6): 621-624.
Published: 01 June 1985
...Jens H. Henriksen; Jens Kastrup; Niels Juel Christensen 1. Plasma noradrenaline and adrenaline concentrations were measured in ten subjects before, during and after intravenous infusion of angiotensin II (ANG II) in order to determine the sympathoadrenal response of ANG II challenge in man. In five...