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Lars M. Ittner, Kerstin Schwerdtfeger, Thomas H. Kunz, Roman Muff, Knut Husmann, Christian Grimm, Farhad Hafezi, Karl S. Lang, Michael O. Kurrer, Jürgen Götz, Walter Born, Jan A. Fischer
Clin Sci (Lond) (2008) 114 (1): 49–58.
Published: 30 November 2007
.... Expression of CLR under the control of a smooth muscle α-actin promoter in these mice augmented signalling of the smooth-muscle-relaxing peptide adrenomedullin in the pupillary sphincter muscle and resulted in pupillary palsy. Elevated IOP was prevented in CLR transgenic mice when mated with hemizygote...
Minami Abe, Masataka Sata, Etsu Suzuki, Ryo Takeda, Masao Takahashi, Hiroaki Nishimatsu, Daisuke Nagata, Kenji Kangawa, Hisayuki Matsuo, Ryozo Nagai, Yasunobu Hirata
Clin Sci (Lond) (2006) 111 (6): 381–387.
Published: 14 November 2006
...Minami Abe; Masataka Sata; Etsu Suzuki; Ryo Takeda; Masao Takahashi; Hiroaki Nishimatsu; Daisuke Nagata; Kenji Kangawa; Hisayuki Matsuo; Ryozo Nagai; Yasunobu Hirata Adrenomedullin exerts not only vasodilatory effects, but also angiogenic effects. In the present study, we investigated the effects...
Clin Sci (Lond) (2006) 111 (1): 61–70.
Published: 14 June 2006
...Jens Michelsen; Helle Thiesson; Steen Walter; Peter D. Ottosen; Ole Skøtt; Boye L. Jensen The peptide AM (adrenomedullin) is stimulated by hypoxia through HIF-1 (hypoxia-inducible factor-1). The majority of human CC-RCCs (clear cell renal cell carcinomas) display mutations in the tumour suppressor...
Clin Sci (Lond) (2006) 110 (3): 337–342.
Published: 10 February 2006
...Alfia Al-Ghafra; Shaun P. Brennecke; Roger G. King; Neil M. Gude The aim of the present study was to investigate whether placental and fetal membrane AdM (adrenomedullin) mRNA expression changes with gestation and human labour, as we have previously found labour-associated changes in AdM content...
Clin Sci (Lond) (2005) 109 (1): 97–102.
Published: 23 June 2005
...Jocelyn DUPUIS; Alexandre CARON; Nathalie RUËL The biodistribution, pharmacokinetics and multi-organ clearance of the vasodilator peptide AM (adrenomedullin) were evaluated in rats and its single-pass pulmonary clearance was measured in dogs by the indicator-dilution technique. Intravenously...
Clin Sci (Lond) (2003) 105 (4): 419–423.
Published: 01 October 2003
...A. AL-GHAFRA; N. M. GUDE; S. P. BRENNECKE; R. G. KING The aim of the present study was to determine the effects of labour and mode of delivery on human placental and fetal membrane content of adrenomedullin (AdM). Placentas and fetal membranes were collected either at term or pre-term gestation...
Kazuhiro TAKAHASHI, Kazuhito TOTSUNE, Tomomi KITAMURO, Masahiko SONE, Osamu MURAKAMI, Shigeki SHIBAHARA
Clin Sci (Lond) (2002) 103 (s2002): 35S–38S.
Published: 01 September 2002
...Kazuhiro TAKAHASHI; Kazuhito TOTSUNE; Tomomi KITAMURO; Masahiko SONE; Osamu MURAKAMI; Shigeki SHIBAHARA Evidence has accumulated showing that vasoactive peptides, such as endothelin-1, adrenomedullin and urotensin-II, are expressed in various kinds of tumour cells. In the present study...
Toshio NISHIKIMI, Ikuko SHIBASAKI, Hiroshi IIDA, Hiroshi ASAKAWA, Yasushi MATSUSHITA, Hideaki MORI, Yoshihiko MOCHIZUKI, Yoshitaka OKAMURA, Shigeo HORINAKA, Kenji KANGAWA, Koichiro SHIMADA, Hiroaki MATSUOKA
Clin Sci (Lond) (2002) 102 (6): 669–677.
Published: 17 May 2002
...Toshio NISHIKIMI; Ikuko SHIBASAKI; Hiroshi IIDA; Hiroshi ASAKAWA; Yasushi MATSUSHITA; Hideaki MORI; Yoshihiko MOCHIZUKI; Yoshitaka OKAMURA; Shigeo HORINAKA; Kenji KANGAWA; Koichiro SHIMADA; Hiroaki MATSUOKA Experimental studies have demonstrated that adrenomedullin (AM) has a positive inotropic...
Miriam T. RADEMAKER, Chris J. CHARLES, Garth J.S. COOPER, David H. COY, Eric A. ESPINER, Lynley K. LEWIS, M. Gary NICHOLLS, A. Mark RICHARDS
Clin Sci (Lond) (2002) 102 (6): 653–660.
Published: 14 May 2002
... of angiotensin-converting enzyme (ACE) inhibition. Importantly, since new treatments are likely to be used in conjunction with ACE inhibition therapy, the effects of the combination of agents need to be assessed. Adrenomedullin (ADM) is a peptide with potent vasodilator and natriuretic actions. ADM and an ACE...
Richard W. TROUGHTON, Christopher M. FRAMPTON, Lynley K. LEWIS, Timothy G. YANDLE, A. Mark RICHARDS, M. Gary NICHOLLS
Clin Sci (Lond) (2001) 101 (1): 103–109.
Published: 14 June 2001
...Richard W. TROUGHTON; Christopher M. FRAMPTON; Lynley K. LEWIS; Timothy G. YANDLE; A. Mark RICHARDS; M. Gary NICHOLLS Experimental data indicate that adrenomedullin (AM) interacts at various levels with the renin–angiotensin–aldosterone system and the hypothalamic–pituitary–adrenal axis, but data...
Chris HILLIER, Mark C. PETRIE, Michael P. LOVE, Fiona JOHNSTON, Margaret R. MACLEAN, John J. V. MCMURRAY
Clin Sci (Lond) (2001) 101 (1): 45–51.
Published: 24 May 2001
...Chris HILLIER; Mark C. PETRIE; Michael P. LOVE; Fiona JOHNSTON; Margaret R. MACLEAN; John J. V. MCMURRAY Endothelin-1 (ET-1) and adrenomedullin (ADM) are both produced in the arterial wall, but have opposing biological actions. Evidence from experimental animals suggests a functional interaction...
Toshio NISHIKIMI, Seiki NAGATA, Tatsuya SASAKI, Fumiki YOSHIHARA, Noritoshi NAGAYA, Takeshi HORIO, Hisayuki MATSUO, Hiroaki MATSUOKA, Kenji KANGAWA
Clin Sci (Lond) (2001) 100 (1): 61–66.
Published: 13 December 2000
...Toshio NISHIKIMI; Seiki NAGATA; Tatsuya SASAKI; Fumiki YOSHIHARA; Noritoshi NAGAYA; Takeshi HORIO; Hisayuki MATSUO; Hiroaki MATSUOKA; Kenji KANGAWA Adrenomedullin (AM), a novel hypotensive peptide, preferentially dilates pulmonary vessels rather than systemic vessels. This suggests the possibility...
Hiroshi ASAKAWA, Toshio NISHIKIMI, Takeshi SUZUKI, Suomi HARA, Yusuke TSUBOKOU, Hiroshi YAGI, Akihisa YABE, Noriaki TSUCHIYA, Shigeo HORINAKA, Kenji KANGAWA, Hiroaki MATSUOKA
Clin Sci (Lond) (2001) 100 (1): 117–126.
Published: 13 December 2000
...Hiroshi ASAKAWA; Toshio NISHIKIMI; Takeshi SUZUKI; Suomi HARA; Yusuke TSUBOKOU; Hiroshi YAGI; Akihisa YABE; Noriaki TSUCHIYA; Shigeo HORINAKA; Kenji KANGAWA; Hiroaki MATSUOKA Adrenomedullin (AM) has vasodilatory, diuretic and natriuretic actions. Two molecular forms of AM circulate in human plasma...
Kazuhito TOTSUNE, Kazuhiro TAKAHASHI, Harald S. MACKENZIE, Osamu MURAKAMI, Zenei ARIHARA, Masahiko SONE, Toraichi MOURI, Barry M. BRENNER, Sadayoshi ITO
Clin Sci (Lond) (2000) 99 (6): 541–546.
Published: 21 November 2000
...Kazuhito TOTSUNE; Kazuhiro TAKAHASHI; Harald S. MACKENZIE; Osamu MURAKAMI; Zenei ARIHARA; Masahiko SONE; Toraichi MOURI; Barry M. BRENNER; Sadayoshi ITO Adrenomedullin is a vasodilator peptide produced in various organs, including heart and kidney. A novel adrenomedullin receptor complex has...
Masaharu NAKAYAMA, Kazuhiro TAKAHASHI, Osamu MURAKAMI, Hiroshi MURAKAMI, Hironobu SASANO, Kunio SHIRATO, Shigeki SHIBAHARA
Clin Sci (Lond) (1999) 97 (2): 247–251.
Published: 15 July 1999
...Masaharu NAKAYAMA; Kazuhiro TAKAHASHI; Osamu MURAKAMI; Hiroshi MURAKAMI; Hironobu SASANO; Kunio SHIRATO; Shigeki SHIBAHARA Macrophages secrete a variety of growth factors, cytokines and vasoactive peptides, which are related to the progression of atherosclerosis. Adrenomedullin (ADM) is a potent...
Muneo YOSHIBAYASHI, Tetsuro KAMIYA, Toshio NISHIKIMI, Yoshihiko SAITO, Hisayuki MATSUO, Kenji KANGAWA
Clin Sci (Lond) (1999) 96 (6): 543–547.
Published: 20 April 1999
...Muneo YOSHIBAYASHI; Tetsuro KAMIYA; Toshio NISHIKIMI; Yoshihiko SAITO; Hisayuki MATSUO; Kenji KANGAWA Adrenomedullin is a novel hypotensive peptide originally isolated from human pheochromocytoma. Accumulating evidence suggests the possible involvement of adrenomedullin in the physiology...
Clin Sci (Lond) (1999) 96 (5): 493–498.
Published: 14 April 1999
...Dominic J. AUTELITANO; F. TANG The prepro-adrenomedullin (prepro-AM) gene encodes several biologically active peptides, including the potent vasodilator AM. At least part of the vasodilator action of AM appears to be mediated via interactions with receptors on vascular smooth muscle cells (VSMC...
Clin Sci (Lond) (1999) 96 (4): 415–420.
Published: 01 April 1999
...Palaniswamy VIJAY; Laszlo SZEKELY; Thomas X. AUFIERO; Thomas G. SHARP Human adrenomedullin (ADM), a peptide comprising 52 amino acids, is a circulating hormone with vasodilator properties. We have evaluated its release by the heart following ischaemic myocardial damage, as indicated by elevated...
Mikio KAKISHITA, Toshio NISHIKIMI, Yoshiaki OKANO, Toru SATOH, Shingo KYOTANI, Noritoshi NAGAYA, Kengo FUKUSHIMA, Norifumi NAKANISHI, Shuichi TAKISHITA, Atsuro MIYATA, Kenji KANGAWA, Hisayuki MATSUO, Takeyoshi KUNIEDA
Clin Sci (Lond) (1998) 96 (1): 33–39.
Published: 01 January 1999
...Mikio KAKISHITA; Toshio NISHIKIMI; Yoshiaki OKANO; Toru SATOH; Shingo KYOTANI; Noritoshi NAGAYA; Kengo FUKUSHIMA; Norifumi NAKANISHI; Shuichi TAKISHITA; Atsuro MIYATA; Kenji KANGAWA; Hisayuki MATSUO; Takeyoshi KUNIEDA Adrenomedullin, a potent hypotensive peptide, reduces blood pressure...
Toshio Nishikimi, Yukio Hayashi, Gentaro Iribu, Shuichi Takishita, Yoshio Kosakai, Naoto Minamino, Atsuro Miyata, Hisayuki Matsuo, Masakazu Kuro, Kenji Kangawa
Clin Sci (Lond) (1998) 94 (6): 585–590.
Published: 01 June 1998
...Toshio Nishikimi; Yukio Hayashi; Gentaro Iribu; Shuichi Takishita; Yoshio Kosakai; Naoto Minamino; Atsuro Miyata; Hisayuki Matsuo; Masakazu Kuro; Kenji Kangawa 1. Adrenomedullin (AM), a potent hypotensive peptide, was originally isolated from human phaeochromocytoma. Plasma AM concentrations...
Michael Kaiser, Ole Kahr, Yasuyuki Shimada, Pamela Smith, Martin Kelly, Harin Mahadeva, Matthew Adams, David Lodwick, Christian Aalkjaer, Metin Avkiran, Nilesh J. Samani
Clin Sci (Lond) (1998) 94 (4): 359–365.
Published: 01 April 1998
...Michael Kaiser; Ole Kahr; Yasuyuki Shimada; Pamela Smith; Martin Kelly; Harin Mahadeva; Matthew Adams; David Lodwick; Christian Aalkjaer; Metin Avkiran; Nilesh J. Samani 1. Adrenomedullin is a recently discovered vasodilating and natriuretic peptide whose physiological and pathophysiological roles...
Yuji Yoshitomi, Toshio Nishikimi, Shunichi Kojima, Morio Kuramochi, Shuichi Takishita, Hiroaki Matsuoka, Atsuro Miyata, Hisayuki Matsuo, Kenji Kangawa
Clin Sci (Lond) (1998) 94 (2): 135–139.
Published: 01 February 1998
...Yuji Yoshitomi; Toshio Nishikimi; Shunichi Kojima; Morio Kuramochi; Shuichi Takishita; Hiroaki Matsuoka; Atsuro Miyata; Hisayuki Matsuo; Kenji Kangawa 1. Adrenomedullin, a newly identified vasorelaxant peptide, participates in the regulation of the cardiovascular system. To investigate...
Mareomi Hamada, Yuji Shigematsu, Hideo Kawakami, Naoto Minamino, Kenji Kangawa, Hisayuki Matsuo, Kunio Hiwada
Clin Sci (Lond) (1998) 94 (1): 21–28.
Published: 01 January 1998
...Mareomi Hamada; Yuji Shigematsu; Hideo Kawakami; Naoto Minamino; Kenji Kangawa; Hisayuki Matsuo; Kunio Hiwada 1. The aim of this study was to elucidate the pathophysiological role of adrenomedullin and the relation between adrenomedullin and other hormones in patients with hypertrophic...
John G. Lainchbury, Garth J. S. Cooper, David H. Coy, Ning-Yi Jiang, Lynley K. Lewis, Timothy G. Yandle, A. Mark Richards, M. Gary Nicholls
Clin Sci (Lond) (1997) 92 (5): 467–472.
Published: 01 May 1997
...John G. Lainchbury; Garth J. S. Cooper; David H. Coy; Ning-Yi Jiang; Lynley K. Lewis; Timothy G. Yandle; A. Mark Richards; M. Gary Nicholls 1. Adrenomedullin, a recently discovered 52-amino-acid peptide hormone, circulates in plasma at low picomolar levels in man. Animal studies and studies...
Clin Sci (Lond) (1997) 92 (1): 59–62.
Published: 01 January 1997
...Bernard Cheung; Raymond Leung 1. Adrenomedullin is a potent vasodilating peptide first isolated from phaeochromocytoma and adrenal medulla but also found in the heart, lungs and kidneys. It may also be a paracrine factor because endothelial and smooth muscle cells synthesize adrenomedullin as well...
Toshihiko Ishimitsu, Toshio Nishikimi, Hiroaki Matsuoka, Kenji Kangawa, Kazuo Kitamura, Jun-Ichi Minami, Hisayuki Matsuo, Tanenao Eto
Clin Sci (Lond) (1996) 91 (3): 293–298.
Published: 01 September 1996
...Toshihiko Ishimitsu; Toshio Nishikimi; Hiroaki Matsuoka; Kenji Kangawa; Kazuo Kitamura; Jun-Ichi Minami; Hisayuki Matsuo; Tanenao Eto 1. Responses of adrenomedullin to acute and chronic salt loading were examined in normotensive and hypertensive subjects. 2. In the acute salt load study, isotonic...