...S. H. L. Thomas; M. J. O'Doherty; C. J. Page; T. O. Nunan 1. This study was performed to determine the variability of two different scintigraphic methods of measuring pulmonary aerosol deposition, and to examine nebulizer particle size and drug output as potential sources of this variability. 2...

... to generate an aerosol of local anaesthetic in particles small enough to allow alveolar deposition. Lignocaine (2% and 5%) produced aerosols with an arithmetic mean diameter (+sd) of 1.5+0.3 and 1.2+0.6 μm respectively, the mass median diameters being 1.7 (geometric standard deviation = 1.2) and 2.5...