... pathogenesis. We discuss airway inflammation (both T2 HIGH and T2 LOW ), airway hyperresponsiveness (AHR) and airways remodelling as four key factors in asthma pathogenesis, and also outline other contributory factors such as genetics and co-morbidities. Response to current asthma therapies also varies greatly...

... to differentiate and function as both airway and lung parenchyma epithelial cells in both in vitro and increasingly in vivo experiments. The hypothesis is that these cells may actively seek out damaged tissue to assist in the local repair, and the hope is that their use will open up new cellular and genetic...

...A. Graham; E. W. F. W. Alton; D. M. Geddes 1. 5-Hydroxytryptamine has been suggested as a candidate for an endogenous inhibitor of airway sodium transport. Amiloride, an inhibitor of epithelial sodium channels, has therapeutic potential in disorders of airway ion transport such as cystic fibrosis...

... patients with cystic fibrosis and asthma. 2. In carcinoma controls, mean B max. values (± sem ) for airway levels 1 and 11 were 89 ± 4 and 133 ± 6 fmol/mg of protein, respectively ( P <0.01). The corresponding K D values at each airway level were similar, i.e. 29 ± 2 and 33 ± 1 pmol/l, respectively...

... impaired or abolished; breathing became slower and deeper; no pathological changes were found in the lungs of these dogs. 3. In man, no untoward effects resulted from a 10 min period of aerosol inhalation; there were no systematic effects on airway resistance or lung volumes and the cough reflex...