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Keywords: amino acid
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Articles
Nasogastric bolus administration of a protein-rich drink augments insulinaemia and aminoacidaemia but not whole-body protein turnover or muscle protein synthesis versus oral administration
Available to PurchaseGeorge F. Pavis, Doaa R. Abdelrahman, Andrew J. Murton, Benjamin T. Wall, Francis B. Stephens, Marlou L. Dirks
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (1): 43–60.
Published: 05 January 2024
... to quantify temporal myofibrillar fractional synthetic rates (myoFSR). Drink administration increased serum insulin and plasma amino acid concentrations, and to a greater extent and duration in NG versus ORAL (all interactions P <0.05). Drink administration increased whole-body protein synthesis ( P...
Articles
Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth
Available to PurchaseHager M. Kowash, Harry G. Potter, Rebecca M. Woods, Nick Ashton, Reinmar Hager, Joanna C. Neill, Jocelyn D. Glazier
Journal:
Clinical Science
Clin Sci (Lond) (2022) 1117–1137.
Published: 05 August 2022
... unclear, dysregulation of placental function is implicated. We hypothesised that maternal infection, leading to maternal immune activation and stimulated cytokine production, alters placental and yolk sac amino acid transport, affecting fetal brain development and thus NDD risk. Using a rat model...
Includes: Supplementary data
Articles
Protein catabolism and impairment of skeletal muscle insulin signalling in heart failure
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (11): 465–466.
Published: 17 August 2010
.... Sinoway L. I. Oxidative stress and the muscle reflex in heart failure J. Physiol. 2009 587 5227 5237 13 Toth M. J. LeWinter M. M. Ades P. A. Matthews D. E. Impaired muscle protein anabolic response to insulin and amino acids in heart failure patients: relationship...
Articles
Impaired muscle protein anabolic response to insulin and amino acids in heart failure patients: relationship with markers of immune activation
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (11): 467–476.
Published: 17 August 2010
... (insulin and amino acids) and whether alterations in protein metabolism correlate to circulating cytokine levels. No differences in phenylalanine balance, rate of appearance or rate of disappearance were found between patients and controls under fasting conditions. However, the anabolic response...
Articles
Glutathione and amino acid concentrations in human liver during short warm ischaemia and reperfusion: a pilot study
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2009) 117 (9): 339–344.
Published: 01 September 2009
... glutathione and amino acid metabolism. Previous studies in humans have demonstrated that ischaemia and reperfusion in skeletal muscle for up to 120 min have no major effect on muscle glutathione concentrations. Liver ischaemia and reperfusion in animals have demonstrated diverging results concerning...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 117 (9): 321–330.
Published: 01 September 2009
... of the glucose- and amino-acid-responsive clonal insulin-secreting cell line BRIN-BD11. Aralar1 overexpression increased long-term (24 h) and acute (20 min) glucose- and amino-acid-stimulated insulin secretion, cellular glucose metabolism, L -alanine and L -glutamine consumption, cellular ATP and glutamate...
Articles
Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic β-cells
Available to PurchaseNeville H. McClenaghan, Siobhan M. Scullion, Brian Mion, Chandralal Hewage, J. Paul G. Malthouse, Peter R. Flatt, Philip Newsholme, Lorraine Brennan
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (4): 341–351.
Published: 15 January 2009
...Neville H. McClenaghan; Siobhan M. Scullion; Brian Mion; Chandralal Hewage; J. Paul G. Malthouse; Peter R. Flatt; Philip Newsholme; Lorraine Brennan Acute insulin-releasing actions of amino acids have been studied in detail, but comparatively little is known about the β-cell effects of long-term...
Articles
Initiation factors for translation of proteins in the rectus abdominis muscle from patients on overnight standard parenteral nutrition before surgery
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (9): 603–610.
Published: 02 April 2008
... of translation was quantified. Plasma glucose, and serum insulin, glycerol, triacylglycerols (triglycerides) and NEFAs (non-esterified fatty acids; ‘free fatty acids’) were not significantly altered during TPN infusion, whereas total plasma amino acids increased, as shown by increases in methionine...
Includes: Supplementary data
Articles
Elevated plasma arginase-1 does not affect plasma arginine in patients undergoing liver resection
Available to PurchaseMarcel C. G. van de Poll, Sebastiaan J. P. Hanssen, Maaike Berbée, Nicolaas E. P. Deutz, Diethard Monbaliu, Wim A. Buurman, Cornelis H. C. Dejong
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (3): 231–241.
Published: 08 January 2008
... in arginine plasma levels occurred in vivo and in vitro . In contrast with commonly held views, moderately increased arginase-1 plasma levels do not affect plasma arginine. Very high plasma arginase-1 levels are required to induce potential clinically relevant effects. amino acid arginase-1 arginine...
Articles
Knee replacement surgery as a human clinical model of the effects of ischaemia/reperfusion upon skeletal muscle
Available to PurchaseBo Westman, Lars Weidenhielm, Olav Rooyackers, Katarina Fredriksson, Jan Wernerman, Folke Hammarqvist
Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (7): 313–318.
Published: 03 September 2007
...Bo Westman; Lars Weidenhielm; Olav Rooyackers; Katarina Fredriksson; Jan Wernerman; Folke Hammarqvist The temporal pattern of metabolic alterations in muscle tissue during total ischaemia and reperfusion are not well-characterized in humans with respect to glutathione, amino acids and energy-rich...
Includes: Supplementary data
Articles
Presence of tumour inhibits the normal post-operative response in arginine and NO production in non-cachectic mice
Available to PurchaseYvonne L. J. Vissers, Maarten F. von Meyenfeldt, Yvette C. Luiking, Cornelis H. C. Dejong, Wim A. Buurman, Nicolaas E. P. Deutz
Journal:
Clinical Science
Clin Sci (Lond) (2007) 112 (10): 527–532.
Published: 12 April 2007
... with an attenuated acute-phase response. This indicates that altered arginine metabolism may be an important characteristic of the metabolic changes in cancer. amino acid arginine cancer metabolism nitric oxide stable isotope surgery SAP concentrations in plasma were measured using a sandwich ELISA...
Articles
Augmentation of endothelial function following exercise training is associated with increased L-arginine transport in human heart failure
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (6): 523–530.
Published: 23 November 2005
... in endothelial dysfunction in CHF. In that study [ 18 ], we found that the expression of the system y + cationic amino acid transporter CAT-1 was reduced, providing a potential explanation for reduced L -arginine transport in CHF. To further define the role of L -arginine transport in the setting...
Articles
Chronic fatigue syndrome: new evidence for a central fatigue disorder
Available to PurchaseEvelina GEORGIADES, Wilhelmina M. H. BEHAN, Liam P. KILDUFF, Marios HADJICHARALAMBOUS, Eileen E. MACKIE, John WILSON, Susan A. WARD, Yannis P. PITSILADIS
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (2): 213–218.
Published: 01 August 2003
... (CFS), a disorder characterized chiefly by persistent, often debilitating, fatigue. We wished to characterize circulating profiles of putative amino acid modulators of CNS 5-hydroxytryptamine (5-HT; serotoninergic) and dopaminergic function in CFS patients at rest, as well as during symptom-limited...
Articles
Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (6): 633–639.
Published: 19 November 2002
...Alan A. JACKSON; Rebecca L. DUNN; Michael C. MARCHAND; Simon C. LANGLEY-EVANS When rat dams consume a diet low in protein during pregnancy, their offspring develop high blood pressure. On a low-protein diet, the endogenous formation of the amino acid glycine is thought to become constrained...
Articles
Effects in vivo of decreased plasma and intracellular muscle glutamine concentration on whole-body and hindquarter protein kinetics in rats
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1999) 96 (6): 639–646.
Published: 11 May 1999
...Steven W. M. OLDE DAMINK; Ivo DE BLAAUW; Nicolaas E. P. DEUTZ; Peter B. SOETERS Glutamine is considered to be a ‘conditionally’ essential amino acid. During situations of severe stress like sepsis or after trauma there is a fall in plasma glutamine levels, enhanced glutamine turnover...
Articles
Effects of Ordinary Meals on Plasma Concentrations of 3,4-Dihydroxyphenylalanine, Dopamine Sulphate and 3,4-Dihydroxyphenylacetic Acid
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (4): 423–430.
Published: 01 April 1997
... or received three meals at 9.00 hours, 13.00 hours and 18.00 hours. Catecholamines and metabolites were determined by reverse-phase HPLC with electrochemical detection. Neutral amino acids were measured by ionexchange chromatography with photometric detection. 3. The food contained relatively little DOPA...
Articles
Muscle Protein and Amino Acid Turnover in Rats in Vivo : Effects of Short-Term and Prolonged Starvation
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1996) 90 (6): 457–466.
Published: 01 June 1996
... enhanced. Using valine and glutamine as tracers, the enhanced amino acid turnover rates were confirmed. 4. In conclusion, our results show that during short periods of starvation both methods give similar results. After prolonged starvation, however, an opposite change in disappearance rate and protein...
Articles
Increased lysine transport capacity in erythrocytes from patients with chronic renal failure
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1989) 76 (4): 419–422.
Published: 01 April 1989
...). A similar increase in V max. in uraemic cells compared with controls was seen in erythrocytes which were studied in zero-trans conditions after depletion of intracellular amino acids. The mean values of K m and K D were not significantly different in uraemia. The origins of this increased membrane transport...
Articles
Apparent compartmentation of body nitrogen in one human subject: its consequences in measuring the rate of whole-body protein synthesis with 15 N
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (3): 271–282.
Published: 01 March 1985
...Edward B. Fern; Peter J. Garlick; John C. Waterlow 1. The rate of protein synthesis in the whole body was measured in one fed subject with seven 15 N-labelled amino acids (intravenous and oral doses) and two 15 N protein mixtures (oral doses only). The rates were determined individually from...
Articles
Plasma Glucose, Non-Esterified Fatty Acids and Amino Acids in Huntington's Chorea
Available to Purchase
Journal:
Clinical Science
Clin Sci Mol Med (1977) 52 (3): 311–318.
Published: 01 March 1977
... 10 1976 © 1977 The Biochemical Society and the Medical Research Society 1977 amino acid glucose Huntington's chorea insulin provocation test non-esterified fatty acids tryptophan Clinical Science and Molecular Medicine (1977) 52, 3 11-3 18. Plasma glucose, non-esterified fatty...
Articles
Studies of Amino Acid and Protein Metabolism in Normal Man with l-[U-14C]Tyrosine
Available to Purchase
Journal:
Clinical Science
Clin Sci Mol Med (1976) 50 (6): 525–532.
Published: 01 June 1976
... of a labelled essential amino acid would therefore give more accurate values for short-term measurements of whole body protein turnover. 14 7 1975 © 1976 The Biochemical Society and the Medical Research Society 1976 amino acid protein [ 14 C]tyrosine Clhical Science and Molecular Medicine...
Articles
A Study of Relations between the Absorption of Amino Acids, Dipeptides, Water and Electrolytes in the Normal Human Jejunum
Available to PurchaseD. B. A. Silk, P. D. Fairclough, Nicola J. Park, Annette E. Lane, Joan P. W. Webb, M. L. Clark, A. M. Dawson
Journal:
Clinical Science
Clin Sci Mol Med (1975) 49 (5): 401–408.
Published: 01 November 1975
...D. B. A. Silk; P. D. Fairclough; Nicola J. Park; Annette E. Lane; Joan P. W. Webb; M. L. Clark; A. M. Dawson 1. A double-lumen perfusion technique was used to study the effect of a wide range of concentrations of the dipeptide glycyl-l-alanine and its constituent amino acids on water...