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Articles

Lactate kinetics and mitochondrial respiration in skeletal muscle of healthy humans under influence of adrenaline

Jonathan Grip, Towe Jakobsson, Christina Hebert, Maria Klaude, Gustaf Sandström, Jan Wernerman, Olav Rooyackers
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (4): 375–384.
https://doi.org/10.1042/CS20140448
Published: 27 May 2015
... in humans and to characterize the response to an exogenous adrenaline challenge. Repeated blood samples from artery and femoral vein together with blood flow measurements and muscle biopsies were obtained from healthy male volunteers ( n =8) at baseline and during an adrenaline infusion. Concentrations...
View articletitled, Lactate kinetics and mitochondrial respiration in skeletal muscle of healthy humans under influence of adrenaline
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Articles

β-Adrenergic receptor blockers and the treatment of vasovagal syncope: more nails in the coffin!

Christopher J. Mathias
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (3): 189–191.
https://doi.org/10.1042/CS20060174
Published: 15 August 2006
... in preventing syncope in a double-blind cross-over trial in eight subjects with a diagnosis based on tilt table testing and elevated plasma adrenaline levels during syncope. Of these, seven did not respond and the authors therefore suggest that this drug has no role in the management of vasovagal syncope...
View articletitled, β-Adrenergic receptor blockers and the treatment of vasovagal syncope: more nails in the coffin!
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Articles

Failure of propranolol to prevent tilt-evoked systemic vasodilatation, adrenaline release and neurocardiogenic syncope

Basil A. Eldadah, Sandra L. Pechnik, Courtney S. Holmes, Jeffrey P. Moak, Ahmed M. Saleem, David S. Goldstein
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (3): 209–216.
https://doi.org/10.1042/CS20060017
Published: 15 August 2006
...Basil A. Eldadah; Sandra L. Pechnik; Courtney S. Holmes; Jeffrey P. Moak; Ahmed M. Saleem; David S. Goldstein In patients with neurocardiogenic syncope, head-up tilt often evokes acute loss of consciousness accompanied by vasodilatation, increased plasma adrenaline and systemic hypotension. Since...
View articletitled, Failure of propranolol to prevent tilt-evoked systemic vasodilatation, adrenaline release and neurocardiogenic syncope
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Articles

White blood cell and hormonal responses to 4300 m altitude before and after intermittent altitude exposure

Beth A. Beidleman, Stephen R. Muza, Charles S. Fulco, Allen Cymerman, Janet E. Staab, Michael N. Sawka, Steven F. Lewis, Gary S. Skrinar
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (2): 163–169.
https://doi.org/10.1042/CS20060012
Published: 13 July 2006
... both exercise work bouts for measurements of WBC count, leucocyte subset counts, cortisol, adrenaline (epinephrine) and noradrenaline (norepinephrine). WBC, neutrophil and lymphocyte counts increased significantly ( P <0.05) during rest and exercise from SL to PreIAE and decreased ( P <0.05...
View articletitled, White blood cell and hormonal responses to 4300 m altitude before and after intermittent altitude exposure
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Articles

Effect of eprosartan on catecholamines and peripheral haemodynamics in subjects with insulin-induced hypoglycaemia

Marina CHRISTENSEN, Hans IBSEN, René WORCK
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (2): 113–119.
https://doi.org/10.1042/CS20040094
Published: 21 January 2005
... monitoring and repeated measurements of FBF (forearm blood flow), arterial and venous concentrations of glucose, catecholamines [EPI (adrenaline) and NE (noradrenaline)], renin, ANG II and aldosterone. EPRO induced an 8–10-fold increase in plasma renin and ANG II concentrations compared with placebo. Plasma...
View articletitled, Effect of eprosartan on catecholamines and peripheral haemodynamics in subjects with insulin-induced hypoglycaemia
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Articles

Effects of euglycaemic and hypoglycaemic hyperinsulinaemia on sympathetic and parasympathetic regulation of haemodynamics in healthy subjects

Tomi LAITINEN, Hanna HUOPIO, Ilkka VAUHKONEN, Cyril CAMARO, Juha HARTIKAINEN, Markku LAAKSO, Leo NISKANEN
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (3): 315–322.
https://doi.org/10.1042/CS20030079
Published: 01 September 2003
... contour method. Euglycaemic hyperinsulinaemia did not change plasma catecholamine concentrations, HRV, BPV, BRS, heart rate, blood pressure, stroke volume, cardiac output or peripheral resistance. However, hyperinsulinaemic hypoglycaemia resulted in an 11.7-fold increase in the plasma adrenaline...
View articletitled, Effects of euglycaemic and hypoglycaemic hyperinsulinaemia on sympathetic and parasympathetic regulation of haemodynamics in healthy subjects
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Articles

Effects of common polymorphisms in the α1A-, α2B-, β1- and β2-adrenoreceptors on haemodynamic responses to adrenaline

Amir SNAPIR, Juha KOSKENVUO, Jyri TOIKKA, Marju ORHO-MELANDER, Susanna HINKKA, Markku SARASTE, Jaakko HARTIALA, Mika SCHEININ
Journal: Clinical Science
Clin Sci (Lond) (2003) 104 (5): 509–520.
https://doi.org/10.1042/CS20020299
Published: 01 May 2003
... insertion/deletion (I/D), β 1 -AR R389G, β 2 -AR G16R and β 2 -AR Q27E] and are associated with modified in vivo and in vitro functionality. We tested their possible effects on the haemodynamic responses to intravenous adrenaline (20, 40, 80 and 160ng/kg of body weight per min; 5min for each infusion rate...
View articletitled, Effects of common polymorphisms in the α1A-, α2B-, β1- and β2-adrenoreceptors on haemodynamic responses to adrenaline
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Articles

Insulin stimulates laser Doppler signal by rat muscle in vivo, consistent with nutritive flow recruitment

Andrew D. H. CLARK, Eugene J. BARRETT, Stephen RATTIGAN, Michelle G. WALLIS, Michael G. CLARK
Journal: Clinical Science
Clin Sci (Lond) (2001) 100 (3): 283–290.
https://doi.org/10.1042/cs1000283
Published: 30 January 2001
... on the surface of muscle detect changes in muscle capillary (nutritive) flow. With this as background, we examined the effects of insulin and adrenaline (epinephrine), which are both known to increase total leg blood flow, on the LDF signals from scanning and stationary probes on the muscle surface in vivo...
View articletitled, Insulin stimulates laser Doppler signal by rat muscle in vivo, consistent with nutritive flow recruitment
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Articles

Circulating stress hormone and insulin concentrations in acute coronary syndromes: identification of insulin resistance on admission

Peter J. STUBBS, John LAYCOCK, J. ALAGHBAND-ZADEH, G. CARTER, Mark I. M. NOBLE
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (6): 589–595.
https://doi.org/10.1042/cs0960589
Published: 07 May 1999
... and the Medical Research Society © 1999 1999 adrenaline catecholamines cortisol glucose infarct size myocardial infarction noradrenaline unstable angina 589Clinical Science (1999) 96, 589ñ595 (Printed in Great Britain) Circulating stress hormone and insulin concentrations in acute coronary...
View articletitled, Circulating stress hormone and insulin concentrations in acute coronary syndromes: identification of insulin resistance on admission
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Articles

Effects of adrenaline on glucose and glutamine metabolism and superoxide production by rat neutrophils

Carolina GARCIA, Tania C. PITHON-CURI, Maria DE LOURDES FIRMANO, Mariza PIRES DE MELO, Philip NEWSHOLME, Rui CURI
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (6): 549–555.
https://doi.org/10.1042/cs0960549
Published: 28 April 1999
...Carolina GARCIA; Tania C. PITHON-CURI; Maria DE LOURDES FIRMANO; Mariza PIRES DE MELO; Philip NEWSHOLME; Rui CURI Despite the large body of information on the role of corticosteroids in regulating lymphocyte and phagocyte function, the role of the hormone adrenaline in immunoregulation is an under...
View articletitled, Effects of adrenaline on glucose and glutamine metabolism and superoxide production by rat neutrophils
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Articles

Regulation of cAMP in a lymphocyte preparation isolated from peripheral venous blood in human subjects: the significance of residual thrombocytes, noradrenaline and prostaglandins

Susanne B. SØNDERGAARD, Jens H. KNUDSEN, Niels J. CHRISTENSEN
Journal: Clinical Science
Clin Sci (Lond) (1998) 95 (3): 377–383.
https://doi.org/10.1042/cs0950377
Published: 01 September 1998
.... A close correlation was also obtained in the present study between lymphocyte noradrenaline and adrenaline and cAMP both in the basal state and after stimulation with isoproterenol ( P < 0.05 to 0.007). 2. Although 99% of the thrombocytes were removed from the LP during the washing procedure, LP...
View articletitled, Regulation of cAMP in a lymphocyte preparation isolated from peripheral venous blood in human subjects: the significance of residual thrombocytes, noradrenaline and prostaglandins
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Articles

Human Muscle Sympathetic Activity and Cardiac Catecholamine Spillover: No Support for Augmented Sympathetic Noradrenaline Release by Adrenaline Co-Transmission

Jane M. Thompson, B. Gunnar Wallin, Gavin W. Lambert, Garry L. Jennings, Murray D. Esler
Journal: Clinical Science
Clin Sci (Lond) (1998) 94 (4): 383–393.
https://doi.org/10.1042/cs0940383
Published: 01 April 1998
...Jane M. Thompson; B. Gunnar Wallin; Gavin W. Lambert; Garry L. Jennings; Murray D. Esler 1. Evidence from animal studies indicates that circulating adrenaline may be taken up into sympathetic nerves, facilitating the release of noradrenaline. To test whether adrenaline acts as a co-transmitter...
View articletitled, Human Muscle Sympathetic Activity and Cardiac Catecholamine Spillover: No Support for Augmented Sympathetic Noradrenaline Release by Adrenaline Co-Transmission
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Articles

Lymphocyte cAMP and Ageing: Significance of Subset Composition, Plasma Noradrenaline, Regular Physical Training and Long-Term Smoking

J. H. Knudsen, F. Gustafsson, J. Toft, N. J. Christensen
Journal: Clinical Science
Clin Sci (Lond) (1996) 91 (5): 621–626.
https://doi.org/10.1042/cs0910621
Published: 01 November 1996
... did not differ between young and elderly non-smokers, whereas plasma noradrenaline increased slightly but significantly with age. Physical training did not influence either plasma noradrenaline or adrenaline at rest or cAMP in lymphocytes. 4. In seven elderly long-term smokers cAMP production...
View articletitled, Lymphocyte cAMP and Ageing: Significance of Subset Composition, Plasma Noradrenaline, Regular Physical Training and Long-Term Smoking
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Articles

Differential Effects of Low- and High-Intensity Lower Body Negative Pressure on Noradrenaline and Adrenaline Kinetics in Humans

Marie-Cecile Jacobs, David S. Goldstein, Jacques J. Willemsen, Paul Smits, Theo Thien, Jacques W. M. Lenders
Journal: Clinical Science
Clin Sci (Lond) (1996) 90 (5): 337–343.
https://doi.org/10.1042/cs0900337
Published: 01 May 1996
... of catecholaminergic responses to lower body negative pressure depends on the intensity of the stimulus (−15 versus −40 mmHg). 2. In 14 healthy subjects, responses of forearm blood flow and noradrenaline spillover and of total body noradrenaline and adrenaline spillover were assessed during infusion of [ 3 H...
View articletitled, Differential Effects of Low- and High-Intensity Lower Body Negative Pressure on Noradrenaline and Adrenaline Kinetics in Humans
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Articles

Postprandial Sympatho-Adrenal Activity: Its Relation to Metabolic and Cardiovascular Events and to Changes in Meal Frequency

Mario Vaz, Andrea Turner, Bronwyn Kingwell, Jaye Chin, Elizabeth Koff, Helen Cox, Garry Jennings, Murray Esler
Journal: Clinical Science
Clin Sci (Lond) (1995) 89 (4): 349–357.
https://doi.org/10.1042/cs0890349
Published: 01 October 1995
...Mario Vaz; Andrea Turner; Bronwyn Kingwell; Jaye Chin; Elizabeth Koff; Helen Cox; Garry Jennings; Murray Esler 1. Sympatho-adrenal activity was measured after the consumption of a 3.15 MJ mixed meal. Whole-body noradrenaline spillover rates, forearm plasma noradrenaline spillover and adrenaline...
View articletitled, Postprandial Sympatho-Adrenal Activity: Its Relation to Metabolic and Cardiovascular Events and to Changes in Meal Frequency
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Articles

Plasma Metadrenalines: Do they Provide Useful Information about Sympatho-Adrenal Function and Catecholamine Metabolism?

Graeme Eisenhofer, Peter Friberg, Karel Pacak, David S. Goldstein, Dennis L. Murphy, Constantine Tsigos, Arshed A. Quyyumi, Han G. Brunner, Jacques W. M. Lenders
Journal: Clinical Science
Clin Sci (Lond) (1995) 88 (5): 533–542.
https://doi.org/10.1042/cs0880533
Published: 01 May 1995
... from plasma measurements of these metabolites in a number of clinical conditions (hypertension, cardiac failure, bilateral adrenalectomy and X-chromosomal deletions of the gene for monoamine oxidase), and before and during activation of sympathetic outflow or infusions of noradrenaline and adrenaline...
View articletitled, Plasma Metadrenalines: Do they Provide Useful Information about Sympatho-Adrenal Function and Catecholamine Metabolism?
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Articles

Sympathoadrenal Responses to Bronchoconstriction in Asthma: An Invasive and Kinetic Study of Plasma Catecholamines

Kjell Larsson, Per Carlens, Sture Bevegård, Paul Hjemdahl
Journal: Clinical Science
Clin Sci (Lond) (1995) 88 (4): 439–446.
https://doi.org/10.1042/cs0880439
Published: 01 April 1995
...Kjell Larsson; Per Carlens; Sture Bevegård; Paul Hjemdahl 1. Bronchoconstriction does not seem to be a stimulus for sympathoadrenal activation, as judged by venous plasma concentrations of noradrenaline, adrenaline or neuropeptide Y-like immunoreactivity. However, venous measurements have...
View articletitled, Sympathoadrenal Responses to Bronchoconstriction in Asthma: An Invasive and Kinetic Study of Plasma Catecholamines
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Articles

Impaired Platelet Aggregation after Cardiopulmonary Bypass in Man: Enhancement of Collagen-Induced Aggregation in whole Blood and Plasma by Adrenaline Ex Vivo

Valentine C. Menys, Philip R. Belcher, Mark I. M. Noble, George E. Drossos, Ravi Pillai, Steve Westaby
Journal: Clinical Science
Clin Sci (Lond) (1995) 88 (3): 269–275.
https://doi.org/10.1042/cs0880269
Published: 01 March 1995
...Valentine C. Menys; Philip R. Belcher; Mark I. M. Noble; George E. Drossos; Ravi Pillai; Steve Westaby 1. We tested the effect of intravenous adrenaline at 0.55–1.10 nmol min −1 kg −1 (for 3–8 min, at 7–10 min post bypass; n = 7) on both microaggregation in hirudinized whole blood, using platelet...
View articletitled, Impaired Platelet Aggregation after Cardiopulmonary Bypass in Man: Enhancement of Collagen-Induced Aggregation in whole Blood and Plasma by Adrenaline Ex Vivo
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Articles

Plasma Adrenaline Concentration is Lower in Post-Obese than in Never-Obese Women in the Basal State, in Response to Sham-Feeding and after Food Intake

H. Bryde Andersen, A. Raben, A. Astrup, N. Juel Christensen
Journal: Clinical Science
Clin Sci (Lond) (1994) 87 (1): 69–74.
https://doi.org/10.1042/cs0870069
Published: 01 July 1994
... between the groups either during fasting (post-obese women 0.08 ± 0.01 ng/ml versus control women 0.10 ± 0.01 ng/ml) or in the significant postprandial increase ( P < 0.001). The plasma adrenaline concentration increased significantly during sham-feeding in the control group from 0.024 ± 0.004 ng/ml...
View articletitled, Plasma Adrenaline Concentration is Lower in Post-Obese than in Never-Obese Women in the Basal State, in Response to Sham-Feeding and after Food Intake
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Articles

Platelet Catecholamine Concentrations after Short-Term Stress in Normal Subjects

E. Carstensen, John S. Yudkin
Journal: Clinical Science
Clin Sci (Lond) (1994) 86 (1): 35–41.
https://doi.org/10.1042/cs0860035
Published: 01 January 1994
... stress. 2. To assess the biological variability within individuals, ten subjects were sampled on five occasions over 8–30 h. The intra-individual coefficients of variation for plasma and platelet noradrenaline levels were 193 +10% and 9.5 +4.2%, respectively, and for plasma and platelet adrenaline levels...
View articletitled, Platelet Catecholamine Concentrations after Short-Term Stress in Normal Subjects
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Articles

Impact of Treatment with Acetylsalicylic Acid on the Proaggregatory Effects of Adrenaline in vitro in Patients with Stable Angina Pectoris: Influence of the Anticoagulant

N. Håkan Wallén, Claes Held, Nina Rehnqvist, Paul Hjemdahl
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (5): 577–583.
https://doi.org/10.1042/cs0850577
Published: 01 November 1993
...N. Håkan Wallén; Claes Held; Nina Rehnqvist; Paul Hjemdahl 1. The impact of oral acetylsalicylic acid treatment on the enhancing effect of adrenaline on platelet aggregation in vitro was investigated in patients with stable angina pectoris. In addition, the influence of different anticoagulants...
View articletitled, Impact of Treatment with Acetylsalicylic Acid on the Proaggregatory Effects of Adrenaline in vitro in Patients with Stable Angina Pectoris: Influence of the Anticoagulant
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Articles

Splanchnic blood flow in man: evidence for mediation via a β -adrenergic mechanism

G. D. Braatvedt, M. D. Flynn, A. Stanners, M. Halliwell, R. J. M. Corrall
Journal: Clinical Science
Clin Sci (Lond) (1993) 84 (2): 201–207.
https://doi.org/10.1042/cs0840201
Published: 01 February 1993
...G. D. Braatvedt; M. D. Flynn; A. Stanners; M. Halliwell; R. J. M. Corrall 1. Superior mesenteric artery blood flow was examined by Doppler ultrasound in six male subjects aged 19–23 years during the infusion of saline (control), 10 and 40 ng of adrenaline min −1 kg −1 for 30 min, or propranolol...
View articletitled, Splanchnic blood flow in man: evidence for mediation via a β -adrenergic mechanism
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Articles

Resting energy expenditure and the thermic effect of adrenaline in patients with liver cirrhosis

Manfred J. Müller, Olaf Willmann, Andrea Fenk, Annette Rieger, Oliver Selberg, Helmut Canzler, Alexander von zur Mühlen, Friedrich W. Schmidt
Journal: Clinical Science
Clin Sci (Lond) (1992) 83 (2): 191–198.
https://doi.org/10.1042/cs0830191
Published: 01 August 1992
...Manfred J. Müller; Olaf Willmann; Andrea Fenk; Annette Rieger; Oliver Selberg; Helmut Canzler; Alexander von zur Mühlen; Friedrich W. Schmidt 1. Resting energy expenditure and the metabolic responses to adrenaline (infusion rate: 0.03 μg min −1 kg −1 fat-free mass for 1 h) were investigated in 25...
View articletitled, Resting energy expenditure and the thermic effect of adrenaline in patients with liver cirrhosis
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Articles

α -Adrenoceptor blockade by phentolamine inhibits adrenaline-induced platelet activation in vivo without affecting resting measurements

P. T. Larsson, N. H. Wallén, N. Egberg, P. Hjemdahl
Journal: Clinical Science
Clin Sci (Lond) (1992) 82 (4): 369–376.
https://doi.org/10.1042/cs0820369
Published: 01 April 1992
...P. T. Larsson; N. H. Wallén; N. Egberg; P. Hjemdahl 1. The effects of phentolamine (500 μg/min) on platelet aggregability in vivo at rest and during adrenaline infusion were assessed by ex vivo filtragometry and measurements of plasma β-thromboglobulin levels in 10 healthy male subjects. Plasma...
View articletitled, α -Adrenoceptor blockade by phentolamine inhibits adrenaline-induced platelet activation in vivo without affecting resting measurements
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Articles

Plasma and platelet free catecholamine concentrations in patients with familial hypercholesterolaemia

C. C. T. Smith, B. N. C. Prichard, D. J. Betteridge
Journal: Clinical Science
Clin Sci (Lond) (1992) 82 (1): 113–116.
https://doi.org/10.1042/cs0820113
Published: 01 January 1992
... higher in both treated and untreated hypercholesterolaemic patients than in normal subjects. Adrenaline concentrations did not differ. 3. Platelet noradrenaline levels were higher in untreated hypercholesterolaemic patients than in normal subjects. 4. Positive correlations between the plasma...
View articletitled, Plasma and platelet free catecholamine concentrations in patients with familial hypercholesterolaemia
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Articles

Metabolic effects of dobutamine in normal man

Ceri J. Green, R. S. Frazer, S. Underhill, Paula Maycock, Judith A. Fairhurst, I. T. Campbell
Journal: Clinical Science
Clin Sci (Lond) (1992) 82 (1): 77–83.
https://doi.org/10.1042/cs0820077
Published: 01 January 1992
... © 1992 The Biochemical Society and the Medical Research Society 1992 adrenaline dobutamine infusion energy expenditure free fatty acids glucose glycerol noradrenaline respiratory exchange ratio Clinical Science (1992) 82,77-83 (Printed in Great Britain) 77 Metabolic effects...
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Articles

Cardiac and Whole-Body [ 3 H]Noradrenaline Kinetics during Adrenaline Infusion in Man

Alastair J. McCance, J. Colin Forfar
Journal: Clinical Science
Clin Sci (Lond) (1991) 80 (3): 227–233.
https://doi.org/10.1042/cs0800227
Published: 01 March 1991
...Alastair J. McCance; J. Colin Forfar 1. To investigate the possible role of adrenaline as a modulator of noradrenaline release from the sympathetic nervous system, the responses of cardiac and whole-body noradrenaline kinetics to intravenous infusions of adrenaline (30 ng min −1 kg −1...
View articletitled, Cardiac and Whole-Body [ 3 H]Noradrenaline Kinetics during Adrenaline Infusion in Man
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Articles

Effects of Oxygen Withdrawal on Catecholamine Release in Patients on Home Oxygen Therapy

M. S. Balter, K. R. Chapman, M. R. Maleki-Yazdi, F. H. H. Leenen, A. S. Rebuck
Journal: Clinical Science
Clin Sci (Lond) (1990) 79 (2): 155–159.
https://doi.org/10.1042/cs0790155
Published: 01 August 1990
... on long-term oxygen therapy, although the mechanism of this response is unknown. 2. To evaluate the effects of transient hypoxaemia on plasma adrenaline and noradrenaline levels, we studied eight oxygen-dependent patients who underwent either a 4 h period of oxygen withdrawal or their routine therapy...
View articletitled, Effects of Oxygen Withdrawal on Catecholamine Release in Patients on Home Oxygen Therapy
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Articles

Stress Hormones Given to Healthy Volunteers Alter the Concentration and Configuration of Ribosomes in Skeletal Muscle, Reflecting Changes in Protein Synthesis

Jan Wernerman, Danielle Botta, Folke Hammarqvist, Stig Thunell, Alexandra von der Decken, Erik Vinnars
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (6): 611–616.
https://doi.org/10.1042/cs0770611
Published: 01 December 1989
... skeletal muscle was investigated. Healthy volunteers were given a 6 h infusion of adrenaline ( n = 8), Cortisol ( n = 8), a triple-hormone combination of adrenaline, Cortisol and glucagon ( n = 8), or saline ( n = 8) 2. The total ribosome concentration declined by 30.4 ± 7.2% in the triple-hormone group...
View articletitled, Stress Hormones Given to Healthy Volunteers Alter the Concentration and Configuration of Ribosomes in Skeletal Muscle, Reflecting Changes in Protein Synthesis
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Articles

Effect of Catecholamines and Insulin on Plasma Volume and Intravascular Mass of Albumin in Man

J. Hilsted, N. J. Christensen, S. Larsen
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (2): 149–155.
https://doi.org/10.1042/cs0770149
Published: 01 August 1989
...J. Hilsted; N. J. Christensen; S. Larsen 1. The effect of intravenous catecholamine infusions and of intravenous insulin on plasma volume and intravascular mass of albumin was investigated in healthy males. 2. Physiological doses of adrenaline (0.5 μg/min and 3 μg/min) increased peripheral venous...
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Articles

Differential effect of high-dose naloxone on the plasma adrenaline response to the cold-pressor test

P. M. G. Bouloux, E. Newbould, R. Causon, L. Perry, L. H. Rees, G. M. Besser, A. Grossman
Journal: Clinical Science
Clin Sci (Lond) (1989) 76 (6): 625–630.
https://doi.org/10.1042/cs0760625
Published: 01 June 1989
... of naloxone. We have therefore investigated the actions of saline placebo and increasing bolus doses of intravenous naloxone (25, 100 and 250 μg/kg) on the plasma noradrenaline, adrenaline, adrenocorticotrophin (ACTH) and cortisol responses to a cold-pressor test in six males and two females in a double-blind...
View articletitled, Differential effect of high-dose naloxone on the plasma adrenaline response to the cold-pressor test
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Articles

Effect of aminophylline on plasma and urinary catecholamine levels during heavy leg exercise in healthy young men

Å. Wennmalm, E. Karwatowska-Prokopczuk, M. Wennmalm
Journal: Clinical Science
Clin Sci (Lond) (1989) 76 (3): 255–260.
https://doi.org/10.1042/cs0760255
Published: 01 March 1989
...Å. Wennmalm; E. Karwatowska-Prokopczuk; M. Wennmalm 1. Methylxanthines have been shown to elevate the basal plasma level and/or urinary excretion of noradrenaline (NA) and adrenaline (ADR) in healthy subjects. The present study addressed the hypothesis that the methylxanthine aminophylline also...
View articletitled, Effect of aminophylline on plasma and urinary catecholamine levels during heavy leg exercise in healthy young men
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Articles

Effect of intravenous infusion of adrenaline on the cardiovascular responses to distal body subatmospheric pressure in man

I. W. Fellows, I. A. MacDonald, T. Bennett, D. P. O'Donoghue
Journal: Clinical Science
Clin Sci (Lond) (1988) 75 (4): 389–394.
https://doi.org/10.1042/cs0750389
Published: 01 October 1988
...I. W. Fellows; I. A. MacDonald; T. Bennett; D. P. O'Donoghue 1. On two separate occasions, at least 1 week apart, seven young healthy male subjects received intravenous infusions of either adrenaline [0.27 nmol (50 ng) min −1 kg −1 ] or saline (154 mmol/l NaCl), plus ascorbic acid (5.68 mmol/l...
View articletitled, Effect of intravenous infusion of adrenaline on the cardiovascular responses to distal body subatmospheric pressure in man
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Articles

Metabolic and cardiovascular effects of infusions of low doses of isoprenaline in man

P. I. Mansell, I. W. Fellows, A. T. Birmingham, I. A. Macdonald
Journal: Clinical Science
Clin Sci (Lond) (1988) 75 (3): 285–291.
https://doi.org/10.1042/cs0750285
Published: 01 September 1988
... sustained effects after the termination of the isoprenaline infusions, as has been observed previously after the infusion of adrenaline. 2. The isoprenaline infusions produced dose-dependent increases in heart rate, systolic blood pressure and metabolic rate, but similar increases in calf blood flow...
View articletitled, Metabolic and cardiovascular effects of infusions of low doses of isoprenaline in man
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Articles

Rapid changes in plasma potassium during a game of squash

A. D. Struthers, C. Quigley, M. J. Brown
Journal: Clinical Science
Clin Sci (Lond) (1988) 74 (4): 397–401.
https://doi.org/10.1042/cs0740397
Published: 01 April 1988
... skeletal muscle blood flow and/or intracellular acidosis. 15 9 1987 1 10 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 adrenaline arrhythmia noradrenaline potassium Clinical Science (1988) 74, 397-401 397 Rapid changes in plasma potassium during...
View articletitled, Rapid changes in plasma potassium during a game of squash
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Articles

Why does vasodilatation occur during syncope?

B. J. Robinson, R. H. Johnson
Journal: Clinical Science
Clin Sci (Lond) (1988) 74 (4): 347–350.
https://doi.org/10.1042/cs0740347
Published: 01 April 1988
...B. J. Robinson; R. H. Johnson 1. Syncopal or near syncopal episodes have been observed in five subjects who stood or were tilted and in whom blood samples were being taken. 2. In all subjects bradycardia and hypotension developed before the onset of symptoms. Increases in plasma adrenaline...
View articletitled, Why does vasodilatation occur during syncope?
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Articles

Effects of a single moderate dose of alcohol on blood pressure, heart rate and associated metabolic and endocrine changes

D. J. Stott, S. G. Ball, G. C. Inglis, D. L. Davies, R. Fraser, G. D. Murray, G. T. McInnes
Journal: Clinical Science
Clin Sci (Lond) (1987) 73 (4): 411–416.
https://doi.org/10.1042/cs0730411
Published: 01 October 1987
... with the control drink there was no evidence from measurements of circulating adrenaline, noradrenaline, Cortisol, aldosterone or renin of activation of the sympathoadrenal axis, adrenal cortex or renin–angiotensin systems after alcohol. adrenaline alcohol aldosterone blood pressure Cortisol heart rate...
View articletitled, Effects of a single moderate dose of alcohol on blood pressure, heart rate and associated metabolic and endocrine changes
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Articles

Multifactorial evaluation of blood pressure fall upon hospitalization in essential hypertensive patients

Hikaru Nishimura, Akinori Nishioka, Shinichiro Kubo, Michihiro Suwa, Masaya Kino, Keishiro Kawamura
Journal: Clinical Science
Clin Sci (Lond) (1987) 73 (2): 135–141.
https://doi.org/10.1042/cs0730135
Published: 01 August 1987
... I showed a greater increase in plasma noradrenaline and adrenaline ( P < 0.05). On multivariate analysis, those with lower systolic blood pressure, better renal function and more reactive sympathetic nervous system were discriminated as group I. 5. These data suggest that group I patients have...
View articletitled, Multifactorial evaluation of blood pressure fall upon hospitalization in essential hypertensive patients
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Articles

Platelet catecholamines and platelet function in normal human subjects

A. P. Wilson, C. C. T. Smith, B. N. C. Prichard, D. J. Betteridge
Journal: Clinical Science
Clin Sci (Lond) (1987) 73 (1): 99–103.
https://doi.org/10.1042/cs0730099
Published: 01 July 1987
... aggregation in response to adenosine 5′-pyrophosphate, thrombin, adrenaline and collagen. Platelet sensitivity to prostacyclin was also examined. 3. Platelet noradrenaline showed a positive correlation with extent of aggregation induced by ‘low-dose’ collagen (1 μg/ml). No correlation was seen at the higher...
View articletitled, Platelet catecholamines and platelet function in normal human subjects
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Articles

Adrenergic control of plasma magnesium in man

Kenneth F. Whyte, George J. Addis, Robert Whitesmith, John L. Reid
Journal: Clinical Science
Clin Sci (Lond) (1987) 72 (1): 135–138.
https://doi.org/10.1042/cs0720135
Published: 01 January 1987
... and insulin-induced hypoglycaemia stress tests. 2. The effects of l -adrenaline infusions, sufficient to achieve pathophysiological levels of adrenaline, and of therapeutic intravenous infusions of salbutamol, a β 2 -agonist, on plasma magnesium, plasma potassium, plasma glucose and plasma insulin levels were...
View articletitled, Adrenergic control of plasma magnesium in man
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Articles

Vasopressin and catecholamine secretion during apomorphine-induced nausea mediate acute changes in haemostatic function in man

P. J. Grant, J. R. Hughes, H. G. Dean, J. A. Davies, C. R. M. Prentice
Journal: Clinical Science
Clin Sci (Lond) (1986) 71 (5): 621–624.
https://doi.org/10.1042/cs0710621
Published: 01 November 1986
...), vasopressin (aVP) and adrenaline. 3. During nausea plasma aVP concentrations rose from median values of 0.4 pg/ml (at time 0) to 76 pg/ml at peak nausea and fell to 32 pg/ml 20 min later. Adrenaline rose from 0.36 to 0.91 nmol/l ( P < 0.05) before falling to 0.55 nmol/l. 4. During nausea, FVIIIC rose from...
View articletitled, Vasopressin and catecholamine secretion during apomorphine-induced nausea mediate acute changes in haemostatic function in man
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Articles

Evidence for adaptive diet-induced thermogenesis in man during intravenous nutrition with hypertonic glucose

R. F. G. J. King, M. J. McMahon, D. J. Almond
Journal: Clinical Science
Clin Sci (Lond) (1986) 71 (1): 31–39.
https://doi.org/10.1042/cs0710031
Published: 01 July 1986
..., then only 9% (31–22%) of the glucose can be accounted for by adaptive thermogenesis. © 1986 The Biochemical Society and the Medical Research Society 1986 adrenaline glucose intravenous nutrition thermogenesis 19 9 1986 3 2 1986 ClinicalScience(1986) 71,31-39 31 Evidence...
View articletitled, Evidence for adaptive diet-induced thermogenesis in man during intravenous nutrition with hypertonic glucose
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Articles

Plasma catecholamines in pregnancy induced hypertension

Peter C. Rubin, Lucy Butters, Rosemary McCabe, John L. Reed
Journal: Clinical Science
Clin Sci (Lond) (1986) 71 (1): 111–115.
https://doi.org/10.1042/cs0710111
Published: 01 July 1986
... hypertension in the human. We describe the results of two studies involving women who developed hypertension during pregnancy. 2. In the first study, plasma concentrations of noradrenaline and adrenaline were measured in 17 women with pregnancy induced hypertension (PIH) and 17 normotensive pregnant control...
View articletitled, Plasma catecholamines in pregnancy induced hypertension
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Articles

Stimulus-induced release of endogenous catecholamines from human washed platelets

C. C. T. Smith, A. P. Wilson, B. N. C. Prichard, D. J. Betteridge
Journal: Clinical Science
Clin Sci (Lond) (1986) 70 (5): 495–500.
https://doi.org/10.1042/cs0700495
Published: 01 May 1986
... irreversible aggregation with 10 μmol/l ADP and 0.3 unit of thrombin/ml, extents of aggregation being 27% and 76% respectively. 3. ADP (10μmol/l) increased noradrenaline release to the medium by 20% and adrenaline by 28%. As observed with aggregation, 0.3 unit of thrombin/ml produced a more marked effect...
View articletitled, Stimulus-induced release of endogenous catecholamines from human washed platelets
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Articles

Effect of low dose adrenaline and noradrenaline infusions on airway calibre in asthmatic patients

K. E. Berkin, G. C. Inglis, S. G. Ball, N. C. Thomson
Journal: Clinical Science
Clin Sci (Lond) (1986) 70 (4): 347–352.
https://doi.org/10.1042/cs0700347
Published: 01 April 1986
...K. E. Berkin; G. C. Inglis; S. G. Ball; N. C. Thomson 1. Airway, cardiovascular and metabolic responses were measured in six asthmatic patients with stable asthma during separate adrenaline, noradrenaline and control infusions. Four incremental infusion rates (4, 10, 25 and 62.5 ng min −1 kg −1...
View articletitled, Effect of low dose adrenaline and noradrenaline infusions on airway calibre in asthmatic patients
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Articles

Cardiovascular and metabolic responses to low dose adrenaline infusion: an invasive study in humans

U. Freyschuss, P. Hjemdahl, A. Juhlin-Dannfelt, B. Linde
Journal: Clinical Science
Clin Sci (Lond) (1986) 70 (2): 199–206.
https://doi.org/10.1042/cs0700199
Published: 01 February 1986
...U. Freyschuss; P. Hjemdahl; A. Juhlin-Dannfelt; B. Linde 1. Cardiovascular and metabolic responses to intravenous infusions of adrenaline (ADR), which raised arterial plasma ADR in a stepwise fashion from 0.3 to 1.3, 2.3 and 6.0 nmol/l, were studied in 11 healthy volunteers. 2. ADR evoked marked...
View articletitled, Cardiovascular and metabolic responses to low dose adrenaline infusion: an invasive study in humans
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Articles

β -Adrenoceptor responsiveness and plasma catecholamines as determinants of cardiovascular reactivity to mental stress

G. Eisenhofer, D. G. Lambie, R. H. Johnson
Journal: Clinical Science
Clin Sci (Lond) (1985) 69 (4): 483–492.
https://doi.org/10.1042/cs0690483
Published: 01 October 1985
... to β-adrenoceptor stimulation was also determined in each subject by measurement of heart rate responses to bolus injections of isoprenaline. 2. Both periods of mental stress were associated with significant increases in systolic and diastolic blood pressures, heart rate and plasma adrenaline...
View articletitled, β -Adrenoceptor responsiveness and plasma catecholamines as determinants of cardiovascular reactivity to mental stress
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Articles

Enhancement of the sympathoadrenal response to the cold-pressor test by naloxone in man

Pierre-Marc Bouloux, Ashley Grossman, Saad Al-Damluji, Timothy Bailey, Michael Besser
Journal: Clinical Science
Clin Sci (Lond) (1985) 69 (3): 365–368.
https://doi.org/10.1042/cs0690365
Published: 01 September 1985
... performance liquid chromatography coupled to electrochemical detection. 2. Cold stimulation induced significant elevations in plasma noradrenaline and adrenaline to reach mean peak levels 61% and 108% above their respective basal levels ( P < 0.05). Systolic blood pressure increased by 23 ± 6.5 mmHg ( P...
View articletitled, Enhancement of the sympathoadrenal response to the cold-pressor test by naloxone in man
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Articles

The effect of Adrenaline upon Cardiovascular and Metabolic Functions in Man

I. W. Fellows, T. Bennett, I. A. Macdonald
Journal: Clinical Science
Clin Sci (Lond) (1985) 69 (2): 215–222.
https://doi.org/10.1042/cs0690215
Published: 01 August 1985
...I. W. Fellows; T. Bennett; I. A. Macdonald 1. On three separate occasions, at least 1 week apart, seven young healthy male subjects received intravenous infusions of either adrenaline, 50 ng min −1 kg −1 (high A), adrenaline, 10 ng min −1 kg −1 (low A) or sodium chloride solution (saline :154 mmol...
View articletitled, The effect of Adrenaline upon Cardiovascular and Metabolic Functions in Man
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Articles

Reduced plasma noradrenaline during angiotensin II-induced acute hypertension in man

Jens H. Henriksen, Jens Kastrup, Niels Juel Christensen
Journal: Clinical Science
Clin Sci (Lond) (1985) 68 (6): 621–624.
https://doi.org/10.1042/cs0680621
Published: 01 June 1985
...Jens H. Henriksen; Jens Kastrup; Niels Juel Christensen 1. Plasma noradrenaline and adrenaline concentrations were measured in ten subjects before, during and after intravenous infusion of angiotensin II (ANG II) in order to determine the sympathoadrenal response of ANG II challenge in man. In five...
View articletitled, Reduced plasma noradrenaline during angiotensin II-induced acute hypertension in man
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