... in the abdominal aortic aneurysm (AAA), a life-threatening disease characterized by inflammation, destructive remodeling, and vascular smooth muscle cells (VSMCs) dysfunction. The current therapy relies on surgical repair, but no effective pharmacological strategies are available to limit aneurysm progression...

...Tomoki Hashimoto; Victor Rizzo Abdominal aortic aneurysm (AAA) is a permanent expansion of the vessel wall with a high prevalence in those 65 years of age and older. Aneurysms are prone to dissection and rupture that carry a mortality rate of over 85%. Currently, surgical repair is the only option...

... in remodelling of the vascular wall by virtue of their association with monogenic syndromes that implicate an aortic aneurysm, including Loeys–Dietz and Marfan's syndromes. Several studies and reviews have focused on the progression of aneurysms in the abdominal aorta, but research efforts are now increasingly...

...Theophilus I. Emeto; Joseph V. Moxon; Erik Biros; Catherine M. Rush; Paula Clancy; Lynn Woodward; Corey S. Moran; Roby J. Jose; Tam Nguyen; Philip J. Walker; Jonathan Golledge AAA (abdominal aortic aneurysm) is an important cause of sudden death in older adults, but there is no current effective...

...Alan Daugherty; Debra L. Rateri; Israel F. Charo; A. Phillip Owens, III; Deborah A. Howatt; Lisa A. Cassis AngII (angiotensin II) induces atherosclerosis and AAAs (abdominal aortic aneurysms) through multiple proposed mechanisms, including chemotaxis. Therefore, we determined the effects of whole...

...N. Vine; Janet T. Powell 1. Atherosclerosis and aneurysm of the abdominal aorta are associated with thinning of the medial connective tissue. We have investigated the presence of the connective-tissue-degrading metalloproteinases in homogenates prepared from atherosclerotic, aneurysmal and control...