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Keywords: alternative splicingClose
Clin Sci (Lond) (2020) 134 (10): 1143–1150.
Published: 22 May 2020
... mature transcript may remove the critical ACE2 residues responsible for the interaction with the receptor-binding domain (RBD) of SARS-CoV-2, thus preventing their binding and entry into the cell. Additionally, inclusion of a novel predicted exons located in the 3′UTR by alternative splicing may remove...
Includes: Supplementary data
Eva Latorre, Luke C. Pilling, Benjamin P. Lee, Stefania Bandinelli, David Melzer, Luigi Ferrucci, Lorna W. Harries
Clin Sci (Lond) (2018) 132 (3): 313–325.
Published: 02 February 2018
...). Published by Portland Press Limited on behalf of the Biochemical Society 2018 aging senescence alternative splicing coronary artery disease Cardiovascular disease is the major cause of mortality and morbidity in the developed world [ 1 , 2 ]. Age is one of the predominant risk factors for...
Clin Sci (Lond) (2017) 131 (5): 355–368.
Published: 15 February 2017
... alternative splicing messenger RNA (mRNA) ribonucleic acid (RNA) sequencing RT-PCR splicing mutations Alterations at the pre-mRNA splicing level play a major role in the development of many human genetic diseases, both monogenic but also complex diseases such as cancer and neurodegeneration [ 1...