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Articles

New insights into amino acid metabolism, β-cell function and diabetes

Philip NEWSHOLME, Lorraine BRENNAN, Blanca RUBI, Pierre MAECHLER

Clin Sci (Lond) (2005) 108 (3): 185–194.

DOI: https://doi.org/10.1042/CS20040290

Published: 18 February 2005

...Philip NEWSHOLME; Lorraine BRENNAN; Blanca RUBI; Pierre MAECHLER Specific amino acids are now known to acutely and chronically regulate insulin secretion from pancreatic β-cells in vivo and in vitro . Understanding the molecular mechanisms by which amino acids regulate insulin secretion may...

View article titled, New insights into amino acid metabolism, β-cell function and diabetes

Articles

A comparative study of the adsorption of amino acids on to calcium minerals found in renal calculi

David E. FLEMING, Wilhelm VAN BRONSWIJK, Rosemary Lyons RYALL

Clin Sci (Lond) (2001) 101 (2): 159–168.

DOI: https://doi.org/10.1042/cs1010159

Published: 20 June 2001

...David E. FLEMING; Wilhelm VAN BRONSWIJK; Rosemary Lyons RYALL To assess the binding of individual amino acids to the principal calcium minerals found in human kidney stones, the adsorption of 20 amino acids on to calcium oxalate monohydrate, CaHPO 4 .2H 2 O, Ca 3 (PO 4 ) 2 and Ca 5 (PO 4 ) 3 OH...

View article titled, A comparative study of the adsorption of amino acids on to calcium minerals found in renal calculi

Articles

Metabolism of lactose-[13C]ureide and lactose-[15N,15N]ureide in normal adults consuming a diet marginally adequate in protein

A. A. JACKSON, R. BUNDY, A. HOUNSLOW, J. L. MURPHY, S. A. WOOTTON

Clin Sci (Lond) (1999) 97 (5): 547–555.

DOI: https://doi.org/10.1042/cs0970547

Published: 28 September 1999

... microflora in normal individuals. Correspondence : Professor Alan A. Jackson (e-mail iohn@soton.ac.uk ). 5 3 1999 4 6 1999 22 7 1999 The Biochemical Society and the Medical Research Society © 1999 1999 amino acids colon nitrogen protein stable isotopes urea...

View article titled, Metabolism of lactose-[13C]ureide and lactose-[15N,15N]ureide in normal adults consuming a diet marginally adequate in protein

Articles

Muscle protein degradation and amino acid metabolism during prolonged knee-extensor exercise in humans

G. VAN HALL, B. SALTIN, A. J. M. WAGENMAKERS

Clin Sci (Lond) (1999) 97 (5): 557–567.

DOI: https://doi.org/10.1042/cs0970557

Published: 17 September 1999

...G. VAN HALL; B. SALTIN; A. J. M. WAGENMAKERS The aim of this study was to investigate whether prolonged one-leg knee-extensor exercise enhances net protein degradation in muscle with a normal or low glycogen content. Net amino acid production, as a measure of net protein degradation, was estimated...

View article titled, Muscle protein degradation and amino acid metabolism during prolonged knee-extensor exercise in humans

Articles

Microdialysis of Human Breast Tissue during the Menstrual Cycle

Charlotta Dabrosin, Åse Hallström, Urban Ungerstedt, Mats Hammar

Clin Sci (Lond) (1997) 92 (5): 493–496.

DOI: https://doi.org/10.1042/cs0920493

Published: 01 May 1997

... acids, lactate and pyruvate change during the menstrual cycle. 2. Microdialysis was performed twice during the menstrual cycle in eight healthy women, in the breast and subcutaneous fat. Amino acids, lactate and pyruvate were analysed by HPLC. 3. None of the women showed any complications...

View article titled, Microdialysis of Human Breast Tissue during the Menstrual Cycle

Articles

Augmented Thermic Effect of Amino Acids under General Anaesthesia Occurs Predominantly in Extra-Splanchnic Tissues

Eva Selldén, Robert Bränstróam, Tomas Brundin

Clin Sci (Lond) (1996) 91 (4): 431–439.

DOI: https://doi.org/10.1042/cs0910431

Published: 01 October 1996

...Eva Selldén; Robert Bränstróam; Tomas Brundin 1. Intravenous infusion of amino acid mixtures stimulates human oxidative heat production more effectively under general anaesthesia than in the unanaesthetized state. To analyse the splanchnic and extra-splanchnic regional distribution...

View article titled, Augmented Thermic Effect of Amino Acids under General Anaesthesia Occurs Predominantly in Extra-Splanchnic Tissues

Articles

Renal Effects of Amino Acids and Dopamine in Renal Transplant Recipients Treated with or without Cyclosporin A

Jesper Melchior Hansen, Niels Vidiendal Olsen, Paul Peter Leyssac

Clin Sci (Lond) (1996) 91 (4): 489–496.

DOI: https://doi.org/10.1042/cs0910489

Published: 01 October 1996

...Jesper Melchior Hansen; Niels Vidiendal Olsen; Paul Peter Leyssac 1. The nephrotoxic effects of cyclosporin A may diminish the ability of the transplanted kidney to increase the glomerular filtration rate and effective renal plasma flow during infusion of dopamine or amino acids. 2. The present...

View article titled, Renal Effects of Amino Acids and Dopamine in Renal Transplant Recipients Treated with or without Cyclosporin A

Articles

Interaction between Nutrients, Pro-Inflammatory Cytokines and Inflammation

Robert F. Grimble

Clin Sci (Lond) (1996) 91 (2): 121–130.

DOI: https://doi.org/10.1042/cs0910121

Published: 01 August 1996

...Robert F. Grimble © 1996 The Biochemical Society and the Medical Research Society 1996 amino acids antioxidants cytokines fats glutathione inflammation interleukin nutrition tumour necrosis factor vitamin E Clinical Science (1996) 91, 121-130 (Printed i n Great Britain...

View article titled, Interaction between Nutrients, Pro-Inflammatory Cytokines and Inflammation

Articles

Effect of Methionine Loading on 5-Methyltetrahydrofolate, S-Adenosylmethionine and S-Adenosylhomocysteine in Plasma of Healthy Humans

Franziska M. T. Loehrer, Walter E. Haefeli, Christian P. Angst, Garry Browne, Greta Frick, Brian Fowler

Clin Sci (Lond) (1996) 91 (1): 79–86.

DOI: https://doi.org/10.1042/cs0910079

Published: 01 July 1996

... 3 1996 © 1996 The Biochemical Society and the Medical Research Society 1996 S-adenosylhomocysteine S-adenosylmethionine amino acids blood homocysteine human metabolism 5-methyltetrahydrofolate Clinical Science (1996) 91, 79-86 (Printed in Great Britain) 79 Effect of methionine...

View article titled, Effect of Methionine Loading on 5-Methyltetrahydrofolate, S-Adenosylmethionine and S-Adenosylhomocysteine in Plasma of Healthy Humans

Articles

Tricarboxylic Acid Cycle Intermediates during Incremental Exercise in Healthy Subjects and in Patients with McArdle's Disease

K. Sahlin, L. Jorfeldt, K.-G. Henriksson, S. F. Lewis, R. G. Haller

Clin Sci (Lond) (1995) 88 (6): 687–693.

DOI: https://doi.org/10.1042/cs0880687

Published: 01 June 1995

... rate in healthy subjects, and that the attenuated peak level in patients with McArdle's disease may be a limitation for aerobic energy transduction. © 1995 The Biochemical Society and the Medical Research Society 1995 amino acids anaplerosis citrate fumarate glycogen storage disease...

View article titled, Tricarboxylic Acid Cycle Intermediates during Incremental Exercise in Healthy Subjects and in Patients with McArdle's Disease

Articles

Prolonged Changes in Protein and Amino Acid Metabolism after Zymosan Treatment in Rats

Olav E. Rooyackers, Wim H. M. Saris, Peter B. Soeters, Anton J. M. Wagenmakers

Clin Sci (Lond) (1994) 87 (5): 619–626.

DOI: https://doi.org/10.1042/cs0870619

Published: 01 November 1994

... for at least 10 days. Changes in amino acid and protein metabolism were studied in both phases. 2. Differences between this modified and the original zymosan model are a lower mortality (16%), which is limited to the first 36 critical hours, and the absence of signs of severe illness during the prolonged...

View article titled, Prolonged Changes in Protein and Amino Acid Metabolism after Zymosan Treatment in Rats

Articles

Augmented Thermic Effect of Amino Acids under General Anaesthesia: A Mechanism Useful for Prevention of Anaesthesia-Induced Hypothermia

EVA Selldén, Tomas Brundin, John Wahren

Clin Sci (Lond) (1994) 86 (5): 611–618.

DOI: https://doi.org/10.1042/cs0860611

Published: 01 May 1994

...EVA Selldén; Tomas Brundin; John Wahren 1. Intravenous infusion of amino acids stimulates energy expenditure and heat accumulation in normal man. To find out whether such stimulation also occurs during general anaesthesia, thermogenesis was measured in 21 patients before, during and after...

View article titled, Augmented Thermic Effect of Amino Acids under General Anaesthesia: A Mechanism Useful for Prevention of Anaesthesia-Induced Hypothermia

Articles

Hydrogen Peroxide Generation in a Model Paediatric Parenteral Amino Acid Solution

Vince Brawley, Jatinder Bhatia, Warren B. Karp

Clin Sci (Lond) (1993) 85 (6): 709–712.

DOI: https://doi.org/10.1042/cs0850709

Published: 01 December 1993

...Vince Brawley; Jatinder Bhatia; Warren B. Karp 1. Parenteral amino acid solutions undergo photo-oxidation, which may be an important factor in total parenteral nutrition-associated hepatic dysfunction. Light-exposed parenteral solutions containing amino acids, in addition to vitamins and trace...

View article titled, Hydrogen Peroxide Generation in a Model Paediatric Parenteral Amino Acid Solution

Articles

Effects of Decreased Glutamine Supply on Gut and Liver Metabolism in vivo in Rats

Sylvia Heeneman, Nicolaas E. P. Deutz

Clin Sci (Lond) (1993) 85 (4): 437–444.

DOI: https://doi.org/10.1042/cs0850437

Published: 01 October 1993

...Sylvia Heeneman; Nicolaas E. P. Deutz 1. It has recently been suggested that glutamine may be a conditionally essential nutrient rather than a non-essential amino acid. Therefore, administration of methionine sulphoximine was used to create a model of decreased arterial glutamine concentrations...

View article titled, Effects of Decreased Glutamine Supply on Gut and Liver Metabolism in vivo in Rats

Articles

Effects of Acid Loading on Serum Amino Acid Profiles and Muscle Composition in Normal Fed Rats

A. Cupisti, F. Baker, J. Brown, C. Lock, A. Bevington, K. P. G. Harris, J. Walls

Clin Sci (Lond) (1993) 85 (4): 445–449.

DOI: https://doi.org/10.1042/cs0850445

Published: 01 October 1993

... acidosis seems to be an important aetio-logical factor. 2. In uraemic patients abnormalities in blood amino acid profiles are present after a protein meal, suggesting impaired metabolism of ingested proteins. 3. This study demonstrates that acidosis induces changes in arterial amino acid profiles in fed...

View article titled, Effects of Acid Loading on Serum Amino Acid Profiles and Muscle Composition in Normal Fed Rats

Articles

Responses of Tissue Protein Synthesis to Nutrient Intake in Rats Exposed to Interleukin-1 β Or Turpentine

Peter E. Ballmer, Margaret A. McNurlan, Ian Grant, Peter J. Garlick

Clin Sci (Lond) (1993) 85 (3): 337–342.

DOI: https://doi.org/10.1042/cs0850337

Published: 01 September 1993

... amino acids) was investigated during experimental inflammation induced by injection of human recombinant interleukin-1β or turpentine in young male rats. 2. Interleukin-1β induced a consistent increase of 3°C in body temperature between 3 and 5 h after injection, whereas turpentine induced a delayed...

View article titled, Responses of Tissue Protein Synthesis to Nutrient Intake in Rats Exposed to Interleukin-1 β Or Turpentine

Articles

Assessment of the mathematical issues involved in measuring the fractional synthesis rate of protein using the flooding dose technique

David L. Chinkes, Judah Rosenblatt, Robert R. Wolfe

Clin Sci (Lond) (1993) 84 (2): 177–183.

DOI: https://doi.org/10.1042/cs0840177

Published: 01 February 1993

... amino acid. The alternative formula is: where E B and E F are the enrichments of bound and free amino acid, respectively (atom per cent excess), and C=1-( E F / E I ), where E I is the enrichment of the infusate. This approach defines the lowest possible value for the fractional synthesis rate...

View article titled, Assessment of the mathematical issues involved in measuring the fractional synthesis rate of protein using the flooding dose technique

Articles

Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs

N. E. P. Deutz, P. L. M. Reijven, G. Athanasas, P. B. Soeters

Clin Sci (Lond) (1992) 83 (5): 607–614.

DOI: https://doi.org/10.1042/cs0830607

Published: 01 November 1992

...N. E. P. Deutz; P. L. M. Reijven; G. Athanasas; P. B. Soeters 1. After operation, changes in nitrogen metabolism occur. Although increased flux of amino acids from peripheral to splanchnic organs after operation has been described, substrate utilization by the individual organs in the splanchnic...

View article titled, Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs

Articles

Effects of early amino acid administration during total parenteral nutrition on protein metabolism in pre-term infants

R. A. van Lingen, J. B. van Goudoever, I. H. T. Luijendijk, J. L. D. Wattimena, P. J. J. Sauer

Clin Sci (Lond) (1992) 82 (2): 199–203.

DOI: https://doi.org/10.1042/cs0820199

Published: 01 February 1992

...R. A. van Lingen; J. B. van Goudoever; I. H. T. Luijendijk; J. L. D. Wattimena; P. J. J. Sauer 1. We investigated the effects of starting amino acid administration on post-natal day 2 on protein turnover and nitrogen balance in appropriate-for-gestational-age, very-low-birth-weight infants...

View article titled, Effects of early amino acid administration during total parenteral nutrition on protein metabolism in pre-term infants

Articles

Mediators of the direct effects of amino acids on the rat kidney

A. A. El Sayed, J. Haylor, A. M. El Nahas

Clin Sci (Lond) (1991) 81 (3): 427–432.

DOI: https://doi.org/10.1042/cs0810427

Published: 01 September 1991

...A. A. El Sayed; J. Haylor; A. M. El Nahas 1. The response of the isolated rat kidney to a mixed amino acid solution was examined in the presence of three renal autacoid inhibitors, indomethacin (a cyclo-oxygenase inhibitor), sulpiride (a dopamine antagonist) and l -nitroarginine methyl ester...

View article titled, Mediators of the direct effects of amino acids on the rat kidney

Articles

Effect of glutamine-enriched total parenteral nutrition on septic rats

M. Salleh M. Ardawi

Clin Sci (Lond) (1991) 81 (2): 215–222.

DOI: https://doi.org/10.1042/cs0810215

Published: 01 August 1991

... of glutamine-enriched total parenteral nutrition is beneficial to septic rats and possibly to septic patients. 7 2 1991 4 3 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 amino acids glutamine metabolism muscle nitrogen balance parenteral nutrition sepsis...

View article titled, Effect of glutamine-enriched total parenteral nutrition on septic rats

Articles

Amino acid metabolism in human subcutaneous adipose tissue in vivo

K. N. Frayn, K. Khan, S. W. Coppack, M. Elia

Clin Sci (Lond) (1991) 80 (5): 471–474.

DOI: https://doi.org/10.1042/cs0800471

Published: 01 May 1991

... of glutamate in each of 11 subjects. 3. In seven subjects, adipose tissue blood flow was measured and the measurements were continued for 6 h after eating a mixed meal. The pattern of amino acid metabolism across the adipose tissue was remarkably little disturbed after the meal, except for a short period...

View article titled, Amino acid metabolism in human subcutaneous adipose tissue in vivo

Articles

Effect of a Test Meal, without and with Protein, on Muscle and Plasma Free Amino Acids

J. Bergström, P. Fürst, E. Vinnars

Clin Sci (Lond) (1990) 79 (4): 331–337.

DOI: https://doi.org/10.1042/cs0790331

Published: 01 October 1990

...J. Bergström; P. Fürst; E. Vinnars 1. The effect of a protein-free meal and a protein-rich meal on the concentration of free amino acids in plasma and muscle tissue was studied in eight healthy subjects. The energy content of the protein-free meal was 3800 kJ. The protein-rich meal was identical...

View article titled, Effect of a Test Meal, without and with Protein, on Muscle and Plasma Free Amino Acids

Articles

Differential Effects of Amino Acids on the Isolated Perfused Rat Kidney

A. A. El Sayed, J. Haylor, A. M. El Nahas

Clin Sci (Lond) (1990) 79 (4): 381–386.

DOI: https://doi.org/10.1042/cs0790381

Published: 01 October 1990

...A. A. El Sayed; J. Haylor; A. M. El Nahas 1. The direct effects of individual amino acids, including glycine (a neutral amino acid), l-glutamic acid (an acidic amino acid), l-leucine (a neutral, branched-chain amino acid) and l-arginine (a basic amino acid), on renal function were compared...

View article titled, Differential Effects of Amino Acids on the Isolated Perfused Rat Kidney

Articles

Glutamine Metabolism in Skeletal Muscle of Glucocorticoid-Treated Rats

M. Salleh M. Ardawi, Yasir S. Jamal

Clin Sci (Lond) (1990) 79 (2): 139–147.

DOI: https://doi.org/10.1042/cs0790139

Published: 01 August 1990

... in efflux and/or increased intracellular formation of glutamine and alanine. 15 11 1989 15 3 1990 26 3 1990 © 1990 The Biochemical Society and the Medical Research Society 1990 amino acids glucocorticoids glutaminase glutamine glutamine synthetase metabolism muscle...

View article titled, Glutamine Metabolism in Skeletal Muscle of Glucocorticoid-Treated Rats

Articles

Skeletal muscle and whole-body protein turnover in cirrhosis

W. L. Morrison, I. A. D. Bouchier, J. N. A. Gibson, M. J. Rennie

Clin Sci (Lond) (1990) 78 (6): 613–619.

DOI: https://doi.org/10.1042/cs0780613

Published: 01 June 1990

... to be a fall in muscle protein synthesis, which is accompanied by an overall fall in whole-body protein turnover. 22 12 1989 16 1 1990 © 1990 The Biochemical Society and the Medical Research Society 1990 amino acids cirrhosis leg muscle protein turnover stable-isotope tracers...

View article titled, Skeletal muscle and whole-body protein turnover in cirrhosis

Articles

Overall renal and tubular function during infusion of amino acids in normal man

N. V. Olsen, J. M. Hansen, S. D. Ladefoged, N. Fogh-Andersen, S. Levin Nielsen, P. P. Leyssac

Clin Sci (Lond) (1990) 78 (5): 497–501.

DOI: https://doi.org/10.1042/cs0780497

Published: 01 May 1990

...N. V. Olsen; J. M. Hansen; S. D. Ladefoged; N. Fogh-Andersen; S. Levin Nielsen; P. P. Leyssac 1. Amino acids have been used to test renal reserve filtration capacity. Previous studies suggest that amino acids increase glomerular filtration rate (GFR) by reducing distal tubular flow...

View article titled, Overall renal and tubular function during infusion of amino acids in normal man

Articles

Increase in anterior tibialis muscle protein synthesis in healthy man during mixed amino acid infusion: studies of incorporation of [1 −13 C]leucine

W. M. Bennet, A. A. Connacher, C. M. Scrimgeour, K. Smith, M. J. Rennie

Clin Sci (Lond) (1989) 76 (4): 447–454.

DOI: https://doi.org/10.1042/cs0760447

Published: 01 April 1989

... taken 30 min after the beginning of leucine infusion (when plasma 13 C enrichment was steady), 240 min later during continued fasting and again after 240 min of infusion of a mixed amino acid solution which increased plasma total amino acid concentrations by 37%. The mean enrichment of 13 C in plasma α...

View article titled, Increase in anterior tibialis muscle protein synthesis in healthy man during mixed amino acid infusion: studies of incorporation of [1 −13 C]leucine

Articles

A prospective controlled trial of topical irrigation in the treatment of delayed cutaneous healing in human leg ulcers

C. J. K. Bulstrode, A. W. Goode, P. J. Scott

Clin Sci (Lond) (1988) 75 (6): 637–640.

DOI: https://doi.org/10.1042/cs0750637

Published: 01 December 1988

...-eight patients with chronic leg ulcers were admitted to hospital for a minimum of 6 weeks bed-rest. During this time the ulcers were continuously irrigated by one of four test solutions. The solutions were: normal saline; a dilute amino acid solution isotonic with the normal saline; a hyperosmolar...

View article titled, A prospective controlled trial of topical irrigation in the treatment of delayed cutaneous healing in human leg ulcers

Articles

Increased hepatic amino nitrogen conversion after elective cholecystectomy in man

Hans Heindorff, Hendrik Vilstrup, Ditlev Bucher, Per Billesbølle, Vibeke Thygesen

Clin Sci (Lond) (1988) 74 (5): 539–545.

DOI: https://doi.org/10.1042/cs0740539

Published: 01 May 1988

...Hans Heindorff; Hendrik Vilstrup; Ditlev Bucher; Per Billesbølle; Vibeke Thygesen 1. The effect of elective, uncomplicated cholecystectomy on plasma clearances of amino acids and on amino acid-stimulated urea synthesis was investigated in 10 patients, pre-operatively and on the first post-operative...

View article titled, Increased hepatic amino nitrogen conversion after elective cholecystectomy in man

Articles

The exchange of blood-borne amino acids in the leg during abdominal surgical trauma: Effects of glucose infusion

J. Lund, H. Stjernström, U. Bergholm, L. Jorfeldt, E. Vinnars, L. Wiklund

Clin Sci (Lond) (1986) 71 (5): 487–496.

DOI: https://doi.org/10.1042/cs0710487

Published: 01 November 1986

...J. Lund; H. Stjernström; U. Bergholm; L. Jorfeldt; E. Vinnars; L. Wiklund 1. The exchange of plasma amino acids and glucose, lactate, glycerol and 3-hydroxybutyrate in the leg was studied in otherwise healthy patients undergoing elective cholecystectomy. 2. Seven patients were given a constant...

View article titled, The exchange of blood-borne amino acids in the leg during abdominal surgical trauma: Effects of glucose infusion

Articles

Insulin resistance and regulation of serum amino acid levels in myotonic dystrophy

Richard T. Moxley, III, William J. Kingston, Kenneth L. Minaker, Alastair J. Corbett, John W. Rowe

Clin Sci (Lond) (1986) 71 (4): 429–436.

DOI: https://doi.org/10.1042/cs0710429

Published: 01 October 1986

... on amino acid uptake and glucose disposal, three separate 120 min studies employing the euglycaemic insulin clamp technique (20, 80 and 200 m-units min −1 m −2 ) were performed on five ambulatory patients with myotonic dystrophy. The results were compared with findings obtained in identical studies in 21...

View article titled, Insulin resistance and regulation of serum amino acid levels in myotonic dystrophy

Articles

Validation of a method for measuring the short-term rate of urea synthesis after an amino acid load

J. D. S. Kay, J. W. T. Seakins, D. Geiseler, M. Hjelm

Clin Sci (Lond) (1986) 70 (1): 31–38.

DOI: https://doi.org/10.1042/cs0700031

Published: 01 January 1986

.... The intravenous administration of alanine appears to be a suitable stimulus for urea synthesis. 25 7 1985 25 7 1985 © 1986 The Biochemical Society and the Medical Research Society 1986 alanine amino acids biological models systems theory urea metabolism Clinical Science (1986) 70, 31...

View article titled, Validation of a method for measuring the short-term rate of urea synthesis after an amino acid load

Articles

Leg Metabolism of Amino Acids and Ammonia in Patients with Chronic Renal Failure

Giacomo Deferrari, Giacomo Garibotto, Cristina Robaudo, Alberto Canepa, Serena Bagnasco, Alberto Tizianello

Clin Sci (Lond) (1985) 69 (2): 143–151.

DOI: https://doi.org/10.1042/cs0690143

Published: 01 August 1985

...Giacomo Deferrari; Giacomo Garibotto; Cristina Robaudo; Alberto Canepa; Serena Bagnasco; Alberto Tizianello 1. Leg metabolism of amino acids and ammonia in the postabsorptive state was evaluated in 10 patients with chronic renal failure (CRF) and in 10 patients with normal renal function (controls...

View article titled, Leg Metabolism of Amino Acids and Ammonia in Patients with Chronic Renal Failure

Articles

Abnormal Regulation of Venous Alanine after Glucose Ingestion in Myotonic Dystrophy

Richard T. Moxley, William Kingston, Robert C. Griggs

Clin Sci (Lond) (1985) 68 (2): 151–157.

DOI: https://doi.org/10.1042/cs0680151

Published: 01 February 1985

...Richard T. Moxley; William Kingston; Robert C. Griggs 1. The concentration of amino acids in whole blood was measured before and during standard 5 h oral glucose tolerance testing in six male patients with myotonic dystrophy and five normal males. The plasma levels of insulin and glucose were also...

View article titled, Abnormal Regulation of Venous Alanine after Glucose Ingestion in Myotonic Dystrophy

Articles

Intravenous Infusion of α -Oxoisocaproate: Influence on Amino Acid and Nitrogen Metabolism in Patients with Liver Cirrhosis

L. S. Eriksson, L. Hagenfeldt, J. Wahren

Clin Sci (Lond) (1982) 62 (3): 285–293.

DOI: https://doi.org/10.1042/cs0620285

Published: 01 March 1982

...L. S. Eriksson; L. Hagenfeldt; J. Wahren 1. The metabolic effect of α-oxoisocaproate (4-methyl-2-oxovalerate) infusion was examined in six patients with cirrhosis and in nine healthy control subjects. The arterial concentrations of amino acids, urea, ammonia, insulin and catecholamines were...

View article titled, Intravenous Infusion of α -Oxoisocaproate: Influence on Amino Acid and Nitrogen Metabolism in Patients with Liver Cirrhosis

Articles

Intracellular Free Amino Acids in Undernourished Patients with or without Sepsis

P. J. Milewski, C. J. Threlfall, D. F. Heath, I. B. Holbrook, K. Wilford, M. H. Irving

Clin Sci (Lond) (1982) 62 (1): 83–91.

DOI: https://doi.org/10.1042/cs0620083

Published: 01 January 1982

... essential amino acids in the septic patients, but not in those with undernutrition, is consistent with the increased catabolic rate of sepsis. 5. However, the branched-chain amino acids, and lysine, threonine, arginine, and histidine, were present in lower concentrations than might be expected from...

View article titled, Intracellular Free Amino Acids in Undernourished Patients with or without Sepsis

Articles

Homocysteine in the Plasma of Renal Transplant Recipients: Effects of Cofactors for Methionine Metabolism

D. E. L. Wilcken, Vatsala J. Gupta, A. K. Betts

Clin Sci (Lond) (1981) 61 (6): 743–749.

DOI: https://doi.org/10.1042/cs0610743

Published: 01 December 1981

...D. E. L. Wilcken; Vatsala J. Gupta; A. K. Betts 1. Homocysteine which is formed during the metabolism of methionine is readily oxidized and is measured by the amino acid analyser as cysteine—homocysteine mixed disulphide and homocystine. We measured plasma amino acid concentrations after...

View article titled, Homocysteine in the Plasma of Renal Transplant Recipients: Effects of Cofactors for Methionine Metabolism

Articles

Influence of Leucine on Arterial Concentrations and Regional Exchange of Amino Acids in Healthy Subjects

L. Hagenfeldt, S. Eriksson, J. Wahren

Clin Sci (Lond) (1980) 59 (3): 173–181.

DOI: https://doi.org/10.1042/cs0590173

Published: 01 September 1980

...L. Hagenfeldt; S. Eriksson; J. Wahren 1. l -Leucine was given to healthy, post-absorptive subjects as a continuous intravenous infusion (300 μmol/min) during 2 1/2 h. Arterial blood concentrations and regional exchange of amino acids were measured across the splanchnic region, the brain and a leg...

View article titled, Influence of Leucine on Arterial Concentrations and Regional Exchange of Amino Acids in Healthy Subjects

Articles

Metabolic Aspects of Hypothermia in the Elderly

H. B. Stoner, K. N. Frayn, R. A. Little, C. J. Threlfall, D. W. Yates, R. N. Barton, D. F. Heath

Clin Sci (Lond) (1980) 59 (1): 19–27.

DOI: https://doi.org/10.1042/cs0590019

Published: 01 July 1980

...H. B. Stoner; K. N. Frayn; R. A. Little; C. J. Threlfall; D. W. Yates; R. N. Barton; D. F. Heath 1. Plasma concentrations of glucose, lactate, amino acids, non-esterified fatty acids, glycerol, ketone bodies, insulin and cortisol were measured in 43 elderly patients with hypothermia. In 15...

View article titled, Metabolic Aspects of Hypothermia in the Elderly

Articles

Metabolic Effects of the Use of Protein-Sparing Infusions in Postoperative Patients

K. J. Foster, K. G. M. M. Alberti, C. Binder, Leslie Hinks, S. Karran, Patricia Smythe, S. Talbot, D. Turnell, H. Ørskov

Clin Sci (Lond) (1980) 58 (6): 507–515.

DOI: https://doi.org/10.1042/cs0580507

Published: 01 June 1980

... concentrations of metabolites and hormones in blood and urine nitrogen excretion in patients receiving (a) sodium chloride solution (saline), (b) 1.5 g of glucose day −1 kg −1 body weight, (c) 1.5 g of glucose day −1 kg −1 with insulin (0.56 unit day −1 kg −1 ) or (d) mixed amino acids (1.5 g day −1 kg −1...

View article titled, Metabolic Effects of the Use of Protein-Sparing Infusions in Postoperative Patients

Articles

Accumulation of Sulphur-Containing Amino Acids Including Cysteine-Homocysteine in Patients on Maintenance Haemodialysis

D. E. L. Wilcken, Vatsala J. Gupta, S. G. Reddy

Clin Sci (Lond) (1980) 58 (5): 427–430.

DOI: https://doi.org/10.1042/cs0580427

Published: 01 May 1980

...D. E. L. Wilcken; Vatsala J. Gupta; S. G. Reddy 1. Plasma sulphur-containing amino acids were measured in 19 patients with renal failure on chronic haemodialysis and in 22 normal subjects, to determine the rate of accumulation of these amino acids in chronic azotaemia. 2. Cysteine-homocysteine...

View article titled, Accumulation of Sulphur-Containing Amino Acids Including Cysteine-Homocysteine in Patients on Maintenance Haemodialysis

Articles

Interaction of Amino Acids with Glycyl-l-leucine Hydrolysis and Transport in Monkey Small Intestine

V. Ganapathy, A. N. Radhakrishnan

Clin Sci (Lond) (1979) 57 (6): 521–527.

DOI: https://doi.org/10.1042/cs0570521

Published: 01 December 1979

... of tissue and k t 33 mmol/l. 2. Glycyl-l-leucine uptake is inhibited by a wide variety of amino acids, although to a variable extent. The inhibition was shown to be competitive with leucine used as the representative amino acid. Phenylalanine, methionine, alanine and leucine are the most potent...

View article titled, Interaction of Amino Acids with Glycyl-l-leucine Hydrolysis and Transport in Monkey Small Intestine

Articles

The Relationships between Plasma Substrates and Hormones and the Severity of Injury in 277 Recently Injured Patients

H. B. Stoner, K. N. Frayn, R. N. Barton, C. J. Threlfall, R. A. Little

Clin Sci (Lond) (1979) 56 (6): 563–573.

DOI: https://doi.org/10.1042/cs0560563

Published: 01 June 1979

...H. B. Stoner; K. N. Frayn; R. N. Barton; C. J. Threlfall; R. A. Little 1. The plasma concentrations of glucose, lactate, amino acids, non-esterified fatty acids, glycerol, ketone bodies, ethanol, cortisol and insulin were measured in patients within a few hours of injury and before treatment...

View article titled, The Relationships between Plasma Substrates and Hormones and the Severity of Injury in 277 Recently Injured Patients

Articles

Effect of Aging on Free Amino Acids and Electrolytes in Leg Skeletal Muscle

P. Möller, J. Bergström, S. Eriksson, P. Fürst, K. Hellström

Clin Sci (Lond) (1979) 56 (5): 427–432.

DOI: https://doi.org/10.1042/cs0560427

Published: 01 May 1979

...P. Möller; J. Bergström; S. Eriksson; P. Fürst; K. Hellström 1. The concentrations of electrolytes and free amino acids in plasma and the quadriceps femoris muscle were studied in ten apparently healthy elderly men, 52–77 years of age. The results were compared with those previously recorded...

View article titled, Effect of Aging on Free Amino Acids and Electrolytes in Leg Skeletal Muscle

Articles

The Metabolism and Clinical Relevance of the Keto Acid Analogues of Essential Amino Acids

P. Richards

Clin Sci Mol Med (1978) 54 (6): 589–593.

DOI: https://doi.org/10.1042/cs0540589

Published: 01 June 1978

...P. Richards © 1978 The Biochemical Society and the Medical Research Society 1978 amino acids keto acid analogues transamination Clinical Science and Molecular Medicine (1978), 54, 589-593 EDITORIAL REVIEW The metabolism and clinical relevance of the keto acid analogues of essential...

View article titled, The Metabolism and Clinical Relevance of the Keto Acid Analogues of Essential Amino Acids

Articles

Intracellular Free Amino Acids in Muscle Tissue of Patients with Chronic Uraemia: Effect of Peritoneal Dialysis and Infusion of Essential Amino Acids

J. Bergström, P. Fürst, L.-O. Norée, E. Vinnars

Clin Sci Mol Med (1978) 54 (1): 51–60.

DOI: https://doi.org/10.1042/cs0540051

Published: 01 January 1978

...J. Bergström; P. Fürst; L.-O. Norée; E. Vinnars 1. Free amino acids were determined in the plasma and in the muscle tissue of 14 patients with chronic uraemia; eight were not on dialysis and six were having regular peritoneal dialysis. The concentration of each amino acid in muscle water...

View article titled, Intracellular Free Amino Acids in Muscle Tissue of Patients with Chronic Uraemia: Effect of Peritoneal Dialysis and Infusion of Essential Amino Acids

Articles

The Role of Alanine and Glutamine in Steroid-Induced Nitrogen Wasting in Man

D. G. Sapir, T. Pozefsky, J. P. Knochel, M. Walser

Clin Sci Mol Med (1977) 53 (3): 215–220.

DOI: https://doi.org/10.1042/cs0530215

Published: 01 September 1977

... arginine remains unexplained. 24 11 1976 4 4 1977 © 1977 The Biochemical Society and the Medical Research Society 1977 alanine amino acids glutamine nitrogen steroids Clinical Science and Molecular Medicine (1977) 53,215-220. The role of alanine and glutamine in steroid...

View article titled, The Role of Alanine and Glutamine in Steroid-Induced Nitrogen Wasting in Man

Articles

Effect of Glycylglycine on Absorption from Human Jejunum of an Amino Acid Mixture Simulating Casein and a Partial Enzymic Hydrolysate of Casein Containing Small Peptides

P. D. Fairclough, D. B. A. Silk, M. L. Clark, D. M. Matthews, T. C. Marrs, D. Burston, K. M. Clegg

Clin Sci Mol Med (1977) 53 (1): 27–33.

DOI: https://doi.org/10.1042/cs0530027

Published: 01 July 1977

...P. D. Fairclough; D. B. A. Silk; M. L. Clark; D. M. Matthews; T. C. Marrs; D. Burston; K. M. Clegg 1. A jejunal perfusion technique has been used in normal volunteer subjects to study jejunal absorption of amino acid residues from a partial enzymic hydrolysate of casein in which about 50...

View article titled, Effect of Glycylglycine on Absorption from Human Jejunum of an Amino Acid Mixture Simulating Casein and a Partial Enzymic Hydrolysate of Casein Containing Small Peptides

Articles

Protein Metabolism in Human Neonates: Nitrogen-Balance Studies, Estimated Obligatory Losses of Nitrogen and Whole-Body Turnover of Nitrogen

P. B. Pencharz, W. P. Steffee, W. Cochran, N. S. Scrimshaw, W. M. Rand, V. R. Young

Clin Sci Mol Med (1977) 52 (5): 485–498.

DOI: https://doi.org/10.1042/cs0520485

Published: 01 May 1977

...% of total daily protein synthesis. 6. These results are discussed in relation to published estimates of whole-body protein synthesis and breakdown at various ages. Their possible significance in the assessment of a ‘maintenance’ requirement for protein and amino acids during the period of rapid growth...

View article titled, Protein Metabolism in Human Neonates: Nitrogen-Balance Studies, Estimated Obligatory Losses of Nitrogen and Whole-Body Turnover of Nitrogen

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