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1-7 of 7
Keywords: animal model
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (3): 127–150.
Published: 17 December 2015
... to manage PAD which can be applied to patients unlikely to benefit from interventional approaches. Many of the therapeutic agents successful in inducing angiogenesis and arteriogenesis in pre-clinical animal models of PAD have failed to have efficacy in human randomized control trials. One possible reason...
Articles
Roumen Parapanov, Jérôme Lugrin, Nathalie Rosenblatt-Velin, François Feihl, Bernard Waeber, Giuseppina Milano, Catherine Vergely, Na Li, Pal Pacher, Lucas Liaudet
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (2): 187–198.
Published: 30 April 2015
...-reperfusion, by enhancing cardiac oxidative stress and p38 activation. TLR5 may thus convey cardioprotective signals during myocardial infarction (MI). animal model inflammation innate immunity myocardial infarction oxidative stress toll-like receptors • MI triggers an inflammatory...
Articles
Amalia Forte, Barbara Rinaldi, Liberato Berrino, Francesco Rossi, Umberto Galderisi, Marilena Cipollaro
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (11): 615–634.
Published: 25 July 2014
... of restenosis, which remains a clinically relevant problem. Biomedical research in pre-clinical animal models of (re)stenosis, despite its limitations, has contributed enormously to the identification of processes involved in restenosis progression, going well beyond the initial dogma of a primarily...
Articles
Najib T. Ayas, Allen A. J. Hirsch, Ismail Laher, T. Douglas Bradley, Atul Malhotra, Vsevolod Y. Polotsky, Esra Tasali
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (4): 209–216.
Published: 10 April 2014
... and increased age, the strongest risk factor is obesity. The aim of the present review is to focus on three cutting-edge topics with respect to OSA. The section on animal models covers various strategies used to simulate the physiology or the effects of OSA in animals, and how these have helped to understand...
Articles
Jason P. Riley, Barbara Fuchs, Lisa Sjöberg, Gunnar P. Nilsson, Lars Karlsson, Sven-Erik Dahlén, Navin L. Rao, Mikael Adner
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (11): 533–542.
Published: 25 July 2013
.... airway hyper-responsiveness (AHR) animal model asthma combination treatment early allergic reaction guinea-pig mast cell • One feature of allergic asthma, the EAR (early allergic reaction), is not present in the commonly used mouse models and therefore we investigated the mediators...
Articles
Alain Rudiger, Alex Dyson, Karen Felsmann, Jane E. Carré, Valerie Taylor, Sian Hughes, Innes Clatworthy, Alessandro Protti, Denis Pellerin, Jana Lemm, Ralf A. Claus, Michael Bauer, Mervyn Singer
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (6): 391–401.
Published: 27 November 2012
... phosphatase 1 catalytic subunit β-isoform) were quantified by real-time PCR. Results were computed with specialized software (qBase plus; Biogazelle) and given as the ratio between the gene of interest and the housekeeping gene HMBS (hydroxymethylbilane synthase). animal model echocardiography...
Includes: Supplementary data
Articles
Masanori Iwase, Miya Wada, Masanori Wakisaka, Hideyuki Yoshizumi, Mototaka Yoshinari, Masatoshi Fujishima
Journal:
Clinical Science
Clin Sci (Lond) (1995) 89 (3): 255–260.
Published: 01 September 1995
... pressure in adult offspring. We recently developed a new animal model of high-risk pregnancy complicated by hypertension and diabetes mellitus [lo]. Spontaneously hyperten- sive rats (SHRs), a genetic hypertensive model, were made diabetic by neonatal STZ treatment. In this model, moderately severe...