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Keyword: angiotensin-(1–7)
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Articles
Clin Sci (Lond) (2019) 133 (1): 55–74.
Published: 08 January 2019
... C. Chappell ( mchappel@wakehealth.edu ) 03 08 2018 20 11 2018 03 12 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 angiotensin converting enzyme 2 angiotensin-(1-7) ACE fetal programming Cardiovascular...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (10): 1021–1038.
Published: 25 May 2018
... ) 28 02 2018 19 04 2018 23 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Alzheimer’s disease angiotensin-(1-7) cognitive impairment hypertension Mas receptor stroke There is a growing increase in the number...
Articles
Clin Sci (Lond) (2016) 130 (24): 2305–2316.
Published: 10 November 2016
... In the present study, we have showed that the Ang-(1–7)/receptor Mas axis contributes to cardiac remodelling development induced by pregnancy. A-779 Angiotensin-(17) cardiac hypertrophy fibrosis heart function • In the present study, we have evaluated the participation of the...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (21): 1983–1991.
Published: 30 September 2016
...Jian Ping Zhou; Wei Tang; Yun Feng; Ning Li; Chen Juan Gu; Qing Yun Li; Huan Ying Wan Previous studies have shown that the RAS (renin–angiotensin system) might participate in airway remodelling in asthma. As a main component of the RAS, Ang-(1–7) [angiotensin-(17)] has been reported in few studies...
Articles
Clin Sci (Lond) (2016) 130 (14): 1247–1255.
Published: 13 June 2016
...Ana Flávia Almeida-Santos; Lucas M. Kangussu; Fabrício A. Moreira; Robson A.S. Santos; Daniele C. Aguiar; Maria José Campagnole-Santos Angiotensin-(17) [Ang-(1–7)], a counter-regulatory peptide of the renin–angiotensin system (RAS) exerts its effects through the G-protein-coupled receptor Mas...
Articles
Clin Sci (Lond) (2015) 129 (6): 461–476.
Published: 22 June 2015
... and muscle mass, an increase in MHC (myosin heavy chain) degradation, and an increase in the expression of atrogin-1 and MuRF-1 (muscle-specific RING-finger protein 1), two ubiquitin E3 ligases belonging to the ubiquitin–proteasome system. Ang-(1–7) [Angiotensin-(17)], through its Mas receptor, has...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (10): 649–663.
Published: 20 February 2015
...Yixuan Shi; Chao-Sheng Lo; Ranjit Padda; Shaaban Abdo; Isabelle Chenier; Janos G. Filep; Julie R. Ingelfinger; Shao-Ling Zhang; John S.D. Chan; John S.D. Chan We investigated the relationship between Ang-(1–7) [angiotensin-(17)] action, sHTN (systolic hypertension), oxidative stress, kidney injury...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (5): 307–319.
Published: 05 November 2014
...) degradation and increase in the expression of two muscle-specific ubiquitin ligases: atrogin-1 and MuRF-1. Angiotensin II (AngII) induces muscle atrophy. Angiotensin-(17) [Ang-(1–7)], through its receptor Mas, produces the opposite effects than AngII. We assessed the effects of Ang-(1–7) on the skeletal...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (5): 295–306.
Published: 07 May 2014
... depressor arm represented by Ang-(1–7) [angiotensin-(17)]/ACE2/Mas receptors. All of the components of the RAS are present in the brain. Within the brain, Ang-(1–7) contributes to the regulation of BP (blood pressure) by acting at regions that control cardiovascular function such that, when Ang-(1–7) is...
Articles
Clin Sci (Lond) (2014) 127 (4): 251–264.
Published: 16 April 2014
... present study, we investigated whether Ang-(1–7) [angiotensin-(17)], through the Mas-1 receptor, can counteract the signalling induced by AngII in mouse skeletal muscle and cause a decrease in the expression and further activity of TGF-β1 in skeletal muscle cells. Our results show that Ang-(1–7...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (10): 695–706.
Published: 27 January 2014
... RAAS consists of an excitatory arm involving AngII (angiotensin II), ACE (angiotensin-converting enzyme) and the AT 1 R (AngII type 1 receptor). The RAAS also consists of a protective arm consisting of Ang-(1–7) [angiotensin-(17)], the AT 2 R (AngII type 2 receptor), ACE2 and the Mas receptor...
Articles
Clin Sci (Lond) (2014) 126 (9): 613–630.
Published: 14 January 2014
... drugs that block the RAS (renin–angiotensin system) may also act to prevent diabetes. Despite its long history, new components within the RAS continue to be discovered. Among them, Ang-(1–7) [angiotensin-(17)] has gained special attention as a counter-regulatory hormone opposing many of the AngII...
Articles
Clin Sci (Lond) (2014) 126 (7): 507–516.
Published: 11 December 2013
...) [angiotensin-(17)]. Enhanced ACE2 expression may be protective in diabetes, cardiovascular disease and cancer. However, relatively little is known about the specific physiological factors regulating ACE2 expression. In the present paper, we show, by Western blotting and qPCR (quantitative real-time PCR), that...
Articles
Clin Sci (Lond) (2014) 126 (7): 471–482.
Published: 06 December 2013
... shown clinical benefits. ACE2, the recently discovered homologue of ACE, is a monocarboxypeptidase which converts AngII into Ang-(1–7) [angiotensin-(17)] which, by virtue of its actions on the MasR (Mas receptor), opposes the effects of AngII. In animal models of diabetes, an early increase in ACE2...
Articles
Clin Sci (Lond) (2014) 126 (7): 461–469.
Published: 06 December 2013
...Carlos Maria Ferrario; Sarfaraz Ahmad; Sayaka Nagata; Stephen W. Simington; Jasmina Varagic; Neal Kon; Louis Joseph Dell’Italia Lessons learned from the characterization of the biological roles of Ang-(1–7) [angiotensin-(17)] in opposing the vasoconstrictor, proliferative and prothrombotic actions...
Articles
Clin Sci (Lond) (2013) 125 (9): 449–459.
Published: 08 July 2013
... coronary effects of Ang-(1–7) [angiotensin-(17)] in hypertrophic rat hearts. Heart hypertrophy was induced by abdominal aorta CoA (coarctation). Ang-(1–7) and AVE 0991, a non-peptide Mas-receptor agonist, at picomolar concentration, induced a significant vasodilation in hearts from sham-operated rats...
Articles
Clin Sci (Lond) (2013) 125 (2): 57–65.
Published: 26 March 2013
...Mariela M. Gironacci; Nadia A. Longo Carbajosa; Jorge Goldstein; Bruno D. Cerrato Ang-(1–7) [angiotensin-(17)] constitutes an important functional end-product of the RAS (renin–angiotensin system) endogenously formed from AngI (angiotensin I) or AngII (angiotensin II) through the catalytic...
Articles
Clin Sci (Lond) (2013) 124 (7): 443–456.
Published: 07 December 2012
... actions of the RAS. However, over the past 10 years, several studies have presented evidence for the existence of a new arm of the RAS, namely the ACE (angiotensin-converting enzyme) 2/Ang-(1–7) [angiotensin-(17)]/Mas axis. Ang-(1–7) can be produced from AngI or AngII via endo- or carboxy-peptidases...
Articles
Clin Sci (Lond) (2012) 123 (1): 29–37.
Published: 12 March 2012
... Bernardi (email stella.bernardi@bakeridi.edu.au ). 11 8 2011 24 1 2012 30 1 2012 30 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiotensin-(17) angiotensin-converting enzyme 2 (ACE2) atrial natriuretic peptide (ANP) diabetes epithelial...
Articles
Clin Sci (Lond) (2011) 121 (7): 297–303.
Published: 07 June 2011
...-(1–7) [angiotensin-(17)]. Of note, although AngIV and Ang-(1–7) exhibited only modest affinity at AT 2 R compared with AngII, these two angiotensin peptides, together with AngIII, had substantial AT 2 R selectivity over AT 1 R. Collectively, our results suggest that shorter angiotensin peptides can...
Articles
Clin Sci (Lond) (2010) 118 (4): 269–279.
Published: 16 November 2009
... use, distribution and reproduction in any medium, provided the original work is properly cited. angiotensin-(17) kidney mas receptor renal injury renin–angiotensin system (RAS) Alterations within the RAS (renin–angiotensin system) are pivotal for the development and progression of...
Articles
Clin Sci (Lond) (2009) 117 (11): 375–386.
Published: 14 September 2009
...John S. Lubel; Chandana B. Herath; Jorge Tchongue; Josephine Grace; Zhiyuan Jia; Karen Spencer; David Casley; Peter Crowley; William Sievert; Louise M. Burrell; Peter W. Angus Ang-(1–7) (angiotensin-17), a peptide product of the recently described ACE (angiotensin-converting enzyme) homologue ACE2...
Includes: Supplementary data