...P. Duane; T. J. Peters 1. Serum carnosinase activity was assayed in a group of alcoholic patients with and without histologically proven atrophy of type II skeletal muscle fibres, and in control subjects. No significant activity was detected in muscle biopsy samples or washed erythrocytes. 2. Serum...

...P. Duane; T. J. Peters 1. Chronic alcoholism is associated with a selective atrophy of type II skeletal muscle fibres. We studied the glucocorticoid status of chronic alcoholics with and without myopathy to determine if hypercortisolism is responsible for the myopathy. 2. Twenty-four hour urinary...

...N. W. Y. Leung; T. J. Peters 1. A micro-technique was developed to measure fatty acid oxidation in vitro and to investigate its possible derangement in alcoholic fatty liver disease. 2. Percutaneous liver biopsy specimens were obtained from nine control subjects and 28 alcoholic patients with mild...

...Michael Öhman; Stefan L. Marklund 1. Disulfiram has long been used in the treatment of chronic alcoholism. It is in vivo partially reduced to diethyldithiocarbamate, which is an efficient inhibitor of Cu, Zn-containing superoxide dismutase both in vitro and in vivo. The recently described...

...E. T. H. Tan; D. G. Lambie; R. H. Johnson; B. J. Robinson; E. A. Whiteside 1. Respiration during sleep was studied in 16 withdrawn alcoholic patients and in 12 control subjects. 2. The alcoholic patients had increased numbers of central ( P < 0.01) and of obstructive ( P < 0.05) apnoea...

...G. Eisenhofer; E. A. Whiteside; R. H. Johnson 1. Plasma catecholamine, blood pressure and heart rate responses to standing were measured in ten alcoholics during withdrawal, ten alcoholics after 2–7 weeks of abstinence from alcohol, six abstinent alcoholics with orthostatic hypotension and ten...

...S. R. Cairns; T. J. Peters 1. Needle biopsy specimens of liver were obtained from six control subjects with histologically normal liver and 11 chronic alcoholics with fatty liver. 2. Micro- and macro-lipid droplet fractions were isolated by differential flotation. These fractions, together...

...Luis A. Videla; Hernán Iturriaga; María E. Pino; Daniel Bunout; Alfonso Valenzuela; Guillermo Ugarte 1. The relationship between the content of hepatic reduced glutathione (GSH) and the length of abstinence was investigated in 45 chronic alcoholic patients. 2. Hepatic GSH levels were significantly...

...S. R. Cairns; T. J. Peters 1. Percutaneous needle biopsy specimens of liver were obtained from alcoholic, diabetic and control patients. Micro-methods of lipid separation and quantification were employed to determine the detailed nature of hepatic lipid. 2. Triglyceride is the major accumulating...

...J. B. Saunders; D. G. Beevers; A. Paton 1. Of 96 alcoholics admitted for detoxification, 48% were hypertensive (systolic blood pressure > 140 mmHg and/or diastolic pressure > 90 mmHg). 2. Elevation of both systolic and diastolic blood pressures was related to the severity of alcohol...