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Keyword: angiotensin II
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Clin Sci (Lond) (2019) 133 (21): 2203-2215.
Published: 12 November 2019
... in human AAA samples but their role is unclear. The effect of conditional depletion of CD11c + cells on experimental AAA was investigated in the angiotensin II (AngII)-infused apolipoprotein E-deficient ( ApoE –/– ) mouse model. Approach: CD11c-diphtheria toxin (DT or D.tox ) receptor ( D TR...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (8): 901-904.
Published: 30 April 2018
... hypertension. Correspondence: Gavin Y. Oudit ( gavin.oudit@ualberta.ca ) 23 03 2018 11 04 2018 13 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 angiotensin II hypertension microbiota patients The...
Clin Sci (Lond) (2018) 132 (1): 127-130.
Published: 11 January 2018
... quantification. Correspondence: A.H. Jan Danser ( a.danser@erasmusmc.nl ) 11 12 2017 20 12 2017 21 12 2017 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 angiotensin II autoantibody hypertension Multiple studies have...
Clin Sci (Lond) (2017) 131 (12): 1261-1281.
Published: 07 June 2017
...) and control mice ( ApoE −/− , n =20) were infused subcutaneously with angiotensin II (AngII) for 28 days. Following AngII infusion, Thbs1 −/− ApoE −/− mice had larger AAAs by ultrasound ( P =0.024) and ex vivo morphometry measurement ( P =0.006). The Thbs1 −/− ApoE −/− mice also showed increased...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (1): 19-33.
Published: 30 November 2015
.... angiotensin II (Ang II). Vascular EGFR has been proposed to be involved in vascular tissue homoeostasis and remodelling. Thus, most studies have focused on its role during long-term vascular changes whereas the relevance for acute regulation of vascular function in vivo and ex vivo is insufficiently...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (10): 665-678.
Published: 20 February 2015
..., but it remains inconclusive whether this gene promotes or inhibits cell apoptosis. In the present study, we attempted to investigate the role of Ankrd1 on AngII (angiotensin II)- or pressure-overload-induced cardiomyocyte apoptosis. In the failing hearts of mice with pressure overload, the protein...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (9): 559-565.
Published: 11 February 2015
... Satoru Eguchi (email seguchi@temple.edu ) 28 10 2014 17 12 2014 22 12 2014 22 12 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 Angiotensin II (Ang II) has been implicated in the development of abdominal aortic aneurysm (AAA). In vascular smooth...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (9): 549-557.
Published: 03 July 2014
...Maria Paz Ocaranza; Luis Michea; Mario Chiong; Carlos F. Lagos; Sergio Lavandero; Jorge E. Jalil Chronic RAS (renin–angiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro-inflammatory, pro-thrombotic and...
Clin Sci (Lond) (2014) 127 (7): 463-474.
Published: 17 June 2014
... administered for 14 days [10 mg/kg per day intraperitoneally (i.p.)]. Both EET-A and EET-X lowered blood pressure in spontaneously hypertensive rats (SHRs) and in angiotensin II (AngII) hypertension. On day 14, the mean arterial pressures in EET analogue-treated AngII-hypertensive and SHRs were 30–50 mmHg (EET...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (4): 251-264.
Published: 16 April 2014
...María Gabriela Morales; Johanna Ábrigo; Carla Meneses; Felipe Simon; Franco Cisternas; Juan Carlos Rivera; Yaneisi Vazquez; Claudio Cabello-Verrugio AngII (angiotensin II) induces pathological conditions such as fibrosis in skeletal muscle. In this process, AngII increases ROS (reactive oxygen...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (2): 123-134.
Published: 28 March 2014
... present study, we examined whether aliskiren limits the progression of AAA (abdominal aortic aneurysm), VH (ventricular hypertrophy) and atherosclerosis in an AngII (angiotensin II)-infused mouse model. ApoE −/− (apolipoprotein-E-deficient) mice were infused subcutaneously with AngII (1000 ng/kg of body...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (12): 837-844.
Published: 26 February 2014
... irisin levels in adults, explaining 17% of the variance, whereas in children AngII (angiotensin II) was the most significant predictor of irisin levels, explaining 19% of the variance ( P =0.003). Circulating irisin appears to be maternally inherited and is predicted by HDL-cholesterol in adults and...
Clin Sci (Lond) (2014) 126 (11): 753-774.
Published: 13 February 2014
... angiotensins and kinins. Correspondence: Professor Claudio M. Costa-Neto (email claudio@fmrp.usp.br ). 23 7 2013 4 12 2013 20 12 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiotensin II angiotensin II type 1 receptor (AT 1 receptor) biased...
Clin Sci (Lond) (2014) 126 (10): 695-706.
Published: 27 January 2014
... RAAS consists of an excitatory arm involving AngII (angiotensin II), ACE (angiotensin-converting enzyme) and the AT 1 R (AngII type 1 receptor). The RAAS also consists of a protective arm consisting of Ang-(1–7) [angiotensin-(1–7)], the AT 2 R (AngII type 2 receptor), ACE2 and the Mas receptor...
Clin Sci (Lond) (2014) 126 (10): 707-720.
Published: 27 January 2014
...Guangyu Zhou; Alfred K. Cheung; Xia Liu; Yufeng Huang Higher doses of AngII (angiotensin II) blockers are intended to optimize albuminuria reduction rather than for blood pressure control in chronic kidney disease. However, the long-term renoprotection of high-dose AngII blockers has yet to be...
Clin Sci (Lond) (2014) 126 (7): 483-495.
Published: 11 December 2013
... cyclic stretch and its role in regulating genetic transcription in cardiomyocytes. Cultured rat neonatal cardiomyocytes were subjected to cyclic stretch, and the expression levels of leptin, ROS (reactive oxygen species) and AngII (angiotensin II) were evaluated. Signal transduction inhibitors were used...
Clin Sci (Lond) (2014) 126 (1): 85-94.
Published: 09 September 2013
...). However, it is not known whether Ac-SDKP decreases collagen cross-linking and lymphocyte infiltration; lymphocytes modulate both collagen cross-linking and ECM (extracellular matrix) formation in hypertension. Thus we hypothesized that (i) in AngII (angiotensin II)-induced hypertension, Ac-SDKP prevents...
Clin Sci (Lond) (2013) 124 (6): 413-422.
Published: 27 November 2012
... subjects ( n =8 young, n =6 old) underwent brachial artery catheterization for administration of AngII (angiotensin II; 0.8–25.6 ng/dl per min), NE [noradrenaline (norepinephrine); 2.5–80 ng/dl per min] and AngII with concomitant α-adrenergic antagonism [PHEN (phentolamine); 10 μg/dl per min]. Ultrasound...
Clin Sci (Lond) (2012) 123 (7): 399-416.
Published: 07 June 2012
... 2012 23 4 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiotensin II arterial calcification arterial stiffness Klotho pulse wave velocity remodelling phosphorus CKD (chronic kidney disease) is a highly prevalent condition, affecting ~10% of the...
Clin Sci (Lond) (2012) 123 (5): 273-284.
Published: 16 May 2012
... © The Authors Journal compilation © 2012 Biochemical Society 2012 angiotensin II angiotensin type 1 receptor cardiovascular system diabetes intracellular renin–angiotensin system The RAS (renin–angiotensin system) is one of the most significant and extensively studied hormonal systems...
Clin Sci (Lond) (2012) 123 (4): 225-239.
Published: 24 April 2012
... (angiotensin-converting enzyme) and the AT 1 receptor [AngII (angiotensin II) type 1 receptor], which play an active role in promoting inflammation and deposition of extracellular matrix. In addition, the more recently recognized structural homologue of ACE, ACE2, is also up-regulated. ACE2 catalyses the...
Clin Sci (Lond) (2012) 122 (11): 513-527.
Published: 10 February 2012
... this transgenic model of angiotensin II-dependent hypertension. Correspondence: Dr Jan Neckář (email neckar@biomed.cas.cz ). 1 12 2011 16 12 2011 16 12 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiotensin II epoxyeicosatrienoic acid...
Includes: Supplementary data
Clin Sci (Lond) (2012) 122 (4): 193-202.
Published: 24 October 2011
...Todd S. Perlstein; Robert R. Henry; Kieren J. Mather; Michael R. Rickels; Nicola I. Abate; Scott M. Grundy; Yabing Mai; Jeanine B. Albu; Jennifer B. Marks; James L. Pool; Mark A. Creager AngII (angiotensin II) may contribute to cardiovascular risk in obesity via adverse effects on insulin...
Clin Sci (Lond) (2012) 122 (2): 63-73.
Published: 20 September 2011
...)]. Volume expansion markedly decreased the plasma levels of renin, AngII (angiotensin II) and aldosterone (all P <0.001), while MABP (oscillometry), heart rate, cardiac output (impedance cardiography), RPF (by p -aminohippurate), GFR [glomerular filtration rate; by using 51 Cr-labelled EDTA] and plasma...
Clin Sci (Lond) (2012) 122 (1): 33-42.
Published: 13 September 2011
...Kou-Gi Shyu; Shih-Chung Chen; Bao-Wei Wang; Wen-Pin Cheng; Huei-Fong Hung Leptin contributes to the pathogenesis of atherosclerosis. Ang II (angiotensin II), a proatherogenic cytokine, increases leptin synthesis in cultured adipocytes. Statin suppresses leptin expression in adipocytes and human...
Includes: Supplementary data
Clin Sci (Lond) (2011) 121 (7): 297-303.
Published: 07 June 2011
...Sanja Bosnyak; Emma S. Jones; Arthur Christopoulos; Marie-Isabel Aguilar; Walter G. Thomas; Robert E. Widdop AT 1 R (angiotensin type 1 receptor) and AT 2 R (angiotensin type 2 receptor) are well known to be involved in the complex cardiovascular actions of AngII (angiotensin II). However, shorter...
Clin Sci (Lond) (2010) 119 (7): 273-282.
Published: 22 June 2010
... myocardial injuries. Previous studies have indicated that AngII (angiotensin II) stimulates both myocardin expression and cardiomyocyte hypertrophy. In the present study, we evaluated the expression of myocardin and AngII after hypoxia in regulating gene transcription in neonatal cardiomyocytes. Cultured rat...
Includes: Supplementary data
Clin Sci (Lond) (2010) 118 (7): 459-461.
Published: 12 January 2010
... Clinical Science , Giachini and co-workers found that clopidogrel could normalize the increased phenylephrine-induced vascular contraction and the impaired acetylcholine-induced vasodilation in mesenteric arteries from AngII (angiotensin II)-infused Sprague–Dawley rats. This might develop a new area for...
Clin Sci (Lond) (2010) 118 (7): 463-471.
Published: 12 January 2010
... and has anti-inflammatory effects. Since P2Y 12 receptors have been identified in the vasculature, we hypothesized that clopidogrel ameliorates AngII (angiotensin II)-induced vascular functional changes by blockade of P2Y 12 receptors in the vasculature. Male Sprague–Dawley rats were infused with...
Clin Sci (Lond) (2010) 118 (4): 291-301.
Published: 16 November 2009
... Sprague–Dawley rats were fed either a normal (7% fat) or high-fat (36% fat) diet for 6 weeks and osmotic pumps were implanted to deliver ANG (angiotensin II) or vehicle for an additional 4 weeks. Treatment with the high-fat diet did not alter ANG-induced hypertension compared with the normal diet (174±6...
Clin Sci (Lond) (2009) 116 (11): 819-826.
Published: 01 May 2009
... and is up-regulated in human aneurysmal aortas, and to assess a possible association with AngII (angiotensin II)-induced aneurysm formation. The presence of EMMPRIN was assessed in 41 surgical specimens from patients with a TAA (thoracic aortic aneurysm) (Type A aortic dissection, n =12; Type B aortic...
Clin Sci (Lond) (2008) 114 (5): 375-380.
Published: 01 February 2008
..., catecholamines and ACE activity were determined in plasma. Circulating noradrenaline levels were significantly elevated in SGA girls compared with AGA girls ( P =0.036). In addition, angiotensin II and ACE activity were higher in SGA boys ( P =0.024 and P =0.050 respectively). There was a significant association...
Clin Sci (Lond) (2007) 113 (11): 449-457.
Published: 01 November 2007
...Julian M. Stewart; Indu Taneja; Marvin S. Medow Altered peripheral haemodynamics, decreased cardiac output, decreased blood volume and increased AngII (angiotensin II) have been reported in POTS (postural tachycardia syndrome). Recent findings indicate that BMI (body mass index) may be reduced. In...
Clin Sci (Lond) (2007) 113 (3): 109-118.
Published: 02 July 2007
... are up-regulated in fibrotic livers of humans and in experimental animal models. Angiotensin II, the main physiological effector molecule of this system, mediates liver fibrosis by stimulating fibroblast proliferation (myofibroblast and hepatic stellate cells), infiltration of inflammatory cells, and...
Clin Sci (Lond) (2007) 112 (8): 417-428.
Published: 13 March 2007
...Sadaharu Higuchi; Haruhiko Ohtsu; Hiroyuki Suzuki; Heigoro Shirai; Gerald D. Frank; Satoru Eguchi The intracellular signal transduction of AngII (angiotensin II) has been implicated in cardiovascular diseases, such as hypertension, atherosclerosis and restenosis after injury. AT 1 receptor (AngII...
Clin Sci (Lond) (2006) 110 (3): 379-386.
Published: 10 February 2006
...Yoshinori Seko Ang II (Angiotensin II) has been shown to play a pivotal role in the pathophysiology of various organs, especially the cardiovascular system. The effects of ARBs (Ang II receptor blockers) in the treatment of hypertension, congestive heart failure and myocardial fibrosis have been...
Clin Sci (Lond) (2006) 110 (2): 255-263.
Published: 17 January 2006
...Julian M. Stewart; June L. Glover; Marvin S. Medow POTS (postural tachycardia syndrome) is associated with low blood volume and reduced renin and aldosterone; however, the role of Ang (angiotensin) II has not been investigated. Previous studies have suggested that a subset of POTS patients with...
Clin Sci (Lond) (2005) 109 (3): 311-317.
Published: 24 August 2005
...Hans Herlitz; Eva Palmgren; Bengt Widgren; Mattias Aurell The renin–angiotensin system is implicated in the pathophysiology of hypertension. Renin release is regulated by a number of factors, including circulating Ang II (angiotensin II), the so-called short feedback loop. The aim of the present...
Clin Sci (Lond) (2005) 108 (6): 523-530.
Published: 24 May 2005
...Giovanna CASTOLDI; Serena REDAELLI; Willy M. M. van de GREEF; Cira R. T. di GIOIA; Giuseppe BUSCA; Giovanni SPERTI; Andrea STELLA Ang II (angiotensin II) has multiple effects on vascular smooth muscle cells through the modulation of different classes of genes. Using the mRNA differential-display...
Clin Sci (Lond) (2005) 108 (2): 113-119.
Published: 21 January 2005
...Marina CHRISTENSEN; Hans IBSEN; René WORCK ANG II (angiotensin II) facilitates catecholamine release from the adrenal medulla and neuronal NE (noradrenaline) release. Since animal experiments point to specific sympatho-inhibitory properties of the AT 1 (ANG II type 1)-receptor blocker EPRO...
Clin Sci (Lond) (2004) 106 (6): 569-576.
Published: 01 June 2004
...Miriam T. RADEMAKER; Chris J. CHARLES; Eric A. ESPINER; Chris M. FRAMPTON; M. Gary NICHOLLS; A. Mark RICHARDS Blockade of AngII (angiotensin II) and ET (endothelin)-1, established and potential therapeutic strategies respectively, for heart failure, may have an adverse effect on the cardiac...
Clin Sci (Lond) (2003) 104 (2): 109-118.
Published: 09 January 2003
...Richard D. PATTEN; Mark J. ARONOVITZ; Michael EINSTEIN; Matthew LAMBERT; Natesa G. PANDIAN; Michael E. MENDELSOHN; Marvin A. KONSTAM Left ventricular (LV) remodelling following myocardial infarction (MI) is associated with increased morbidity and mortality. Previous data suggest that angiotensin II...
Clin Sci (Lond) (2002) 103 (s2002): 380S-384S.
Published: 01 September 2002
...Isabelle BROCHU; Julie LABONTÉ; Ghassan BKAILY; Pedro D'ORLÉANS-JUSTE Mice with disruption of the kinin B 2 receptor (B 2 KO mice) are sensitive to salt-rich diets, which causes hypertension. The aim of the study was to assess the role of endothelin-1 (ET-1) and angiotensin-II in hypertensive B 2...
Clin Sci (Lond) (2002) 102 (1): 15-21.
Published: 28 November 2001
... ]angiotensin II bound with sub-nanomolar affinity, with a corresponding K D of 0.42±0.09nM, a B max of 11.2±2.3fmolċmg -1 protein and a Hill slope of 1.04±0.04. The rank order of inhibitory potency of competing ligands for the 125 I-[Sar 1 ,Ile 8 ]angiotensin II binding site was CGP42112 > angiotensin II...
Clin Sci (Lond) (2001) 101 (1): 103-109.
Published: 14 June 2001
... from humans are scant. We examined the effects of intermediate-dose, short-term AM infusion on angiotensin II- and adrenocorticotrophic hormone (ACTH)-mediated hormone and haemodynamic responses in healthy subjects. Seven normal volunteers (age 18–25 years) completed a placebo-controlled crossover...
Clin Sci (Lond) (2001) 100 (3): 249-257.
Published: 25 January 2001
... 11 9 2000 13 11 2000 The Biochemical Society and the Medical Research Society © 2001 2001 advanced glycation end-products albuminuria angiotensin II glomeruli mesenteric artery retina 249Clinical Science (2001) 100, 249 257 (Printed in Great Britain) Aminoguanidine and...
Clin Sci (Lond) (2001) 100 (1): 19-23.
Published: 05 December 2000
...A. J. BROWN; J. E. NALLY Angiotensin II potentiates methacholine-evoked bronchoconstriction both in bovine airways in vitro and in asthmatic patients in vivo . Angiotensin II also potentiates endothelin-1-evoked contractions in vitro , but fails to alter such contractions in vivo . One possible...
Clin Sci (Lond) (2000) 98 (1): 1-7.
Published: 19 November 1999
...Scott G. RAMSAY; Christopher J. KENYON; Niall WHYTE; Ian C. MCKAY; Neil C. THOMSON; George B. M. LINDOP Airway remodelling occurs in chronic asthma. Angiotensin II promotes growth in cardiovascular remodelling. Since the renin–angiotensin system is activated in acute severe asthma, we hypothesized...
Clin Sci (Lond) (1999) 96 (3): 261-270.
Published: 01 March 1999
...Claudio FERRI; Giovambattista DESIDERI; Roberta BALDONCINI; Cesare BELLINI; Marco VALENTI; Anna SANTUCCI; Giancarlo DE MATTIA We investigated the effect of angiotensin II on endothelin-1 secretion in vitro and in vivo. In vivo , angiotensin II was given intravenously to 23 essential hypertensive...
Clin Sci (Lond) (1998) 96 (1): 5-15.
Published: 01 January 1999
... angiotensin II arginine vasopressin atrial natriuretic peptide brain natriuretic peptide cyclic GMP glomerular filtration rate heart failure lithium renal plasma flow renin sodium 5Clinical Science (1999) 96, 5 15 (Printed in Great Britain) Renal effects of brain natriuretic peptide in patients...