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Clin Sci (Lond) (2021) 135 (15): 1915–1927.
Published: 10 August 2021
...Makoto Kuro-o The klotho gene, named after a Greek goddess who spins the thread of life, was identified as a putative ‘ageing-suppressor’ gene. Klotho-deficient mice exhibit complex ageing-like phenotypes including hypogonadism, arteriosclerosis (vascular calcification), cardiac hypertrophy...
Clin Sci (Lond) (2021) 135 (10): 1251–1272.
Published: 26 May 2021
...Lu Dai; Leon Schurgers; Paul G. Shiels; Peter Stenvinkel The worldwide landscape of an ageing population and age-related disease brings with it huge socio-economic and public healthcare concerns across nations. Correspondingly, monumental human and financial resources have been invested...
Leanne Mooney, Carl S. Goodyear, Tamir Chandra, Kristina Kirschner, Mhairi Copland, Mark C. Petrie, Ninian N. Lang
Clin Sci (Lond) (2021) 135 (7): 991–1007.
Published: 16 April 2021
...Leanne Mooney; Carl S. Goodyear; Tamir Chandra; Kristina Kirschner; Mhairi Copland; Mark C. Petrie; Ninian N. Lang Ageing is a major risk factor for the development of cardiovascular disease (CVD) and cancer. Whilst the cumulative effect of exposure to conventional cardiovascular risk factors...
Rungong Yang, Shuhong Fu, Liang Zhao, Bei Zhen, Ling Ye, Xiaolu Niu, Xiaoxia Li, Pumin Zhang, Jie Bai
Clin Sci (Lond) (2017) 131 (15): 1895–1904.
Published: 07 July 2017
...Rungong Yang; Shuhong Fu; Liang Zhao; Bei Zhen; Ling Ye; Xiaolu Niu; Xiaoxia Li; Pumin Zhang; Jie Bai Growth differentiation factor 11 (GDF-11) has been implicated in reverse effects of ageing on the central nervous system of humans. β2-microglobulin (β2-MG) has been reported to negatively regulate...
Clin Sci (Lond) (2017) 131 (11): 1069–1092.
Published: 17 May 2017
...Marie Frimat; Maité Daroux; Rachel Litke; Rémi Nevière; Frédéric J. Tessier; Eric Boulanger Advanced glycation end-product (AGE) is the generic term for a heterogeneous group of derivatives arising from a non-enzymatic reaction between reducing sugars and proteins. In recent years, evidence has...
Renée Ventura-Clapier, Maryline Moulin, Jérôme Piquereau, Christophe Lemaire, Mathias Mericskay, Vladimir Veksler, Anne Garnier
Clin Sci (Lond) (2017) 131 (9): 803–822.
Published: 19 April 2017
... part in the sex specificity of important pathologies mainly CVDs and neurological disorders. ageing cardiovascular diseases gender metabolic diseases mitochondria neurological disorders oxidative stress sex sexual dimorphism Mitochondria exhibit a strong tissue and sex specificity...
Clin Sci (Lond) (2016) 130 (5): 337–348.
Published: 26 January 2016
... of chronic disease. Sex has an impact on the severity of cardiovascular risk in experimental models of developmental insult. Yet, few studies examine the influence of sex on blood pressure and cardiovascular health in low-birth weight men and women. Fewer still assess the impact of ageing on sex differences...
Sónia Gouveia, Manuel G. Scotto, Gian Domenico Pinna, Roberto Maestri, Maria Teresa La Rovere, Paulo J.S.G. Ferreira
Clin Sci (Lond) (2015) 129 (12): 1163–1172.
Published: 30 October 2015
... property of baroreflex functioning, so our goal is to investigate whether it represents a ‘natural’ partition of BRS values. As reduced baroreflex responsiveness is also associated with ageing, we investigated whether a BRS estimate <3 ms/mmHg could be the result of a process of physiological senescence...
Clin Sci (Lond) (2015) 129 (2): 159–167.
Published: 24 April 2015
... hypothesized that (i) local 5-MTHF administration and (ii) chronic folic acid supplementation would improve cutaneous microvascular function in ageing through NO-dependent mechanisms. There were two separate studies in which there were 11 young (Y: 22±1 years) and 11 older (O: 71±3 years) participants. In both...
Clin Sci (Lond) (2015) 128 (12): 839–861.
Published: 27 March 2015
...Dionne E.M. Maessen; Coen D.A. Stehouwer; Casper G. Schalkwijk The formation and accumulation of advanced glycation endproducts (AGEs) are related to diabetes and other age-related diseases. Methylglyoxal (MGO), a highly reactive dicarbonyl compound, is the major precursor in the formation of AGEs...
Clin Sci (Lond) (1998) 94 (5): 549–555.
Published: 01 May 1998
... formation and rate of fracture repair observed with ageing and in osteoporosis has been suggested to be due to a decrease in numbers of these progenitors, but human studies are limited. 2. We have tested the potential to form CFU-F in a total of 99 patients undergoing corrective surgery (16 controls, 14–48...
Clin Sci (Lond) (1996) 91 (5): 621–626.
Published: 01 November 1996
...J. H. Knudsen; F. Gustafsson; J. Toft; N. J. Christensen 1. We studied 37 healthy men at rest in the supine position to examine the effect of ageing, smoking and physical training on β 2 -adrenoceptor function, plasma catecholamines and the proportions of various lymphocyte subsets. 2. In 14 young...
Clin Sci (Lond) (1996) 90 (6): 485–492.
Published: 01 June 1996
... in the elderly ( P < 0.002). 4. Interactions between facial cooling and orthostatic reflexes induced by lower-body negative pressure showed significantly different age-related linear trends. Facial cooling diminished the hypotension induced by lower-body negative pressure in both groups. Facial cooling had...
Clin Sci (Lond) (1995) 88 (2): 211–217.
Published: 01 February 1995
... of these mediators. Mortality from endotoxaemia is highly age related. 2. These studies focus on the role of hepatic Kupffer cells in the increased sensitivity of old rats to bacterial endotoxins. Possible age-related changes in the production of eicosanoids and induction of gene expression and secretion...
Clin Sci (Lond) (1994) 87 (3): 297–302.
Published: 01 September 1994
...G. A. Ford; O. F. W. James 1. Cardiac chronotropic responses to isoprenaline are reduced with ageing in man. It is unclear whether this is due to reduced cardiac β-adrenergic sensitivity or to age-associated differences in reflex cardiovascular responses to the vasodilatory effects of isoprenaline...
Lewis A. Lipsitz, Rene W. M. M. Jansen, Carolyn M. Connelly, Margaret M. Kelley-Gagnon, Anthony J. Parker
Clin Sci (Lond) (1994) 87 (2): 259–267.
Published: 01 August 1994
... vasodilatory adenosine receptors in the splanchnic circulation, we postulated that caffeine would reduce splanchnic blood pooling and prevent the development of postprandial hypotension. 3. We conducted a randomized, double-blind, placebo-controlled, cross-over study in nine elderly patients [age 76 ± 9 (SD...
Penelope J. Neild, Denise Syndercombe-Court, W. R. Keatinge, G. C. Donaldson, M. Mattock, Maria Caunce
Clin Sci (Lond) (1994) 86 (1): 43–48.
Published: 01 January 1994
... prevent them rising substantially during cold-in- duced haemoconcentration. METHODS The subjects were six healthy volunteers aged 20-23 years and six aged 6 6 7 1 years. Half of each group were women. All gave their informed consent, and were asked to inform the experimenters if the thermal stresses...
Clin Sci (Lond) (1993) 85 (2): 203–211.
Published: 01 August 1993
...N. Meskini; G. Nemoz; P. Chapuy; P. Haond; J. F. Pageaux; E. Vericel; M. Lagarde; A. F. Prigent 1. Since ageing has been associated with a decrease in both immune responses and antioxidant defences, this study was undertaken to compare the glutathione peroxidase activity in peripheral blood...
A. P. Corfield, S. A. Wagner, A. Safe, R. A. Mountford, J. R. Clamp, J. P. Kamerling, J. F. G. Vliegenthart, R. Schauer
Clin Sci (Lond) (1993) 84 (5): 573–579.
Published: 01 May 1993
.... The sialic acid content of gastric aspirates collected under resting conditions from 77 patients with non-ulcer dyspepsia was found to decrease with age from >100 μg/ml at 25 years and younger to <20 μg/ml above 70 years of age. 3. Analysis of the sialic acids by gas chromatography, mass spectrometry...
Clin Sci (Lond) (1993) 84 (3): 331–337.
Published: 01 March 1993
...E. J. Bassey; U. J. Harries 1. The maximal grip strength of the hand has been measured in a random sample of 359 men and 561 women aged over 65 years living in their own homes. The response rate was 80% from a representative demographic area of the U.K. Measurements were made of body mass, skeletal...
Clin Sci (Lond) (1993) 84 (1): 95–98.
Published: 01 January 1993
...S. K. Phillips; K. M. Rook; N. C. Siddle; S. A. Bruce; R. C. Woledge 1. The time-course of the age-related decline in specific muscle force (maximum voluntary force per cross-sectional area) in men and women was determined by measuring the maximum voluntary force and cross-sectional area...
Clin Sci (Lond) (1992) 83 (4): 489–494.
Published: 01 October 1992
... challenge samples. 2. Using a multivariate regression model, with predictor variables of chronological age, menopausal age and body mass index, neither chronological age nor menopausal age correlated with fasting or post-challenge plasma glucose or C-peptide concentrations. In contrast, menopausal age...
Clin Sci (Lond) (1992) 83 (3): 301–306.
Published: 01 September 1992
...M. Rathaus; Z. Greenfeld; E. Podjarny; M. Brezis; J. Green; J. Bernheim 1. The aim of this investigation was to study the role of prostaglandins in the impaired Na + conservation of the ageing kidney. 2. We measured the urinary excretion of thromboxane B 2 , 6-keto-prostaglandin F 1α...
Richard Eastell, Patricia S. Simmons, Antony Colwell, Adel M. A. Assiri, Mary F. Burritt, R. Graham, G. Russell, B. Lawrence Riggs
Clin Sci (Lond) (1992) 83 (3): 375–382.
Published: 01 September 1992
...) concentration every 2 h and urinary deoxypyridinoline (a marker of bone collagen resorption) excretion for 8 h periods in 10 pubertal girls (aged 10–14 years), 15 premenopausal women (aged 20–49 years) and 17 postmenopausal women (aged 50–75 years). 2. The serum concentration of bone Gla-protein and the urinary...
Clin Sci (Lond) (1992) 83 (2): 149–155.
Published: 01 August 1992
...W. Wieling; D. P. Veerman; J. H. A. Dambrink; B. P. M. Imholz 1. The circulatory adjustment to standing was investigated in two age groups. Young subjects consisted of 20 healthy 10–14-year-old girls and boys. Elderly subjects consisted of 40 70–86-year-old healthy and active females and males...
Clin Sci (Lond) (1991) 81 (s25): 509–514.
Published: 01 October 1991
...J. Duggan; S. Kilfeather; S. L. Lightman; E. O'Brien; K. O'Malley 1. Ageing and hypertension are associated with changes in the way in which the body handles sodium. This may involve changes in plasma atrial natriuretic peptide concentration, since atrial natriuretic peptide is a regulator...
Clin Sci (Lond) (1990) 79 (5): 467–470.
Published: 01 November 1990
... women. 2. In contrast, the ability of these cells to bind guanosine 5′-[β, γ-imido]triphosphate, a non-hydrolysable analogue of guanosine 5′-triphosphate, was the same in both groups. 3. These findings are discussed in the context of the decline in immune function which occurs with increasing age. ©...
Clin Sci (Lond) (1990) 79 (1): 73–79.
Published: 01 July 1990
...B. P. M. Imholz; J. H. A. Dambrink; J. M. Karemaker; W. Wieling 1. Continuous orthostatic responses of blood pressure and heart rate were measured in 40 healthy and active elderly subjects over 70 years of age in order to assess the time course and rapidity of orthostatic cardiovascular adaptation...
Clin Sci (Lond) (1989) 77 (3): 265–272.
Published: 01 September 1989
... and the Medical Research Society 1989 ageing autonomic function catecholamines insulin postprandial blood pressure Clinical Science ( 1 989) 77,265-272 265 Effects of meal composition on the postprandial blood pressure, catecholamine and insulin changes in elderly subjects J. F. POTTER, D. HESELTINE...
Clin Sci (Lond) (1989) 76 (5): 487–494.
Published: 01 May 1989
...-asthmatic men who were never-smokers (aged 26-61 years) and in 41 male cigarette smokers (aged 32-64 years). The results were compared with those for spirometry and the single-breath N 2 test which are the most commonly used techniques in epidemiological surveys for detecting the effects of smoking...
Clin Sci (Lond) (1988) 74 (3): 331–334.
Published: 01 March 1988
...Scott L. Mader; Alan S. Robbins; Laurence Z. Rubenstein; Michael L. Tuck; Philip J. Scarpace 1. A number of age-related changes have been reported in the catecholamine–adrenoceptor–adenylate cyclase system. Most of the data available on these alterations come from resting subjects; the response...
Clin Sci (Lond) (1987) 73 (5): 507–513.
Published: 01 November 1987
...Pamela B. Davis; Catherine Silski 1. Platelets taken from healthy unmedicated subjects over 65 years of age display less inhibition of prostaglandin E 1 (PGE 1 )-stimulated adenosine 3′:5′-cyclic monophosphate (cyclic AMP) synthesis by noradrenaline than do platelets taken from young adults aged 18...
Yoko Nagata, Toyoaki Akino, Kimiyoshi Ohno, Yoshimitsu Kataoka, Takahiro Ueda, Tetsuo Sakurai, Koh-Ichi Shiroshita, Takuji Yasuda
Clin Sci (Lond) (1987) 73 (1): 105–108.
Published: 01 July 1987
...Yoko Nagata; Toyoaki Akino; Kimiyoshi Ohno; Yoshimitsu Kataoka; Takahiro Ueda; Tetsuo Sakurai; Koh-Ichi Shiroshita; Takuji Yasuda 1. Minute but appreciable amounts of d -amino acids were detected in normal human plasma. 2. The content was significantly higher in an elderly population (age 76 ± 6...
Clin Sci (Lond) (1986) 70 (1): 59–62.
Published: 01 January 1986
... previously published by us, suggest that cyclic AMP production and cellular functions which this molecule participates in are reduced in cells from elderly individuals. Clinical Science (1986) 70,59-62 59 Age-related differences in granulocyte chemotaxis and degranulation B. McLAUGHLIN, K . O MALLEY A N D T...
Clin Sci (Lond) (1985) 69 (3): 337–341.
Published: 01 September 1985
...Lewis A. Lipsitz; Helene A. Storch; Kenneth L. Minaker; John W. Rowe 1. Orthostatic hypotension, an age-related phenomenon, has been associated with hypertension and body weight variability. To evaluate the relative contributions of blood pressure elevation and abnormalities in extracellular volume...
Clin Sci (Lond) (1985) 69 (2): 197–205.
Published: 01 August 1985
...Lydia Makrides; George J. F. Heigenhauser; Neil Mccartney; Norman L. Jones 1. Fifty males and 50 females, 15-71 years of age, exercised maximally for 30 s on an isokinetic ergometer at a pedalling frequency of 60 rev./min. Results were compared with maximal oxygen uptake (VO 2 max.) obtained...
Clin Sci (Lond) (1985) 68 (s10): 133s–136s.
Published: 01 January 1985
...J. R. Docherty; K. O'Malley 1. Ageing changes in α-adrenoceptors can be summarized as follows: except in the eye, where there is an apparent increased responsiveness with increasing age in man, peripheral α-adrenoceptor responsiveness has generally been found to be either unchanged or reduced...
Clin Sci (Lond) (1984) 66 (6): 697–699.
Published: 01 June 1984
...D. Fitzgerald; V. Doyle; J. G. Kelly; K. O'Malley 1. The heart rate response to isoprenaline in 11 subjects aged 19–46 years was compared with lymphocyte β-adrenoceptor numbers and lymphocyte cyclic AMP responsiveness. 2. The dose of isoprenaline required to increase heart rate by 25 beats/min...
Clin Sci (Lond) (1982) 63 (s8): 305s–308s.
Published: 01 October 1982
... prazosin's α-receptor-blocking effects. 6. Although there is no evidence of an age-related increase in the sensitivity of α-adrenoceptor-mediated vasoconstriction, the results are not inconsistent with an age-related reduction in α-adrenoceptor responsiveness. © 1982 The Biochemical Society and the Medical...
Clin Sci Mol Med (1976) 51 (6): 609–612.
Published: 01 December 1976
...% and there was no significant difference between the two age groups. 5. The assessment was found to correlate moderately well with a conventional assessment of physical condition based on oxygen uptake from tests on a bicycle ergometer. 6. The test could also be used as a performance index since walking speed...
Clin Sci Mol Med (1974) 47 (1): 93–95.
Published: 01 July 1974
...A. De Bats; A. H. Gordon; E. L. Rhodes 1. The glomerular sialic acid content of kidneys from diabetic subjects, aged subjects and healthy young individuals was determined. 2. Similar mean sialic acid contents were found in the glomeruli of elderly diabetic subjects, and in age- and sex-matched non...