..., and androgen deprivation therapy. Despite sharing some risk factors, most importantly advancing age, there are numerous reports from population studies of, currently poorly explained inverse associations between cancer and Alzheimer's disease. We previously reviewed important components of the phosphoinositide...

... arrested at the germinal vesicle stage correlated with persistent high levels of androgen and estrogen. We further showed that ovulation failure in these mice could be a result of elevated Nppc/Npr2 gene transcription that was directly increased by androgen (AR) and estrogen (ER) receptor signaling...

... inhibitor, 1.25×10 −3 mol/l, 1 h prior to testosterone or saline), flutamide (androgen receptor antagonist, 10 −5 mol/l), apocynin (NADPHox inhibitor, 3×10 −4 mol/l), N -[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide (NS398, COX2 inhibitor, 10 −4 mol/l) or saline, 4 h before testosterone or saline...

... this ‘physiological window’ these steroids may promote insulin resistance. Considerable research has been carried out on polycystic ovarian syndrome, a common disorder associated with excessive androgen production and insulin resistance. Hyperinsulinaemia in patients with this condition is believed to stimulate...

...Katherine M. ENGLISH; Peter J. PUGH; Helen PARRY; Nanette E. SCUTT; Kevin S. CHANNER; T. Hugh JONES The effect of smoking on androgen levels is important given the recent interest in the link between low levels of androgens and the development of cardiovascular disease. Numerous studies examining...

... be related to endogenous androgen levels in postmenopausal women in the absence of overt clinical disease. 2. In a Southern Californian cohort of 848 non-diabetic postmenopausal women aged 50–79 years, fasting plasma glucose levels positively correlated with levels of the endogenous androgens...

... in normal male mice. 6. Our findings suggest that the sex difference in inactive plasma renin in mice may be explained by an increased secretion of inactive renin in male mice stimulated by androgens. 7. Since we have recently found that inactive plasma renin in male mice is mainly of renal origin...