... cerebral blood flow or oxygenation. The present study was designed to evaluate the effect of sildenafil on cerebral haemodynamics during acute exposure to altitude and after acclimatization. Ten subjects were studied 1 and 3 days after rapid ascent to 3480 m before and for two consecutive hours after...

... is of no clinical importance. Correspondence: Dr Lionel Dumont (e-mail [email protected] ). 27 5 2003 24 9 2003 22 10 2003 22 10 2003 © 2004 The Biochemical Society 2004 altitude bloodbrain barrier cerebral oedema hypobaric hypoxia magnesium randomized controlled...

...P.W. Barry; N.P. Mason; M. Riordan; C. O'Callaghan 1. Travellers to high altitude often complain of paroxysmal cough, which has not been previously investigated. We recorded overnight cough frequency and cough-receptor sensitivity to inhaled citric acid in a group of climbers travelling to 5300 m...

... altitude or contribute to altitude sickness. We studied the relationship between spirometry, arterial oxygen saturation and end-tidal carbon dioxide (ETCO 2 ) concentration in a group of healthy lowland adults during a stay at high altitude, and then evaluated the response to supplementary oxygen...

... to high altitude, when performing the same type of activity. 2. Taking into account their long-life climbing experience at extreme altitudes, we examined seven of the most recognized Sherpas with the aim of performing a comprehensive neurological evaluation based on medical history, physical examination...

...Rachel C. Wilson; W. L. G. Oldfield; P. W. Jones 1. The effect of residence at altitude on the perception of breathlessness after return to sea level was examined in normal subjects. Breathlessness (Borg scale), minute ventilation, respiratory frequency, tidal volume, ‘oxygen pulse’ (oxygen...

...Thomas E. Schlaepfer; Peter Bärtsch; Hans U. Fisch 1. Prolonged (> 10h) exposure to hypoxia and high altitude (> 5000 m) invariably have detrimental effects on cognitive performance. Paradoxically, mild improvements in cognitive function in patients with chronic obstructive pulmonary disease...

...Gwenda R. Barer; C. W. Edwards; Angela I. Jolly 1. Young rats were kept in a hypoxic chamber for 2–11 weeks and compared with littermate control animals. 2. The carotid bodies of the hypoxic rats enlarged, resembling those of men and animals living at high altitude. 3. Permanent blunting...

...Dr T. A. Kotchen; R. P. Hogan; A. E. Boyd; T.-K. Li; Helen C. Sing; J. W. Mason 1. Plasma renin activity, plasma adrenaline and noradrenaline concentrations, and urinary adrenaline and noradrenaline excretion rates were measured in ten subjects during 3 days of exposure to a simulated altitude...