... samples but their role is unclear. The effect of conditional depletion of CD11c + cells on experimental AAA was investigated in the angiotensin II (AngII)-infused apolipoprotein E-deficient ( ApoE –/– ) mouse model. Approach: CD11c-diphtheria toxin (DT or D.tox ) receptor ( D TR), ovalbumin ( O VA...

... determinant of LDL-receptor degradation, is strongly related to total cholesterol and triacylglycerol levels in homozygous carriers of the apolipoprotein ε2 allele. This observation provides new insight into the pathogenesis of type III hyperlipidaemia and its treatment. apolipoprotein E familial...

... their dietary sodium intake. However, although salt intake is correlated with BP (blood pressure), it also partly determines the activation state of the RAAS (renin–angiotensin–aldosterone system), a key mediator of diabetes-associated atherosclerosis. apoE KO (apolipoprotein E knockout) mice were allocated...

...Mark A. WATSON; Laura GAY; William S. L. STEBBINGS; Chris T. M. SPEAKMAN; Sheila A. BINGHAM; Alexandre LOKTIONOV Apolipoprotein E ( ApoE ) gene polymorphism is a major factor in lipid metabolism. It has been suggested that this polymorphism can modulate colorectal tumour risk. We tested...

... and the other arising in the C-terminal domain. 26 2 1997 17 2 1997 © 1997 The Biochemical Society and the Medical Research Society 1997 Clinical Science (1997) 93,89-95 (Printed in Great Britain) 09 Compound heterozygote for both rare apolipoprotein E I (Gly'27-+Asp, Arg'58+Cys) and E3(Cysi...

... where two rare apolipoprotein E mutants, APOE*3(Cys-112→Arg; Arg-251→Gly) and APOE*2(Val-236 →Glu), segregate were analysed to determine whether the APOE mutants were associated with dyslipidaemia. 2. The proband, a 51-year-old Caucasian male, was a carrier of APOE*3(Cys-112→Arg; Arg-251→Gly) and his...