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Keywords: angiotensin-(1–7)
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Clin Sci (Lond) (2021) 135 (23): 2619–2623.
Published: 08 December 2021
... 2021 Angiotensin-(1-7) Cardiovascular System Renin-Angiotensin System Sympathetic Nervous System Transgenic Rat Vasopressin Correspondence: Robert C. Speth ( rs1251@nova.edu ) The renin–angiotensin system (RAS) regulates hydromineral balance, cardiovascular, renal, neuronal...
Clin Sci (Lond) (2021) 135 (18): 2197–2216.
Published: 21 September 2021
... of the Biochemical Society 2021 Angiotensin-(1-7) ANP Arterial Pressure Brain endothelial cells Transgenic rats The renin–angiotensin system (RAS) is an important systemic, tissue and cellular modulator of the function of basically all organs. Actions of the RAS depend essentially on the balance...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (23): 3063–3078.
Published: 02 December 2020
... angiotensin converting enzyme 2 angiotensin-(1-7) Covid-19 Renin-angiotensin system The renin–angiotensin system (RAS) is composed by a number of different enzymes and effector peptides that are involved in the dynamic control of many body functions. Many components of the RAS have opposing actions...
Clin Sci (Lond) (2020) 134 (22): 2929–2941.
Published: 16 November 2020
... Ang-(1-7). Correspondence: Adelina M. Reis ( adelina@icb.ufmg.br ) or Fernando M. Reis ( fmreis@ufmg.br ) 11 09 2020 13 10 2020 30 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 ACE2 Angiotensin-(1-7...
Clin Sci (Lond) (2020) 134 (19): 2645–2664.
Published: 16 October 2020
... by Portland Press Limited on behalf of the Biochemical Society 2020 angiotensin II angiotensin-(1-7) cardiovascular disease coronavirus chymase innate immunity Since December 2019, coronavirus disease 2019 (COVID-19) has spread rapidly around the world, causing a pandemic that threatens...
Clin Sci (Lond) (2020) 134 (19): 2581–2595.
Published: 14 October 2020
.... ACE2 functions as a carboxymonopeptidase hydrolyzing the cleavage of a single C-terminal residue from Angiotensin-II (Ang-II), the key peptide hormone of RAS, to form Angiotensin-(1-7) (Ang-(1-7)), which binds to the G-protein–coupled Mas receptor and activates signaling pathways that counteract...
Clin Sci (Lond) (2019) 133 (1): 55–74.
Published: 08 January 2019
...@wakehealth.edu ) 03 08 2018 20 11 2018 03 12 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 angiotensin converting enzyme 2 angiotensin-(1-7) ACE fetal programming Cardiovascular disease including its primary risk...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (10): 1021–1038.
Published: 25 May 2018
... ) 28 02 2018 19 04 2018 23 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Alzheimer’s disease angiotensin-(1-7) cognitive impairment hypertension Mas receptor stroke Regarding ACE2, ACE2 is widespread...
Clin Sci (Lond) (2016) 130 (24): 2305–2316.
Published: 10 November 2016
... by Portland Press Limited on behalf of the Biochemical Society 2016 In the present study, we have showed that the Ang-(1–7)/receptor Mas axis contributes to cardiac remodelling development induced by pregnancy. A-779 Angiotensin-(17) cardiac hypertrophy fibrosis heart function...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (21): 1983–1991.
Published: 30 September 2016
...Jian Ping Zhou; Wei Tang; Yun Feng; Ning Li; Chen Juan Gu; Qing Yun Li; Huan Ying Wan Previous studies have shown that the RAS (renin–angiotensin system) might participate in airway remodelling in asthma. As a main component of the RAS, Ang-(1–7) [angiotensin-(17)] has been reported in few studies...
Clin Sci (Lond) (2016) 130 (14): 1247–1255.
Published: 13 June 2016
...Ana Flávia Almeida-Santos; Lucas M. Kangussu; Fabrício A. Moreira; Robson A.S. Santos; Daniele C. Aguiar; Maria José Campagnole-Santos Angiotensin-(17) [Ang-(1–7)], a counter-regulatory peptide of the renin–angiotensin system (RAS) exerts its effects through the G-protein-coupled receptor Mas...
Clin Sci (Lond) (2015) 129 (6): 461–476.
Published: 22 June 2015
... and muscle mass, an increase in MHC (myosin heavy chain) degradation, and an increase in the expression of atrogin-1 and MuRF-1 (muscle-specific RING-finger protein 1), two ubiquitin E3 ligases belonging to the ubiquitin–proteasome system. Ang-(1–7) [Angiotensin-(17)], through its Mas receptor, has...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (10): 649–663.
Published: 20 February 2015
...Yixuan Shi; Chao-Sheng Lo; Ranjit Padda; Shaaban Abdo; Isabelle Chenier; Janos G. Filep; Julie R. Ingelfinger; Shao-Ling Zhang; John S.D. Chan We investigated the relationship between Ang-(1–7) [angiotensin-(17)] action, sHTN (systolic hypertension), oxidative stress, kidney injury, ACE2...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (5): 307–319.
Published: 05 November 2014
...) degradation and increase in the expression of two muscle-specific ubiquitin ligases: atrogin-1 and MuRF-1. Angiotensin II (AngII) induces muscle atrophy. Angiotensin-(17) [Ang-(1–7)], through its receptor Mas, produces the opposite effects than AngII. We assessed the effects of Ang-(1–7) on the skeletal...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (5): 295–306.
Published: 07 May 2014
...), and the depressor arm represented by Ang-(1–7) [angiotensin-(17)]/ACE2/Mas receptors. All of the components of the RAS are present in the brain. Within the brain, Ang-(1–7) contributes to the regulation of BP (blood pressure) by acting at regions that control cardiovascular function such that, when Ang-(1–7...
Clin Sci (Lond) (2014) 127 (4): 251–264.
Published: 16 April 2014
.... In the present study, we investigated whether Ang-(1–7) [angiotensin-(17)], through the Mas-1 receptor, can counteract the signalling induced by AngII in mouse skeletal muscle and cause a decrease in the expression and further activity of TGF-β1 in skeletal muscle cells. Our results show that Ang-(1–7...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (10): 695–706.
Published: 27 January 2014
.... The RAAS consists of an excitatory arm involving AngII (angiotensin II), ACE (angiotensin-converting enzyme) and the AT 1 R (AngII type 1 receptor). The RAAS also consists of a protective arm consisting of Ang-(1–7) [angiotensin-(17)], the AT 2 R (AngII type 2 receptor), ACE2 and the Mas receptor...
Clin Sci (Lond) (2014) 126 (9): 613–630.
Published: 14 January 2014
... drugs that block the RAS (renin–angiotensin system) may also act to prevent diabetes. Despite its long history, new components within the RAS continue to be discovered. Among them, Ang-(1–7) [angiotensin-(17)] has gained special attention as a counter-regulatory hormone opposing many of the AngII...
Clin Sci (Lond) (2014) 126 (7): 507–516.
Published: 11 December 2013
...) [angiotensin-(17)]. Enhanced ACE2 expression may be protective in diabetes, cardiovascular disease and cancer. However, relatively little is known about the specific physiological factors regulating ACE2 expression. In the present paper, we show, by Western blotting and qPCR (quantitative real-time PCR...
Clin Sci (Lond) (2014) 126 (7): 471–482.
Published: 06 December 2013
... shown clinical benefits. ACE2, the recently discovered homologue of ACE, is a monocarboxypeptidase which converts AngII into Ang-(1–7) [angiotensin-(17)] which, by virtue of its actions on the MasR (Mas receptor), opposes the effects of AngII. In animal models of diabetes, an early increase in ACE2...
Clin Sci (Lond) (2014) 126 (7): 461–469.
Published: 06 December 2013
...Carlos Maria Ferrario; Sarfaraz Ahmad; Sayaka Nagata; Stephen W. Simington; Jasmina Varagic; Neal Kon; Louis Joseph Dell’Italia Lessons learned from the characterization of the biological roles of Ang-(1–7) [angiotensin-(17)] in opposing the vasoconstrictor, proliferative and prothrombotic actions...
Clin Sci (Lond) (2013) 125 (9): 449–459.
Published: 08 July 2013
... the coronary effects of Ang-(1–7) [angiotensin-(17)] in hypertrophic rat hearts. Heart hypertrophy was induced by abdominal aorta CoA (coarctation). Ang-(1–7) and AVE 0991, a non-peptide Mas-receptor agonist, at picomolar concentration, induced a significant vasodilation in hearts from sham-operated rats...
Clin Sci (Lond) (2013) 125 (2): 57–65.
Published: 26 March 2013
...Mariela M. Gironacci; Nadia A. Longo Carbajosa; Jorge Goldstein; Bruno D. Cerrato Ang-(1–7) [angiotensin-(17)] constitutes an important functional end-product of the RAS (renin–angiotensin system) endogenously formed from AngI (angiotensin I) or AngII (angiotensin II) through the catalytic...
Clin Sci (Lond) (2013) 124 (7): 443–456.
Published: 07 December 2012
... of the actions of the RAS. However, over the past 10 years, several studies have presented evidence for the existence of a new arm of the RAS, namely the ACE (angiotensin-converting enzyme) 2/Ang-(1–7) [angiotensin-(17)]/Mas axis. Ang-(1–7) can be produced from AngI or AngII via endo- or carboxy-peptidases...
Clin Sci (Lond) (2012) 123 (1): 29–37.
Published: 12 March 2012
... removed and snap frozen [ 18 ]. © The Authors Journal compilation © 2012 Biochemical Society 2012 angiotensin-(17) angiotensin-converting enzyme 2 (ACE2) atrial natriuretic peptide (ANP) diabetes epithelial tubular cell kidney disease For the gene expression analysis, 3 μg...
Clin Sci (Lond) (2011) 121 (7): 297–303.
Published: 07 June 2011
...-(1–7) [angiotensin-(17)]. Of note, although AngIV and Ang-(1–7) exhibited only modest affinity at AT 2 R compared with AngII, these two angiotensin peptides, together with AngIII, had substantial AT 2 R selectivity over AT 1 R. Collectively, our results suggest that shorter angiotensin peptides can...
Clin Sci (Lond) (2010) 118 (4): 269–279.
Published: 16 November 2009
... discovered monocarboxypeptidase that regulates RAS through degradation of the vasoconstrictor and pro-fibrotic peptide AngII (angiotensin II) into Ang-(1–7) [angiotensin-(17)], a peptide reported to have vasodilatory and anti-fibrotic actions [ 6 , 7 ] via actions at the Ang-(1–7) or mas receptor [ 8...
Clin Sci (Lond) (2009) 117 (11): 375–386.
Published: 14 September 2009
...John S. Lubel; Chandana B. Herath; Jorge Tchongue; Josephine Grace; Zhiyuan Jia; Karen Spencer; David Casley; Peter Crowley; William Sievert; Louise M. Burrell; Peter W. Angus Ang-(1–7) (angiotensin-17), a peptide product of the recently described ACE (angiotensin-converting enzyme) homologue ACE2...
Includes: Supplementary data