...Qin Yang; Hai-Yong Chen; Jia-nan Wang; Huai-Qin Han; Ling Jiang; Wei-Feng Wu; Biao Wei; Li Gao; Qiu-ying Ma; Xue-qi Liu; Qi Chen; Jia-gen Wen; Juan Jin; Yan Huang; Wei-jian Ni; Tao-tao Ma; Jun Li; Xiao-Ming Meng Alcohol consumption causes renal injury and compromises kidney function. The underlying...

...-old rats, and 32-week-old rats receiving 0.4% ethanol for 8 days * P <0.05 compared with the ACE activity in the aorta of 10-week-old rats ( n =6–9 for each experimental point). age alcohol angiotensin-converting enzyme glucocorticoid hormone N G -nitro- L -arginine methyl ester ( L...

...Michael KOLL; Julie A. BEESO; Frank J. KELLY; Ulrich A. SIMANOWSKI; Helmut K. SEITZ; Timothy J. PETERS; Victor R. PREEDY Chronic alcohol muscle disease is characterized by reduced skeletal muscle mass precipitated by acute reduction in protein synthesis. The pathogenic mechanisms remain obscure...

...Junichi MINAMI; Masakatsu TODOROKI; Masayoshi YOSHII; Shinichiro MITA; Toshio NISHIKIMI; Toshihiko ISHIMITSU; Hiroaki MATSUOKA We investigated the effects of smoking cessation or alcohol restriction on metabolic and fibrinolytic variables in Japanese men. In the smoking study, 35 male subjects [32...

...Toshihiko Ishimitsu; Kaori Yoshida; Miki Nakamura; Kohju Tsukada; Shigeru Yagi; Masami Ohrui; Tohru Hisauchi; Hiroaki Matsuoka 1. This cross-sectional study examined the influence of alcohol intake on organ injuries in normotensive and hypertensive subjects. 2. A total of 514 normotensive subjects...

.... 3. In the pancreas the level of pancreatitis-associated protein mRNA was also increased by alcohol and iron overload, but not by paracetamol. 4. In the small intestine expression of pancreatitis-associated protein mRNA was higher in normal ileum than in duodenum. In the ileum pancreatitis-associated...

... blood pressure data were recorded and stored in a minicomputer during 5 min of controlled breathing (15 cycles/min) and during deep breathing (5 s inpiration, 5 s expiration, four cycles) before drinking and hourly thereafter for 3 h. 2. Mean breath alcohol concentration rose to 18.9 mg/100 ml...

...S. Maule; K. Ray Chaudhuri; T. Thomaides; D. Pavitt; J. McCleery; C. J. Mathias 1. The cardiovascular effects of oral alcohol (0.5 g/kg body weight diluted to 300 ml in sugar-free orange juice) were compared with those of placebo in 10 normal subjects. Measurements were made while the subjects were...

... year period of dietary supplementation with alcohol, iron, or alcohol and iron. In alcohol-fed, iron-fed and alcohol- and iron-fed animals, mild histological damage was seen on light microscopy and evidence of mitochondrial and nuclear injury was identified by electron microscopy. 2. Subcellular...

...N. M. Lowe; A. Green; J. M. Rhodes; M. Lombard; R. Jalan; M. J. Jackson 1. The short-term (120 min) kinetics of Zn turnover has been studied in control subjects and patients with alcoholic liver disease after intravenous injection of 0.5 mg of 96.5% enriched 70 ZnCl 2 . 2. The 70 Zn enrichment...

...V. Burke; K. D. Croft; I. B. Puddey; K. L. Cox; L. J. Beilin; R. Vandongen 1. This study was designed to determine prospectively whether changing alcohol consumption influenced the proportion of plasma linoleic acid independently of diet or smoking habits, and to evaluate changes in the plasma...

...D. J. Stott; S. G. Ball; G. C. Inglis; D. L. Davies; R. Fraser; G. D. Murray; G. T. McInnes 1. The effects of a single moderate dose of alcohol on blood pressure, heart rate and associated metabolic and endocrine changes were studied in 10 healthy subjects and compared with those of an isocaloric...

...L. G. Howes; J. L. Reid 1. The effects of alcohol (0.9 g/kg) compared with placebo (400 ml of orange juice) on plasma noradrenaline and 3,4-dihydroxyphenylethylene glycol levels, and on erect and supine blood pressures and heart rates, were studied in eight normal male volunteers. 2. Alcohol caused...

...F. C. Martin; A. J. Levi; G. Slavin; T. J. Peters 1. The capacity for glycolysis in muscle biopsies obtained from long-term heavy alcohol drinking patients has been compared with tissue from control subjects by assay in vitro of the total activities of glycogen phosphorylase, phosphofructokinase...

...Masao Kondo; Gumpei Urata; Yoshitaka Shimizu 1. δ-Aminolaevulinate dehydratase activity was measured in liver biopsy specimens from 13 patients with porphyria cutanea tarda, 13 alcoholics and 10 control subjects. 2. The mean enzyme activities in liver of porphyria cutanea tarda and alcoholics were...

...H. Ibsen; N. J. Christensen; S. Rasmussen; Hanne Hollnagel; M. Damkjaer Nielsen; J. Giese 1. Sixteen 44-year-old males with chronic high alcohol intake were investigated. Seventeen 44-year-old males with low alcohol intake from the same population served as controls. 2. Plasma noradrenaline...

...D. Kelly; B. Reed; D. Weir; J. Scott 1. Folate deficiency is commonly found in alcoholic subjects although the causative mechanism is uncertain. It has been suggested that microsomal enzyme induction resulting from chronic alcohol ingestion might accelerate the rate of folate catabolism thus...

... as a measure of cerebral function. 3. The control group showed a small but statistically insignificant improvement on retesting with Watson-Glaser test form ZM after preliminary administration of form YM. 4. The relationship between the blood alcohol time curve and the alcohol effect was analysed for each...

... Society and the Medical Research Society 1977 alcohol ethanol glycogen lipids muscle oleic acid Clinical Science and Molecular Medicine (1977) 53, 205-214. Influence of ethanol on non-esterified fatty acid and carbohydrate metabolism during exercise in man A. JUHLIN-DANNFELT, L. JORFELDT, L...

... in cirrhotic patients and subjects ingesting anticonvulsants; (c) other important routes exist for disposition of haem precursors in these subjects, besides utilization for haem synthesis. alcohol δ-aminolaevulinic acid synthase anticonvulsants iron liver cirrhosis porphobilinogen porphyrins succinyl...

...J. D. Mathews 1. Male death rates from hypertension and stroke in England and Wales in 1949–53 were highest in those socio-economic and occupational groups with the highest death rates for cirrhosis of the liver (and presumably with highest alcohol intake). 2. In prevalence data from the Busselton...

...J. Dow; N. Krasner; A. Goldberg 1. Hepatic alcohol dehydrogenase activity and leucocyte ascorbic acid content were measured in thirty-five patients with liver disease and in ten control subjects with duodenal ulcer. The patients with liver disease were divided into three groups consisting of non...