..., preventing the formation of monosodium urate crystals. Allopurinol is established as first-line therapy for gout; a newer alternative, febuxostat, is used in patients unable to tolerate allopurinol. This review provides an overview of gout, a detailed analysis of the structure and function of XOR, discussion...

...H. A. Simmonds; S. Reiter; P. M. Davies; J. S. Cameron 1. A compound identified as orotidine has been found in the erythrocytes of all subjects on allopurinol. 2. The erythrocyte orotidine concentrations were much higher in patients with renal failure or with the Lesch-Nyhan syndrome. 3...

..., allopurinol or mannitol. One group was not pretreated and served as a control. 2. A moderate transient increase in serum creatinine concentration was observed in the control rabbits, while a significantly less pronounced increase was noted after pretreatment with superoxide dismutase, catalase and mannitol. 3...

... mucosa. Thus production of superoxide radicals in such cells via this route would be impossible, and consequently unaffected either by ADA deficiency or the xanthine oxidase inhibitor allopurinol. Clinical Science (1985) 68, 561-565 561 Super oxide radicals, immunodeficiency and xanthine oxidase activity...

... or hyperuricaemia secondary to renal failure, with or without allopurinol therapy. 3. The average synthesis was higher in gouty patients without therapy than in control subjects, but the values obtained overlap the normal range. In secondary hyperuricaemia the synthesis was at same value as in control subjects. 4...

...H. A. Simmonds; B. Levin; J. S. Cameron 1. The metabolism of allopurinol was studied in a newly discovered patient with xanthinuria. 2. No oxipurinol was detectable in the urine during allopurinol administration, in direct contrast to the results in a patient previously studied by one of us. 3...