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Keywords: antioxidant
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Clin Sci (Lond) (2025) 139 (03): 259–280.
Published: 03 February 2025
...Khalid Alotaibi; Nishkantha Arulkumaran; Alex Dyson; Mervyn Singer Mitochondrial reactive oxygen species (mROS) play a crucial physiological role in intracellular signalling. However, high levels of ROS can overwhelm antioxidant defences and lead to detrimental modifications in protein, lipid...
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Clin Sci (Lond) (2022) 136 (13): 1019–1023.
Published: 01 July 2022
... of synthesis of long chain highly unsaturated PUFAs. The authors interpreted their findings to indicate that a low hepatic content of n - 3 PUFAs has a causal role in NAFLD. The second paper reported lower hepatic antioxidant defences and increased markers of oxidative stress in NAFLD, consistent with a role...
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Clin Sci (Lond) (2012) 123 (3): 173–192.
Published: 12 April 2012
... that scavenge ROS (reactive oxygen species) and antioxidants in the management of several diseases related to free radical damage. The majority of free radicals are generated by mitochondria as a consequence of the mitochondrial cycle, whereas free radical accumulation is limited by the action of a variety...
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Clin Sci (Lond) (2012) 122 (6): 289–299.
Published: 22 November 2011
... cells and in blood vessels in muscle biopsies of patients. Antioxidant vitamins transiently restored FMD in patients [ΔAUC/τ (change in AUC/τ) for the brachial artery, +1.38±0.49%, P <0.05; ΔAUC/τ for the femoral artery, +0.98±0.24%, P <0.01] but had no effect on FMD in controls (brachial artery...
Includes: Supplementary data
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Clin Sci (Lond) (2011) 121 (10): 427–436.
Published: 25 July 2011
... and anxiety disorders, we increased fetal glucocorticoid exposure by administering the 11β-HSD inhibitor CBX (carbenoxolone; 12 mg·kg −1 of body weight·day −1 ) during the final week of murine gestation. We hypothesized that maternal antioxidant (tempol throughout pregnancy) would block glucocorticoid...
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Clin Sci (Lond) (2009) 116 (8): 659–668.
Published: 16 March 2009
... of age. AmplexRed was used to measure H 2 O 2 production. Activities of the antioxidant enzymes Mn-SOD (manganese superoxide dismutase), GPx (glutathione peroxidase) and catalase were measured. Compared with controls, a significant increase in Complex I H 2 O 2 production was found in intact mitochondria...
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Clin Sci (Lond) (2009) 116 (2): 87–98.
Published: 15 December 2008
... levels and CHD (coronary heart disease) risk. The cardioprotective effects of HDLs have been attributed to several mechanisms, including their involvement in the reverse cholesterol transport pathway. HDLs also have antioxidant, anti-inflammatory and antithrombotic properties and promote endothelial...
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Clin Sci (Lond) (2009) 116 (1): 41–43.
Published: 28 November 2008
...Adam Mullan; Naveed Sattar The oxidation hypothesis for CHD (coronary heart disease) is attractive; however, the almost universal failure of antioxidant vitamin supplementation as a CVD (cardiovascular disease) risk modifier challenges the oxidation hypothesis, at least as a concept that easily...
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Clin Sci (Lond) (2009) 116 (1): 71–79.
Published: 28 November 2008
...Ying-Ying Yang; Yi-Tsau Huang; Kuei-Chuan Lee; Fa-Yauh Lee; Tzung-Yan Lee; Ming-Chih Hou; Han-Chieh Lin; Shou-Dong Lee Liver cirrhosis is characterized by increased IHR (intrahepatic resistance) and lipid peroxidation, and decreased antioxidative defence. The present study investigates the effects...
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Clin Sci (Lond) (2008) 114 (4): 265–273.
Published: 15 January 2008
... of endothelial regeneration and neointimal growth. Moreover, evidence suggests antioxidants improve re-endothelialization and inhibit ISR. By promoting, rather than blocking, the healing process, antioxidant and other therapies may offer an alternative or additional approach over the antiproliferative approaches...
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Clin Sci (Lond) (2007) 113 (12): 459–466.
Published: 14 November 2007
... to evaluate further differences between group pairs. The Statistical Package for the Social Sciences (version 10.0) was used for all analysis. The significance level was set at 5%. apoptotic signalling antioxidant high altitude membrane integrity mitochondrial dysfunction vitamin E (α...
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Clin Sci (Lond) (2007) 112 (11): 543–555.
Published: 01 May 2007
... of anti-inflammatory cytokines, whereas chronic exercise reduces basal levels of pro-inflammatory cytokines. Exercise training also induces the expression of antioxidant and anti-inflammatory mediators in the vascular wall that may directly inhibit the development of atherosclerosis. Limited studies...
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Clin Sci (Lond) (2004) 107 (6): 589–600.
Published: 24 November 2004
.... Sixteen mountaineers (11 males/five females) were matched for physical fitness and caloric intake and assigned in a double-blind manner to either antioxidant ( n =8) or placebo ( n =8) supplementation, which was enforced for 7 days at sea level and during an 11-day ascent to 4780 m. Enteral prophylaxis...
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Clin Sci (Lond) (2004) 107 (6): 625–629.
Published: 24 November 2004
... demonstrated NEFA-induced endothelial dysfunction of large conduit arteries, reversible by the antioxidant ascorbic acid. We therefore investigated the effect of NEFAs on carbachol-induced endothelium-dependent vasodilation of rat resistance arteries in vitro using the technique of wire myography. In addition...
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Clin Sci (Lond) (2004) 106 (1): 107–109.
Published: 01 January 2004
... intrinsic antioxidant, during exhaustive exercise, we performed a randomized, blinded, placebo-controlled study on eight male well-trained athletes. subjects were randomly allocated to either a group given 1000 mg of ascorbate daily ( n =4) or a placebo group ( n =4). Fasting serum lipids and urate...
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Clin Sci (Lond) (2003) 105 (4): 425–430.
Published: 01 October 2003
...W. S. WARING; A. CONVERY; V. MISHRA; A. SHENKIN; D. J. WEBB; S. R. J. MAXWELL Uric acid (UA) possesses free-radical-scavenging properties, and systemic administration is known to increase serum antioxidant capacity. However, it is not known whether this protects against oxidative stress...
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Clin Sci (Lond) (2003) 105 (2): 173–180.
Published: 01 August 2003
..., lipid peroxidation, cellular fibronectin and ferric reducing ability of plasma (FRAP; i.e. antioxidant capacity). After methionine loading, whole-blood levels of free and oxidized cysteine and homocysteine were increased in both groups. Furthermore, the total plasma levels of homocysteine were higher...
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Clin Sci (Lond) (1998) 95 (4): 459–465.
Published: 01 October 1998
... concerning the therapeutic benefit of the former which is an expensive form of treatment. 2. Albumin has several biological functions, in particular as a ligand binder. It also acts as an extracellular transition metal ion-binding and radical-scavenging antioxidant. These functions are influenced...
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Clin Sci (Lond) (1991) 81 (3): 413–417.
Published: 01 September 1991
...John M. C. Gutteridge 1. The copper-containing protein caeruloplasmin has several oxidase activities. 2. Its ability to catalyse the oxidation of ferrous ions to the ferric state (ferroxidase activity) makes it an important antioxidant in vivo . 3. Recent reports have suggested that oral...
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