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1-29 of 29
Keywords: ammonia
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Articles
Rana Rustom, J. Steve Grime, Michael Costigan, Paul Maltby, Anthony Hughes, Alan Shenkin, Mair Critchley, J. Michael Bone
Journal:
Clinical Science
Clin Sci (Lond) (1998) 94 (4): 425–430.
Published: 01 April 1998
... renal tubular protein catabolism or markers of tubular injury before and after lisinopril. We developed a method to allow such studies, and found increased tubular catabolism of 99m Tc-labelled aprotinin (Trasylol) in patients with nephrotic range proteinuria which was associated with increased ammonia...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1996) 90 (1): 73–75.
Published: 01 January 1996
... turnover (25%), synthesis (26%) and breakdown (25%), but short-term urinary nitrogen excretion remained unchanged. 9 10 1995 16 10 1995 © 1996 The Biochemical Society and the Medical Research Society 1996 ammonia bed rest exercise glycine post-absorptive protein turnover urea...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (5): 499–503.
Published: 01 November 1994
... to some of the pathophysiology observed in patients with Reye's syndrome, and enzyme defects of the urea cycle. 16 2 1994 20 6 1994 7 7 1994 © 1994 The Biochemical Society and the Medical Research Society 1994 ammonia mitochondria pyruvate oxidation Reye's syndrome...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (4): 437–444.
Published: 01 October 1993
... amino acids and ammonia and production of urea by the liver were determined concomitantly. 2. Methionine sulphoximine treatment for 4 days resulted in a 50% decrease in arterial glutamine concentration. Although the glutamine consumption and the intracellular glutamine concentration of the intestine...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (5): 607–614.
Published: 01 November 1992
... area is less well characterized. We were specifically interested in substrate flux across the spleen as it is an organ with important immunological functions. 2. Therefore, hindquarter, gut, spleen and liver fluxes of amino acids, ammonia, glucose, lactate and blood gases were measured for 4 days after...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1987) 72 (6): 679–682.
Published: 01 June 1987
...P. E. Hall; S. R. Smith; M. J. Kendall 1. Plasma ammonia and heart rate were measured in normal volunteers before, during and after an exercise test following administration of placebo, propranolol, pindolol, metoprolol and nadolol. 2. Small changes in plasma ammonia occurred during exercise after...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1987) 72 (2): 187–193.
Published: 01 February 1987
... of these results in determining the distribution of flux control of urea synthesis, the discrepancy between them and predicted results and the necessary modifications to quantitative simulations are discussed. alanine ammonia biological models defects in urea cycle heritable disorders of metabolism...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1986) 70 (6): 627–634.
Published: 01 June 1986
...Rita A. Klim; Marta Albajar; Reginald Hems; Dermot H. Williamson 1. The effects of chronic uraemia on glucose production and nitrogen release (urea plus ammonia formation) from alanine, glutamine or serine in isolated rat hepatocytes were studied. 2. Uraemia increased the rate of formation of urea...
Articles
Giacomo Deferrari, Giacomo Garibotto, Cristina Robaudo, Alberto Canepa, Serena Bagnasco, Alberto Tizianello
Journal:
Clinical Science
Clin Sci (Lond) (1985) 69 (2): 143–151.
Published: 01 August 1985
...Giacomo Deferrari; Giacomo Garibotto; Cristina Robaudo; Alberto Canepa; Serena Bagnasco; Alberto Tizianello 1. Leg metabolism of amino acids and ammonia in the postabsorptive state was evaluated in 10 patients with chronic renal failure (CRF) and in 10 patients with normal renal function (controls...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (2): 193–199.
Published: 01 February 1985
...O. M. Wrong; A. J. Vince; J. C. Waterlow 1. To establish the role of endogenous urea as a source of faecal ammonia, the plasma urea of two healthy men was labelled with 15 N at a constant level for several days and its 15 N enrichment was compared with that of faecal ammonia and total nitrogen. 2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 64 (3): 247–252.
Published: 01 March 1983
... by the liver. Although no single toxin has yet been identified which alone can be responsible for hepatic encephalopathy, excess ammonia, mercaptans, fatty acids and an abnormal plasma amino acid profile have been incriminated in its pathogenesis. Irrespective of the ‘toxin’, three main pathogenetic mechanisms...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 64 (1): 101–108.
Published: 01 January 1983
... of 15 N in ammonia and in urea over a 9 h period after an oral dose of [ 15 N]glycine. 2. The food intake during the 2 study days was identical for individual patients. The amount each received was determined from measurement of their intake of food ad libitum on the day preceding the pre-operative...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (3): 285–293.
Published: 01 March 1982
...L. S. Eriksson; L. Hagenfeldt; J. Wahren 1. The metabolic effect of α-oxoisocaproate (4-methyl-2-oxovalerate) infusion was examined in six patients with cirrhosis and in nine healthy control subjects. The arterial concentrations of amino acids, urea, ammonia, insulin and catecholamines were...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (3): 273–277.
Published: 01 March 1982
... be carefully monitored in the comparison of the different procedures for dehepatization and in the assessment of experimental therapeutic methods for acute liver failure. 24 4 1981 2 9 1981 © 1982 The Biochemical Society and the Medical Research Society 1982 ammonia body temperature...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (3): 299–305.
Published: 01 March 1982
...M. H. N. Golden; P. Jahoor; A. A. Jackson 1. Glutamine [ 15 N]amide was infused at a steady rate of 33.34 μmol/h into seven male adult volunteers who were in the fed state and normal acid-base status. 2. Plasma glutamine amide N enrichment and urinary ammonia N enrichment rose to a constant value...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (2): 217–228.
Published: 01 August 1981
...E. B. Fern; P. J. Garlick; Margaret A. McNurlan; J. C. Waterlow 1. Four normal adults were given [ 15 N]-glycine in a single dose either orally or intravenously. Rates of whole-body protein turnover were estimated from the excretion of 15 N in ammonia and in urea during the following 9 h. The rate...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (4): 305–312.
Published: 01 October 1979
... bicarbonate and total ammonia than has been reported for faecal dialysate in normal subjects. 2. Total ammonia concentrations in urine– faeces specimens obtained by catheter suggest that urine excreted by the kidneys in these patients becomes increasingly acid with increasing systemic acidosis. The highly...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 56 (1): 95–97.
Published: 01 January 1979
...W. R. Ellis; P. K. Chu; I. M. Murray-Lyon 1. We have investigated the effect of intermittent doses of ammonia and octanoic acid on liver regeneration in the rat after partial hepatectomy. Regeneration was assessed by uptake of tritiated thymidine into liver deoxyribonucleic acid. 2. We have found...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 54 (5): 503–508.
Published: 01 May 1978
...A. Fine; F. I. Bennett; G. A. O. Alleyne 1. The effects of acute acid—base alterations on renal ammonia production and glutamine metabolism were studied in anaesthetized dogs. 2. Plasma glutamine rose with acidosis and also when both P co 2 and plasma HCO − 3 were raised isohydrically. 3. Blood...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1977) 52 (1): 9–17.
Published: 01 January 1977
...J. Kopstein; O. M. Wrong 1. Saliva obtained from the parotid duct of normal and uraemic subjects had an average urea concentration of 86% of the plasma concentration whereas in mixed saliva obtained from the mouth the urea concentration was only 31% of the plasma concentration. Ammonia...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1976) 51 (3): 313–322.
Published: 01 September 1976
... of ammonia, particularly those in which bacterial counts fell during incubation. As normal faeces contain negligible amounts of urea this ammonia must have been generated from sources other than urea. 3. Ammonia was also generated by faeces delivered by sodium chloride enema, and by ileostomy fluid...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1976) 50 (6): 493–498.
Published: 01 June 1976
... to the same degree by 3-mercaptopicolinate in the kidneys of well-fed or starved rats. 3. Inhibition of gluconeogenesis from glutamine (1 mmol/l) by 3-mercaptopicolinate is accompanied by 50% inhibition of ammonia production, and 34% inhibition of glutamine uptake, in the kidneys of acidotic rats. Ammonia...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1975) 48 (4): 279–287.
Published: 01 April 1975
...R. L. Bown; J. A. Gibson; J. C. B. Fenton; W. Snedden; M. L. Clark; G. E. Sladen 1. Ammonia and urea transport across the colonic mucosa was studied by a perfusion technique in four subjects with colonic exclusion for chronic hepatic encephalopathy. 2. Reduction of luminal pH inhibited net...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1975) 48 (1): 33–37.
Published: 01 January 1975
...B. Hindfelt 1. The distribution of ammonia between extra- and intra-cellular compartments of the brain was evaluated in anaesthetized rats exposed to sustained hyperammonaemia and superimposed acute hypo- or hyper-capnia. 2. It is concluded that the concentration gradient for ammonia between...
Articles
Francine Degos, J.-D. Degos, Denise Bourdiau, Michèle Peignoux, Danièle Prandi, Jacqueline Roche-Sicot, C. Sicot, B. Rueff, J.-P. Benhamou
Journal:
Clinical Science
Clin Sci Mol Med (1974) 47 (6): 599–608.
Published: 01 December 1974
... released from the intestine, in particular ammonia, play a major part in the mechanism of hepatic encephalopathy. 2. The animals were prepared according to a three-stage procedure: ligation of inferior vena cava; 3 weeks later, end-to-side portacaval shunt; 2 days later, removal of the liver (liverless...
Articles
Jacqueline Roche-Sicot, C. Sicot, Michèle Peignoux, Denise Bourdiau, Francine Degos, J.-D. Degos, Danièle Prandi, B. Rueff, J.-P. Benhamou
Journal:
Clinical Science
Clin Sci Mol Med (1974) 47 (6): 609–615.
Published: 01 December 1974
... to be efficient, and (b) that, for the same exchange-flow rate, systemio portal cross-circulation is more efficient than systemiosystemic cross-circulation. Key words : ammonia, electroencephalography, hepatectomy, hepatic coma. Cross-circulation (CC) has been proposed for the treatment of patients with severe...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1974) 46 (6): 715–727.
Published: 01 June 1974
... in which most of the urea is synthesized in the liver, but most of the urinary argininosuccinate is peripheral in origin. 17 1 1974 © 1974 The Biochemical Society and the Medical Research Society 1974 urea cycle ammonia citrulline arginine Clinical Science and Molecular Medicine...
Articles
Journal:
Clinical Science
Clin Sci (1972) 43 (1): 101–114.
Published: 01 July 1972
...P. F. Down; L. Agostini; J. Murison; O. M. Wrong 1. Ammonia, bicarbonate and pH were measured in samples of faecal dialysate from thirteen healthy subjects taking free diets. To observe the effect of marked changes in faecal pH, three subjects were also studied while taking 25 mmol/day of MgCO 3...
Articles
Journal:
Clinical Science
Clin Sci (1972) 42 (1): 105–112.
Published: 01 January 1972
...J. D. Swales; J. D. Tange; D. J. Evans 1. The effects of intestinal ammonia in uraemia have been studied by administering a urease inhibitor, acetohydroxamic acid, to bilaterally nephrectomized rats. 2. Ammonia concentration was significantly decreased in the colon although it remained slightly...
