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Keywords: angiotensin-converting enzyme
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Clin Sci (Lond) (2014) 126 (10): 695–706.
Published: 27 January 2014
.... The RAAS consists of an excitatory arm involving AngII (angiotensin II), ACE (angiotensin-converting enzyme) and the AT 1 R (AngII type 1 receptor). The RAAS also consists of a protective arm consisting of Ang-(1–7) [angiotensin-(1–7)], the AT 2 R (AngII type 2 receptor), ACE2 and the Mas receptor...
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Clin Sci (Lond) (2012) 123 (9): 531–543.
Published: 13 July 2012
[email protected] ). 21 2 2012 27 4 2012 8 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 abdominal aortic aneurysm angiotensin angiotensin-converting enzyme renin–angiotensin system thoracic aortic aneurysm Aortic aneurysms are relatively common...
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Clin Sci (Lond) (2012) 123 (8): 487–498.
Published: 27 June 2012
...Dinesh Shrikrishna; Ronan Astin; Paul R. Kemp; Nicholas S. Hopkinson ACE (angiotensin-converting enzyme) inhibitors and ARBs (angiotensin II receptor blockers) are already widely used for the treatment and prevention of cardiovascular disease and their potential role in other disease states has...
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Clin Sci (Lond) (2012) 123 (4): 225–239.
Published: 24 April 2012
... (angiotensin-converting enzyme) and the AT 1 receptor [AngII (angiotensin II) type 1 receptor], which play an active role in promoting inflammation and deposition of extracellular matrix. In addition, the more recently recognized structural homologue of ACE, ACE2, is also up-regulated. ACE2 catalyses...
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Clin Sci (Lond) (2008) 115 (1): 35–42.
Published: 02 June 2008
...Zhen Huang; Leif Jansson; Åke Sjöholm Patients with diabetes are often treated with a statin for hyperlipidaemia and an ACE (angiotensin-converting enzyme) inhibitor or angiotensin receptor antagonist for hypertension or albuminuria. These drugs may also exert beneficial metabolic effects, causing...
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Clin Sci (Lond) (2003) 105 (3): 339–345.
Published: 01 September 2003
...Eiji KUBOTA; Rachael G. DEAN; Richard A. HUBNER; David J. CASLEY; Colin I. JOHNSTON; Louise M. BURRELL Vasopeptidase inhibitors simultaneously inhibit angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP). The present study characterized the tissue distributions of ACE and NEP...
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Clin Sci (Lond) (2003) 104 (4): 341–347.
Published: 06 March 2003
... hypertrophy in diabetic spontaneously hypertensive rats (SHR). SHR with streptozotocin-induced diabetes were treated with one of the following therapies for 32 weeks: the angiotensin-converting enzyme (ACE) inhibitor captopril (100mg/kg); the angiotensin AT 1 receptor antagonist valsartan (30mg/kg...
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Clin Sci (Lond) (2002) 102 (1): 15–21.
Published: 28 November 2001
... left ventricle. Using competitive radioligand binding assays, we were able to demonstrate that the chymase/cathepsin G enzyme inhibitor chymostatin was more potent than the angiotensin-converting enzyme (ACE) inhibitor captopril at inhibiting the conversion of angiotensin I in the human left ventricle...
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Clin Sci (Lond) (1999) 96 (5): 441–448.
Published: 25 March 1999
...Alison F. C. LEE; John B. C. DICK; Clare E. BONNAR; Allan D. STRUTHERS Endothelial function is defective in hypercholesterolaemia, and animal models have suggested that angiotensin-converting enzyme inhibitors may prevent arterial damage. We studied the effect of 6 months treatment with lisinopril...
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Clin Sci (Lond) (1995) 88 (4): 433–437.
Published: 01 April 1995
... or identical placebo tablets followed 3 h later by nebulized salbutamol or placebo inhalation; plasma renin, angiotensin II, serum angiotensin-converting enzyme and potassium were measured at intervals for 120 min after inhalation. 3. Following salbutamol, plasma renin and angiotensin II concentrations were...
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Clin Sci (Lond) (1991) 80 (3): 241–247.
Published: 01 March 1991
...-treated with inhalation of either saline or a combination of the peptidase inhibitors phosphoramidon (0.1 mmol/l: 60 breaths; 7.5 nmol), to inhibit neutral endopeptidase, and captopril (4.6 mmol/l: 60 breaths; 350 nmol), to inhibit angiotensin-converting enzyme. 2. Airway microvascular leakage...
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Clin Sci (Lond) (1981) 61 (s7): 223s–225s.
Published: 01 December 1981
..., for the increase in renin secretion which follows the blockade of angiotensin-converting enzyme. © 1981 The Biochemical Society and the Medical Research Society 1981 angiotensin-converting enzyme captopril renal nerves sympathetic nervous system teprotide Clinical Science (1981) 6 1 , 2 2 3 ~ 2 2 5...
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Clin Sci (Lond) (1981) 61 (1): 97–105.
Published: 01 July 1981
...R. A. Banks; L. J. Beilin 1. Systemic and regional vascular changes were measured in conscious rabbits after intravenous sodium meclofenamate, captopril and phentolamine. These drugs were used respectively to inhibit prostaglandin synthesis and angiotensin-converting enzyme, and to block α...
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Clin Sci (Lond) (1979) 57 (s5): 255s–258s.
Published: 01 December 1979
... pressure. It may play an important antihypertensive role in benign two-kidney, one-clip Goldblatt hypertension, a role which might be impaired in malignant hypertension. © 1979 The Biochemical Society and the Medical Research Society 1979 angiotensin-converting enzyme aprotinin hypertension...
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