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Articles

Aging and sinus node dysfunction: mechanisms and future directions

Thassio Mesquita, Rodrigo Miguel-dos-Santos, Eugenio Cingolani

Clin Sci (Lond) (2025) 139 (11): 577–593.

https://doi.org/10.1042/CS20231025

Published: 11 June 2025

...Thassio Mesquita; Rodrigo Miguel-dos-Santos; Eugenio Cingolani Aging is a natural biological process influenced by endogenous and exogenous factors such as genetics, environment, and individual lifestyle. The aging-dependent decline in resting and maximum heart rate is a conserved feature across...

View article titled, Aging and sinus node dysfunction: mechanisms and future directions

Articles

Aging and sex differences in salt sensitivity of blood pressure

In Collection

The biology of ageing: Geroscience and the exposome

Mert Demirci, Jeremiah M. Afolabi, Annet Kirabo

Clin Sci (Lond) (2025) 139 (02): 199–212.

https://doi.org/10.1042/CS20240788

Published: 28 January 2025

...Mert Demirci; Jeremiah M. Afolabi; Annet Kirabo Salt sensitivity of blood pressure (SSBP) is a complex physiological trait characterized by changes in blood pressure in response to dietary salt intake. Aging introduces an additional layer of complexity to the pathophysiology of SSBP...

View article titled, Aging and sex differences in salt sensitivity of blood pressure

Articles

The dietary exposome: a brief history of diet, longevity, and age-related health in rodents

In Collection

The biology of ageing: Geroscience and the exposome

Colin Selman

Clin Sci (Lond) (2024) 138 (21): 1343–1356.

https://doi.org/10.1042/CS20241248

Published: 24 October 2024

...Colin Selman It has been recognized for over a century that feeding animals less food than they would normally eat increases lifespan and leads to broad-spectrum improvements in age-related health. A significant number of studies have subsequently shown that restricting total protein, branched...

View article titled, The dietary exposome: a brief history of diet, longevity, and age-related health in rodents

Articles

Skeletal muscle dysfunction with advancing age

In Collection

The biology of ageing: Geroscience and the exposome

Pardeep Pabla, Eleanor J. Jones, Mathew Piasecki, Bethan E. Phillips

Clin Sci (Lond) (2024) 138 (14): 863–882.

https://doi.org/10.1042/CS20231197

Published: 12 July 2024

...’ (the length of time spent in a healthy, disease-free state) has also increased, with skeletal muscle being a substantial contributor to this. Biological ageing is accompanied by declines in both skeletal muscle mass and function, termed sarcopenia. The mechanisms underpinning sarcopenia are multifactorial...

View article titled, Skeletal muscle dysfunction with advancing age

Articles

Astrocytes at the intersection of ageing, obesity, and neurodegeneration

In Collection

The biology of ageing: Geroscience and the exposome

Wyn Firth, Katherine R Pye, Paul G Weightman Potter

Clin Sci (Lond) (2024) 138 (8): 515–536.

https://doi.org/10.1042/CS20230148

Published: 23 April 2024

..., a heterogeneous group of glial cells, play key roles in regulating the metabolic and inflammatory landscape of the CNS and have emerged as potential therapeutic targets for a variety of disorders. This review will outline astrocyte functions in the CNS in healthy ageing, obesity, and neurodegeneration...

View article titled, Astrocytes at the intersection of ageing, obesity, and neurodegeneration

Articles

Restoration of the gut barrier integrity and restructuring of the gut microbiome in aging by angiotensin-(1–7)

In Collection

The biology of ageing: Geroscience and the exposome

Kishore Chittimalli, Jesmin Jahan, Anil Sakamuri, Zachary L. McAdams, Aaron C. Ericsson, Yagna P.R. Jarajapu

Clin Sci (Lond) (2023) 137 (11): 913–930.

https://doi.org/10.1042/CS20220904

Published: 14 June 2023

...Kishore Chittimalli; Jesmin Jahan; Anil Sakamuri; Zachary L. McAdams; Aaron C. Ericsson; Yagna P.R. Jarajapu Compromised barrier function of colon epithelium with aging is largely due to gut microbial dysbiosis. Recent studies implicate an important role for angiotensin converting enzymes, ACE...

View article titled, Restoration of the gut barrier integrity and restructuring of the gut microbiome in aging by angiotensin-(1–7)

Includes: Supplementary data

Articles

Novel mediators of idiopathic pulmonary fibrosis

Shigeki Saito, Brian Deskin, Mohammad Rehan, Santosh Yadav, Yasuka Matsunaga, Joseph A. Lasky, Victor J. Thannickal

Clin Sci (Lond) (2022) 136 (16): 1229–1240.

https://doi.org/10.1042/CS20210878

Published: 31 August 2022

... therapy. The most common form is referred to as ‘idiopathic’ since a causal agent or specific association has not been determined; the strongest risk factor for idiopathic pulmonary fibrosis is aging. Emerging studies indicate that targeting certain components of aging biology may be effective...

View article titled, Novel mediators of idiopathic pulmonary fibrosis

Articles

Cellular and molecular mechanisms of breast cancer susceptibility

Sundus F. Shalabi, Mark A. LaBarge

Clin Sci (Lond) (2022) 136 (13): 1025–1043.

https://doi.org/10.1042/CS20211158

Published: 04 July 2022

... are weak and there is little understanding of mechanism. Aging is by far the greatest risk factor for BC, and there are specific forms of inherited genetic risk that are well-understood to cause BC. We propose that bringing focus to the biology underlying these forms of risk will illuminate biological...

View article titled, Cellular and molecular mechanisms of breast cancer susceptibility

Articles

Mechanisms of immune aging in HIV

Manon Chauvin, Delphine Sauce

Clin Sci (Lond) (2022) 136 (1): 61–80.

https://doi.org/10.1042/CS20210344

Published: 05 January 2022

...Manon Chauvin; Delphine Sauce Massive CD4 + T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws an intriguing parallel between HIV-1 infection and aging. Indeed, many...

View article titled, Mechanisms of immune aging in HIV

Articles

Using nuclear envelope mutations to explore age-related skeletal muscle weakness

Edmund Battey, Matthew J. Stroud, Julien Ochala

Clin Sci (Lond) (2020) 134 (16): 2177–2187.

https://doi.org/10.1042/CS20190066

Published: 26 August 2020

...Edmund Battey; Matthew J. Stroud; Julien Ochala Skeletal muscle weakness is an important determinant of age-related declines in independence and quality of life but its causes remain unclear. Accelerated ageing syndromes such as Hutchinson–Gilford Progerin Syndrome, caused by mutations in genes...

View article titled, Using nuclear envelope mutations to explore age-related skeletal muscle weakness

Articles

Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

Clin Sci (Lond) (2020) 134 (7): 727–746.

https://doi.org/10.1042/CS20190124

Published: 07 April 2020

... Beusekom; Mohsen Ghanbari; Jan H.J. Hoeijmakers; Radislav Sedlacek; Rhian M. Touyz; Augusto C. Montezano; Ingrid van der Pluijm; A.H. Jan Danser; Kristian A. Haanes; Anton J.M. Roks We previously identified genomic instability as a causative factor for vascular aging. In the present study, we determined...

View article titled, Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

Includes: Supplementary data

Articles

Amino acid and lipid associated plasma metabolomic patterns are related to healthspan indicators with ageing

Lawrence C. Johnson, Christopher R. Martens, Jessica R. Santos-Parker, Candace J. Bassett, Talia R. Strahler, Charmion Cruickshank-Quinn, Nichole Reisdorph, Matthew B. McQueen, Douglas R. Seals

Clin Sci (Lond) (2018) 132 (16): 1765–1777.

https://doi.org/10.1042/CS20180409

Published: 30 August 2018

...Lawrence C. Johnson; Christopher R. Martens; Jessica R. Santos-Parker; Candace J. Bassett; Talia R. Strahler; Charmion Cruickshank-Quinn; Nichole Reisdorph; Matthew B. McQueen; Douglas R. Seals Advancing age is associated with impairments in numerous physiological systems, leading to an increased...

View article titled, Amino acid and lipid associated plasma metabolomic patterns are related to healthspan indicators with ageing

Includes: Supplementary data

Articles

The aging heart

Vanessa Obas, Ramachandran S. Vasan

Clin Sci (Lond) (2018) 132 (13): 1367–1382.

https://doi.org/10.1042/CS20171156

Published: 09 July 2018

...Vanessa Obas; Ramachandran S. Vasan As the elderly segment of the world population increases, it is critical to understand the changes in cardiac structure and function during the normal aging process. In this review, we outline the key molecular pathways and cellular processes that underlie...

View article titled, The aging heart

Articles

The VEGFA 156 b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease

Eva Latorre, Luke C. Pilling, Benjamin P. Lee, Stefania Bandinelli, David Melzer, Luigi Ferrucci, Lorna W. Harries

Clin Sci (Lond) (2018) 132 (3): 313–325.

https://doi.org/10.1042/CS20171556

Published: 02 February 2018

...Eva Latorre; Luke C. Pilling; Benjamin P. Lee; Stefania Bandinelli; David Melzer; Luigi Ferrucci; Lorna W. Harries Coronary heart disease (CHD) is a leading cause of morbidity in people over 65 years of age; >40% of all deaths are due to this condition. The association between increasing age...

View article titled, The VEGFA 156 b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease

Articles

Post-prandial hyperlipidaemia results in systemic nitrosative stress and impaired cerebrovascular function in the aged

Christopher J. Marley, Danielle Hodson, Julien V. Brugniaux, Lewis Fall, Damian M. Bailey

Clin Sci (Lond) (2017) 131 (23): 2807–2812.

https://doi.org/10.1042/CS20171406

Published: 28 November 2017

... (oxidative–nitrosative stress). However, it remains to be determined whether this extends to the cerebrovasculature. To examine this, 38 (19 young (≤35 years) and 19 aged (≥60 years)) healthy males were recruited. Cerebrovascular function (middle cerebral artery velocity, MCAv) and cerebrovascular reactivity...

View article titled, Post-prandial hyperlipidaemia results in systemic nitrosative stress and impaired cerebrovascular function in the aged

Articles

Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1 Δ/− mice

Haiyan Wu, Bibi S. van Thiel, Paula K. Bautista-Niño, Erwin Reiling, Matej Durik, Frank P.J. Leijten, Yanto Ridwan, Renata M.C. Brandt, Harry van Steeg, Martijn E.T. Dollé, Wilbert P. Vermeij, Jan H.J. Hoeijmakers, Jeroen Essers, Ingrid van der Pluijm, A.H. Jan Danser, Anton J.M. Roks

Clin Sci (Lond) (2017) 131 (15): 1941–1953.

https://doi.org/10.1042/CS20170026

Published: 13 July 2017

... is an important contributor to endothelial dysfunction and age-related vascular disease. Recently, we demonstrated in a DNA repair-deficient, prematurely aging mouse model ( Ercc1 Δ/− mice) that dietary restriction (DR) strongly increases life- and health span, including ameliorating endothelial dysfunction...

View article titled, Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1 Δ/− mice

Includes: Supplementary data

Articles

Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine

Rita Ostan, Daniela Monti, Paola Gueresi, Mauro Bussolotto, Claudio Franceschi, Giovannella Baggio

Clin Sci (Lond) (2016) 130 (19): 1711–1725.

https://doi.org/10.1042/CS20160004

Published: 23 August 2016

...Rita Ostan; Daniela Monti; Paola Gueresi; Mauro Bussolotto; Claudio Franceschi; Giovannella Baggio Data showing a remarkable gender difference in life expectancy and mortality, including survival to extreme age, are reviewed starting from clinical and demographic data and stressing the importance...

View article titled, Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine

Articles

Exercise-induced mitochondrial dysfunction: a myth or reality?

Sergej M. Ostojic

Clin Sci (Lond) (2016) 130 (16): 1407–1416.

https://doi.org/10.1042/CS20160200

Published: 07 July 2016

...Sergej M. Ostojic Beneficial effects of physical activity on mitochondrial health are well substantiated in the scientific literature, with regular exercise improving mitochondrial quality and quantity in normal healthy population, and in cardiometabolic and neurodegenerative disorders and aging...

View article titled, Exercise-induced mitochondrial dysfunction: a myth or reality?

Articles

Mitochondrial health, the epigenome and healthspan

Miguel A. Aon, Sonia Cortassa, Magdalena Juhaszova, Steven J. Sollott

Clin Sci (Lond) (2016) 130 (15): 1285–1305.

https://doi.org/10.1042/CS20160002

Published: 29 June 2016

... the transcriptional process, acting at the epigenomic interface between metabolism and the genome. Within this framework, we review existing evidence showing that preservation of mitochondrial network function is directly involved in decreasing the rate of damage accumulation thus slowing aging and improving...

View article titled, Mitochondrial health, the epigenome and healthspan

Articles

Epochs in the depressor/pressor balance of the renin–angiotensin system

Katrina M. Mirabito Colafella, Lucinda M. Hilliard, Kate M. Denton

Clin Sci (Lond) (2016) 130 (10): 761–771.

https://doi.org/10.1042/CS20150939

Published: 01 April 2016

... that therapies targeting the RAS could be optimized for discrete epochs in life. aging angiotensin receptors cardiovascular disease hypertension sex differences The renin–angiotensin system (RAS) is a key regulator of arterial pressure and water and electrolyte balance in health and disease...

View article titled, Epochs in the depressor/pressor balance of the renin–angiotensin system

Articles

NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

Sanghamitra Sahoo, Daniel N. Meijles, Patrick J. Pagano

Clin Sci (Lond) (2016) 130 (5): 317–335.

https://doi.org/10.1042/CS20150087

Published: 26 January 2016

...Sanghamitra Sahoo; Daniel N. Meijles; Patrick J. Pagano Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial fibrillation (AF). NADPH oxidases (Nox) are a major source...

View article titled, NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

Articles

Cyclic nucleotide phosphodiesterase 1 and vascular aging

Chen Yan

Clin Sci (Lond) (2015) 129 (12): 1077–1081.

https://doi.org/10.1042/CS20150605

Published: 13 October 2015

...Chen Yan VSMCs (vascular smooth muscle cells) play critical roles in arterial remodelling with aging, hypertension and atherosclerosis. VSMCs exist in diverse phenotypes and exhibit phenotypic plasticity, e.g. changing from a quiescent/contractile phenotype to an active myofibroblast-like, often...

View article titled, Cyclic nucleotide phosphodiesterase 1 and vascular aging

Articles

Phosphodiesterase 1 regulation is a key mechanism in vascular aging

Paula K. Bautista Niño, Matej Durik, A.H. Jan Danser, René de Vries, Usha M. Musterd-Bhaggoe, Marcel E. Meima, Maryam Kavousi, Mohsen Ghanbari, Jan H. Hoeijmakers, Christopher J. O'Donnell, Nora Franceschini, Ger M.J. Janssen, Jo G.R. De Mey, Yiwen Liu, Catherine M. Shanahan, Oscar H. Franco, Abbas Dehghan, Anton J.M. Roks

Clin Sci (Lond) (2015) 129 (12): 1061–1075.

https://doi.org/10.1042/CS20140753

Published: 13 October 2015

... Dehghan; Anton J.M. Roks Reduced nitric oxide (NO)/cGMP signalling is observed in age-related vascular disease. We hypothesize that this disturbed signalling involves effects of genomic instability, a primary causal factor in aging, on vascular smooth muscle cells (VSMCs) and that the underlying mechanism...

View article titled, Phosphodiesterase 1 regulation is a key mechanism in vascular aging

Includes: Supplementary data

Articles

A breakdown in communication? Understanding the effects of aging on the human small intestine epithelium

Neil A. Mabbott

Clin Sci (Lond) (2015) 129 (7): 529–531.

https://doi.org/10.1042/CS20150364

Published: 03 July 2015

... are poorly understood. Our current understanding of the effects of aging on the physical and immunological properties of the intestinal epithelial barrier is also very limited. In this issue of Clinical Science , Man et al. provide further insight into the effects of aging on small intestinal barrier...

View article titled, A breakdown in communication? Understanding the effects of aging on the human small intestine epithelium

Articles

Age-associated modifications of intestinal permeability and innate immunity in human small intestine

Angela L. Man, Eugenio Bertelli, Silvia Rentini, Mari Regoli, Graham Briars, Mario Marini, Alastair J. M. Watson, Claudio Nicoletti

Clin Sci (Lond) (2015) 129 (7): 515–527.

https://doi.org/10.1042/CS20150046

Published: 03 July 2015

...Angela L. Man; Eugenio Bertelli; Silvia Rentini; Mari Regoli; Graham Briars; Mario Marini; Alastair J. M. Watson; Claudio Nicoletti The physical and immunological properties of the human intestinal epithelial barrier in aging are largely unknown. Ileal biopsies from young (7–12 years), adult (20–40...

View article titled, Age-associated modifications of intestinal permeability and innate immunity in human small intestine

Includes: Supplementary data

Articles

Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions

Yun Lin, Amanda Damjanovic, E. Jeffrey Metter, Huy Nguyen, Thai Truong, Kevin Najarro, Christa Morris, Dan L. Longo, Ming Zhan, Luigi Ferrucci, Richard J. Hodes, Nan-ping Weng

Clin Sci (Lond) (2015) 128 (6): 367–377.

https://doi.org/10.1042/CS20140481

Published: 28 November 2014

... length in peripheral blood mononuclear cells (PBMCs) with age is well documented from cross-sectional studies. But the actual in vivo changes in telomere lengths and its relationship with the contributing factors within the individuals with age have not been fully addressed. In the present paper, we...

View article titled, Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions

Includes: Supplementary data

Articles

Prevention of age-related endothelial dysfunction by habitual aerobic exercise in healthy humans: possible role of nuclear factor κB

Ashley E. Walker, Rachelle E. Kaplon, Gary L. Pierce, Molly J. Nowlan, Douglas R. Seals

Clin Sci (Lond) (2014) 127 (11): 645–654.

https://doi.org/10.1042/CS20140030

Published: 29 July 2014

...Ashley E. Walker; Rachelle E. Kaplon; Gary L. Pierce; Molly J. Nowlan; Douglas R. Seals Habitual aerobic exercise prevents age-related impairments in endothelium-dependent dilation (EDD). We have hypothesized that the pro-inflammatory transcription factor nuclear factor κB (NF-κB) impairs EDD...

View article titled, Prevention of age-related endothelial dysfunction by habitual aerobic exercise in healthy humans: possible role of nuclear factor κB

Includes: Supplementary data

Articles

Cellular aging of skeletal muscle: telomeric and free radical evidence that physical inactivity is responsible and not age

Massimo Venturelli, Garrett R. Morgan, Anthony J. Donato, Van Reese, Renato Bottura, Cantor Tarperi, Chiara Milanese, Federico Schena, Carlo Reggiani, Fabio Naro, Richard M. Cawthon, Russell S. Richardson

Clin Sci (Lond) (2014) 127 (6): 415–421.

https://doi.org/10.1042/CS20140051

Published: 04 June 2014

... of physiological stressors. Although the age-related shortening of TL (telomere length) in highly proliferative tissue is predominantly due to the replication process, the mechanism for telomere shortening in skeletal muscle, which is minimally proliferative, is unclear. By studying TL in both the upper and lower...

View article titled, Cellular aging of skeletal muscle: telomeric and free radical evidence that physical inactivity is responsible and not age

Articles

The Bioenergetic Health Index: a new concept in mitochondrial translational research

Balu K. Chacko, Philip A. Kramer, Saranya Ravi, Gloria A. Benavides, Tanecia Mitchell, Brian P. Dranka, David Ferrick, Ashwani K. Singal, Scott W. Ballinger, Shannon M. Bailey, Robert W. Hardy, Jianhua Zhang, Degui Zhi, Victor M. Darley-Usmar

Clin Sci (Lond) (2014) 127 (6): 367–373.

https://doi.org/10.1042/CS20140101

Published: 29 May 2014

... the terms of the Creative Commons Attribution Non-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. aging cardiovascular disease haplotype...

View article titled, The Bioenergetic Health Index: a new concept in mitochondrial translational research

Articles

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro

Mauricio Krause, Kevin Keane, Josianne Rodrigues-Krause, Domenico Crognale, Brendan Egan, Giuseppe De Vito, Colin Murphy, Philip Newsholme

Clin Sci (Lond) (2014) 126 (10): 739–752.

https://doi.org/10.1042/CS20130678

Published: 03 February 2014

... aging is associated with a low-grade inflammation and IR (insulin resistance), we aimed to: (i) analyse the concentration of eHSP72 in elderly people and determine correlation with insulin resistance, and (ii) determine the effects of eHSP72 on β-cell function and viability in human and rodent...

View article titled, Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro

Articles

In vivo evidence of an age-related increase in ATP cost of contraction in the plantar flexor muscles

Gwenael Layec, Joel D. Trinity, Corey R. Hart, Seong-Eun Kim, Henderik Jonathan Groot, Yann Le Fur, Jacob R. Sorensen, Eun-Kee Jeong, Russell S. Richardson

Clin Sci (Lond) (2014) 126 (8): 581–592.

https://doi.org/10.1042/CS20130442

Published: 08 December 2013

...Gwenael Layec; Joel D. Trinity; Corey R. Hart; Seong-Eun Kim; Henderik Jonathan Groot; Yann Le Fur; Jacob R. Sorensen; Eun-Kee Jeong; Russell S. Richardson Impaired skeletal muscle efficiency potentially contributes to the age-related decline in exercise capacity and may explain the altered...

View article titled, In vivo evidence of an age-related increase in ATP cost of contraction in the plantar flexor muscles

Articles

Mediterranean diet- and exercise-induced improvement in age-dependent vascular activity

Markos Klonizakis, Ahmad Alkhatib, Geoff Middleton, Mark F. Smith

Clin Sci (Lond) (2013) 124 (9): 579–587.

https://doi.org/10.1042/CS20120412

Published: 21 January 2013

...Markos Klonizakis; Ahmad Alkhatib; Geoff Middleton; Mark F. Smith The aging effect on microvascular integrity, marked by endothelial dysfunction and reduction in exercise tolerance, is a major cause of CVD (cardiovascular disease). Improved dietary habits, known to reduce morbidity and mortality...

View article titled, Mediterranean diet- and exercise-induced improvement in age-dependent vascular activity

Articles

Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging

Allison E. DeVan, Iratxe Eskurza, Gary L. Pierce, Ashley E. Walker, Kristen L. Jablonski, Rachelle E. Kaplon, Douglas R. Seals

Clin Sci (Lond) (2013) 124 (5): 325–331.

https://doi.org/10.1042/CS20120291

Published: 12 November 2012

...Allison E. DeVan; Iratxe Eskurza; Gary L. Pierce; Ashley E. Walker; Kristen L. Jablonski; Rachelle E. Kaplon; Douglas R. Seals In the present study, we tested the hypothesis that age-associated vascular endothelial dysfunction is exacerbated by IFG (impaired fasting plasma glucose) and that regular...

View article titled, Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging

Articles

Sirtuins and renal diseases: relationship with aging and diabetic nephropathy

Munehiro Kitada, Shinji Kume, Ai Takeda-Watanabe, Keizo Kanasaki, Daisuke Koya

Clin Sci (Lond) (2013) 124 (3): 153–164.

https://doi.org/10.1042/CS20120190

Published: 05 October 2012

... restriction conditions and are considered anti-aging molecules. SIRT1 has been the most extensively studied. SIRT1 deacetylates target proteins using the coenzyme NAD + and is therefore linked to cellular energy metabolism and the redox state through multiple signalling and survival pathways. SIRT1 deficiency...

View article titled, Sirtuins and renal diseases: relationship with aging and diabetic nephropathy

Articles

Effect of short- and long-term portal hypertension on adrenergic, nitrergic and sensory functioning in rat mesenteric artery

Esther Sastre, Gloria Balfagón, Elena Revuelta-López, Maria-Ángeles Aller, Maria-Paz Nava, Jaime Arias, Javier Blanco-Rivero

Clin Sci (Lond) (2012) 122 (7): 337–348.

https://doi.org/10.1042/CS20110303

Published: 07 December 2011

... in vasoconstrictor response to EFS, vasomotor responses or neurotransmitter release when compared with age-matched SO animals. In conclusion, the mesenteric innervation may participate in the development of the characteristic hyperdynamic circulation observed in STPH through the joint action of decreased adrenergic...

View article titled, Effect of short- and long-term portal hypertension on adrenergic, nitrergic and sensory functioning in rat mesenteric artery

Articles

Effects of variations in duodenal glucose load on blood pressure, heart rate, superior mesenteric artery blood flow and plasma noradrenaline in healthy young and older subjects

Laurence G. Trahair, Lora Vanis, Diana Gentilcore, Kylie Lange, Christopher K. Rayner, Michael Horowitz, Karen L. Jones

Clin Sci (Lond) (2012) 122 (6): 271–279.

https://doi.org/10.1042/CS20110270

Published: 11 November 2011

... (intraduodenal) glucose loads on BP, HR (heart rate), SMA (superior mesenteric artery) flow and vascular conductance and plasma NA (noradrenaline) in ‘young’ and ‘older’ subjects. A total of 12 ‘young’ (six male and six female; age, 22.2±2.3 years) and 12 ‘older’ (six male and six female; age, 68.7±1.0 years...

View article titled, Effects of variations in duodenal glucose load on blood pressure, heart rate, superior mesenteric artery blood flow and plasma noradrenaline in healthy young and older subjects

Articles

Molecular mechanisms of cardiomyocyte aging

Anna Sheydina, Daniel R. Riordon, Kenneth R. Boheler

Clin Sci (Lond) (2011) 121 (8): 315–329.

https://doi.org/10.1042/CS20110115

Published: 24 June 2011

...Anna Sheydina; Daniel R. Riordon; Kenneth R. Boheler Western societies are rapidly aging, and cardiovascular diseases are the leading cause of death. In fact, age and cardiovascular diseases are positively correlated, and disease syndromes affecting the heart reach epidemic proportions in the very...

View article titled, Molecular mechanisms of cardiomyocyte aging

Articles

From cell to cognition: can changes in telomere length indicate patterns of cognitive aging?

Vanja Kljajevic

Clin Sci (Lond) (2011) 121 (7): 313–314.

https://doi.org/10.1042/CS20110227

Published: 07 June 2011

...Vanja Kljajevic The issue of how to study the impact of biological age on non-pathological cognitive aging is tightly related to the question of when cognitive decline begins. Theories on cognitive decline typically assume that deterioration occurs at older age. However, not all researchers...

View article titled, From cell to cognition: can changes in telomere length indicate patterns of cognitive aging?

Articles

Endothelin-1 vasoconstriction and the age-related decline in endothelium-dependent vasodilatation in men

Christian M. Westby, Brian R. Weil, Jared J. Greiner, Brian L. Stauffer, Christopher A. Desouza

Clin Sci (Lond) (2011) 120 (11): 485–491.

https://doi.org/10.1042/CS20100475

Published: 15 February 2011

... in several pathologies associated with human aging, including hypertension, Type 2 diabetes and coronary artery disease. However, it is currently unknown whether the decline in endothelial vasodilatation with advancing age is due to elevated ET-1 vasconstrictor activity. Accordingly, we tested the hypothesis...

View article titled, Endothelin-1 vasoconstriction and the age-related decline in endothelium-dependent vasodilatation in men

Articles

Healthy aging and disease: role for telomere biology?

Haidong Zhu, Matthew Belcher, Pim van der Harst

Clin Sci (Lond) (2011) 120 (10): 427–440.

https://doi.org/10.1042/CS20100385

Published: 28 January 2011

...Haidong Zhu; Matthew Belcher; Pim van der Harst Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease, Type 2 diabetes, neurological diseases and cancer...

View article titled, Healthy aging and disease: role for telomere biology?

Articles

Aging and vascular endothelial function in humans

Douglas R. Seals, Kristen L. Jablonski, Anthony J. Donato

Clin Sci (Lond) (2011) 120 (9): 357–375.

https://doi.org/10.1042/CS20100476

Published: 18 January 2011

...Douglas R. Seals; Kristen L. Jablonski; Anthony J. Donato Advancing age is the major risk factor for the development of CVD (cardiovascular diseases). This is attributable, in part, to the development of vascular endothelial dysfunction, as indicated by reduced peripheral artery EDD (endothelium...

View article titled, Aging and vascular endothelial function in humans

Articles

Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults

Gary L. Pierce, Iratxe Eskurza, Ashley E. Walker, Tara N. Fay, Douglas R. Seals

Clin Sci (Lond) (2011) 120 (1): 13–23.

https://doi.org/10.1042/CS20100174

Published: 14 September 2010

...Gary L. Pierce; Iratxe Eskurza; Ashley E. Walker; Tara N. Fay; Douglas R. Seals Brachial artery FMD (flow-mediated dilation) is impaired with aging and is associated with an increased risk of CVD (cardiovascular disease). In the present study, we determined whether regular aerobic exercise improves...

View article titled, Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults

Includes: Supplementary data

Articles

Relationship between circulating progenitor cells, vascular function and oxidative stress with long-term training and short-term detraining in older men

Sarah Witkowski, Michael M. Lockard, Nathan T. Jenkins, Thomas O. Obisesan, Espen E. Spangenburg, James M. Hagberg

Clin Sci (Lond) (2010) 118 (4): 303–311.

https://doi.org/10.1042/CS20090253

Published: 16 November 2009

... cell number and function, and (ii) whether oxidative stress affected these factors. Participants included men with a history of more than 30 years of moderate-to-high-intensity exercise (HI group) and healthy low-active age- and BMI (body mass index)-matched control subjects (LO group). Vascular...

View article titled, Relationship between circulating progenitor cells, vascular function and oxidative stress with long-term training and short-term detraining in older men

Articles

Long-term portal hypertension increases the vasodilator response to acetylcholine in rat aorta: role of prostaglandin I 2

Javier Blanco-Rivero, Ma Angeles Aller, Jaime Arias, Mercedes Ferrer, Gloria Balfagón

Clin Sci (Lond) (2009) 117 (10): 365–374.

https://doi.org/10.1042/CS20080499

Published: 07 September 2009

... an increased vasodilator response. In contrast with the situation in short-term PH, endothelial dysfunction and an increase in endothelium-dependent contraction have been reported during aging. This effect of aging is mainly mediated by an increase in vasoconstrictor prostanoids [ 9 , 10 ] and/or a decrease...

View article titled, Long-term portal hypertension increases the vasodilator response to acetylcholine in rat aorta: role of prostaglandin I 2

Articles

Aging is associated with an increased susceptibility to ischaemic necrosis due to microvascular perfusion failure but not a reduction in ischaemic tolerance

Yves Harder, Michaela Amon, Mirko Georgi, Claudia Scheuer, Rene Schramm, Martin Rücker, Brigitte Pittet, Dominique Erni, Michael D. Menger

Clin Sci (Lond) (2007) 112 (8): 429–440.

https://doi.org/10.1042/CS20060187

Published: 13 March 2007

...Yves Harder; Michaela Amon; Mirko Georgi; Claudia Scheuer; Rene Schramm; Martin Rücker; Brigitte Pittet; Dominique Erni; Michael D. Menger In the present study in a murine model of chronic ischaemia, we analysed: (i) whether aging was associated with an increased susceptibility to ischaemic...

View article titled, Aging is associated with an increased susceptibility to ischaemic necrosis due to microvascular perfusion failure but not a reduction in ischaemic tolerance

Articles

Effect of aging and obesity on the expression of dyslipidaemia in children from families with familial combined hyperlipidaemia

Ewoud ter Avest, Allan D. Sniderman, Sebastian J. H. Bredie, Albert Wiegman, Anton F. H. Stalenhoef, Jacqueline de Graaf

Clin Sci (Lond) (2007) 112 (2): 131–139.

https://doi.org/10.1042/CS20060234

Published: 11 December 2006

... (familial combined hyperlipidaemia). In 194 young adults (<25 years of age) recruited from families with FCH, we investigated how plasma lipids, (apo)lipoproteins and BMI (body mass index) varied with age. Furthermore, we performed a 5-year follow-up study of clinical and biochemical characteristics...

View article titled, Effect of aging and obesity on the expression of dyslipidaemia in children from families with familial combined hyperlipidaemia

Articles

Mitochondrial DNA and aging

Mikhail F. ALEXEYEV, Susan P. LeDOUX, Glenn L. WILSON

Clin Sci (Lond) (2004) 107 (4): 355–364.

https://doi.org/10.1042/CS20040148

Published: 24 September 2004

...Mikhail F. ALEXEYEV; Susan P. LeDOUX; Glenn L. WILSON Among the numerous theories that explain the process of aging, the mitochondrial theory of aging has received the most attention. This theory states that electrons leaking from the ETC (electron transfer chain) reduce molecular oxygen to form O...

View article titled, Mitochondrial DNA and aging

Articles

Factors influencing heart rate variability power spectral analysis during controlled breathing in patients with chronic heart failure or hypertension and in healthy normotensive subjects

Gianfranco PICCIRILLO, Damiano MAGRÌ, Camilla NASO, Silvia di CARLO, Antonio MOISÈ, Tiziana DE LAURENTIS, Alessia TORRINI, Sabrina MATERA, Marialuce NOCCO

Clin Sci (Lond) (2004) 107 (2): 183–190.

https://doi.org/10.1042/CS20030401

Published: 27 July 2004

... with CHF (chronic heart failure). In the present study, we evaluated factors (age, arterial pressures and HR) influencing LFP and HFP (high-frequency power) components in short-term recordings during controlled breathing in patients with CHF or hypertension, and healthy normotensive subjects. In patients...

View article titled, Factors influencing heart rate variability power spectral analysis during controlled breathing in patients with chronic heart failure or hypertension and in healthy normotensive subjects

Articles

Does the level of chronic physical activity alter heart rate variability in healthy older women?

Sylvia RELAND, Nathalie S. VILLE, Sara WONG, Lotfi SENHADJÏ, François CARRÉ

Clin Sci (Lond) (2004) 107 (1): 29–35.

https://doi.org/10.1042/CS20030405

Published: 23 June 2004

.... Correspondence: Dr Sylvia Reland, present address: Unité de Biologie et Médecine du sport, Centre Hospitalier Universitaire Pontchaillou, 35000 Rennes, France (e-mail [email protected] ). 23 2 2004 8 12 2003 11 2 2004 23 2 2004 aerobic fitness level aging autonomic nervous...

View article titled, Does the level of chronic physical activity alter heart rate variability in healthy older women?

Articles

Aging, physical fitness and endothelial function: are all ultracentenarians marathon runners?

Guido GRASSI

Clin Sci (Lond) (2004) 106 (3): 239–240.

https://doi.org/10.1042/CS20030378

Published: 01 March 2004

..., individuals. The main features of the study as well as its potential limitations will be also highlighted. Correspondence: Professor Guido Grassi (e-mail [email protected] ). 18 11 2003 19 11 2003 19 11 2003 © 2004 The Biochemical Society 2004 aging endothelial...

View article titled, Aging, physical fitness and endothelial function: are all ultracentenarians marathon runners?

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