... pulmonary disease. These changes have been attributed to the anti-inflammatory properties of the drug. However, airways function can be improved by other means, e.g. improved ventilation/perfusion ratio or reduced airways resistance. The possibility that fenspiride may have actions other than anti...

...K. B. Saunders; M. Rudolf 1. We measured changes in peak expiratory flow rate (PEFR), forced expiratory volume in 1 s (FEV 1·0 ), airways resistance ( R aw), specific conductance (s G aw), residual volume (RV), functional residual capacity (FRC) and total lung capacity (TLC) in 44 patients...

...A. R. Rubinfeld; M. C. F. Pain 1. Lung volumes, airway resistance and flow/volume curves were measured in ten asthmatic subjects at times when tightness in the chest was just sensed (threshold symptom). 2. These measurements when the threshold symptom was induced by methacholine inhalation were...

...D. I. McCloskey 1. It was confirmed that normal subjects can detect an increase in airways resistance of 1.2 cmH 2 O 1 −1 s when this is presented during a sequence of otherwise unresisted breaths. 2. In contrast when such subjects meet the same resistance presented unexpectedly during a sequence...

...T. W. Astin 1. Measurements of airways resistance and lung volume were made in sixteen patients with chronic bronchitis and ten patients without chest disease before and after intravenous propranolol administration. 2. The airways resistance of the patients with chronic bronchitis increased...

... rates the distribution was normal. 4. Insofar as the bolus in the fast inspiration was distributed according to regional airway conductances, these results suggest that in normal subjects differences in airway resistance exist between the upper and lower zones of the upright lung. An early abnormality...