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Keywords: allosteric
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Clin Sci (Lond) (2018) 132 (21): 2323–2338.
Published: 02 November 2018
... subtype 5 (mGlu 5 ) has emerged as a promising target for a broad range of psychiatric and neurological disorders. Drug discovery programs targetting mGlu 5 are primarily focused on development of allosteric modulators that interact with sites distinct from the endogenous agonist glutamate. Significant...