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Keywords: amino acid
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Clin Sci (Lond) (2022) 1117–1137.
Published: 05 August 2022
... unclear, dysregulation of placental function is implicated. We hypothesised that maternal infection, leading to maternal immune activation and stimulated cytokine production, alters placental and yolk sac amino acid transport, affecting fetal brain development and thus NDD risk. Using a rat model...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2010) 119 (11): 465–466.
Published: 17 August 2010
.... Sinoway L. I. Oxidative stress and the muscle reflex in heart failure J. Physiol. 2009 587 5227 5237 13 Toth M. J. LeWinter M. M. Ades P. A. Matthews D. E. Impaired muscle protein anabolic response to insulin and amino acids in heart failure patients: relationship...
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Clin Sci (Lond) (2010) 119 (11): 467–476.
Published: 17 August 2010
... (insulin and amino acids) and whether alterations in protein metabolism correlate to circulating cytokine levels. No differences in phenylalanine balance, rate of appearance or rate of disappearance were found between patients and controls under fasting conditions. However, the anabolic response...
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Clin Sci (Lond) (2009) 117 (9): 339–344.
Published: 01 September 2009
... glutathione and amino acid metabolism. Previous studies in humans have demonstrated that ischaemia and reperfusion in skeletal muscle for up to 120 min have no major effect on muscle glutathione concentrations. Liver ischaemia and reperfusion in animals have demonstrated diverging results concerning...
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Clin Sci (Lond) (2008) 114 (9): 603–610.
Published: 02 April 2008
... of translation was quantified. Plasma glucose, and serum insulin, glycerol, triacylglycerols (triglycerides) and NEFAs (non-esterified fatty acids; ‘free fatty acids’) were not significantly altered during TPN infusion, whereas total plasma amino acids increased, as shown by increases in methionine...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2008) 114 (3): 231–241.
Published: 08 January 2008
... in arginine plasma levels occurred in vivo and in vitro . In contrast with commonly held views, moderately increased arginase-1 plasma levels do not affect plasma arginine. Very high plasma arginase-1 levels are required to induce potential clinically relevant effects. amino acid arginase-1 arginine...
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Clin Sci (Lond) (2007) 113 (7): 313–318.
Published: 03 September 2007
...Bo Westman; Lars Weidenhielm; Olav Rooyackers; Katarina Fredriksson; Jan Wernerman; Folke Hammarqvist The temporal pattern of metabolic alterations in muscle tissue during total ischaemia and reperfusion are not well-characterized in humans with respect to glutathione, amino acids and energy-rich...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2007) 112 (10): 527–532.
Published: 12 April 2007
... with an attenuated acute-phase response. This indicates that altered arginine metabolism may be an important characteristic of the metabolic changes in cancer. amino acid arginine cancer metabolism nitric oxide stable isotope surgery SAP concentrations in plasma were measured using a sandwich ELISA...
Articles
Clin Sci (Lond) (2005) 109 (6): 523–530.
Published: 23 November 2005
... in endothelial dysfunction in CHF. In that study [ 18 ], we found that the expression of the system y + cationic amino acid transporter CAT-1 was reduced, providing a potential explanation for reduced L -arginine transport in CHF. To further define the role of L -arginine transport in the setting...
Articles
Clin Sci (Lond) (2003) 105 (2): 213–218.
Published: 01 August 2003
... (CFS), a disorder characterized chiefly by persistent, often debilitating, fatigue. We wished to characterize circulating profiles of putative amino acid modulators of CNS 5-hydroxytryptamine (5-HT; serotoninergic) and dopaminergic function in CFS patients at rest, as well as during symptom-limited...
Articles
Clin Sci (Lond) (2002) 103 (6): 633–639.
Published: 19 November 2002
...Alan A. JACKSON; Rebecca L. DUNN; Michael C. MARCHAND; Simon C. LANGLEY-EVANS When rat dams consume a diet low in protein during pregnancy, their offspring develop high blood pressure. On a low-protein diet, the endogenous formation of the amino acid glycine is thought to become constrained...
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Articles
Clin Sci (Lond) (1997) 92 (4): 423–430.
Published: 01 April 1997
... or received three meals at 9.00 hours, 13.00 hours and 18.00 hours. Catecholamines and metabolites were determined by reverse-phase HPLC with electrochemical detection. Neutral amino acids were measured by ionexchange chromatography with photometric detection. 3. The food contained relatively little DOPA...
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Clin Sci (Lond) (1996) 90 (6): 457–466.
Published: 01 June 1996
... enhanced. Using valine and glutamine as tracers, the enhanced amino acid turnover rates were confirmed. 4. In conclusion, our results show that during short periods of starvation both methods give similar results. After prolonged starvation, however, an opposite change in disappearance rate and protein...
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Clin Sci (Lond) (1989) 76 (4): 419–422.
Published: 01 April 1989
...). A similar increase in V max. in uraemic cells compared with controls was seen in erythrocytes which were studied in zero-trans conditions after depletion of intracellular amino acids. The mean values of K m and K D were not significantly different in uraemia. The origins of this increased membrane transport...
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Clin Sci (Lond) (1985) 68 (3): 271–282.
Published: 01 March 1985
...Edward B. Fern; Peter J. Garlick; John C. Waterlow 1. The rate of protein synthesis in the whole body was measured in one fed subject with seven 15 N-labelled amino acids (intravenous and oral doses) and two 15 N protein mixtures (oral doses only). The rates were determined individually from...
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Clin Sci Mol Med (1977) 52 (3): 311–318.
Published: 01 March 1977
... 10 1976 © 1977 The Biochemical Society and the Medical Research Society 1977 amino acid glucose Huntington's chorea insulin provocation test non-esterified fatty acids tryptophan Clinical Science and Molecular Medicine (1977) 52, 3 11-3 18. Plasma glucose, non-esterified fatty...
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Clin Sci Mol Med (1976) 50 (6): 525–532.
Published: 01 June 1976
... of a labelled essential amino acid would therefore give more accurate values for short-term measurements of whole body protein turnover. 14 7 1975 © 1976 The Biochemical Society and the Medical Research Society 1976 amino acid protein [ 14 C]tyrosine Clhical Science and Molecular Medicine...
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Clin Sci Mol Med (1975) 49 (5): 401–408.
Published: 01 November 1975
...D. B. A. Silk; P. D. Fairclough; Nicola J. Park; Annette E. Lane; Joan P. W. Webb; M. L. Clark; A. M. Dawson 1. A double-lumen perfusion technique was used to study the effect of a wide range of concentrations of the dipeptide glycyl-l-alanine and its constituent amino acids on water...