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Clin Sci (Lond) (2017) 131 (14): 1631–1647.
Published: 30 June 2017
... by Portland Press Limited on behalf of the Biochemical Society 2017 albumin drug-toxin interactions protein binding renal secretion uremic toxin Based on their chemical properties that affect their removal by dialysis, uremic toxins can be divided in three classes: class 1 consists...
Giuseppe Caso, James A. Vosswinkel, Peter J. Garlick, Mohamed K. Barry, Thomas V. Bilfinger, Margaret A. Mcnurlan
Clin Sci (Lond) (2008) 114 (4): 339–346.
Published: 15 January 2008
... protein fibrinogen and the negative acute-phase protein albumin. Synthesis rates of muscle protein, fibrinogen and albumin were measured simultaneously before and 4 h after the end of surgery from the incorporation of L -[ 2 H 5 ]phenylalanine (given at 43 mg/kg of body weight) in 12 patients undergoing...
Clin Sci (Lond) (2008) 114 (3): 251–256.
Published: 08 January 2008
...Patrice Faure; Nicolas Wiernsperger; Camille Polge; Alain Favier; Serge Halimi Free radical production is increased during diabetes. Serum albumin is a major antioxidant agent, and structural modification of albumin induced by glucose or free radicals impairs its antioxidant properties. Therefore...
Clin Sci (Lond) (2008) 114 (2): 123–130.
Published: 11 December 2007
... on the injection of proteins that differ significantly in size and have spectrally distinguishable fluorophores. Control ( n =11) and post-CLP (caecal ligation and puncture; n =14) Sprague–Dawley rats were injected with tracer amounts of albumin and PEG–Alb [albumin covalently linked to methoxy-poly(ethylene...
Clin Sci (Lond) (2006) 111 (6): 389–399.
Published: 14 November 2006
...Neil Ashman; Tatiana M. Brunini; Giovanni E. Mann; A. Claudio Mendes Ribeiro; Muhammad M. Yaqoob Albumin has complex effects on PTECs (proximal tubular epithelial cells) and is able to stimulate growth or injury depending on its bound moieties. Albumin itself is a mitogen, inducing proliferation...
Clin Sci (Lond) (2005) 108 (3): 217–224.
Published: 18 February 2005
...Annika HEDIN; Robert G. HAHN Autologous plasma may be used to replace plasma volume and plasma proteins during surgery, but its effectiveness is largely unknown. In the present study, the characteristics of predonated frozen and thawed autologous plasma were compared with those of 5% albumin in 15...
Clin Sci (Lond) (2004) 106 (5): 501–509.
Published: 01 May 2004
..., glycerol, lactate/pyruvate ratio, hydroxyl radicals and neuronal damage score were 42±3 mmHg, 33±3 mmHg, 9±3 mmHg, 109±20 BPU (blood perfusion units), 6±1 mmHg, 51±7 µmol/l, 24±3 µmol/l, 124±32, 694±22% of baseline and 2.25±0.05 respectively. In animals treated with 10% albumin immediately after the onset...
Clin Sci (Lond) (2004) 106 (5): 467–474.
Published: 01 May 2004
... volume expansion on the severity of HE, plasma and urinary ammonia in patients with diuretic-induced HE. Fifteen patients with alcoholic cirrhosis and diuretic-induced HE of Grade 2 or more were enrolled. In eight patients, 4.5% human albumin solution (HAS) was used for volume expansion and in seven...
Matthew D. BARBER, Tom PRESTON, Donald C. McMILLAN, Christine SLATER, James A. ROSS, Kenneth C. H. FEARON
Clin Sci (Lond) (2004) 106 (4): 359–364.
Published: 01 April 2004
.... An n -3 fatty-acid-enriched nutritional supplement will moderate aspects of cachexia in cancer patients. The present study examined the effect of such a supplement on hepatic synthesis of albumin and fibrinogen. Albumin and fibrinogen synthesis were measured in the fed and fasting state in eight weight...
Clin Sci (Lond) (2003) 104 (1): 17–24.
Published: 10 December 2002
...Fiona REID; Dileep N. LOBO; Robert N. WILLIAMS; Brian J. ROWLANDS; Simon P. ALLISON In this double-blind crossover study, the effects of bolus infusions of 0.9% saline (NaCl) and Hartmann's solution on serum albumin, haematocrit and serum and urinary biochemistry were compared in healthy subjects...
Dileep N. LOBO, Zeno STANGA, J.Alastair D SIMPSON, John A. ANDERSON, Brian J. ROWLANDS, Simon P. ALLISON
Clin Sci (Lond) (2001) 101 (2): 173–179.
Published: 17 July 2001
... study, the effects of bolus infusions of crystalloids on serum albumin, haematocrit, serum and urinary biochemistry and bioelectrical impedance analysis were measured in healthy subjects. Ten male volunteers received 2-litre infusions of 0.9% (w/v) saline or 5% (w/v) dextrose over 1 h; infusions were...
Clin Sci (Lond) (2000) 98 (3): 295–301.
Published: 09 February 2000
... in tubular cell growth and proliferation. We have used the opossum kidney proximal tubular cell line to investigate the effects of albumin on cell growth. The effect of albumin on cell proliferation was investigated by cell counting and measurement of [ 3 H]thymidine incorporation. We studied the effect...
Clin Sci (Lond) (1998) 95 (4): 459–465.
Published: 01 October 1998
...Gregory J. QUINLAN; Michael P. MARGARSON; Sharon MUMBY; Timothy W. EVANS; John M. C. GUTTERIDGE 1. Albumin is often administered intravenously to critically ill patients as a volume expander, to combat hypoalbuminaemia, and to decrease hyperbilirubinaemia. There is, however, an ongoing debate...
Clin Sci (Lond) (1998) 95 (1): 67–72.
Published: 01 July 1998
...Melissa J. BURNE; Sianna PANAGIOTOPOULOS; George JERUMS; Wayne D. COMPER 1. Albumin is normally excreted as a mixture of intact protein and fragments that are produced during renal passage. The purpose of this study was to investigate the ratio of intact versus degraded forms of excreted albumin...
Nathalie Caillol, Eric Pasqualini, Eric Mas, Régis Guieu, Anne Valette, Jean Boyer, Dominique Lombardo
Clin Sci (Lond) (1998) 94 (2): 181–188.
Published: 01 February 1998
.... In the present study, we investigated the effect of glycation and particularly that of human serum albumin on the activity of bile-salt-dependent lipase. In vitro , bile-salt-dependent lipase activity decreased in the presence of human serum albumin; however, this was less pronounced in the presence of glycated...
Clin Sci (Lond) (1997) 93 (6): 557–564.
Published: 01 December 1997
...Tanya M. Osicka; Sianna Panagiotopoulos; George Jerums; Wayne D. Comper 1. The fractional clearance of intact albumin as determined by fractionation of urine by gel chromatography gave a value of 3.9 ± 1.6 × 10 −4 for the isolated perfused kidney and 2.1 ± 0.6 × 10 −4 in vivo using ALZET osmotic...
Clin Sci (Lond) (1997) 93 (5): 445–451.
Published: 01 November 1997
...Amanda Loban; Robert Kime; Hilary Powers 1. The extracellular proteins caeruloplasmin and transferrin have important antioxidant properties by virtue of the fact that they inhibit iron-dependent free radical production, and ensuing damage to cells. 2. Albumin is a plasma protein which can loosely...
Clin Sci (Lond) (1997) 93 (1): 65–72.
Published: 01 July 1997
...Tanya M. Osicka; Wayne D. Comper 1. Tritium labelled proteins, namely bovine serum albumin ([ 3 H]BSA), rat serum albumin ([ 3 H]RSA), anionic horseradish peroxidase ([ 3 H]aHRP) and immunoglobulin present in urine fractions from rat filtration studies in vivo and isolated perfused rat kidneys...
Yasunobu Hirata, Yasuko Suzuki, Hiroshi Hayakawa, Etsu Suzuki, Kenjiro Kimura, Atsuo Goto, Kenji Kangawa, Hisayuki Matsuo, Masao Omata
Clin Sci (Lond) (1995) 88 (4): 413–419.
Published: 01 April 1995
... the effects of administration of glucose, albumin, atrial natriuretic peptide and an atrial natriuretic peptide receptor antagonist on renal function in rats with streptozotocin-induced diabetes mellitus and vehicle-treated control rats. 2. Four weeks after treatment, rats with diabetes mellitus had a higher...
Clin Sci (Lond) (1993) 84 (6): 627–632.
Published: 01 June 1993
...Ton J. Rabelink; Joost A. Bijlsma; Hein A. Koomans 1. In previous studies we found that albumin infusions caused only a modest natriuresis in the nephrotic syndrome, suggesting that hypovolaemia played no part in the sodium retention of these patients. However, this finding was inconclusive, since...
Clin Sci (Lond) (1992) 83 (6): 731–735.
Published: 01 December 1992
... were obtained at timed intervals (0–14 days) after the injection for determination of albumin, total protein, α 2 -macroglobulin (a major acute-phase protein in the rat) and interleukin-6 concentrations. The magnitude and pattern of the acute-phase protein response was then compared with the local...
Clin Sci (Lond) (1989) 77 (2): 149–155.
Published: 01 August 1989
...J. Hilsted; N. J. Christensen; S. Larsen 1. The effect of intravenous catecholamine infusions and of intravenous insulin on plasma volume and intravascular mass of albumin was investigated in healthy males. 2. Physiological doses of adrenaline (0.5 μg/min and 3 μg/min) increased peripheral venous...
Clin Sci (Lond) (1989) 77 (1): 105–111.
Published: 01 July 1989
..., but the potassium rhythm had a different phase, probably because urinary potassium is largely derived from tubular secretion. 5. Urinary albumin and β 2 -microglobulin excretion had a circadian rhythm in phase with the GFR rhythm. 6. The highest quantity of sodium, water and β 2 -microglobulin was reabsorbed...
Clin Sci (Lond) (1987) 72 (6): 725–735.
Published: 01 June 1987
... women with essential or renovascular hypertension. Plasma albumin, Cortisol and oestriol were measured concurrently. 2. Plasma CBG increased two and a half to three times during pregnancy. In those women who developed hypertension in pregnancy (mean arterial pressure > 107 mmHg), the plasma CBG...
Clin Sci (Lond) (1987) 72 (2): 245–249.
Published: 01 February 1987
... molecular weight proteins, retinol-binding protein and β 2 -microglobulin, increased 1000- and 500-fold respectively above the values found after administration of saline as a control. The urinary excretion of albumin did not change significantly ( P > 0.5). 4. In the hour after Haemaccel administration...
Clin Sci (Lond) (1987) 72 (1): 11–17.
Published: 01 January 1987
...Rita Aldini; Aldo Roda; Antonio Maria Morselli-Labate; Patrizia Simoni; Enrico Roda; Luigi Barbara 1. Isolated rat livers were perfused in a single pass with increasing doses of taurocholate with and without albumin in the perfusion media. 2. The kinetics of taurocholate uptake were thus evaluated...
Clin Sci (Lond) (1986) 70 (5): 469–475.
Published: 01 May 1986
...P. G. Lunn; C. A. Northrop; R. H. Behrens; J. Martin; M. Wainwright 1. Alterations in plasma albumin concentration and gastrointestinal permeability have been investigated in rats infected with the nematode Nippostrongylus brasiliensis and fed adequate or low protein diets. 2. Infection caused only...
Clin Sci (Lond) (1985) 69 (3): 321–326.
Published: 01 September 1985
...David J. Bliss; Douglas B. Brewer 1. Female Wistar rats were made heavily proteinuric by daily intraperitoneal injections of bovine serum albumin over 5 days. 2. The size and charge permeability characteristics of the glomerular filter in this condition were determined by studying the renal...
Clin Sci (Lond) (1984) 66 (2): 201–206.
Published: 01 February 1984
...Gillian M. Lawrence; D. B. Brewer 1. Intraperitoneal injection of anionic carbamylated bovine albumin derivatives induced glomerular epithelial cell foot process loss and increased urinary protein excretion, the severity of which rose with the dose administered. 2. The effects induced at a given...
Clin Sci (Lond) (1983) 64 (3): 307–314.
Published: 01 March 1983
...M. Jawed Iqbal; Maureen Dalton; Robert S. Sawers 1. The percentage binding of testosterone (T) and oestradiol (E 2 ) to sex hormone binding globulin (SHBG) and human serum albumin (HSA) was determined over a range of SHBG concentrations of 16–250 nmol of dihydrotestosterone (DHT) bound/l...
Clin Sci (Lond) (1982) 63 (s8): 415s–418s.
Published: 01 October 1982
... measured blood pressure, total exchangeable sodium, plasma volume, transcapillary escape rate of albumin, and plasma concentrations of angiotensin II and aldosterone. 2. With improved diabetic control there was a small but significant fall in arterial pressure. Total exchangeable sodium was normal when...
Clin Sci (Lond) (1981) 61 (1): 119–121.
Published: 01 July 1981
...I. E. Brajkovich; R. S. De Leon; K. Mashiter 1. Serum albumin, total protein, oncotic pressure and osmolality were measured in a group of patients with hyperprolactinaemia due to a prolactin secreting tumour, normal subjects and normoprolactinaemic acromegalic patients. 2. A significant increase...
Clin Sci (Lond) (1980) 59 (2): 105–113.
Published: 01 August 1980
...J. S. Prichard; B. Rajagopalan; G. de J. Lee 1. External counting of radioactivity over the lung has been used to measure the size of the interstitial compartment and transvascular albumin fluxes under normal and pathological conditions in the lungs of open-chested ventilated dogs. 2. When...
Clin Sci (Lond) (1979) 56 (1): 99–100.
Published: 01 January 1979
...Ann-Margret Östlund-Lindqvist; J. Boberg 1. Commercially available bovine serum albumin as Cohn fraction V was demonstrated to contain small amounts of apolipoprotein-CII. 2. This apolipoprotein activated lipoprotein lipase in the same way as apolipoprotein-CII purified from human very-low-density...
Clin Sci Mol Med (1978) 55 (4): 369–376.
Published: 01 October 1978
...J. F. Donohoe; Gertrude S. Lefavour; S. Cortell; F. J. Gennari 1. Proximal tubular fluid flow rate was deliberately reduced to control values in rats after acute volume expansion with hyperoncotic albumin, to determine if the depression of reabsorption by albumin-induced expansion could...
Clin Sci Mol Med (1976) 51 (s3): 203s–205s.
Published: 01 December 1976
...M. Ulrych 1. Analysis of relationships between blood volume, vascular capacitance, cardiopulmonary and peripheral blood volumes, labelled albumin disappearance rate, plasma renin activity, blood pressure and age was performed in essential hypertensive males. 2. The results indicate that capacitance...
Clin Sci Mol Med (1976) 51 (s3): 211s–213s.
Published: 01 December 1976
...M. Ulrych; Z. Ulrych 1. Relationships between labelled albumin disappearance rate (LADR), plasma volume, blood volume, plasma renin activity (PRA) and blood pressure (BP) were studied in normotensive control subjects and patients with hypertension of different aetiology and severity. In essential...
Clin Sci Mol Med (1974) 47 (5): 415–424.
Published: 01 November 1974
... by adding tryptophan to plasma in vitro or from plasma taken during tryptophan infusion indicate one tryptophan binding site per albumin molecule and an inverse relationship between binding constants and NEFA concentration. 3. A single normal subject was atypical as the apparent number of binding sites...
Clin Sci Mol Med (1974) 46 (6): 775–784.
Published: 01 June 1974
...S. Lavender; J. Bennett; P. F. Morse; A. Polak 1. The ratio of albumin clearance to creatinine clearance (C A /C C ) was determined on 129 occasions in forty patients with a wide variety of renal diseases, both 24 h collections of urine and random mid-morning samples being used. The clearance...
Clin Sci Mol Med (1973) 45 (4): 505–516.
Published: 01 October 1973
...J. R. Bloomer; P. D. Berk; J. Vergalla; N. I. Berlin 1. The initial distribution volumes of [ 3 H]bilirubin in six adult subjects were equivalent to those of 131 I-labelled albumin following simultaneous intravenous injection of both compounds. However, the initial rate of loss of [ 3 H]bilirubin...
Clin Sci Mol Med (1973) 45 (4): 517–526.
Published: 01 October 1973
...J. R. Bloomer; P. D. Berk; J. Vergalla; N. I. Berlin 1. [ 3 H]Bilirubin and 131 I-labelled albumin were given simultaneously to six healthy adults by intravenous route and the amounts in the plasma were measured for several days. Multicompartmental analysis of the data showed that the rate...
Clin Sci (1972) 43 (5): 639–644.
Published: 01 November 1972
...P. Ranløv; N. Rossing; M. Schwartz; B. Eskesen; G. Rasmussen 1. Plasma albumin concentration was decreased in thirty-five of eighty-six mobilized para- or tetra-plegic patients studied months or years after injury to the spinal cord causing a medullary cross-sectional syndrome. The colloid osmotic...