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Keyword: aorta
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Articles
Clin Sci (Lond) (2014) 126 (8): 545-556.
Published: 20 December 2013
... been performed by using isolated mouse aortas. Both S1P and PAR-2 agonists induced endothelium-dependent vasorelaxation. L -NAME ( N G -nitro- L -arginine methyl ester) and wortmannin abrogated the S1P-induced vasorelaxatioin, while significantly inhibiting the PAR-2-mediated effect. Either ENMD1068, a...
Articles
Clin Sci (Lond) (2012) 122 (5): 215-226.
Published: 28 October 2011
... functionally evaluate Ca 2+ influx-induced contractions. Compared with females, aorta from male SHRSP displayed: (i) increased contraction during the Ca 2+ -loading period; (ii) similar transient contraction during Ca 2+ release from the intracellular stores; (iii) increased activation of STIM1 and Orai1, as...
Articles
Clin Sci (Lond) (2010) 118 (11): 681-689.
Published: 09 March 2010
... circumscribed area of the anterior region of ascending aortas in which elastin breaks were focal and almost transmural. All regions of the ascending aorta of AngII-infused mice had diffuse medial macrophage accumulation. Deficiency of CCR2 greatly attenuated the AngII-induced lumen dilatation in the ascending...
Articles
Clin Sci (Lond) (2010) 118 (11): 657-668.
Published: 09 March 2010
... concentrations of ethanol remains unclear. Correspondence: Professor Carlos R. Tirapelli (email crtirapelli@eerp.usp.br ). 6 7 2009 12 11 2009 3 12 2009 3 12 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 aorta calcium hydrogen peroxide...
Articles
Clin Sci (Lond) (2006) 111 (2): 145-151.
Published: 13 July 2006
... undertaken to define the inhibitory effects of saturated NEFAs on EDR (endothelium-dependent relaxation). Experiments were performed in rings of rabbit aorta to establish (i) dose–response relationships, (ii) the effect of chain length, (iii) the effect of the presence of double bonds, (iv) reversibility and...
Articles
Clin Sci (Lond) (2005) 109 (1): 103-107.
Published: 23 June 2005
... different change in arterial elastic behaviour. 1 These authors contributed equally to this work. Correspondence: Dr Márk Kollai (email kollai@elet2.sote.hu ). 10 12 2004 22 2 2005 1 3 2005 1 3 2005 The Biochemical Society 2005 aorta carotid artery...
Articles
Clin Sci (Lond) (2004) 107 (2): 205-211.
Published: 27 July 2004
... waveform parameters, than using a generalized transfer function. Correspondence: Professor James D. Cameron (email James.Cameron@med.monash.edu.au ). 4 9 2003 18 3 2004 13 5 2004 13 5 2004 The Biochemical Society 2004 aorta arterial transfer function augmentation...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 13S-15S.
Published: 01 September 2002
...Tobias TRAUPE; Livius V. D'USCIO; Klaus MUENTER; Henning MORAWIETZ; Wilhelm VETTER; Matthias BARTON This study investigated vascular reactivity in response to acetylcholine, in the presence of acute inhibition of nitric oxide synthase, in the carotid artery and aorta of obese C57Bl6/J mice fed on a...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 357S-362S.
Published: 01 September 2002
... in plasma ET-1 and systemic blood pressure (46%) 4 days after viral administration, compared with β-galactosidase (Ad.CMV.β-gal) injected as control. The density ( B max ) of the ET receptor ET A measured in aortas was reduced significantly by more than 50% to 17±2fmol·mg -1 of protein for the...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 118S-123S.
Published: 01 September 2002
... produced by vascular endothelial cells. Because ET-1 has a potent vasoconstrictor effect on vessels, it may be involved in the regulation of vascular tonus. We hypothesized that aging causes a decrease in ET-1 expression in aorta, and that exercise training improves the aging-induced decrease in ET-1...
Articles
Clin Sci (Lond) (2002) 103 (1): 7-13.
Published: 24 June 2002
... pressure. We tested the hypothesis that a fixed form factor can also be used at the aortic root level. We recorded systolic aortic pressure (SAP) and diastolic aortic pressure (DAP), and we calculated aortic pulse pressure (PP) and the time-averaged MAP in the aorta of resting adults ( n = 73; age 43±14...
Articles
Clin Sci (Lond) (2000) 99 (2): 141-147.
Published: 17 July 2000
... arteries, descending aorta, both renal artery origins, ascending aorta, including the aortic arch, main pulmonary artery and its bifurcation, as well as head and neck vessels. Novel intracardiac views were obtained, including right ventricular long axis, left ventricular apex and ‘flask’ views of the left...
Includes: Supplementary data
Articles
Clin Sci (Lond) (1998) 96 (1): 41-47.
Published: 01 January 1999
...Claire CONNOLLY; Teresa CAWLEY; P. Aiden MCCORMICK; James R. DOCHERTY We have examined the effects of pre-hepatic portal hypertension on the responsiveness of aorta from Wistar and Sprague–Dawley rats. Rats were made portal hypertensive by creating a calibrated portal vein stenosis, or sham...
Articles
Clin Sci (Lond) (1998) 95 (5): 589-593.
Published: 01 November 1998
... indicate a more important role for these two agents in combination than for either agent alone. Correspondence : Dr J. J. Liu. 29 1 1998 20 4 1998 20 5 1998 The Biochemical Society and the Medical Research Society © 1998 1998 aorta cholesterol elastic lamina...
Articles
Clin Sci (Lond) (1996) 91 (6): 733-738.
Published: 01 December 1996
... 1996 acetylcholine aorta endothelium liver cirrhosis nitric oxide phenylephrine Clinical Science (1996) 91, 733-738 (Printed in Great Britain) 733 Vascular hyporesponsiveness in aortic rings from cirrhotic rats: role of nitric oxide and endothelium M. Clara ORT/Z, Lourdes A. FORTEPIANI...
Articles
Clin Sci (Lond) (1995) 89 (5): 497-504.
Published: 01 November 1995
...Ming-Fong Chen; Hsiu-Ching Hsu; Yuan-Teh Lee 1. The effects of fish oil supplementation on atherosclerosis in different regions of the aorta in rabbits with diet-induced hypercholesterolaemia were studied. Control and experimental rabbits were fed a 1% cholesterol-enriched diet with or without 10...
Articles
Clin Sci (Lond) (1991) 81 (2): 233-239.
Published: 01 August 1991
...N. Vine; Janet T. Powell 1. Atherosclerosis and aneurysm of the abdominal aorta are associated with thinning of the medial connective tissue. We have investigated the presence of the connective-tissue-degrading metalloproteinases in homogenates prepared from atherosclerotic, aneurysmal and control...
Articles
Clin Sci (Lond) (1985) 69 (4): 383-393.
Published: 01 October 1985
... physiological role of this plasma activity is probably to protect the vascular prostacyclin forming system from exhaustion during persistent irritation. 11 2 1985 16 4 1985 © 1985 The Biochemical Society and the Medical Research Society 1985 aorta cyclo-oxygenase glutathione human...
Articles
Clin Sci (Lond) (1985) 68 (s10): 9s-15s.
Published: 01 January 1985
...Robert R. Ruffolo, Jr 1. Relative potencies (ED 50 ), affinities (assessed as dissociation constants) and efficacies (i.e. ability to activate the receptor) of agonists are useful in subclassifying and differentiating α-adrenoceptors. 2. The postsynaptic α-adrenoceptor of rat aorta is of the α 1...
Articles
Clin Sci (Lond) (1983) 65 (4): 351-357.
Published: 01 October 1983
...P. G. Carlier; G. Rorive; H. Barbason 1. Wistar female rats were made hypertensive by applying a silver clip to the left renal artery and removing the right kidney. In aortas, the proliferation fraction of smooth muscle cells, DNA synthesis and wet weight have been correlated with the blood...
Articles
Clin Sci (Lond) (1983) 65 (1): 85-87.
Published: 01 July 1983
... 1α (6-oxo-PGF 1α ) was measured by radioimmunoassay of the supernatant fluid from rings of aorta incubated in vitro. 2. Up to 32 days after adrenalectomy, neither adrenalectomy nor dexamethasone (2 μg/day and 20 μg/day) influenced aortic 6-oxo-PGF 1α production. 3. High doses of dexamethasone (60 μg...
Articles
Clin Sci (Lond) (1982) 63 (s8): 73s-75s.
Published: 01 October 1982
...)-hypertensive and Sprague-Dawley normotensive rats. 3. Arteries from hypertensive rats (except SHR aorta) were more sensitive (lower ED 30 ) to noradrenaline, serotonin and methysergide relative to those from controls. 4. The magnitude of the leftward shift in ED 30 was similar for the three agonists in...
Articles
Clin Sci (Lond) (1982) 63 (s8): 253s-255s.
Published: 01 October 1982
... Biochemical Society and the Medical Research Society 1982 aorta kidney prostaglandins Clinical Science (1982) 6 3 , 2 5 3 ~ ~ 2 5 5 ~ 253s Renal and vascular wall prostaglandins in spontaneously hypertensive rats Y U K I O O Z A W A , K E I K A K A N , K O N O S U K E K O N I S H I , W A I C H I K...
Articles
Clin Sci (Lond) (1981) 61 (6): 671-678.
Published: 01 December 1981
...J. D. Barrett; P. Eggena; J. F. Krall; M. P. Sambhi 1. Renin-like enzymes have been isolated from aorta, plasma and kidney tissue of the rat. The enzymes have been compared with respect to pH optima, molecular weight and isoelectric points. 2. Two distinct molecular-weight forms were isolated from...
Articles
Clin Sci (Lond) (1981) 61 (2): 249-251.
Published: 01 August 1981
...Kenji Mizuno; Shunichi Hata; Soitsu Fukuchi 1. The effect of sodium intake on angiotensin-converting enzyme activity in subcellular fractions of aorta (homogenate, mitochondria, microsomes and supernatant) was studied in normotensive and spontaneously hypertensive rats. 2. Angiotensin-converting...
Articles
Clin Sci (Lond) (1981) 61 (s7): 249s-251s.
Published: 01 January 1981
... heparin under conditions where lipoprotein lipase was effectively removed. © 1981 The Biochemical Society and the Medical Research Society 1981 angiotensin aorta converting enzyme microvessels CIinicaZScience (1981) 61,249s-251s 249s Distribution and properties of angio tensin-converting...
Articles
Clin Sci (Lond) (1981) 61 (s7): 185s-186s.
Published: 01 January 1981
...Marie Sumitani; E. M. Krieger 1. The extent of reversal of baroreceptor resetting after pressure normalization was studied in rats with renal hypertension of up to 6 months duration. The aortas of these rats when compared with those of 2 month hypertensive rats were thicker (44%) and had a larger...
Articles
Clin Sci (Lond) (1979) 57 (s5): 209s-211s.
Published: 01 January 1979
...M. Pagani; M. Bergamaschi; A. Malliani 1. The effects of mechanical activation of aortic sympathetic sensory fibres have been studied in conscious dogs. 2. A cannula covered by an inflatable rubber balloon, previously implanted in the descending thoracic aorta, was used to stretch the aortic walls...
Articles
Clin Sci (Lond) (1979) 57 (s5): 7s-9s.
Published: 01 January 1979
...R. D. Bevan; P. Eggena; W. R. Hume; L. T. Lais; E. Van Marthens; J. A. Bevan 1. Long-term changes in the function and structure of arteries and veins in response to an elevation in arterial pressure have been studied in the rabbit after partial abdominal aorta constriction. 2. Transient changes...
Articles
Clin Sci Mol Med (1977) 53 (5): 467-471.
Published: 01 November 1977
... appears that aortic tissue can actively transport sodium and it is suggested that this mechanism could play a part in blood pressure control. 1 10 1976 30 6 1977 © 1977 The Biochemical Society and the Medical Research Society 1977 aorta β-adrenoreceptor-blocking agents sodium...