... (alcoholic liver disease) and NAFLD (non-alcoholic fatty liver disease) share pathological features, pathogenic mechanisms and pattern of disease progression. In NAFLD, steatosis, lipotoxicity and liver inflammation participate to hepatic insulin resistance. The aim of the present study was to verify...

...I. M. NAKSHABENDI; S. DOWNIE; R. I. RUSSELL; M. J. RENNIE We used stable-isotope-labelled amino acids to measure the effects of alcoholic liver disease (ALD) on whole-body protein turnover and small-intestinal mucosal protein synthesis. Groups comprising eight patients with ALD and eight healthy...

... status of the hepatocytes, and was unchanged between patients and controls. 25 5 1989 4 7 1989 © 1990 The Biochemical Society and the Medical Research Society 1990 alcoholic hepatitis alcoholic liver disease 31 P magnetic resonance spectroscopy Clinical Science (1990) 78, 33...

... ethanol did not alter the fatty acid synthesis rates in vitro. It is concluded that enhanced lipogenesis is not the major cause of fatty liver in patients with alcoholic fatty liver. alcoholic liver disease diabetes fatty acid synthesis liver ClinicalScience (1986) 71,723-728 723 Fatty acid...

... liver disease. 2 4 1986 16 4 1986 © 1986 The Biochemical Society and the Medical Research Society 1986 acetaldehyde alcoholic liver disease free radicals neutrophils Clinical Science ( 1 986) 7 1, 31 3-3 18 313 Superoxide anion production and degranulation of rat neutrophils...

...K. Matthewson; C. O. Record 1. Erythrocyte aldehyde dehydrogenase activity was assayed in actively drinking alcoholics, patients with alcoholic liver disease who claimed to be abstaining, patients with non-alcoholic liver disorders and normal controls. Hepatic cytosolic aldehyde dehydrogenase...

... with alcoholic liver disease, three of whom showed low serum concentrations of labelled 25-hydroxyvitamin D 3 suggesting impaired hepatic synthesis. The 25-hydroxylation response was quantified as the relative index of 25-hydroxylation and was significantly related to two other indices of liver function...

... suggest that depressed lipolysis due to a relative deficiency of triglyceride lipase is not a causal factor in triglyceride accumulation in chronic alcoholic fatty liver. 17 4 1985 17 5 1985 © 1985 The Biochemical Society and the Medical Research Society 1985 alcoholic liver disease...

...Carol A. Seymour; T. J. Peters 1. Liver biopsy specimens obtained from patients with alcoholic liver disease of varying severity were assayed for lysosomal and microsomal enzyme activities, the results being compared with values previously obtained in control subjects. 2. Analytical subcellular...