... display an excessive accumulation of neutrophils in the airways; an inflammation that responds poorly to established therapy. Thus, there is a need to identify new molecular targets for the development of effective therapy. Here, we hypothesized that the neutrophil-mobilizing cytokine interleukin (IL)-26...

... was significantly lower in smokers (4±2p.p.b.) than in non-smokers (7±5p.p.b.; P = 0.007). A calculation of the contributions from different areas of the lung showed that the NO flux from the airways was significantly lower (14±10 compared with 36±26nl/min; P = 0.0001) and the alveolar fraction was significantly...

... stimulus in asthmatic patients. This infer- ence is drawn from the very many studies which have demonstrated a fall in maximum expiratory flow rate or an increase in airway resistance after exercise. There are very few studies in Which measurements of airway resistance have been made during exercise...

... on to the luminal aspect of the tissue. This method has previously been used to study airway secretions in animals [R. J. Phipps, J. A. Nadel & B. Davis, American Review of Respiratory Disease , (1980) 121 , 359–365]. Evidence is given that the radiolabelled molecules are secretory glycoproteins, probably mucus...