... to airway adiposity was considered in the present study through kisspeptin/kisspeptin receptor signalling, known to modulate systemic adiposity and potentially drive airway remodelling. Therefore, the aim of the study was to determine the effects of kisspeptin/kisspeptin receptor signalling in the lung...

... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . airway remodelling asthma biologics chronic rhinosinusitis precision...

... hyperproduction contribute to airway remodelling in asthma resulting in small airways disease, non-specific AHR and accelerated lung function decline leading to fixed airflow obstruction [ 85 ]. Recent advances in cell biology allowed deeper understanding of the role of diverse non-immune cells contributing...

... and negatively affects lung function in these patients. Thus, there is clear unmet clinical need for finding new therapies which can target airway remodeling and disease progression in COPD. Apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed mitogen-activated protein kinase (MAPK) kinase...

...Simon G. Royce; Anna M. Tominaga; Matthew Shen; Krupesh P. Patel; Brooke M. Huuskes; Rebecca Lim; Sharon D. Ricardo; Chrishan S. Samuel Current asthma therapies primarily target airway inflammation (AI) and suppress episodes of airway hyperresponsiveness (AHR) but fail to treat airway remodelling...

...Jian Ping Zhou; Wei Tang; Yun Feng; Ning Li; Chen Juan Gu; Qing Yun Li; Huan Ying Wan Previous studies have shown that the RAS (renin–angiotensin system) might participate in airway remodelling in asthma. As a main component of the RAS, Ang-(1–7) [angiotensin-(1–7)] has been reported in few studies...

... with these agents, probably due to progressive airway remodelling. Identifying novel therapies that can target airway remodelling and/or airway reactivity may improve symptom control in these patients. We have demonstrated previously that the anti-fibrotic hormone RLN (relaxin) can reverse airway remodelling...

...Scott G. RAMSAY; Christopher J. KENYON; Niall WHYTE; Ian C. MCKAY; Neil C. THOMSON; George B. M. LINDOP Airway remodelling occurs in chronic asthma. Angiotensin II promotes growth in cardiovascular remodelling. Since the renin–angiotensin system is activated in acute severe asthma, we hypothesized...