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Keywords: airway smooth muscleClose
Mathew S. Eapen, Anudeep Kota, Howard Vindin, Kielan D. McAlinden, Dia Xenaki, Brian G. Oliver, Deepak A. Deshpande, Sukhwinder Singh Sohal, Pawan Sharma
Clin Sci (Lond) (2018) 132 (14): 1615–1627.
Published: 31 July 2018
...Mathew S. Eapen; Anudeep Kota; Howard Vindin; Kielan D. McAlinden; Dia Xenaki; Brian G. Oliver; Deepak A. Deshpande; Sukhwinder Singh Sohal; Pawan Sharma Increased airway smooth muscle (ASM) mass is observed in chronic obstructive pulmonary disease (COPD), which is correlated with disease severity...
Kimberley C.W. Wang, Timothy D. Le Cras, Alexander N. Larcombe, Graeme R. Zosky, John G. Elliot, Alan L. James, Peter B. Noble
Clin Sci (Lond) (2018) 132 (3): 327–338.
Published: 02 February 2018
... study investigated the separate and combined effects of increased airway smooth muscle (ASM) layer thickness and allergy on AHR. We integrated a protocol of ovalbumin (OVA)-induced allergy into a non-inflammatory mouse model of ASM remodelling induced by conditional and airway-specific expression of...
Clin Sci (Lond) (2005) 108 (6): 463–477.
Published: 24 May 2005
...Tony R. BAI; Darryl A. KNIGHT Structural changes reported in the airways of asthmatics include epithelial fragility, goblet cell hyperplasia, enlarged submucosal mucus glands, angiogenesis, increased matrix deposition in the airway wall, increased airway smooth muscle mass, wall thickening and...
Clin Sci (Lond) (2002) 103 (s2002): 345S–348S.
Published: 01 September 2002
... sensitivity and maximum response to carbachol and ET-1 was not altered in tissue from day 4 post-inoculation compared with the control. There seems to be a significant functional reserve for both receptor subtypes in this species that buffers the impact of P-3 infection on airway smooth muscle responsiveness...
Clin Sci (Lond) (2002) 103 (s2002): 349S–352S.
Published: 01 September 2002
... studies involving the endothelins (ETs). Freshly harvested sheep bronchial airway smooth muscle contains a homogeneous population of the ET A receptor. However, the potency of ET-1 and maximum contractile response of sheep bronchial explants to ET-1 increased with time in culture, despite these parameters...
Clin Sci (Lond) (2002) 103 (2): 201–211.
Published: 17 July 2002
... only difference we observed was that, in asthma, the airway smooth muscle (ASM) was infiltrated by mast cells, suggesting that airway obstruction and AHR are due to an ASM mast cell myositis. This observation emphasizes that the features that characterize asthma, as opposed to bronchitis, are due to...
Clin Sci (Lond) (1994) 86 (6): 647–652.
Published: 01 June 1994
...Alan J. Knox © 1994 The Biochemical Society and the Medical Research Society 1994 airway smooth muscle asthma Clinical Science (1994) 86, 64Y-652 (Printed in Great Britain) Editorial Review MY Airway remodelling in asthma: role of airway smooth muscle Alan J. KNOX Respiratory Medicine...
Clin Sci (Lond) (1990) 79 (4): 315–323.
Published: 01 October 1990
...Alan J. Knox; Paul Ajao; John R. Britton; Anne E. Tattersfield 1. To determine whether alterations in membrane sodium transport in airway smooth muscle can alter its contractility, we studied the effect of ouabain (a Na + /K + -adenosine triphosphatase inhibitor) and amiloride on contractile...