... angiotensinase converting enzyme inhibitors degradation renin C/itiicnlScietice( 1987) 72, 387-389 SHORT COMMUNICATION 387 Lack of angiotensin I accumulation after converting enzyme blockade by enalapril or lisinopril in man J. NUSSBERGER, D. B. BRUNNER, B. WAEBER, J. BIOLLAZ AND H. R. BRUNNER Divisiori o...

... of angiotensinase inhibitors, active renin declined. This decline was shown to be due to the conversion of active renin into an inactive form, which could be re-activated by trypsin. 3. In plasma from renin-stimulated rats, the rate of decline of active renin in vitro was accelerated; however, the relative amount...

.... Angiotensin I-converting enzyme (kininase II) and angiotensinase were localized in the brush border membrane. 2. It is suggested that kallikrein in the urine may originate from plasma membrane distal to the brush border of proximal tubules and the conversion of angiotensin I and the inactivation of bradykinin...