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Keywords: angiotensin converting enzyme 2
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Articles
Clin Sci (Lond) (2022) 136 (5): 309–321.
Published: 02 March 2022
...-ND) . abdominal aortic aneurysm angiotensin converting enzyme 2 calcium chloride fevipiprant laropiprant prostaglandin D2 Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease, characterized by immune cell infiltration and proteolytic degradation of the vascular wall...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (24): 2667–2689.
Published: 15 December 2021
... in the cytokine storm , and (4) production of pro-apoptotic factors causing EC death. Next, adopting a blocking strategy against the S protein receptors angiotensin-converting enzyme 2 (ACE2) and CD147, we discovered that the S protein stimulates the phosphorylation/activation of the extracellular signal...
Articles
Clin Sci (Lond) (2021) 135 (15): 1805–1824.
Published: 02 August 2021
... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . angiotensin converting enzyme 2 cardiovascular disease COVID-19 placental biology pregnancy SARS-COV-2 The world is facing one of the greatest pandemics in history. The coronavirus disease 2019 (COVID...
Articles
Clin Sci (Lond) (2021) 135 (7): 911–924.
Published: 12 April 2021
... ) * These authors contributed equally to this work. 20 11 2020 23 03 2021 29 03 2021 30 03 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 angiotensin converting enzyme 2 Blood pressure hypertension immunsystem renin...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (6): 775–791.
Published: 17 March 2021
... therefore hypothesized that another metabolic pathway of brain angiotensin II, such as the conversion of angiotensin II into angiotensin 1-7 (Ang 1-7) by angiotensin-converting enzyme 2 (ACE2) might be activated following brain APA inhibition. We found that the intracerebroventricular (icv) administration...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (5): 683–686.
Published: 02 March 2021
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 adipocytes angiotensin converting enzyme 2 heart failure vascular endothelial growth factor Obesity and overweight, facilitated by an increased consumption of processed food and sedentary lifestyles...
Articles
Clin Sci (Lond) (2021) 135 (2): 387–407.
Published: 29 January 2021
... the Creative Commons Attribution License 4.0 (CC BY) . angiotensin converting enzyme 2 COVID-19 endothelial cells vascular smooth muscle The renin–angiotensin system (RAS) plays a pivotal role in the regulation of blood pressure, electrolyte and water homeostasis, vascular tone...
Articles
Clin Sci (Lond) (2021) 135 (2): 367–385.
Published: 27 January 2021
.../progenitor cells have the potential of revascularization; however, diabetes attenuates vasoreparative functions. Angiotensin-converting enzyme 2 (ACE2) is the vasoprotective enzyme of renin–angiotensin system in contrast with the canonical angiotensin-converting enzyme (ACE). The present study tested...
Articles
Clin Sci (Lond) (2020) 134 (23): 3229–3232.
Published: 11 December 2020
...Michael Bader; Anthony J. Turner; Natalia Alenina This Editorial, written by Guest Editors Professor Michael Bader, Professor Anthony J. Turner and Dr Natalia Alenina, proudly introduces the Clinical Science -themed collection on angiotensin-converting enzyme 2 (ACE2), a multifunctional protein...
Articles
Clin Sci (Lond) (2020) 134 (23): 3137–3158.
Published: 07 December 2020
...Fiona J. Warner; Harinda Rajapaksha; Nicholas Shackel; Chandana B. Herath Twenty years ago, the discovery of angiotensin-converting enzyme 2 (ACE2) was an important breakthrough dramatically enhancing our understanding of the renin–angiotensin system (RAS). The classical RAS is driven by its key...
Articles
Clin Sci (Lond) (2020) 134 (23): 3063–3078.
Published: 02 December 2020
...Thiago Verano-Braga; Ana Luiza Valle Martins; Daisy Motta-Santos; Maria José Campagnole-Santos; Robson Augusto Souza Santos In 2020 we are celebrating the 20th anniversary of the angiotensin-converting enzyme 2 (ACE2) discovery. This event was a landmark that shaped the way that we see the renin...
Articles
Clin Sci (Lond) (2020) 134 (22): 3047–3062.
Published: 24 November 2020
...Koichi Yamamoto; Hikari Takeshita; Hiromi Rakugi Angiotensin converting enzyme-2 (ACE2) is a multifunctional transmembrane protein recently recognised as the entry receptor of the virus causing COVID-19. In the renin–angiotensin system (RAS), ACE2 cleaves angiotensin II (Ang II) into angiotensin 1...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (22): 2987–3006.
Published: 19 November 2020
...(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . angiotensin converting enzyme 2 AT2 receptor COVID-19 inflammation The discovery...
Articles
Clin Sci (Lond) (2020) 134 (21): 2851–2871.
Published: 04 November 2020
... inhibitor angiotensin converting enzyme 2 COVID-19 metalloproteases Regulatory peptides control various physiological processes ranging from fertilisation and development to immunity and nervous system function. Active peptides are formed from precursors and are degraded by peptidases after...
Articles
Clin Sci (Lond) (2020) 134 (21): 2823–2833.
Published: 03 November 2020
... transporters angiotensin converting enzyme 2 kidney tubule small intestine © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 As mentioned above, mutations in the gene coding for the transporter B 0 AT1 ( SLC6A19 , chromosomal locus 5p15.33) can...
Articles
Clin Sci (Lond) (2020) 134 (21): 2791–2805.
Published: 02 November 2020
... ) 04 09 2020 14 10 2020 16 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 angiotensin converting enzyme 2 COVID-19 renin-angiotensin system SARS-CoV-2 Angiotensin‐converting enzyme II (ACE2...
Articles
Clin Sci (Lond) (2020) 134 (18): 2489–2501.
Published: 29 September 2020
... opportunities arising from its multiple biological roles. angiotensin converting enzyme 2 coronavirus COVID-19 metalloproteases renin-angiotensin system SARS 17 07 2020 12 09 2020 15 09 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf...
Articles
Clin Sci (Lond) (2020) 134 (17): 2319–2336.
Published: 09 September 2020
...) by promoting angiotensin converting enzyme 2 ( ACE2 ) transcription leading to increased ACE2 protein and activity while also antagonizing the effects of angiotensin II (Ang II). Apelin modulation of the RAS by increasing ACE2 action is limited due to its rapid degradation by proteases, including ACE2...
Articles
Clin Sci (Lond) (2020) 134 (5): 543–545.
Published: 13 March 2020
..., 2020. It has been known since the 2003 SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2). The S1 domain of the spike protein of SARS-CoV attaches the virus to its cellular receptor ACE2 on the host cells. We thought...
Articles
Clin Sci (Lond) (2019) 133 (18): 2005–2018.
Published: 24 September 2019
... ) 28 05 2019 30 08 2019 12 09 2019 13 09 2019 We recently identified angiotensin-converting enzyme 2 (ACE2) as a candidate molecule associated with muscle weakness due to aging in mice. We found that ACE2 knockout (ACE2KO) mice exhibit earlier aging-associated muscle weakness...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (1): 55–74.
Published: 08 January 2019
...@wakehealth.edu ) 03 08 2018 20 11 2018 03 12 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 angiotensin converting enzyme 2 angiotensin-(1-7) ACE fetal programming Cardiovascular disease including its primary risk...
Includes: Supplementary data