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Keywords: amiloride
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Articles
Clin Sci (Lond) (1995) 88 (3): 277–283.
Published: 01 March 1995
... kinase C inhibitor), calphostin C (highly selective protein kinase C inhibitor) or 5-( N,N -hexamethylene) amiloride (highly selective Na + -H + exchange blocker) significantly inhibited ( P < 0.01) thrombin-stimulated platelet responses and suppressed the inhibitory effect of endothelin-1 on thrombin...
Articles
Clin Sci (Lond) (1993) 84 (2): 133–139.
Published: 01 February 1993
... activity specific inhibitor ethylisopropyl amiloride. However, in the presence of HCO - 3 , H + efflux rate was enhanced, and ethylisopropyl amiloride led to only partial inhibition of H + efflux. Complete inhibition was achieved only with further addition of the anion-transport inhibitor 4,4′-di...
Articles
Clin Sci (Lond) (1992) 82 (6): 635–640.
Published: 01 June 1992
...Michael SHALMI; Jørn Bech Laursen; Jacob Plange-RHULE; Sten Christensen; John Atherton; Peter Bie 1. The influences of lithium dosage, urine flow rate and acute administration of amiloride on the renal handling of lithium in normal conscious dogs were investigated. 2. Lithium was administered...
Articles
Clin Sci (Lond) (1991) 81 (6): 809–814.
Published: 01 December 1991
.... Clearance experiments were performed during water diuresis (20 mmol/l NaCl and 110 mmol/l glucose, 3 ml/h). After a control period, animals were randomized to one of the following treatments: time-control ( n = 9), doxazosin (50 μg primer; 30 μg h −1 kg −1 ) ( n = 10), amiloride (1 mg primer; 2.4 mg h −1 kg...
Articles
Clin Sci (Lond) (1991) 80 (5): 509–516.
Published: 01 May 1991
... smooth muscle cells from other cells that have been studied in this way. 6 12 1990 31 12 1990 © 1991 The Biochemical Society and the Medical Research Society 1991 amiloride hypertension skeletal muscle cells sodium/hydrogen antiport vascular smooth muscle cells Clinical...
Articles
Clin Sci (Lond) (1991) 80 (2): 95–99.
Published: 01 February 1991
..., although in vivo the presence of HCO − 3 /Cl − exchangers may also contribute to intracellular pH homoeostasis. 7 8 1990 16 8 1990 © 1991 The Biochemical Society and the Medical Research Society 1991 amiloride leucocytes pH sodium Clinical Science ( 199 1 ) 80, 95-99 95 Na+/H...
Articles
Clin Sci (Lond) (1990) 79 (4): 325–330.
Published: 01 October 1990
...Alan J. Knox; John R. Britton; Anne E. Tattersfield 1. We have recently shown that ouabain, an inhibitor of Na + /K + -adenosine triphosphatase, causes contraction of bovine and human airways in vitro , and that amiloride causes relaxation and inhibits receptor-operated contraction in bovine...
Articles
Clin Sci (Lond) (1990) 79 (4): 315–323.
Published: 01 October 1990
...Alan J. Knox; Paul Ajao; John R. Britton; Anne E. Tattersfield 1. To determine whether alterations in membrane sodium transport in airway smooth muscle can alter its contractility, we studied the effect of ouabain (a Na + /K + -adenosine triphosphatase inhibitor) and amiloride on contractile...
Articles
Clin Sci (Lond) (1989) 77 (4): 417–423.
Published: 01 October 1989
... suitable for the study of Na + /H + antiport activity. The addition of external Na + to cells acid-loaded to an internal pH of 6.7 led to an ethyl isopropyl amiloride-sensitive 1:1 stoichiometric exchange of external Na + for internal H + . amiloride leucocytes sodium © 1989 The Biochemical...
Articles
Clin Sci (Lond) (1989) 77 (1): 21–27.
Published: 01 July 1989
... increase in urinary kallikrein excretion than in the control rats. 4. The Na + -channel blocker, amiloride (8.5 mg/kg body weight), significantly increased urinary kallikrein excretion immediately after injection in control and K + -adapted rats. However, in the subsequent 60 min, kallikrein excretion...
Articles
Clin Sci (Lond) (1988) 75 (5): 521–526.
Published: 01 November 1988
...L. L. Ng; M. Harker; E. D. Abel 1. Leucocyte Na + influx in media containing 10 mmol/l Na + was studied directly using a triple-isotope method for measuring initial 22 Na uptake rates in 20 normal and 18 untreated hypertensive subjects. The effects of 1 mmol/l amiloride (a Na + -H + -antiport...
Articles
Clin Sci (Lond) (1988) 75 (2): 179–184.
Published: 01 August 1988
...L. L. Ng; M. Harker 1. A triple-isotope method for measuring initial 22 Na uptake rates in unactivated human leucocytes in the presence of serum, using 3 H 2 O, [ 14 C]sucrose and 22 Na, is described. 2. This 22 Na influx is inhibited by amiloride, with half-maximal inhibition at a concentration...
Articles
Clin Sci (Lond) (1987) 73 (6): 645–651.
Published: 01 December 1987
...J. C. Atherton; R. Green; S. Hughes; V. McFall; J. A. Sharples; L. R. Solomon; L. Wilson 1. The effects of amiloride and frusemide on lithium clearance were studied during changes in dietary sodium chloride intake and during infusion of 0.9% NaCl in normal human volunteers. 2. Lithium...
Articles
Clin Sci (Lond) (1987) 72 (5): 577–583.
Published: 01 May 1987
... + ] in the cortical collecting duct luminal fluid can be estimated; dividing this value by the plasma [K + ] yields an index of the transtubular [K + ] gradient (TTKG) in vivo. 3. The TTKG was close to 7 in aldosterone deficient ADX rats while on a normal K + diet and fell towards unity when amiloride or a low K...
Articles
Clin Sci (Lond) (1987) 72 (4): 449–454.
Published: 01 April 1987
...L. F. O. Obika; M. MARIN-GREZ 1. The effect of amiloride administration on the urinary kallikrein response to the injection or continuous infusion of frusemide in normal Sprague–Dawley rats was investigated. 2. Injections of frusemide induced repeatedly an increase in urinary kallikrein excretion...
Articles
Clin Sci Mol Med (1978) 55 (s4): 353s–354s.
Published: 01 December 1978
..., administered alone, and combined two-by-two. 3. Some 75% of patients had a supine diastolic blood pressure of less than 95 mmHg after 4 months treatment. 4. A total of 12% of patients had dropped out by 4 months from entry; no clear relationship was established between side effects and drop out. amiloride...
Articles
Clin Sci Mol Med (1978) 55 (6): 555–559.
Published: 01 December 1978
...P. A. Poole-Wilson; S. M. Cobbe; C. H. Fry 1. We have studied the acute effects of frusemide, triamterene and amiloride on potassium exchange, the action potential and mechanical function of isolated rabbit myocardium. 2. Potassium exchange in the myocardium was unaltered by these diuretics. 3...
Articles
Clin Sci Mol Med (1978) 55 (3): 231–234.
Published: 01 September 1978
...F. Mohamed; P. McSorley; D. J. Warren 1. Two methods for measurement of rectal potential difference in man were compared. A saline-filled catheter technique gave more reproducible results and was better tolerated by patients than the solid probe technique. 2. Infusion of amiloride...
Articles
Clin Sci Mol Med (1973) 45 (s1): 213s–218s.
Published: 01 August 1973
... in suspected mineralocorticoid excess not associated with elevation of aldosterone or DOC. 4. Studies of amiloride reveal similar effectiveness to spironolactone in low-renin hyperaldosteronism and in suspected mineralocorticoid excess. © 1994 The Biochemical Society and the Medical Research Society 1994...