...Johannes A. Kramps; Claus Franken; Joop H. Dijkman 1. Peripheral airspaces were selectively lavaged using balloon-tipped catheters of 2 mm diameter. 2. Molar anti-leucoprotease/α 1 -proteinase inhibitor ratios as determined in these lavage fluids by enzyme immunoassays ranged from 0.02 to 0.14...

.... Both α 1 PI (2 P < 0.01) and anti-leucoprotease (ALP) (2 P < 0.01) concentrations were lower in sol-phase from the α 1 PI-deficient group, although α 2 -macroglobulin (α 2 M) levels were similar. 3. There was no difference in α 1 PI function between the two groups, but the inhibitor was only ≃ 30...

... profile of the BAL fluid. 2. α 1 PI, anti-leucoprotease and α 2 -macroglobuin were present in all the samples. BAL fluid α 1 PI concentrations were significantly lower in the group with serum α 1 PI deficiency. 3. Lavage fluid from α 1 PI deficient subjects inhibited less porcine pancreatic elastase than...