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Clin Sci (Lond) (1996) 91 (3): 337–345.
Published: 01 September 1996
...Ken D. O'halloran; Aidan K. Curran; Aidan Bradford 1. Ventilation was measured during normoxia, hypoxia and hypercapnia before and after administration of almitrine in conscious, unrestrained, tracheostomized rats with the superior laryngeal nerves intact or cut. In superior laryngeal nerve-intact...
Clin Sci (Lond) (1992) 82 (3): 265–272.
Published: 01 March 1992
...P. C. Russell; C. J. Emery; J. Nicholl; G. R. Barer; P. Howard 1. To test whether almitrine might improve the arterial partial pressure of O 2 in patients with chronic obstructive airways disease by improvement of ventilation-perfusion matching, we looked at the interaction between hypoxic and...
Clin Sci (Lond) (1989) 77 (4): 431–437.
Published: 01 October 1989
...M. A. A. Airlie; D. C. Flenley; P. M. Warren 1. In a double-blind placebo-controlled study, we have investigated the effect of the peripheral chemoreceptor stimulant drug almitrine bismesylate on hypoxic ventilatory drive (expressed as the slope of the minute ventilation/arterial oxygen saturation...
Clin Sci (Lond) (1986) 70 (6): 555–564.
Published: 01 June 1986
...J. M. B. Hughes; D. J. Allison; A. Goatcher; A. Tripathi 1. Almitrine bismesylate (5–10 μg/kg) was given as an intravenous bolus to anaesthetized, paralysed dogs (a) with closed-chest ( n = 5) and (b) with open-chest ( n = 7) in whom the retrocardiac lobe was separately ventilated. Pulmonary, lobar...
Clin Sci (Lond) (1984) 66 (4): 435–442.
Published: 01 April 1984
...J. R. Stradling; C. G. Nicholl; D. Cover; E. E. Davies; J. M. B. Hughes; N. B. Pride 1. Almitrine at a low dose of 100 mg orally significantly raises P ao 2 and lowers P aco 2 in patients with chronic obstructive pulmonary disease, compared with placebo, when they were breathing air or 28% oxygen...
Clin Sci (Lond) (1983) 64 (1): 25–31.
Published: 01 January 1983
...W. L. Dull; J. M. Polu; P. Sadoul 1. Almitrine, an agonist of peripheral chemoreceptors, has been shown to be effective in lowering P aco 2 in patients with chronic obstructive lung disease. The aim of this investigation was to evaluate the pulmonary haemodynamic response to almitrine in clinically...
Clin Sci (Lond) (1982) 63 (4): 401–404.
Published: 01 October 1982
...J. R. Stradling; P. Barnes; N. B. Pride 1. Almitrine at a dose of 0·5 mg h −1 kg −1 given intravenously over 2 h had no effect on resting ventilation in normal males. 2. There was a small, but insignificant, rise in the hypercapnic drive to breathe as compared with placebo. 3. A large rise in the...