... vascular myogenic tone and blood pressure. The function of Ca V 1.2 channel can be subtly modulated by alternative splicing (AS), and its aberrant splicing involves in the pathogenesis of multiple cardiovascular diseases. The RNA-binding protein Rbfox1 is reported to regulate the AS events of Ca V 1.2...

... in the mature transcript may remove the critical ACE2 residues responsible for the interaction with the receptor-binding domain (RBD) of SARS-CoV-2, thus preventing their binding and entry into the cell. Additionally, inclusion of a novel predicted exons located in the 3′UTR by alternative splicing may remove...

... than one gene product (isoform) under different physiological conditions [ 15 ]. Splice-site usage and patterns of alternative splicing are driven by a battery of splicing regulatory proteins termed as splicing factors [ 16 , 17 ]. Some studies have shown that genes encoding splicing factors...

... to the clinic, and are already changing clinical approaches. alternative splicing messenger RNA (mRNA) ribonucleic acid (RNA) sequencing RT-PCR splicing mutations Alterations at the pre-mRNA splicing level play a major role in the development of many human genetic diseases, both monogenic...