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Articles

The association between etanercept serum concentration and psoriasis severity is highly age-dependent

Iris Detrez, Kristel Van Steen, Siegfried Segaert, Ann Gils

Clin Sci (Lond) (2017) 131 (11): 1179–1189.

https://doi.org/10.1042/CS20170048

Published: 22 May 2017

...) and Physician Global Assessment (PGA), and etanercept and anti-etanercept antibody concentrations were determined every 3 months for a period of 1 year. The present study demonstrated that the association between etanercept concentration and psoriasis severity is age-dependent: when patients were stratified...

View articletitled, The association between etanercept serum concentration and psoriasis severity is highly age-dependent

Articles

The causal exposure model of vascular disease

Allan D. Sniderman, Patrick R. Lawler, Ken Williams, George Thanassoulis, Jacqueline de Graaf, Curt D. Furberg

Clin Sci (Lond) (2012) 122 (8): 369–373.

https://doi.org/10.1042/CS20110449

Published: 14 December 2011

... associations, but which has important limitations: most critically, that effective treatment to reduce arterial damage is often delayed until the age at which cardiovascular events become common. This delay means that many of the early victims of vascular disease will not be identified in time. This delay also...

View articletitled, The causal exposure model of vascular disease

Articles

Low doses of ethanol decrease the activity of the angiotensin-converting enzyme in the aorta of aging rats and rats treated with a nitric oxide synthase inhibitor and dexamethasone

Maksim O. Emel'yanov, Antonina F. Korystova, Ludmila N. Kublik, Maria Kh. Levitman, Vera V. Shaposhnikova, Yuri N. Korystov

Clin Sci (Lond) (2012) 122 (2): 75–81.

https://doi.org/10.1042/CS20110181

Published: 20 September 2011

... -nitro- L -arginine methyl ester) or dexamethasone and the effect of low doses of ethanol (0.2–1.2 g/kg of body weight, daily for 8–12 days) on this activity were studied. We found that ACE activity increased with age and in response to L -NAME and dexamethasone treatment. Ethanol at a dose of 0.4 g/kg...

View articletitled, Low doses of ethanol decrease the activity of the angiotensin-converting enzyme in the aorta of aging rats and rats treated with a nitric oxide synthase inhibitor and dexamethasone

Articles

Clinical and haemodynamic correlates of heart rate turbulence as a non-invasive index of baroreflex sensitivity in chronic heart failure

Maria Teresa La Rovere, Roberto Maestri, Gian Domenico Pinna, Peter Sleight, Oreste Febo

Clin Sci (Lond) (2011) 121 (6): 279–284.

https://doi.org/10.1042/CS20110063

Published: 27 May 2011

... and haemodynamic evaluation. TO and TS significantly correlated with Phe-slope ( r =−0.39, P <0.0001 and r =0.66, P <0.0001 respectively). Age, baseline heart rate, LVEF (left ventricular ejection fraction), PCP (pulmonary capillary pressure), CI (cardiac index) and sodium were significant and independent...

View articletitled, Clinical and haemodynamic correlates of heart rate turbulence as a non-invasive index of baroreflex sensitivity in chronic heart failure

Articles

Relationship between age and measures of balance, strength and gait: linear and non-linear analyses

Natalie El Haber, Bircan Erbas, Keith D. Hill, John D. Wark

Clin Sci (Lond) (2008) 114 (12): 719–727.

https://doi.org/10.1042/CS20070301

Published: 14 May 2008

...Natalie El Haber; Bircan Erbas; Keith D. Hill; John D. Wark An age-related decline in balance, gait and lower-extremity muscle strength measures may lead to increased risk of falls and fractures. Previous studies have reported a possible non-linear age-related decline in these measures...

View articletitled, Relationship between age and measures of balance, strength and gait: linear and non-linear analyses

Articles

Impact of age on the vasovagal response provoked by sublingual nitroglycerine in routine tilt testing

Bart Verheyden, Janneke Gisolf, Frank Beckers, John M. Karemaker, Karel H. Wesseling, André E. Aubert, Wouter Wieling

Clin Sci (Lond) (2007) 113 (7): 329–337.

https://doi.org/10.1042/CS20070042

Published: 03 September 2007

...Bart Verheyden; Janneke Gisolf; Frank Beckers; John M. Karemaker; Karel H. Wesseling; André E. Aubert; Wouter Wieling NTG (nitroglycerine) is used in routine tilt testing to elicit a vasovagal response. In the present study we hypothesized that with increasing age NTG triggers a more gradual BP...

View articletitled, Impact of age on the vasovagal response provoked by sublingual nitroglycerine in routine tilt testing

Articles

Exaggerated postprandial lipaemia and lower post-heparin lipoprotein lipase activity in middle-aged men

Kim G. JACKSON, Jacky M. E. KNAPPER-FRANCIS, Linda M. MORGAN, Diane H. WEBB, Antonis ZAMPELAS, Christine M. WILLIAMS

Clin Sci (Lond) (2003) 105 (4): 457–466.

https://doi.org/10.1042/CS20030134

Published: 01 October 2003

... for coronary heart disease. A small number of limited studies have compared postprandial lipaemia in subjects of varying age, but have not investigated mechanisms underlying age-associated changes in postprandial lipaemia. In order to test the hypothesis that impaired lipaemia in older subjects is associated...

View articletitled, Exaggerated postprandial lipaemia and lower post-heparin lipoprotein lipase activity in middle-aged men

Articles

Dynamics of the heart rate response to sinusoidal work in humans: influence of physical activity and age

Yoshiyuki FUKUOKA, Yoko NAKAGAWA, Katsutoshi OGOH, Tomoyuki SHIOJIRI, Yoshiyuki FUKUBA

Clin Sci (Lond) (2002) 102 (1): 31–38.

https://doi.org/10.1042/cs1020031

Published: 03 December 2001

...Yoshiyuki FUKUOKA; Yoko NAKAGAWA; Katsutoshi OGOH; Tomoyuki SHIOJIRI; Yoshiyuki FUKUBA The purpose of the present study was to define the influence of age and exercise training on the heart rate (HR) dynamic response (i.e. kinetics) to sinusoidal work. A total of 63 healthy subjects (31 men and 32...

View articletitled, Dynamics of the heart rate response to sinusoidal work in humans: influence of physical activity and age

Articles

Age-related changes in microvascular permeability: a significant factor in the susceptibility of children to shock?

J. GAMBLE, D. BETHELL, N. P. J. DAY, P. P. LOC, N. H. PHU, I. B. GARTSIDE, J. F. FARRAR, N. J. WHITE

Clin Sci (Lond) (2000) 98 (2): 211–216.

https://doi.org/10.1042/cs0980211

Published: 31 January 2000

... controls, age-matched to children with dengue shock syndrome, gave high values of filtration capacity ( K f ), a factor describing vascular permeability. We hypothesized that K f might be age dependent. Calf K f was studied in 89 healthy Vietnamese subjects aged 5 to 77 years. The K f was highest...

View articletitled, Age-related changes in microvascular permeability: a significant factor in the susceptibility of children to shock?

Articles

Characteristics of small bowel motility in patients with irritable bowel syndrome and normal humans: an Oriental study

Ching-Liang LU, Chih-Yen CHEN, Full-Young CHANG, Shou-Dong LEE

Clin Sci (Lond) (1998) 95 (2): 165–169.

https://doi.org/10.1042/cs0950165

Published: 01 August 1998

... and 85.3±37.3 ;min respectively ( P < 0.05). Delayed transit characterized constipation-predominant patients with irritable bowel syndrome, whereas accelerated transit was observed in diarrhoea-predominant patients with irritable bowel syndrome. The ages of constipation-predominant and diarrhoea...

View articletitled, Characteristics of small bowel motility in patients with irritable bowel syndrome and normal humans: an Oriental study

Articles

Normal values for handgrip strength in 920 men and women aged over 65 years, and longitudinal changes over 4 years in 620 survivors

E. J. Bassey, U. J. Harries

Clin Sci (Lond) (1993) 84 (3): 331–337.

https://doi.org/10.1042/cs0840331

Published: 01 March 1993

...E. J. Bassey; U. J. Harries 1. The maximal grip strength of the hand has been measured in a random sample of 359 men and 561 women aged over 65 years living in their own homes. The response rate was 80% from a representative demographic area of the U.K. Measurements were made of body mass, skeletal...

View articletitled, Normal values for handgrip strength in 920 men and women aged over 65 years, and longitudinal changes over 4 years in 620 survivors

Articles

Afferent baroreflex dysfunction and age-related orthostatic hypotension

A. L. Tonkin, L. M. H. Wing, M. J. Morris, V. Kapoor

Clin Sci (Lond) (1991) 81 (s25): 531–538.

https://doi.org/10.1042/cs0810531

Published: 01 October 1991

... baroreceptor (head-up tilt) and non-baroreceptor (cold stress, isometric exercise) afferent pathways. 2. In 15 healthy elderly control subjects blood pressure did not change with 60° head-up tilting and there was a moderate increase in heart rate, whereas in 13 subjects with age-related orthostatic hypotension...

View articletitled, Afferent baroreflex dysfunction and age-related orthostatic hypotension

Articles

Age-independent forearm vasodilatation by acetylcholine and adenosine 5′-triphosphate in humans

Tsutomu Imaizumi, Akira Takeshita, Satoshi Suzuki, Megumu Yoshida, Shinichi Ando, Motoomi Nakamura

Clin Sci (Lond) (1990) 78 (1): 89–93.

https://doi.org/10.1042/cs0780089

Published: 01 January 1990

...Tsutomu Imaizumi; Akira Takeshita; Satoshi Suzuki; Megumu Yoshida; Shinichi Ando; Motoomi Nakamura 1. Forearm vasodilator responses to acetylcholine, ATP and sodium nitroprusside were examined in healthy young (20 ± 1 years, n = 9), middle-aged (46 ± 2 years, n = 6) and old (57 ± 1 years, n = 6...

View articletitled, Age-independent forearm vasodilatation by acetylcholine and adenosine 5′-triphosphate in humans

Articles

Haemodynamic responses to vasopressin in anaesthetized young and adult Brattleboro rats

L. F. O. Obika, J. F. Laycock

Clin Sci (Lond) (1989) 76 (6): 667–671.

https://doi.org/10.1042/cs0760667

Published: 01 June 1989

... BDI rats, whereas in the adult animals vasopressin had the greater pressor effect in the BDI rats compared with the LE rats of comparable age. 4. There was little effect of vasopressin on cardiac output after the initial decrease, particularly in the BDI rats whether immature or adult, despite more...

View articletitled, Haemodynamic responses to vasopressin in anaesthetized young and adult Brattleboro rats

Articles

Influence of age on glomerular binding of angiotensin II in normotensive and spontaneously hypertensive rats

E. A. Messenger, C. Stonier, G. M. Aber

Clin Sci (Lond) (1989) 76 (6): 619–623.

https://doi.org/10.1042/cs0760619

Published: 01 June 1989

...E. A. Messenger; C. Stonier; G. M. Aber 1. Glomerular angiotensin II (ANG II) binding has been studied in normotensive (NTR) and spontaneously hypertensive (SHR) rats at 5, 10, 15 and 20 weeks of age. 2. Binding of 125 I-labelled ANG II by glomeruli from NTR and SHR was similar at 5 and 10 weeks...

View articletitled, Influence of age on glomerular binding of angiotensin II in normotensive and spontaneously hypertensive rats

Articles

Plasma levels of the lyso-derivative of platelet-activating factor are related to age

Roger R. Taylor, Marian Sturm, Philip J. Kendrew, Robert Vandongen, Lawrence J. Beilin

Clin Sci (Lond) (1989) 76 (2): 195–198.

https://doi.org/10.1042/cs0760195

Published: 01 February 1989

...Roger R. Taylor; Marian Sturm; Philip J. Kendrew; Robert Vandongen; Lawrence J. Beilin 1. The effect of age on the plasma level of the lyso-derivative of platelet-activating factor (lyso-PAF) was studied in 72 normal subjects, (32 females, 40 males) aged 12–64 years. Lyso-PAF was acetylated...

View articletitled, Plasma levels of the lyso-derivative of platelet-activating factor are related to age

Articles

Age-related changes in factor VII activation in healthy women

P. Y. Scarabin, P. Van Dreden, C. Bonithon-Kop, G. Orssaud, L. Bara, J. Conard, M. Samama

Clin Sci (Lond) (1988) 75 (4): 341–343.

https://doi.org/10.1042/cs0750341

Published: 01 October 1988

...P. Y. Scarabin; P. Van Dreden; C. Bonithon-Kop; G. Orssaud; L. Bara; J. Conard; M. Samama 1. To investigate the age-related changes in factor VII activation in healthy women, a regular factor VII clotting assay (factor VIIc) was carried out simultaneously with a new enzyme immunoassay...

View articletitled, Age-related changes in factor VII activation in healthy women

Articles

Cardiovascular responses to stimulation of carotid baroreceptors in healthy subjects

R. Hainsworth, Y. M. H. Al-Shamma

Clin Sci (Lond) (1988) 75 (2): 159–165.

https://doi.org/10.1042/cs0750159

Published: 01 August 1988

... pressures, ± 10.0 (− 16.9) and ± 5.4 (− 10.1) mmHg, respectively. 5. Control values and responses to neck suction at − 30 mmHg were compared in subjects grouped in four age bands between 19 and 80 years. With increasing age, the control value of cardiac index (cardiac output divided by calculated body...

View articletitled, Cardiovascular responses to stimulation of carotid baroreceptors in healthy subjects

Articles

Cardiovascular responses to upright tilting in healthy subjects

R. Hainsworth, Y. M. H. Al-Shamma

Clin Sci (Lond) (1988) 74 (1): 17–22.

https://doi.org/10.1042/cs0740017

Published: 01 January 1988

...R. Hainsworth; Y. M. H. Al-Shamma 1. The cardiovascular responses to passive upright tilting were determined in healthy human subjects of various ages using entirely ‘non-invasive’ techniques. Cardiac output was determined by a single breath method and arterial blood pressure by an automatic...

View articletitled, Cardiovascular responses to upright tilting in healthy subjects

Articles

Influence of age on deterioration of the remnant kidney in uninephrectomized rats

Seiya Okuda, Kenichi Motomura, Tohru Sanai, Hiroshi Tsuruda, Yukinori Oh, Kaoru Onoyama, Masatoshi Fujishima

Clin Sci (Lond) (1987) 72 (5): 571–576.

https://doi.org/10.1042/cs0720571

Published: 01 May 1987

...Seiya Okuda; Kenichi Motomura; Tohru Sanai; Hiroshi Tsuruda; Yukinori Oh; Kaoru Onoyama; Masatoshi Fujishima 1. To investigate the influence of age on the remnant kidney, unilateral nephrectomy was performed in rats at 1 day (group N-0), 2 weeks (group N-2), 4 weeks (group N-4) or 8 weeks (group N...

View articletitled, Influence of age on deterioration of the remnant kidney in uninephrectomized rats

Articles

Circulatory response to postural change in healthy male subjects in relation to age

J. H. A. Dambrink, W. Wieling

Clin Sci (Lond) (1987) 72 (3): 335–341.

https://doi.org/10.1042/cs0720335

Published: 01 March 1987

...J. H. A. Dambrink; W. Wieling 1. The initial heart rate (HR) response evoked by standing up and 70° head-up tilt from the supine resting position, as well as the changes in HR and blood pressure after 1–2 min in the upright position, was analysed in teenage boys (aged 10–15 years) and healthy old...

View articletitled, Circulatory response to postural change in healthy male subjects in relation to age

Articles

Brown adipose tissue uncoupling protein content in human infants, children and adults

M. E. J. Lean, W. P. T. James, G. Jennings, P. Trayhurn

Clin Sci (Lond) (1986) 71 (3): 291–297.

https://doi.org/10.1042/cs0710291

Published: 01 September 1986

... and capacity, were observed in different groups of subjects. Sig- nificantly lower concentrations were found in adults and in pre-term and stillborn infants than in older infants and children. Key words: age, brown adipose tissue, mitochon- drion, premature infants, radioimmunoassay, thermogenesis, uncoupling...

View articletitled, Brown adipose tissue uncoupling protein content in human infants, children and adults

Articles

Differences in age-independent effects of blood pressure on baroreflex sensitivity between normal and hypertensive subjects

Kazuyuki Shimada, Tadao Kitazumi, Hisakazu Ogura, Noriko Sadakane, Toshio Ozawa

Clin Sci (Lond) (1986) 70 (5): 489–494.

https://doi.org/10.1042/cs0700489

Published: 01 May 1986

...Kazuyuki Shimada; Tadao Kitazumi; Hisakazu Ogura; Noriko Sadakane; Toshio Ozawa 1. Inter-relationship between age, systolic blood pressure and baroreflex sensitivity index derived from the Valsalva manoeuvre was investigated in either combined or separated groups of normal and hypertensive subjects...

View articletitled, Differences in age-independent effects of blood pressure on baroreflex sensitivity between normal and hypertensive subjects

Articles

Evaluation of an isotope washout technique to measure skin vascular resistance and skin perfusion pressure: influence of age, site and arterial surgery

Henry J. Duncan, Irwin B. Faris

Clin Sci (Lond) (1986) 70 (3): 249–255.

https://doi.org/10.1042/cs0700249

Published: 01 March 1986

... patients <30 years of age, 13 patients ≥.30 years of age and in 15 patients with peripheral vascular disease (PVD). With increasing age the SPP and SVR were increased. The SPP was similar to the mean arterial pressure in normal individuals but was decreased in patients with PVD. The SPP is a useful...

View articletitled, Evaluation of an isotope washout technique to measure skin vascular resistance and skin perfusion pressure: influence of age, site and arterial surgery

Articles

The effect of undernutrition on thermoregulation in the elderly

I. W. Fellows, I. A. Macdonald, T. Bennett, S. P. Allison

Clin Sci (Lond) (1985) 69 (5): 525–532.

https://doi.org/10.1042/cs0690525

Published: 01 November 1985

... 1985 The Biochemical Society and the Medical Research Society 1985 age thermoregulation undernutrition Clinical Science (1985) 69, 525-532 525 The effect of undernutrition on thermoregulation in the elderly I . W. F E L L O W S , I . A. M A C D O N A L D , T . B E N N E T T A N D S . P . A L...

View articletitled, The effect of undernutrition on thermoregulation in the elderly

Articles

Influence of age, sex and potassium excretion on urinary prostaglandins in children

A. Barden, L. J. Beilin, R. Vandongen, I. Rouse

Clin Sci (Lond) (1985) 68 (5): 601–604.

https://doi.org/10.1042/cs0680601

Published: 01 May 1985

...A. Barden; L. J. Beilin; R. Vandongen; I. Rouse 1. Measurement of urinary 6-ketoprostaglandin (PG) F 1α and PGE 2 excretion in 83 healthy children, aged 5-15 years, revealed that supervised 4 h urine collections under mild water diuresis provided more consistent results than overnight 12 h urine...

View articletitled, Influence of age, sex and potassium excretion on urinary prostaglandins in children

Articles

Changes in Gastric Emptying Rates with Age

Michael Horowitz, Guy J. Maddern, Barry E. Chatterton, Peter J. Collins, Philip E. Harding, David J. C. Shearman

Clin Sci (Lond) (1984) 67 (2): 213–218.

https://doi.org/10.1042/cs0670213

Published: 01 August 1984

...Michael Horowitz; Guy J. Maddern; Barry E. Chatterton; Peter J. Collins; Philip E. Harding; David J. C. Shearman 1. A dual isotope technique which measures simultaneously the emptying of solids and liquids by the stomach was used to study gastric emptying in 35 subjects in the age range 21-84 years...

View articletitled, Changes in Gastric Emptying Rates with Age

Articles

Influence of Age on Pulmonary Haemodynamics at Rest and during Supine Exercise

Rolf E. Ehrsam, André Perruchoud, Martin Oberholzer, Felix Burkart, Heinrich Herzog

Clin Sci (Lond) (1983) 65 (6): 653–660.

https://doi.org/10.1042/cs0650653

Published: 01 December 1983

...Rolf E. Ehrsam; André Perruchoud; Martin Oberholzer; Felix Burkart; Heinrich Herzog 1. To determine the effects of age on the pulmonary circulation at rest and on exercise we analysed the results of right heart catheterization studies performed in 125 asymptomatic subjects aged 14-68 years, who...

View articletitled, Influence of Age on Pulmonary Haemodynamics at Rest and during Supine Exercise

Articles

The Rising Ventilatory Cost of Bicycle Exercise in the Seventh Decade: A Longitudinal Study of Nine Healthy Men

J. M. Patrick, E. J. Bassey, P. H. Fentem

Clin Sci (Lond) (1983) 65 (5): 521–526.

https://doi.org/10.1042/cs0650521

Published: 01 November 1983

...J. M. Patrick; E. J. Bassey; P. H. Fentem 1. Submaximal bicycle exercise tests have been performed in nine healthy men on seven annual occasions between the ages of 64 and 70 years. Ten younger men (average age 33 years) have also been studied once for comparison. 2. The ventilatory cost...

View articletitled, The Rising Ventilatory Cost of Bicycle Exercise in the Seventh Decade: A Longitudinal Study of Nine Healthy Men

Articles

Hypertension in the Elderly: Haemodynamic, Fluid Volume and Endocrine Findings

F. H. Messerli, L. B. Glade, G. R. Dreslinski, F. G. Dunn, E. Reisin, A. A. MacPhee, E. D. Frohlich

Clin Sci (Lond) (1981) 61 (s7): 393s–394s.

https://doi.org/10.1042/cs061393s

Published: 01 December 1981

... than 60 years of age. Each patient was matched with respect to mean arterial pressure, body surface area, race and sex with a patient that was younger than 42 years of age. 2. When compared with the younger group, elderly patients had a lower cardiac output, impaired myocardial reserve, lesser aortic...

View articletitled, Hypertension in the Elderly: Haemodynamic, Fluid Volume and Endocrine Findings

Articles

α-Adrenoceptors and Age-Dependent Decrease of Plasma Renin Activity in Essential Hypertension

A. Salvetti, R. Pedrinelli, F. Arzilli, P. Sassano, G. Leonetti, L. Terzoli, C. Bianchini, M. Fruscio

Clin Sci (Lond) (1981) 61 (s7): 311s–313s.

https://doi.org/10.1042/cs061311s

Published: 01 December 1981

...A. Salvetti; R. Pedrinelli; F. Arzilli; P. Sassano; G. Leonetti; L. Terzoli; C. Bianchini; M. Fruscio 1. A stepwise infusion of phentolamine was administered to 26 patients with mild uncomplicated essential hypertension, whose basal renin was inversely related to age. 2. Phentolamine caused a dose...

View articletitled, α-Adrenoceptors and Age-Dependent Decrease of Plasma Renin Activity in Essential Hypertension

Articles

Arterial Plasma Histamine after Exercise in Normal Individuals and in Patients with Exercise-Induced Asthma

J. P. R. Hartley, T. J. Charles, R. D. H. Monie, A. Seaton, W. H. Taylor, A. Westwood, J. D. Williams

Clin Sci (Lond) (1981) 61 (2): 151–157.

https://doi.org/10.1042/cs0610151

Published: 01 August 1981

... and decrease in lung function. 5. Three non-atopic asthmatic patients had a significantly higher mean plasma histamine concentration during exercise than had the atopic subjects. 6. A strong positive correlation in asthmatic patients, and asthmatic and control subjects together was found between age and mean...

View articletitled, Arterial Plasma Histamine after Exercise in Normal Individuals and in Patients with Exercise-Induced Asthma

Articles

Age-Dependence of Noradrenaline Kinetics in Normal Subjects

M. Esler, H. Skews, P. Leonard, G. Jackman, A. Bobik, P. Korner

Clin Sci (Lond) (1981) 60 (2): 217–219.

https://doi.org/10.1042/cs0600217

Published: 01 February 1981

...M. Esler; H. Skews; P. Leonard; G. Jackman; A. Bobik; P. Korner 1. The influence of age on the rate of spillover of noradrenaline into plasma, clearance of noradrenaline from plasma, and plasma noradrenaline concentration at rest was studied in 34 healthy subjects aged 20–69 years. 2. The plasma...

View articletitled, Age-Dependence of Noradrenaline Kinetics in Normal Subjects

Articles

The Effect of Age on the Pharmacokinetics of Diazepam

A. F. MacKlon, M. Barton, O. James, M. D. Rawlins

Clin Sci (Lond) (1980) 59 (6): 479–483.

https://doi.org/10.1042/cs0590479

Published: 01 December 1980

...A. F. MacKlon; M. Barton; O. James; M. D. Rawlins 1. After intravenous administration to 19 subjects, aged 18–95 years, plasma diazepam concentrations were measured over 160 h. Plasma protein binding of diazepam was also measured in each subject. 2. The terminal plasma half-life of diazepam ranged...

View articletitled, The Effect of Age on the Pharmacokinetics of Diazepam

Articles

Total Body Potassium Falls with Age

B. Rajagopalan, G. W. Thomas, L. J. Beilin, J. G. G. Ledingham

Clin Sci (Lond) (1980) 59 (s6): 427s–429s.

https://doi.org/10.1042/cs059427s

Published: 01 December 1980

...B. Rajagopalan; G. W. Thomas; L. J. Beilin; J. G. G. Ledingham 1. Plasma volume, 24 h urine sodium and total body potassium were similar among 89 previously untreated patients with mild hypertension and 89 control subjects matched for age and sex. 2. Total body potassium correlated with renin...

View articletitled, Total Body Potassium Falls with Age

Articles

Blood Pressure Variability in Man: Its Relation to High Blood Pressure, Age and Baroreflex Sensitivity

G. Mancia, A. Ferrari, L. Gregorini, G. Parati, G. Pomidossi, G. Bertinieri, G. Grassi, A. Zanchetti

Clin Sci (Lond) (1980) 59 (s6): 401s–404s.

https://doi.org/10.1042/cs059401s

Published: 01 December 1980

...G. Mancia; A. Ferrari; L. Gregorini; G. Parati; G. Pomidossi; G. Bertinieri; G. Grassi; A. Zanchetti 1. Intra-arterial blood pressure and heart rate were recorded for 24 h in ambulant hospitalized patients of variable age who had normal blood pressure or essential hypertension. Mean 24 h values...

View articletitled, Blood Pressure Variability in Man: Its Relation to High Blood Pressure, Age and Baroreflex Sensitivity

Articles

Effect of Age on Hypertensive Stimuli and the Development of Hypertension in Brattleboro Rats

H. Dlouhá, J. Křeček, J. Zicha

Clin Sci (Lond) (1979) 57 (3): 273–275.

https://doi.org/10.1042/cs0570273

Published: 01 September 1979

... before puberty. 2 2 1979 24 4 1979 © 1979 The Biochemical Society and the Medical Research Society 1979 age diabetes insipidus hypertension Clinical Science (1979) 51,273-275 SHORT COMMUNICATION Effect of age on hypertensive stimuli and the development of hypertension...

View articletitled, Effect of Age on Hypertensive Stimuli and the Development of Hypertension in Brattleboro Rats

Articles

Plasma Noradrenaline, Age and Blood Pressure: A Population Study

D. H. Jones, C. A. Hamilton, J. L. Reid

Clin Sci Mol Med (1978) 55 (s4): 73s–75s.

https://doi.org/10.1042/cs055073s

Published: 01 December 1978

...D. H. Jones; C. A. Hamilton; J. L. Reid 1. Mean supine plasma noradrenaline was lower in 12 male laboratory staff (0·24 ± 0·02 μg/l) than similarly normotensive out-patients (0·44 ± 0·07 μg/l). 2. In 164 non-medical hospital staff, plasma noradrenaline increased with age in white males only. 3...

View articletitled, Plasma Noradrenaline, Age and Blood Pressure: A Population Study

Articles

Biochemical Correlates of the Increase in Blood Pressure with Age

C. E. Grim, M. H. Weinberger, D. P. Henry, F. C. Luft, N. S. Fineberg

Clin Sci Mol Med (1978) 55 (s4): 377s–379s.

https://doi.org/10.1042/cs055377s

Published: 01 December 1978

...C. E. Grim; M. H. Weinberger; D. P. Henry; F. C. Luft; N. S. Fineberg 1. Blood pressure, plasma renin activity, plasma aldosterone, urinary noradrenaline during sleep (U NA-S ) and several estimates of sodium intake were determined in 379 normotensive subjects (age 13–70) to investigate...

View articletitled, Biochemical Correlates of the Increase in Blood Pressure with Age

Articles

Intestinal Cholecalciferol Absorption in the Elderly and in Younger Adults

J. M. Barragry, M. W. France, D. Corless, S. P. Gupta, S. Switala, B. J. Boucher, R. D. Cohen

Clin Sci Mol Med (1978) 55 (2): 213–220.

https://doi.org/10.1042/cs0550213

Published: 01 August 1978

... groups. 6. It is suggested that there is a defect in intestinal absorption of cholecalciferol in the elderly. 12 1 1978 16 4 1978 © 1978 The Biochemical Society and the Medical Research Society 1978 age cholecalciferol intestinal absorption Clinical Science andMolecular...

View articletitled, Intestinal Cholecalciferol Absorption in the Elderly and in Younger Adults

Articles

Bone Blood Flow and Age in the Rat

J. N. MacPherson, P. Tothill

Clin Sci Mol Med (1978) 54 (1): 111–113.

https://doi.org/10.1042/cs0540111

Published: 01 January 1978

...J. N. MacPherson; P. Tothill 1. The proportion of the cardiac output delivered to the skeleton and individual bones has been determined in rats of differing ages and weights with radioactive microspheres. 2. There was a decrease in the blood flow to the tibia—fibula, jaw, femur, pelvis, humerus...

View articletitled, Bone Blood Flow and Age in the Rat

Articles

Haemodynamic Characteristics of Low-Renin Hypertension

M. A. D. H. Schalekamp, W. H. Birkenhäger, G. A. Zaal, G. Kolsters

Clin Sci Mol Med (1977) 52 (4): 405–412.

https://doi.org/10.1042/cs0520405

Published: 01 April 1977

... blood flow were significantly lower in low-renin hypertension. Total peripheral and renal vascular resistance were markedly higher in this group. 3. Plasma renin concentration correlated inversely with both total peripheral and renal vascular resistance as well as with age. Multiple regression analysis...

View articletitled, Haemodynamic Characteristics of Low-Renin Hypertension

Articles

Solitary Kidney and Ageing as Causes of Low Renin and Aldosterone Concentrations: Relevance to ‘Low-Renin’ Essential Hypertension

R. Gordon, Freda Doran, M. Thomas, Frances Thomas, P. Cheras

Clin Sci Mol Med (1976) 51 (s3): 177s–180s.

https://doi.org/10.1042/cs051177s

Published: 01 December 1976

...R. Gordon; Freda Doran; M. Thomas; Frances Thomas; P. Cheras 1. As experimental models of reduced nephron population in man, (a) twelve men aged 15–32 years who had one kidney removed 1–13 years previously and (b) fourteen normotensive men aged 70–90 years were studied. Results were compared...

View articletitled, Solitary Kidney and Ageing as Causes of Low Renin and Aldosterone Concentrations: Relevance to ‘Low-Renin’ Essential Hypertension

Articles

Reduced Plasma Renin Activity in Essential Hypertension: Effects of Blood Pressure, Age and Sodium

G. W. Thomas, J. G. G. Ledingham, L. J. Beilin, A. N. Stott

Clin Sci Mol Med (1976) 51 (s3): 185s–188s.

https://doi.org/10.1042/cs051185s

Published: 01 December 1976

...G. W. Thomas; J. G. G. Ledingham; L. J. Beilin; A. N. Stott 1. Supine plasma renin activity and its responsiveness to erect posture and frusemide were reduced in fifty-one patients with essential hypertension, compared with fifty-one age- and sex-matched control subjects. 2. Twenty-four hour...

View articletitled, Reduced Plasma Renin Activity in Essential Hypertension: Effects of Blood Pressure, Age and Sodium

Articles

Deoxyribonucleic Acid Repair Synthesis: A new Factor for Defining High Blood Pressure

T. Thulin, R. W. Pero, C. Bryngelsson, F. Mitelman, Å. Nordén, B. Scherstén

Clin Sci Mol Med (1976) 51 (s3): 695s–696s.

https://doi.org/10.1042/cs051695s

Published: 01 December 1976

...T. Thulin; R. W. Pero; C. Bryngelsson; F. Mitelman; Å. Nordén; B. Scherstén 1. The level of DNA repair synthesis has been compared in males diagnosed as having hypertension (diastolic blood pressure ≥ 100 mmHg), males with slightly elevated blood pressure (>95th percentile corrected for age...

View articletitled, Deoxyribonucleic Acid Repair Synthesis: A new Factor for Defining High Blood Pressure

Articles

Effect of Age on Oxygen-Binding in Normal Human Subjects

P. M. Tweeddale, R. J. E. Leggett, D. C. Flenley

Clin Sci Mol Med (1976) 51 (2): 185–188.

https://doi.org/10.1042/cs0510185

Published: 01 August 1976

...P. M. Tweeddale; R. J. E. Leggett; D. C. Flenley 1. Oxygen-binding, plasma and intra-erythrocytic pH, and haemoglobin, 2,3-diphosphoglycerate and inorganic phosphate concentrations were measured in sixty-two healthy non-smokers aged between 18 and 89 years. 2. P 50 (oxygen tension at 50% oxygen...

View articletitled, Effect of Age on Oxygen-Binding in Normal Human Subjects

Articles

Renal Haemodynamics and Plasma Renin in Patients with Essential Hypertension

E. B. Pedersen, H. J. Kornerup

Clin Sci Mol Med (1976) 50 (5): 409–414.

https://doi.org/10.1042/cs0500409

Published: 01 May 1976

... and in fifteen control subjects. 2. GFR and RPF were similar in the hypertensive group and in the control group, whereas the renal vascular resistance was significantly higher in the hypertensive patients. GFR and RPF decreased with increasing blood pressure in both groups. Increasing age induced a further...

View articletitled, Renal Haemodynamics and Plasma Renin in Patients with Essential Hypertension

Articles

Plasma Renin Activity as a Function of Age in Two New Strains of Spontaneously Hypertensive and Normotensive Rats

Madeleine Vincent, Jeanne Dupont, J. Sassard

Clin Sci Mol Med (1976) 50 (2): 103–107.

https://doi.org/10.1042/cs0500103

Published: 01 February 1976

... was significantly higher in young spontaneously hypertensive than in normotensive rats of the same age (5–7 weeks). After the ninth week plasma renin activity decreased and, at week 45, became significantly lower in hypertensive than in normotensive rats. 4. When hypertension was established a significant inverse...

View articletitled, Plasma Renin Activity as a Function of Age in Two New Strains of Spontaneously Hypertensive and Normotensive Rats

Articles

Long-Term Study of Relationships between Blood Pressure, Age and Body Weight in Steelmill Workers

M. Ulrych, J. Tauber, A. P. Shapiro

Clin Sci Mol Med (1973) 45 (s1): 107s–110s.

https://doi.org/10.1042/cs045107s

Published: 01 August 1973

...M. Ulrych; J. Tauber; A. P. Shapiro 1. In 404 male steelmill workers blood pressure and body weight were followed for 15–25 years and their relationships analysed. 2. It appears that age on average has a negligible influence on diastolic pressure and has a positive influence on systolic pressure...

View articletitled, Long-Term Study of Relationships between Blood Pressure, Age and Body Weight in Steelmill Workers

Articles

Blood Pressure and Ageing; Results of a 15–17 Year Follow-Up Study in South Wales

W. E. Miall, Susan Chinn

Clin Sci Mol Med (1973) 45 (s1): 23s–33s.

https://doi.org/10.1042/cs045023s

Published: 01 August 1973

...W. E. Miall; Susan Chinn 1. Several recent studies of the relation between blood pressure and ageing have been re-examined, and it is concluded that none satisfactorily investigates the possibility of separate influences of age and attained pressure in determining the rate of change of pressure...

View articletitled, Blood Pressure and Ageing; Results of a 15–17 Year Follow-Up Study in South Wales

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