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1-32 of 32
Keywords: aorta
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Articles
Rafael Almendra-Pegueros, Cristina Rodriguez, Mercedes Camacho, David Sánchez-Infantes, J. Luis Sánchez-Quesada, Susana Cáncer, Elvira Pérez-Marlasca, Gema Medina-Gómez, José Martinez-González, Ana B. García-Redondo, María Galán
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (06): 357–372.
Published: 25 March 2025
... in AAA. RNA sequencing was carried out in abdominal aorta from patients with AAA and healthy donors. We identified 6576 differentially expressed (DE)-mRNAs and 1283 DE-lncRNAs. Interestingly, bioinformatic analysis revealed a set of 368 DE-lncRNAs related to ER stress. The differential expression...
Includes: Supplementary data
Articles
Adventitial recruitment of Lyve-1 − macrophages drives aortic aneurysm in an angiotensin-2-based murine model
Available to PurchaseAntigona Ulndreaj, Angela Li, Yonghong Chen, Rickvinder Besla, Shaun Pacheco, Marwan G. Althagafi, Myron I. Cybulsky, Thomas Lindsay, Clinton S. Robbins, John S. Byrne
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1295–1309.
Published: 28 May 2021
... the incidence of AAA. Conditional depletion of Lyve-1 + aortic macrophages was achieved by generating Lyve-1 wt/cre Csf1r fl/fl mice. Selective depletion of Lyve-1 + aortic macrophages had no protective effects following AT2/BAPN administration and resulted in increased aortic dilatation in the suprarenal aorta...
Includes: Supplementary data
Articles
Involvement of proteinase activated receptor-2in the vascular response to sphingosine 1-phosphate
Available to PurchaseFiorentina Roviezzo, Antonella De Angelis, Luana De Gruttola, Antonio Bertolino, Nikol Sullo, Vincenzo Brancaleone, Mariarosaria Bucci, Raffaele De Palma, Konrad Urbanek, Bruno D’Agostino, Angela Ianaro, Raffaella Sorrentino, Giuseppe Cirino
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (8): 545–556.
Published: 20 December 2013
... been performed by using isolated mouse aortas. Both S1P and PAR-2 agonists induced endothelium-dependent vasorelaxation. L -NAME ( N G -nitro- L -arginine methyl ester) and wortmannin abrogated the S1P-induced vasorelaxatioin, while significantly inhibiting the PAR-2-mediated effect. Either ENMD1068...
Articles
STIM1/Orai1 contributes to sex differences in vascular responses to calcium in spontaneously hypertensive rats
Available to PurchaseFernanda R. C. Giachini, Victor V. Lima, Fernando P. Filgueira, Anne M. Dorrance, Maria Helena C. Carvalho, Zuleica B. Fortes, R. Clinton Webb, Rita C. Tostes
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (5): 215–226.
Published: 28 October 2011
... to functionally evaluate Ca 2+ influx-induced contractions. Compared with females, aorta from male SHRSP displayed: (i) increased contraction during the Ca 2+ -loading period; (ii) similar transient contraction during Ca 2+ release from the intracellular stores; (iii) increased activation of STIM1 and Orai1...
Articles
Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE −/− mice
Open AccessAlan Daugherty, Debra L. Rateri, Israel F. Charo, A. Phillip Owens, III, Deborah A. Howatt, Lisa A. Cassis
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (11): 681–689.
Published: 09 March 2010
... in a circumscribed area of the anterior region of ascending aortas in which elastin breaks were focal and almost transmural. All regions of the ascending aorta of AngII-infused mice had diffuse medial macrophage accumulation. Deficiency of CCR2 greatly attenuated the AngII-induced lumen dilatation in the ascending...
Articles
Ethanol-induced vasoconstriction is mediated via redox-sensitive cyclo-oxygenase-dependent mechanisms
Available to PurchaseAlvaro Yogi, Glaucia E. Callera, Ulisses V. Hipólito, Catiane R. Silva, Rhian M. Touyz, Carlos R. Tirapelli
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (11): 657–668.
Published: 09 March 2010
... on the basis the H 2 O 2 standard curve. aorta calcium hydrogen peroxide prostanoid reactive oxygen species superoxide anion Several studies in animals and humans have demonstrated that ethanol consumption is associated with cardiovascular pathologies such as hypertension [ 1 – 3...
Articles
Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2006) 111 (2): 145–151.
Published: 13 July 2006
... was undertaken to define the inhibitory effects of saturated NEFAs on EDR (endothelium-dependent relaxation). Experiments were performed in rings of rabbit aorta to establish (i) dose–response relationships, (ii) the effect of chain length, (iii) the effect of the presence of double bonds, (iv) reversibility...
Articles
Opposite changes in carotid versus aortic stiffness during healthy human pregnancy
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (1): 103–107.
Published: 23 June 2005
... These authors contributed equally to this work. Correspondence: Dr Márk Kollai (email [email protected] ). 10 12 2004 22 2 2005 1 3 2005 1 3 2005 The Biochemical Society 2005 aorta carotid artery elasticity pregnancy stiffness Pregnancy is associated...
Articles
Effect of non-invasive calibration of radial waveforms on error in transfer-function-derived central aortic waveform characteristics
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (2): 205–211.
Published: 27 July 2004
... fidelity pressure transducer at the tip designed for non-invasive use. aorta arterial transfer function augmentation index blood pressure radial artery tonometry Over recent years there has been increasing interest in the technique of reconstruction of central aortic pressure waveforms...
Articles
Sabine TÉLÉMAQUE-POTTS, Rhoda E. KUC, Janet J. MAGUIRE, Eliot OHLSTEIN, Masashi YANAGISAWA, Anthony P. DAVENPORT
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 357S–362S.
Published: 01 September 2002
... in plasma ET-1 and systemic blood pressure (46%) 4 days after viral administration, compared with β-galactosidase (Ad.CMV.β-gal) injected as control. The density ( B max ) of the ET receptor ET A measured in aortas was reduced significantly by more than 50% to 17±2fmol·mg -1 of protein for the Ad.CMV.ET-1...
Articles
Effects of obesity on endothelium-dependent reactivity during acute nitric oxide synthase inhibition: modulatory role of endothelin
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 13S–15S.
Published: 01 September 2002
...Tobias TRAUPE; Livius V. D'USCIO; Klaus MUENTER; Henning MORAWIETZ; Wilhelm VETTER; Matthias BARTON This study investigated vascular reactivity in response to acetylcholine, in the presence of acute inhibition of nitric oxide synthase, in the carotid artery and aorta of obese C57Bl6/J mice fed...
Articles
Effects of exercise training on expression of endothelin-1 mRNA in the aorta of aged rats
Available to PurchaseSeiji MAEDA, Takashi MIYAUCHI, Motoyuki IEMITSU, Takumi TANABE, Tomoko YOKOTA, Katsutoshi GOTO, Iwao YAMAGUCHI, Mitsuo MATSUDA
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 118S–123S.
Published: 01 September 2002
... produced by vascular endothelial cells. Because ET-1 has a potent vasoconstrictor effect on vessels, it may be involved in the regulation of vascular tonus. We hypothesized that aging causes a decrease in ET-1 expression in aorta, and that exercise training improves the aging-induced decrease in ET-1...
Articles
Empirical estimates of mean aortic pressure: advantages, drawbacks and implications for pressure redundancy
Available to PurchaseDenis CHEMLA, Jean-Louis HÉBERT, Eduardo APTECAR, Jean-Xavier MAZOIT, Karen ZAMANI, Robert FRANK, Guy FONTAINE, Alain NITENBERG, Yves LECARPENTIER
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (1): 7–13.
Published: 24 June 2002
... pressure. We tested the hypothesis that a fixed form factor can also be used at the aortic root level. We recorded systolic aortic pressure (SAP) and diastolic aortic pressure (DAP), and we calculated aortic pulse pressure (PP) and the time-averaged MAP in the aorta of resting adults ( n = 73; age 43±14...
Articles
Transvenous echo Doppler in baboons: a new window to the cardiovascular system
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2000) 99 (2): 141–147.
Published: 17 July 2000
... arteries, descending aorta, both renal artery origins, ascending aorta, including the aortic arch, main pulmonary artery and its bifurcation, as well as head and neck vessels. Novel intracardiac views were obtained, including right ventricular long axis, left ventricular apex and ‘flask’ views of the left...
Includes: Supplementary data
Articles
Portal hypertension increases vasoconstrictor responsiveness of rat aorta
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Journal:
Clinical Science
Clin Sci (Lond) (1998) 96 (1): 41–47.
Published: 01 January 1999
...Claire CONNOLLY; Teresa CAWLEY; P. Aiden MCCORMICK; James R. DOCHERTY We have examined the effects of pre-hepatic portal hypertension on the responsiveness of aorta from Wistar and Sprague–Dawley rats. Rats were made portal hypertensive by creating a calibrated portal vein stenosis, or sham...
Articles
Augmented effects of methionine and cholesterol in decreasing the elastic lamina while thickening the aortic wall in the rat aorta
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1998) 95 (5): 589–593.
Published: 01 November 1998
... important role for these two agents in combination than for either agent alone. Correspondence : Dr J. J. Liu. 29 1 1998 20 4 1998 20 5 1998 The Biochemical Society and the Medical Research Society © 1998 1998 aorta cholesterol elastic lamina homocysteine synergism...
Articles
Vascular Hyporesponsiveness in Aortic Rings from Cirrhotic Rats: Role of Nitric Oxide and Endothelium
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1996) 91 (6): 733–738.
Published: 01 December 1996
.... In contrast, endothelial vasodilatory response to acetylcholine is not altered in this model of cirrhosis, which indicates that not all mechanisms of nitric oxide release are abnormal. acetylcholine aorta endothelium liver cirrhosis nitric oxide phenylephrine Clinical Science (1996) 91, 733-738...
Articles
Effects of Fish Oil Supplementation on Atherosclerosis in Different Regions of the Aorta of Rabbits with Diet-Induced Hypercholesterolaemia
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1995) 89 (5): 497–504.
Published: 01 November 1995
...Ming-Fong Chen; Hsiu-Ching Hsu; Yuan-Teh Lee 1. The effects of fish oil supplementation on atherosclerosis in different regions of the aorta in rabbits with diet-induced hypercholesterolaemia were studied. Control and experimental rabbits were fed a 1% cholesterol-enriched diet with or without 10...
Articles
Metalloproteinases in degenerative aortic disease
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (2): 233–239.
Published: 01 August 1991
...N. Vine; Janet T. Powell 1. Atherosclerosis and aneurysm of the abdominal aorta are associated with thinning of the medial connective tissue. We have investigated the presence of the connective-tissue-degrading metalloproteinases in homogenates prepared from atherosclerotic, aneurysmal and control...
Articles
Partial isolation and function of the prostacyclin regulating plasma factor
Available to PurchaseH. Deckmyn, C. Zoja, J. Arnout, A. Todisco, F. VANDEN Bulcke, L. D'hondt, N. Hendrickx, P. Gresele, J. Vermylen
Journal:
Clinical Science
Clin Sci (Lond) (1985) 69 (4): 383–393.
Published: 01 October 1985
... role of this plasma activity is probably to protect the vascular prostacyclin forming system from exhaustion during persistent irritation. 11 2 1985 16 4 1985 © 1985 The Biochemical Society and the Medical Research Society 1985 aorta cyclo-oxygenase glutathione human plasma...
Articles
Relative agonist potency as a means of differentiating α-adrenoceptors and α-adrenergic mechanisms
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (s10): 9s–15s.
Published: 01 January 1985
...Robert R. Ruffolo, Jr 1. Relative potencies (ED 50 ), affinities (assessed as dissociation constants) and efficacies (i.e. ability to activate the receptor) of agonists are useful in subclassifying and differentiating α-adrenoceptors. 2. The postsynaptic α-adrenoceptor of rat aorta is of the α 1...
Articles
Kinetics of Proliferation of Rat Aortic Smooth Muscle Cells in Goldblatt One-Kidney, one-Clip Hypertension
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1983) 65 (4): 351–357.
Published: 01 October 1983
...P. G. Carlier; G. Rorive; H. Barbason 1. Wistar female rats were made hypertensive by applying a silver clip to the left renal artery and removing the right kidney. In aortas, the proliferation fraction of smooth muscle cells, DNA synthesis and wet weight have been correlated with the blood...
Articles
Adrenalectomy and Glucocorticoid Administration In Vivo do Not Affect Production of 6-Oxoprostaglandin F 1α by Rat Aortae
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1983) 65 (1): 85–87.
Published: 01 July 1983
... 1α (6-oxo-PGF 1α ) was measured by radioimmunoassay of the supernatant fluid from rings of aorta incubated in vitro. 2. Up to 32 days after adrenalectomy, neither adrenalectomy nor dexamethasone (2 μg/day and 20 μg/day) influenced aortic 6-oxo-PGF 1α production. 3. High doses of dexamethasone (60 μg...
Articles
Increased Vascular Sensitivity to Serotonin and Methysergide in Hypertension in Rats
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Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 73s–75s.
Published: 01 October 1982
...)-hypertensive and Sprague-Dawley normotensive rats. 3. Arteries from hypertensive rats (except SHR aorta) were more sensitive (lower ED 30 ) to noradrenaline, serotonin and methysergide relative to those from controls. 4. The magnitude of the leftward shift in ED 30 was similar for the three agonists...
Articles
Renal and Vascular Wall Prostaglandins in Spontaneously Hypertensive Rats
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 253s–255s.
Published: 01 October 1982
... The Biochemical Society and the Medical Research Society 1982 aorta kidney prostaglandins Clinical Science (1982) 6 3 , 2 5 3 ~ ~ 2 5 5 ~ 253s Renal and vascular wall prostaglandins in spontaneously hypertensive rats Y U K I O O Z A W A , K E I K A K A N , K O N O S U K E K O N I S H I , W A I C H I K...
Articles
Distribution and Properties of Angiotensin-Converting Enzyme in Cerebral Microvessels of the Rabbit and Rat
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Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 249s–251s.
Published: 01 December 1981
... by heparin under conditions where lipoprotein lipase was effectively removed. © 1981 The Biochemical Society and the Medical Research Society 1981 angiotensin aorta converting enzyme microvessels CIinicaZScience (1981) 61,249s-251s 249s Distribution and properties of angio tensin-converting...
Articles
Regression of the Baroreceptor Resetting in Hypertension of Long Duration in Rats
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Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 185s–186s.
Published: 01 December 1981
...Marie Sumitani; E. M. Krieger 1. The extent of reversal of baroreceptor resetting after pressure normalization was studied in rats with renal hypertension of up to 6 months duration. The aortas of these rats when compared with those of 2 month hypertensive rats were thicker (44%) and had a larger...
Articles
A Comparison of Physical Characteristics of Active Renin Isolated from Aorta, Plasma and Kidney of the Rat
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Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (6): 671–678.
Published: 01 December 1981
...J. D. Barrett; P. Eggena; J. F. Krall; M. P. Sambhi 1. Renin-like enzymes have been isolated from aorta, plasma and kidney tissue of the rat. The enzymes have been compared with respect to pH optima, molecular weight and isoelectric points. 2. Two distinct molecular-weight forms were isolated from...
Articles
Effect of Sodium Intake on Angiotensin-Converting Enzyme Activity of Aorta in Rats
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (2): 249–251.
Published: 01 August 1981
...Kenji Mizuno; Shunichi Hata; Soitsu Fukuchi 1. The effect of sodium intake on angiotensin-converting enzyme activity in subcellular fractions of aorta (homogenate, mitochondria, microsomes and supernatant) was studied in normotensive and spontaneously hypertensive rats. 2. Angiotensin-converting...
Articles
A Sympathetic Pressor Reflex in the Conscious Dog
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (s5): 209s–211s.
Published: 01 December 1979
...M. Pagani; M. Bergamaschi; A. Malliani 1. The effects of mechanical activation of aortic sympathetic sensory fibres have been studied in conscious dogs. 2. A cannula covered by an inflatable rubber balloon, previously implanted in the descending thoracic aorta, was used to stretch the aortic walls...
Articles
An 8 Month Longitudinal Study of Changes in Elastic and Muscular Arteries and Veins of the Rabbit with Sustained Hypertension after Abdominal Aorta Constriction
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Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (s5): 7s–9s.
Published: 01 December 1979
...R. D. Bevan; P. Eggena; W. R. Hume; L. T. Lais; E. Van Marthens; J. A. Bevan 1. Long-term changes in the function and structure of arteries and veins in response to an elevation in arterial pressure have been studied in the rabbit after partial abdominal aorta constriction. 2. Transient changes...
Articles
Some Aspects of Sodium Movement across Porcine Aortic Walls in Vitro
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Journal:
Clinical Science
Clin Sci Mol Med (1977) 53 (5): 467–471.
Published: 01 November 1977
... that aortic tissue can actively transport sodium and it is suggested that this mechanism could play a part in blood pressure control. © 1977 The Biochemical Society and the Medical Research Society 1977 aorta β-adrenoreceptor-blocking agents sodium 1 10 1976 30 6 1977 Clinical...
