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Keyword: angiotensin
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Articles
Clin Sci (Lond) (2018) 132 (16): 1837–1853.
Published: 30 August 2018
... ) 12 04 2018 19 07 2018 23 07 2018 31 07 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 angiotensin ERM hypertension MYPT1 Rho kinase reverse remodeling Asymptomatic organ damage due to cardiovascular...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (10): 1055–1067.
Published: 25 May 2018
.... Consequently, there remains a need for agents that will protect neurones against death following ischemic stroke. Here, we evaluate angiotensin II (Ang II) type 2 (AT 2 ) receptor agonists as a possible therapeutic target for this disease. We first provide an overview of stroke epidemiology, pathophysiology...
Articles
Clin Sci (Lond) (2018) 132 (8): 839–850.
Published: 30 April 2018
...Estrellita Uijl; Liwei Ren; A.H. Jan Danser The existence of a so-called brain renin-angiotensin system (RAS) is controversial. Given the presence of the blood–brain barrier, angiotensin generation in the brain, if occurring, should depend on local synthesis of renin and angiotensinogen. Yet...
Articles
Clin Sci (Lond) (2018) 132 (5): 581–593.
Published: 15 March 2018
...Douglas M. Bennion; Chad H. Jones; Alex N. Dang; Jacob Isenberg; Justin T. Graham; Lena Lindblad; Oliver Domenig; Michael F. Waters; Marko Poglitsch; Colin Sumners; Colin Sumners; Ulrike Muscha Steckelings; Ulrike Muscha Steckelings Significant neuroprotective effects of angiotensin II type 2 (AT 2...
Articles
Clin Sci (Lond) (2017) 131 (15): 1989–2005.
Published: 13 July 2017
...Friedrich Krueger; Kai Kappert; Anna Foryst-Ludwig; Frederike Kramer; Markus Clemenz; Aleksandra Grzesiak; Manuela Sommerfeld; Jan Paul Frese; Andreas Greiner; Ulrich Kintscher; Thomas Unger; Elena Kaschina The renin–angiotensin system (RAS) and obesity have been implicated in vascular outward...
Articles
Clin Sci (Lond) (2016) 130 (10): 773–783.
Published: 01 April 2016
... jensullivan@gru.edu ). 1 9 2015 26 1 2016 4 2 2016 © 2016 Authors; published by Portland Press Limited 2016 angiotensin blood pressure regulation inflammation sex differences Th17 cell T regulatory cell Hypertension affects one-third of adults in the Western world and...
Articles
Clin Sci (Lond) (2014) 126 (12): 815–827.
Published: 26 February 2014
...Clare A. McKinney; Caroline Fattah; Christopher M. Loughrey; Graeme Milligan; Stuart A. Nicklin The RAS (renin–angiotensin system) is integral to cardiovascular physiology; however, dysregulation of this system largely contributes to the pathophysiology of CVD (cardiovascular disease). It is well...
Articles
Clin Sci (Lond) (2014) 126 (3): 195–205.
Published: 01 October 2013
...Robert W. Regenhardt; Douglas M. Bennion; Colin Sumners The goal of the present review is to examine the evidence for beneficial actions of manipulation of the RAS (renin–angiotensin system) in stroke, with particular focus on Ang-(1–7) [angiotensin-(1–7)] and its receptor Mas. The RAS appears to...
Articles
Clin Sci (Lond) (2012) 123 (9): 531–543.
Published: 13 July 2012
... diseases in humans that appear to have distinct pathologies and mechanisms. Despite this divergence, there are numerous and consistent demonstrations that overactivation of the RAS (renin–angiotensin system) promotes both AAAs and TAAs in animal models. For example, in mice, both AAAs and TAAs are formed...
Articles
Clin Sci (Lond) (2012) 123 (8): 519–529.
Published: 03 July 2012
...Chris Tikellis; Raelene Pickering; Despina Tsorotes; Xiao-Jun Du; Helen Kiriazis; Thu-Phuc Nguyen-Huu; Geoffrey A. Head; Mark E. Cooper; Merlin C. Thomas Local and systemic AngII (angiotensin II) levels are regulated by ACE2 (angiotensin-converting enzyme 2), which is reduced in diabetic tissues...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 123 (6): 333–346.
Published: 29 May 2012
...Danielle Zimmerman; Kevin D. Burns Ang-(1–7) [angiotensin-(1–7)] is a biologically active heptapeptide component of the RAS (renin–angiotensin system), and is generated in the kidney at relatively high levels, via enzymatic pathways that include ACE2 (angiotensin-converting enzyme 2). The...
Articles
Clin Sci (Lond) (2012) 123 (4): 205–223.
Published: 24 April 2012
...Matej Durik; Bruno Sevá Pessôa; Anton J. M. Roks Modulation of the RAS (renin–angiotensin system), in particular of the function of the hormones AngII (angiotensin II) and Ang-(1–7) [angiotensin-(1–7)], is an important target for pharmacotherapy in the cardiovascular system. In the classical view...
Articles
Clin Sci (Lond) (2010) 118 (11): 681–689.
Published: 09 March 2010
...Alan Daugherty; Debra L. Rateri; Israel F. Charo; A. Phillip Owens, III; Deborah A. Howatt; Lisa A. Cassis AngII (angiotensin II) induces atherosclerosis and AAAs (abdominal aortic aneurysms) through multiple proposed mechanisms, including chemotaxis. Therefore, we determined the effects of whole...
Articles
Clin Sci (Lond) (2009) 116 (4): 301–314.
Published: 15 January 2009
...Cheng Qian; Regien G. Schoemaker; Wiek H. van Gilst; Anton J. M. Roks Intervention in the RAAS (renin–angiotensin–aldosterone system) is one of the leading pharmacotherapeutic strategies, among others, used for the treatment of cardiovascular disease to improve the prognosis after myocardial...
Articles
Clin Sci (Lond) (2004) 107 (2): 145–147.
Published: 27 July 2004
...Jean-Baptiste MICHEL In the present issue of Clinical Science , Brown and co-workers report preliminary results of Ang I (angiotensin I) immunization in humans. They demonstrate the presence of antibodies in human plasma and report that the procedure is well tolerated, but the blood pressure does...
Articles
Clin Sci (Lond) (2004) 107 (2): 167–173.
Published: 27 July 2004
...Morris J. BROWN; John COLTART; Kulasiri GUNEWARDENA; James M. RITTER; Timothy R. AUTON; James F. GLOVER Immunization against components of the renin–angiotensin system offers a potential alternative to daily medication in some patients with hypertension or heart failure. Our primary objective was...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 363S–366S.
Published: 01 September 2002
... rats and spontaneously hypertensive rats (SHRs). At that dose, the magnitude of the antihypertensive effects was greater in SHRs than in normotensive rats. Additional administration of an angiotensin-converting enzyme (ACE) inhibitor benazapril (lotensin) further reduced MABP in normotensive rats and...
Articles
Clin Sci (Lond) (2002) 103 (1): 101–106.
Published: 20 June 2002
...Sabine HERTWIG; Henry VÖLZKE; Daniel M. ROBINSON; Wolfgang MOTZ; Rainer RETTIG The present study was designed to prospectively test the hypothesis that gene polymorphisms of the renin-angiotensin system are associated with recurrent restenosis after repeated percutaneous transluminal coronary...
Articles
Clin Sci (Lond) (2001) 101 (6): 559–566.
Published: 24 October 2001
...J. C. VAILE; S. CHOWDHARY; F. OSMAN; H. F. ROSS; J. FLETCHER; W. A. LITTLER; J. H. COOTE; J. N. TOWNEND The objective of the present study was to determine the autonomic effects of angiotensin II (AT 1 ) receptor blocker therapy in heart failure. In a randomized double-blind cross-over study, we...
Articles
Clin Sci (Lond) (2001) 100 (5): 481–492.
Published: 27 March 2001
...Diem T. DINH; Albert G. FRAUMAN; Colin I. JOHNSTON; Maurice E. FABIANI Angiotensin II (Ang II) is a multi-functional hormone that plays a major role in regulating blood pressure and cardiovascular homoeostasis. The actions of Ang II are mediated by at least two receptor subtypes, designated AT 1...
Articles
Clin Sci (Lond) (2000) 99 (4): 331–341.
Published: 15 September 2000
...Maurice E. FABIANI; Diem T. DINH; Labrini NASSIS; David J. CASLEY; Colin I. JOHNSTON We examined the ability of the new non-peptide angiotensin II receptor antagonist irbesartan to inhibit AT 1 receptors in vivo in the rat kidney following oral administration, compared with the prototype drug...
Articles
Clin Sci (Lond) (2000) 99 (1): 19–25.
Published: 06 June 2000
..., genetic factors may be involved. In the present study, we investigated the associations between the angiotensinogen T174M and M235T, the angiotensin I-converting enzyme (ACE) I/D and the angiotensin II type 1 receptor A1166C gene polymorphisms and restenosis in 511 patients who had undergone successful...
Articles
Clin Sci (Lond) (1995) 89 (3): 273–276.
Published: 01 September 1995
...Evelyn A. Millar; Robert M. Angus; Jane E. Nally; Robin Clayton; Neil C. Thomson 1. We have reported that the renin-angiotensin system is activated in acute asthma, and also by high-dose nebulized β 2 -agonists. The contribution of other possible stimuli such as hypoxia is unknown. The present...
Articles
Clin Sci (Lond) (1993) 84 (5): 525–529.
Published: 01 May 1993
...David J. Leehey 1. Decreased pressor sensitivity to angiotensin II occurs in cirrhosis, but the mechanism remains unclear. 2. Angiotensin II dose-response studies were performed in conscious, chronically instrumented cirrhotic and control rats, and angiotensin II concentration-response studies were...
Articles
Clin Sci (Lond) (1990) 79 (5): 523–530.
Published: 01 November 1990
...James J. Morton; Elisabeth C. Beattie; Sheila A. Griffin; Fiona MacPherson; Fiona Lyall; Domenico Russo 1. Cardiovascular reactivity, blood vessel morphology, blood pressure and the activity of the renin—angiotensin system were determined in the 3-week-old spontaneously hypertensive (SHR), Wistar...
Articles
Clin Sci (Lond) (1990) 79 (5): 505–511.
Published: 01 November 1990
... hypertension are able to stimulate release of active renin. 2. Active plasma renin concentration was measured as the generation of angiotensin I at physiological pH in the presence of excess renin substrate, and total renin concentration was determined in the same way after trypsin activation. Inactive plasma...
Articles
Clin Sci (Lond) (1990) 78 (6): 605–612.
Published: 01 June 1990
... angiotensin atrial natriuretic peptide diet diuresis kidney renin saliva sodium vasopressin Clinical Science (1990) 78,605-612 605 Time-course and relationship of the early changes in renal sodium excretion and aldosterone secretion during dietary sodium restriction in normal man D. J. S...
Articles
Clin Sci (Lond) (1986) 71 (1): 97–104.
Published: 01 July 1986
... concentrations of arginine vasopressin (AVP), angiotensin II (ANG II) and aldosterone (Aldo), were determined before and three times during the first 4 h after loading. 2. D and C water increased to a significantly lower level ( P < 0.01) after water loading in patients with nephrotic syndrome than in control...
Articles
Clin Sci (Lond) (1985) 68 (s10): 99s–104s.
Published: 01 January 1985
... smooth muscle, e.g. Ca 2+ -entry blockers or angiotensin converting enzyme (ACE) inhibitors. However, the extent of these influences depends on which agonist is used. 2. The pressor response to intravenous injection of α-adrenoceptor agonists consists of two phases: an initial rapid but transient...
Articles
Clin Sci (Lond) (1984) 67 (3): 365–368.
Published: 01 September 1984
...Theodore A. Kotchen; Tam T. Guyenne; Pierre Corvol; Joel Menard 1. Plasma renin reactivity (PRR) is the rate of angiotensin I production after addition of renin to plasma, minus endogenous renin activity. PRR is increased in plasma of patients with renal failure compared with that of normal...
Articles
Clin Sci (Lond) (1984) 66 (1): 17–25.
Published: 01 January 1984
... antagonist ketanserin on another occasion. The effects of ketanserin on the components of the renin—angiotensin—aldosterone system, on plasma catecholamines and on exercise capacity for graded uninterrupted exercise were also investigated. 2. At rest in recumbency rapid intravenous injection of 10 mg of...
Articles
Clin Sci (Lond) (1982) 63 (s8): 223s–225s.
Published: 01 October 1982
... patients with essential hypertension, whereas the renal response was unchanged in normotensive subjects. © 1982 The Biochemical Society and the Medical Research Society 1982 angiotensin converting enzyme essential hypertension volume expansion Clinical Science (1982) 63 ,223~225s 223s Effect...
Articles
Clin Sci (Lond) (1982) 62 (2): 169–176.
Published: 01 February 1982
...R. A. Banks; L. J. Beilin; J. Soltys; L. Davidson 1. The role of prostaglandins and angiotensin II in blood flow regulation was studied in conscious rabbits subjected to mild haemorrhage. 2. Haemorrhage caused a 13% fall in arterial pressure and a 21% fall in cardiac output, responses which were...
Articles
Clin Sci (Lond) (1981) 61 (5): 535–539.
Published: 01 November 1981
...J. P. M. Finberg; H. A. Syrop; O. S. Better 1. The pressor and heart rate response to angiotensin II, noradrenaline, isoprenaline, tyramine and β-phenylethylamine were examined before and after bile-duct ligation in conscious trained dogs. 2. The pressor response to angiotensin II was markedly...
Articles
Clin Sci (Lond) (1981) 61 (5): 553–557.
Published: 01 November 1981
...P. C. Wong; B. G. Zimmerman 1. Successive infusions of SQ 20 881 given intra-arterially (i.a.) to the kidney at 0.4 and 0.8 μg min −1 kg −1 for 50 min each did not alter renal blood flow and renal vascular resistance in spite of 40–47% blockade of the angiotensin I (ANG I i.a.)-induced...
Articles
Clin Sci (Lond) (1981) 61 (3): 281–286.
Published: 01 September 1981
...M. G. Collis; J. R. Keddie 1. Angiotensin-converting enzyme inhibitors can attenuate reflex sympathetic vasoconstriction in vivo. We have investigated the effects of captopril (SQ 14 225) on adrenergic vasoconstrictor mechanisms in isolated, Krebs-Ringer solution perfused, rat mesenteric arteries...
Articles
Clin Sci (Lond) (1981) 61 (1): 75–83.
Published: 01 July 1981
...J. A. Millar; B. P. McGrath; P. G. Matthews; C. I. Johnston 1. The acute effects of a single oral dose of captopril on blood pressure, pulse rate and circulating levels of angiotensin I (ANG I), angiotensin II (ANG II), renin, bradykinin and catecholamines were studied in three groups: eight normal...
Articles
Clin Sci (Lond) (1981) 61 (s7): 285s–287s.
Published: 01 January 1981
... circulating angiotensin II may be one of the determinants of the natriuretic response to volume expansion in normal man. © 1981 The Biochemical Society and the Medical Research Society 1981 angiotensin captopril converting enzyme angiotensin II volume expansion ChicalScience (1981) 6 1 , 2 8 5...
Articles
Clin Sci (Lond) (1981) 61 (s7): 245s–247s.
Published: 01 January 1981
... specifically bound 125 I-labelled angiotensin II (ANG II) with high affinity ( K d ≅ 1.0 nmol/l). Saralasin ANG III and ANG II competed with tracer for ligand whereas ANG I did so less effectively and neurotensin not at all. 3. These results suggest the presence of specific nuclear intracellular ANG II...
Articles
Clin Sci (Lond) (1981) 61 (s7): 249s–251s.
Published: 01 January 1981
...P. Brecher; Vandana Hingorani; Karen Reininga; A. V. Chobanian 1. Angiotensin-converting enzyme (ACE) activity was threefold greater in isolated cerebral microvessels obtained from rabbit brain than rat brain. 2. ACE activity was distributed throughout the cerebral microvasculature, since...
Articles
Clin Sci (Lond) (1981) 61 (s7): 265s–268s.
Published: 01 January 1981
... conclude that the renin—angiotensin system may interact with the pituitary—adrenal axis to influence circulating levels of cortisol. This effect might conceivably contribute to the pathogenesis of certain high-renin states. © 1981 The Biochemical Society and the Medical Research Society 1981...
Articles
Clin Sci (Lond) (1980) 59 (6): 451–456.
Published: 01 December 1980
...M. Tree; J. J. Morton 1. Captopril infused into sodium-loaded dogs produced a fall in both blood pressure [117 ± 9.7 to 96.6 ± 11.4 (sd) mmHg] and plasma angiotensin II [11.0 ± 3.0 to 1.6 ± 1.3 (sd) pmol/l]. Plasma aldosterone fell while both blood angiotensin I and renin concentration rose. 2...
Articles
Clin Sci (Lond) (1980) 59 (1): 55–62.
Published: 01 July 1980
...M. Epstein; M. D. Lifschitz; R. Re; E. Haber 1. The relationship of the renin-angiotensin-aldosterone axis with renal prostaglandin E is complex. Although studies have suggested that these two hormonal systems respond to experimental manipulations in a parallel manner, their interdependence has not...
Articles
Clin Sci (Lond) (1980) 58 (6): 445–450.
Published: 01 June 1980
...J. J. Morton; M. Tree; J. Casals-Stenzel 1. Changes in arterial blood pressure, blood angiotensin I, plasma angiotensin II and plasma angiotensin III were measured in conscious sodium—depleted dogs after infusion of captopril, an orally active inhibitor of converting enzyme. 2. Angiotensins II and...
Articles
Clin Sci (Lond) (1980) 59 (s6): 95s–99s.
Published: 01 January 1980
... not the high sodium diet. 4. These results suggest that the renin-angiotensin-aldosterone system is a normal mechanism for maintaining blood pressure and aldosterone secretion in normotensive man. The system may also be involved in the maintenance of sodium balance. 5. These results may lead to a...
Articles
Clin Sci (Lond) (1980) 59 (s6): 57s–60s.
Published: 01 January 1980
...M. M. Kilcoyne; D. L. Hoffman; E. A. Zimmerman 1. By immunoperoxidase technique, immunoreactive angiotensin II (ANG II) was located in the cell bodies of many magnocellular neurons in the supraoptic and paraventricular nuclei of the hypothalamus and their pathways to median eminence and posterior...
Articles
Clin Sci (Lond) (1980) 59 (s6): 71s–74s.
Published: 01 January 1980
...S. C. Textor; H. R. Brunner; H. Gavras 1. To investigate the non-angiotensin effects of converting enzyme inhibition, angiotensin II was infused intravenously at 30 ng/min for 9 days in conscious rats to produce moderate blood pressure elevation. One group was given captopril (SQ 14 225) by gavage...
Articles
Clin Sci (Lond) (1980) 59 (s6): 35s–36s.
Published: 01 January 1980
... active form. © 1980 The Biochemical Society and the Medical Research Society 1980 angiotensin inactive renin juxtaglomerular apparatus macula densa renin salt balance Clinical Science (1980) 59,35~-36s 35s Active and inactive renin in individual juxtaglomerular apparatuses A. G I L L I E...
Articles
Clin Sci (Lond) (1980) 59 (s6): 137s–139s.
Published: 01 January 1980
... synthesis. 5. These findings suggest that PGE 1 and PGE 2 might be inhibitory factors in the regulation of renin substrate synthesis. © 1980 The Biochemical Society and the Medical Research Society 1980 angiotensin liver perfusion nephrectomy prostaglandins renin substrate Clinicalscience...
Articles
Clin Sci (Lond) (1979) 56 (6): 585–589.
Published: 01 June 1979
...J. F. E. Mann; W. Rascher; R. Dietz; A. Schömig; D. Ganten 1. Two hours after oral feeding of normotensive Wistar Kyoto rats with the converting-enzyme inhibitor SQ 14225 (1 and 10 mg/kg), an increase of angiotensin I plasma concentrations from 892 ± 113 to 1660 ± 167 and 2951 ± 405 pg/ml was...