..., albuminuria, or renal function and this supports the hypothesis of an important role of M-Sec in the protective action of exogenous MSCs. Additionally, MSC-derived mitochondria were observed in the glomerular podocytes of diabetic mice, suggesting in vivo mitochondrial transfer. Importantly, this phenomenon...

[email protected] ) 19 04 2022 22 08 2022 12 09 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 albuminuria diabetic kidney disease structure type 2 diabetes youth Underlying causes for the increased severity...

...Montserrat Baldan-Martin; Elena Rodríguez-Sánchez; Laura González-Calero; Luis M. Ruilope; Gloria Alvarez-Llamas; María G. Barderas; Gema Ruiz-Hurtado The development of de novo albuminuria during chronic renin–angiotensin system (RAS) suppression is a clinical entity that remains poorly recognized...

...Helena Pulido-Olmo; Concha F. García-Prieto; Gloria Álvarez-Llamas; María G. Barderas; Fernando Vivanco; Isabel Aranguez; Beatriz Somoza; Julián Segura; Reinhold Kreutz; María S. Fernández-Alfonso; Luis M. Ruilope; Gema Ruiz-Hurtado Resistant albuminuria, developed under adequate chronic blockade...

...Guangyu Zhou; Alfred K. Cheung; Xia Liu; Yufeng Huang Higher doses of AngII (angiotensin II) blockers are intended to optimize albuminuria reduction rather than for blood pressure control in chronic kidney disease. However, the long-term renoprotection of high-dose AngII blockers has yet...

... approach to traditional anti-inflammatory therapies for treatment of diabetic renal injury. Moreover, inducers of HO-1 could be synergized with inhibitors of sEH to prevent diabetic renal deterioration. albuminuria diabetic renal injury haem oxygenase inflammation soluble epoxide hydrolase...

...). To test the role of genetic factors in the development of low grade albuminuria in female MWF rats, we analysed the role of a major UAE QTL on rat chromosome 6. To this end, we analysed a consomic MWF-6 SHR strain in which chromosome 6 from SHRs was introgressed into the MWF rat background. Time course...

... never-treated uncomplicated hypertensive men and 16 normotensive men as controls. Evaluation variables were TERalb (transcapillary escape rate of albumin; the 1-h decline rate of intravenous 125 I-albumin, a measure of integrity of systemic capillary endothelium), albuminuria and forearm vasodilation...

..., targeted gene disruption in mouse models and cultured glomerular cells in vitro have dramatically improved our understanding of the cellular and molecular basis of albuminuria. This review aims to summarize the current state of knowledge, to illustrate known mechanisms of proteinuria in disease states...

... subjects. In patients with Type II diabetes and normal albumin excretion rate, the polypeptide pattern in urine differed significantly from normal, indicating a specific ‘diabetic’ pattern of polypeptide excretion. In patients with higher grade albuminuria, we were able to detect a polypeptide pattern...

... Territory of Australia. Main outcome measures were CRP, fibrinogen and IgG concentrations, blood pressure (BP), presence of diabetes, lipids, albuminuria, seropositivity to three common micro-organisms, as well as carotid intima-media thickness (IMT). Serum concentrations of CRP [7 (5–13) mg/l; median...

.... After 24 weeks of diabetes, both aminoguanidine and ramipril prevented the diabetes-related increases in PKC activity in all three tissues, in parallel with suppression of albuminuria by both agents. Aminoguanidine also prevented diabetes-related increases in retinal permeability at 16 weeks...

... by the measurement of albumin—creatinine ratio in a random urine sample, with a threshold of ≧ 3.0 mg/mmol. 6 10 1994 24 10 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 aged albuminuria blood pressure elderly hypertension Clinical Science (1995) 88, 185-190...

... albuminuria glomerular filtration rate pre-eclampsia hypertension pregnancy Clinical Science (1994) 86, 251-255 (Printed in Great Britain) 251 Albumin excretory rate in normal and hypertensive pregnancy Mark A. BROWN Min-Xia WANG Megan L. BUDDLE', Mark A. CARLTON', Gregory M. CARIO', Vivienne C. ZAMMIT...

... either uninephrectomy ( n = 6) or sham operation ( n = 6). 3. Glomerular leucocyte number was significantly increased in uninephrectomized animals (15.7 ± 0.9 versus 8.9 ± 0.4, P <0.001), with some glomeruli having leucocyte numbers comparable with those seen in glomerulonephritis. 4. Albuminuria...

.... The supine systolic blood pressure (mean ± sd ) was higher in patients with abnormal albuminuria (group 1: 140.9 ± 27.4 mmHg; group 2: 158.1 ± 26.4 mmHg; group 3: 166.7 ± 23.9 mmHg; F = 13.1, P <0.001, analysis of variance). Urinary sodium output was similar in these three groups of patients...

...Michele Stornello; Enrico V. Valvo; Luigi Scapellato 1. Some non-insulin-dependent (type II) diabetic patients show albuminuria without arterial hypertension. In these patients, angiotensin-converting enzyme inhibitors reduce urinary albumin excretion without producing any changes in systemic blood...

.../12.0 kPa). 21 4 1988 2 6 1988 © 1989 The Biochemical Society and the Medical Research Society 1989 albuminuria blood pressure Clinical Science (1989) 76, 39-42 39 Urinary albumin excretion andblood pressure in the general population PETER GOSLING AND D. G. BEEVERS...

... Research Society 1982 albuminuria kidney proteinuria Clinical Science (1982) 62,495-502 495 A biochemical and immunological investigation into the physiological basis of the increased albumin filtration induced in hyperalbuminaemic female Wistar rats G I L L I A N M. L A W R E N C E A N D D. B...

...Gillian M. Lawrence; D. B. Brewer 1. Normal female Wistar rats showed a wide range of baseline protein excretion and albuminuria and could be divided into two distinct groups: (a) low-to-intermediate excretors, where daily baseline albumin excretion was below 1.8 mg/24 h and (b) high excretors...