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Keywords: angiotensin-converting enzymeClose
Clin Sci (Lond) (2014) 126 (10): 695–706.
Published: 27 January 2014
.... The RAAS consists of an excitatory arm involving AngII (angiotensin II), ACE (angiotensin-converting enzyme) and the AT 1 R (AngII type 1 receptor). The RAAS also consists of a protective arm consisting of Ang-(1–7) [angiotensin-(1–7)], the AT 2 R (AngII type 2 receptor), ACE2 and the Mas receptor...
Candice M. Thomas, Qian Chen Yong, Rachid Seqqat, Niketa Chandel, David L. Feldman, Kenneth M. Baker, Rajesh Kumar
Clin Sci (Lond) (2013) 124 (8): 529–545.
Published: 08 January 2013
... (angiotensin receptor blockers) or ACEis (angiotensin-converting enzyme inhibitors). In the present study, we determined whether renin inhibition is more effective at preventing diabetic cardiomyopathy than an ARB or ACEi. Diabetes was induced in adult mice for 10 weeks by STZ (streptozotocin). Diabetic mice...
Includes: Supplementary data
Clin Sci (Lond) (2012) 123 (11): 649–658.
Published: 01 August 2012
...Luke J. Burchill; Elena Velkoska; Rachael G. Dean; Karen Griggs; Sheila K. Patel; Louise M. Burrell The RAS (renin–angiotensin system) is activated after MI (myocardial infarction), and RAS blockade with ACEis [ACE (angiotensin-converting enzyme) inhibitors] or ARBs (angiotensin receptor blockers...
Clin Sci (Lond) (2012) 123 (9): 531–543.
Published: 13 July 2012
... abdominal aortic aneurysm angiotensin angiotensin-converting enzyme renin–angiotensin system thoracic aortic aneurysm Correspondence: Professor Alan Daugherty (email Alan.Daugherty@uky.edu ). 21 2 2012 27 4 2012 8 5 2012 Table 2 Recent studies on potential...
Clin Sci (Lond) (2012) 123 (8): 487–498.
Published: 27 June 2012
...Dinesh Shrikrishna; Ronan Astin; Paul R. Kemp; Nicholas S. Hopkinson ACE (angiotensin-converting enzyme) inhibitors and ARBs (angiotensin II receptor blockers) are already widely used for the treatment and prevention of cardiovascular disease and their potential role in other disease states has...
Clin Sci (Lond) (2012) 123 (4): 225–239.
Published: 24 April 2012
... (angiotensin-converting enzyme) and the AT 1 receptor [AngII (angiotensin II) type 1 receptor], which play an active role in promoting inflammation and deposition of extracellular matrix. In addition, the more recently recognized structural homologue of ACE, ACE2, is also up-regulated. ACE2 catalyses...
Maksim O. Emel'yanov, Antonina F. Korystova, Ludmila N. Kublik, Maria Kh. Levitman, Vera V. Shaposhnikova, Yuri N. Korystov
Clin Sci (Lond) (2012) 122 (2): 75–81.
Published: 20 September 2011
...Maksim O. Emel'yanov; Antonina F. Korystova; Ludmila N. Kublik; Maria Kh. Levitman; Vera V. Shaposhnikova; Yuri N. Korystov In the present study, the activity of ACE (angiotensin-converting enzyme) in the aorta of senescent rats and rats treated with the NOS (NO synthase) inhibitor L -NAME ( N G...
John S. Lubel, Chandana B. Herath, Jorge Tchongue, Josephine Grace, Zhiyuan Jia, Karen Spencer, David Casley, Peter Crowley, William Sievert, Louise M. Burrell, Peter W. Angus
Clin Sci (Lond) (2009) 117 (11): 375–386.
Published: 14 September 2009
...John S. Lubel; Chandana B. Herath; Jorge Tchongue; Josephine Grace; Zhiyuan Jia; Karen Spencer; David Casley; Peter Crowley; William Sievert; Louise M. Burrell; Peter W. Angus Ang-(1–7) (angiotensin-1–7), a peptide product of the recently described ACE (angiotensin-converting enzyme) homologue ACE2...
Includes: Supplementary data
Clin Sci (Lond) (2008) 115 (1): 35–42.
Published: 02 June 2008
...Zhen Huang; Leif Jansson; Åke Sjöholm Patients with diabetes are often treated with a statin for hyperlipidaemia and an ACE (angiotensin-converting enzyme) inhibitor or angiotensin receptor antagonist for hypertension or albuminuria. These drugs may also exert beneficial metabolic effects, causing...
Eiji KUBOTA, Rachael G. DEAN, Richard A. HUBNER, David J. CASLEY, Colin I. JOHNSTON, Louise M. BURRELL
Clin Sci (Lond) (2003) 105 (3): 339–345.
Published: 01 September 2003
...Eiji KUBOTA; Rachael G. DEAN; Richard A. HUBNER; David J. CASLEY; Colin I. JOHNSTON; Louise M. BURRELL Vasopeptidase inhibitors simultaneously inhibit angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP). The present study characterized the tissue distributions of ACE and NEP...
Clin Sci (Lond) (2003) 104 (4): 341–347.
Published: 06 March 2003
... hypertrophy in diabetic spontaneously hypertensive rats (SHR). SHR with streptozotocin-induced diabetes were treated with one of the following therapies for 32 weeks: the angiotensin-converting enzyme (ACE) inhibitor captopril (100mg/kg); the angiotensin AT 1 receptor antagonist valsartan (30mg/kg...
Clin Sci (Lond) (2002) 102 (1): 15–21.
Published: 28 November 2001
... left ventricle. Using competitive radioligand binding assays, we were able to demonstrate that the chymase/cathepsin G enzyme inhibitor chymostatin was more potent than the angiotensin-converting enzyme (ACE) inhibitor captopril at inhibiting the conversion of angiotensin I in the human left ventricle...
Clin Sci (Lond) (1999) 97 (2): 165–174.
Published: 16 June 1999
...Regina M. GOETZ; Juergen HOLTZ Endothelial vasomotor function is impaired in a variety of disorders representing both early and late stages of atherosclerosis. There is experimental evidence for enhanced vascular angiotensin-converting enzyme (ACE) activity in these disorders. We explored whether...
Clin Sci (Lond) (1999) 96 (5): 441–448.
Published: 25 March 1999
...Alison F. C. LEE; John B. C. DICK; Clare E. BONNAR; Allan D. STRUTHERS Endothelial function is defective in hypercholesterolaemia, and animal models have suggested that angiotensin-converting enzyme inhibitors may prevent arterial damage. We studied the effect of 6 months treatment with lisinopril...
Clin Sci (Lond) (1996) 91 (5): 617–620.
Published: 01 November 1996
...I. G. Chadwick; M. Kraskiewicz; W. W. Yeo; K. S. Higgins; P. R. Jackson; L. E. Ramsay 1. The dermal wheal response to bradykinin is increased by drugs which inhibit angiotensin-converting enzyme, and thus provides a measure of angiotensin-converting enzyme activity at the tissue level. An insertion...
Clin Sci (Lond) (1995) 89 (3): 261–265.
Published: 01 September 1995
... circulating endothelial cell markers (angiotensin-converting enzyme, von Willebrand factor antigen and thrombomodulin) and exertional heat stroke was studied. 2. Twelve recruits who had succumbed to exertional heat stroke during basic physical training (5000 m running) were included in the study. Another 10...
Clin Sci (Lond) (1995) 88 (4): 433–437.
Published: 01 April 1995
... or identical placebo tablets followed 3 h later by nebulized salbutamol or placebo inhalation; plasma renin, angiotensin II, serum angiotensin-converting enzyme and potassium were measured at intervals for 120 min after inhalation. 3. Following salbutamol, plasma renin and angiotensin II concentrations were...
Clin Sci (Lond) (1991) 81 (s25): 491–497.
Published: 01 October 1991
... hypertensive rats both before and after the administration of one of three angiotensin-converting enzyme inhibitors, captopril, enalapril or fosinopril, for 10 days. 2. Measurements of glomerular eicosanoid production were made under basal conditions and in the presence of excess exogenous arachidonic acid. 3...
Clin Sci (Lond) (1991) 80 (3): 241–247.
Published: 01 March 1991
...-treated with inhalation of either saline or a combination of the peptidase inhibitors phosphoramidon (0.1 mmol/l: 60 breaths; 7.5 nmol), to inhibit neutral endopeptidase, and captopril (4.6 mmol/l: 60 breaths; 350 nmol), to inhibit angiotensin-converting enzyme. 2. Airway microvascular leakage...
Clin Sci (Lond) (1990) 79 (1): 29–35.
Published: 01 July 1990
...Françoise Praddaude; Tuan Tran-Van; Jeannine Marchetti; Jean-Pierre Girolami; Jean-Louis Ader 1. To determine whether chronic angiotensin-converting enzyme inhibition induces a decrease in proximal tubular angiotensin-converting enzyme activity, urine and blood samples were collected in conscious...
Clin Sci (Lond) (1988) 75 (4): 411–414.
Published: 01 October 1988
... activity changed significantly. 5. Our observation points to RS being an acute-phase protein in man. 6. Serum angiotensin-converting enzyme was measured by both an enzymatic and an inhibitor-binding assay. Both assays showed decreased levels of angiotensin-converting enzyme during acute inflammation...
Clin Sci (Lond) (1984) 66 (1): 39–45.
Published: 01 January 1984
...Mizuo Miyazaki; Hideki Okunishi; Kazuo Nishimura; Noboru Toda 1. Angiotensin-converting enzyme (ACE) activity in blood vessels of different species was determined. 2. ACE was solubilized by Nonidet P-40, and assayed by reversible phase high performance liquid chromatography. Approximately 98% ACE...
Clin Sci (Lond) (1982) 63 (s8): 183s–185s.
Published: 01 October 1982
... blood pressure was observed at 3–4 h, whereas the maximum decrease of diastolic blood pressure was observed at 6 h. 4. Plasma angiotensin-converting enzyme activity was significantly reduced at all doses. The reduction persisted through 24 h after dosage. Plasma renin activity significantly increased...
Clin Sci (Lond) (1981) 61 (s7): 223s–225s.
Published: 01 December 1981
..., for the increase in renin secretion which follows the blockade of angiotensin-converting enzyme. © 1981 The Biochemical Society and the Medical Research Society 1981 angiotensin-converting enzyme captopril renal nerves sympathetic nervous system teprotide Clinical Science (1981) 6 1 , 2 2 3 ~ 2 2 5...
Clin Sci (Lond) (1981) 61 (s7): 277s–280s.
Published: 01 December 1981
...F. A. O. Mendelsohn; J. Csicsmann; J. S. Hutchinson 1. The kinetics of the inhibitory action of four different angiotensin-converting enzyme inhibitors was evaluated in vitro with rat lung enzyme and the substrate hippuryl-histidyl-leucine. 2. Enzyme velocity against substrate concentration curves...
Clin Sci (Lond) (1981) 61 (1): 75–83.
Published: 01 July 1981
... does not play a primary role in essential hypertension. 12 12 1980 2 2 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 angiotensin angiotensin-converting enzyme bradykinin sodium depletion Clinical Science (1981) 61,75-83 75 Acute effects...
Clin Sci (Lond) (1981) 61 (1): 97–105.
Published: 01 July 1981
...R. A. Banks; L. J. Beilin 1. Systemic and regional vascular changes were measured in conscious rabbits after intravenous sodium meclofenamate, captopril and phentolamine. These drugs were used respectively to inhibit prostaglandin synthesis and angiotensin-converting enzyme, and to block α...
Clin Sci (Lond) (1979) 57 (s5): 255s–258s.
Published: 01 December 1979
... pressure. It may play an important antihypertensive role in benign two-kidney, one-clip Goldblatt hypertension, a role which might be impaired in malignant hypertension. © 1979 The Biochemical Society and the Medical Research Society 1979 angiotensin-converting enzyme aprotinin hypertension...
J. G. Johnson, W. D. Black, R. A. Vukovich, F. E. Hatch, Jr, B. I. Friedman, C. F. Blackwell, A. N. Shenouda, L. Share, R. E. Shade, S. R. Acchiardo, E. E. Muirhead
Clin Sci Mol Med (1975) 48 (s2): 53s–56s.
Published: 01 January 1975
... and the Medical Research Society 1975 angiotensin-converting enzyme blood volume hypertension inhibitor renin Clinical Science and Molecular Medicine (1975) 48, 53s-56s. Treatment of patients with severe hypertension by inhibition of angiotensin-converting enzyme J . G . J O H N S O N , W. D . BLACK...