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Keywords: amino acid transporters
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Articles

Overexpression of the LAT1 in primary human trophoblast cells increases the uptake of essential amino acids and activates mTOR signaling

In Collection
Reproductive Physiology and Disease
Fredrick J. Rosario, Johann Urschitz, Theresa L. Powell, Thomas L. Brown, Thomas Jansson
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (21): 1651–1664.
https://doi.org/10.1042/CS20230490
Published: 10 November 2023
...Fredrick J. Rosario; Johann Urschitz; Theresa L. Powell; Thomas L. Brown; Thomas Jansson The System L amino acid transporter, particularly the isoform Large Neutral Amino Acid Transporter Small Subunit 1 (LAT1) encoded by SLC7A5 , is believed to mediate the transfer of essential amino acids...
View articletitled, Overexpression of the LAT1 in primary human trophoblast cells increases the uptake of essential amino acids and activates mTOR signaling
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Articles

Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat

Alaa Alkhalefah, Warwick B. Dunn, James W. Allwood, Kate L. Parry, Franchesca D. Houghton, Nick Ashton, Jocelyn D. Glazier
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1445–1466.
https://doi.org/10.1042/CS20210137
Published: 11 June 2021
... restriction in both sexes. Normal fetal growth is supported by the collective activity of several placental amino acid transporters [ 24 ]. The activity of system A, a sodium-dependent co-transporter that transports both essential and non-essential amino acids [ 24 ], is known to be crucial for optimal...
View articletitled, Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat
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Includes: Supplementary data
Articles

ACE2 and gut amino acid transport

In Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
Simone M.R. Camargo, Raphael N. Vuille-dit-Bille, Chantal F. Meier, François Verrey
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2823–2833.
https://doi.org/10.1042/CS20200477
Published: 03 November 2020
... and a lower expression in stomach and colon. In small intestinal mucosa, ACE2 mRNA expression appears to increase with age and to display higher levels in patients taking ACE-inhibitors (ACE-I). There, ACE2 protein heterodimerizes with the neutral amino acid transporter B road neutral A mino acid T ransporter...
View articletitled, ACE2 and gut amino acid transport
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