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Keywords: apoptosis
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) CS20242052.
Published: 07 November 2024
... Copyright 2024 The Author(s) 2024 This is an Accepted Manuscript; not the final Version of Record. Archiving permitted only in line with the archiving policy of Portland Press Limited. Cell free DNA apoptosis secondary necrosis oxidative damage hypobaric hypoxia high altitude pulmonary edema...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (6): 351–369.
Published: 12 March 2024
... the signaling pathways involved in septic AKI using the mouse models of lipopolysaccharide (LPS) treatment and cecal ligation and puncture (CLP). In these models, renal inflammation and tubular cell apoptosis were accompanied by the aberrant activation of the mechanistic target of rapamycin (mTOR...
Includes: Supplementary data
Articles
Marharyta Semenikhina, Mykhailo Fedoriuk, Mariia Stefanenko, Christine A. Klemens, Alena Cherezova, Brendan Marshall, Gentzon Hall, Vladislav Levchenko, Ashish K. Solanki, Joshua H. Lipschutz, Daria V. Ilatovskaya, Alexander Staruschenko, Oleg Palygin
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (24): 1789–1804.
Published: 21 December 2023
..., foot process effacement, and apoptosis, possibly leading to severe defects in glomerular filtration barrier integrity and kidney health. Under these circumstances, the potential therapeutic application of TRV for hypertension treatment requires further investigation to assess the balance...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (15): 1195–1208.
Published: 10 August 2023
...Qiaoli Tang; Wanting Shi; Ming Liu; Liqin Tang; Wei Ren; Shaolin Shi MPV17 is a mitochondrial inner membrane protein, and its deficiency can cause mitochondrial DNA (mtDNA) depletion, increase reactive oxygen species (ROS), and promote apoptosis in several cell types, suggesting that MPV17 plays...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (6): 453–468.
Published: 21 March 2023
...Jinshan Xing; Gan Qiao; Xin Luo; Shuang Liu; Shaokun Chen; Geng Ye; Chunxiang Zhang; Jingyan Yi Polycystic ovary syndrome (PCOS), a common reproductive endocrine disorder in women of reproductive age, causes anovulatory infertility. Increased apoptosis of granulosa cells has been identified as one...
Articles
Jianmin Liu, Daoquan Liu, Xueneng Zhang, Yan Li, Xun Fu, Weixiang He, Mingzhou Li, Ping Chen, Guang Zeng, Michael E. DiSanto, Xinghuan Wang, Xinhua Zhang
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1591–1608.
Published: 07 July 2021
... were utilized. Immunohistochemical staining, immunofluorescent staining, RT-polymerase chain reaction (PCR) and Western blotting were performed. We further generated cell models with NELL2 silenced or overexpressed. Subsequently, proliferation, cycle, and apoptosis of prostate cells were determined...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (4): 613–627.
Published: 18 February 2021
... extracellular matrix (ECM) synthesis and significantly inhibited HG-induced HaCaT cell damage. Further analysis indicated that BBR activated TrxR1, suppressed its downstream JNK signaling, thereby inhibiting oxidative stress and apoptosis, promoted cell proliferation, down-regulated matrix metalloproteinase...
Articles
Yu-Lien Tsai, Chih-Wei Liu, Chien-Fu Hsu, Chia-Chang Huang, Ming-Wei Lin, Shiang-Fen Huang, Tzu-Hao Li, Kuei-Chuan Lee, Yun-Cheng Hsieh, Ying-Ying Yang, Tzung-Yan Lee, Hsuan-Miao Liu, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (15): 2055–2073.
Published: 10 August 2020
... oxidative stress (8-iso-PGF2α)-activated cyclooxygenase-thromboxane A2 [COX-TXA 2 ] pathway, apoptosis, and tubular injury accompanied by a decrease in hyper-responsiveness to the vasoconstrictor 8-iso-PGF2α in perfused kidneys. In vitro experiments revealed that 8-iso-PGF2α induced oxidative stress...
Articles
Jiaxi Chen, Tongtian Zhuang, Jianru Chen, Yangzi Tian, Xiuli Yi, Qingrong Ni, Weigang Zhang, Pu Song, Zhe Jian, Ling Liu, Tingting Cui, Kai Li, Tianwen Gao, Chunying Li, Shuli Li
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (10): 1127–1141.
Published: 21 May 2020
... the effect of Hcy on melanocytic destruction and its involvement in the pathogenesis of vitiligo. Our results showed that Hcy level was significantly elevated in the serum of progressive vitiligo patients. Notably, Hcy induced cell apoptosis in melanocytes via activating reactive oxygen species (ROS...
Includes: Supplementary data
Articles
Yingjin Qiao, Pei Wang, Mingyang Chang, Bohan Chen, Yan Ge, Deepak K. Malhotra, Lance D. Dworkin, Rujun Gong
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (7): 695–710.
Published: 30 March 2020
... of NDP-MSH, because Adriamycin-inflicted cytopathic signs in primary podocytes prepared from WT mice were all mitigated by NDP-MSH, including apoptosis, loss of podocyte markers, de novo expression of the podocyte injury marker desmin, actin cytoskeleton derangement and podocyte hypermotility. Consistent...
Articles
Xiao-Yu Liu, Chang-Bo Zheng, Teng Wang, Jian Xu, Meng Zhang, Ling-Shan Gou, Linfang Jin, Xiaowei Qi, Xianhai Zeng, Hongwen Li, Shuqi Qiu, Peng Zhang
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (2): 155–167.
Published: 23 January 2020
... and suppressed apoptosis during the development and progression of the disease. Previous studies have shown that a novel tumor oncogene, spermatogenic basic helix-loop-helix transcription factor zip 1 (SPZ1), can promote proliferation. However, it is unclear whether SPZ1 plays a role in suppressing apoptosis...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (22): 2245–2264.
Published: 19 November 2019
.... We focus on processes triggering and exacerbating apoptotic signalling in the liver of NAFLD patients and their metabolic and pathological implications. Indeed, liver injury and inflammation are cardinal histopathological features of NASH, a duo in which derailment of apoptosis is of paramount...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (19): 2029–2044.
Published: 14 October 2019
...Ting Xie; Wing Yan So; Xing Yu Li; Po Sing Leung Fibroblast growth factor 21 (FGF21) is known as a potent metabolic regulator but its protective mechanisms against lipotoxicity-induced β-cell dysfunction and apoptosis remain elusive. Here, we aimed to examine the regulatory pathways whereby FGF21...
Includes: Supplementary data
Articles
Yanxian Lai, Jianyong Li, Lintao Zhong, Xiang He, Xiaoyun Si, Yili Sun, Yanmei Chen, Jiayuan Zhong, Yinlan Hu, Bing Li, Wangjun Liao, Cheng Liu, Yulin Liao, Jiancheng Xiu, Jianping Bin
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (13): 1439–1455.
Published: 15 July 2019
... ten (PTEN), has been implicated in smooth muscle cell (SMC) proliferation and apoptosis. PTENP1 is the pseudogene of PTEN. However, it is unclear whether and how PTENP1 functions in the proliferation and apoptosis of human aortic SMCs (HASMCs). Here, we hypothesised that PTENP1 inhibits HASMC...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (13): 1523–1536.
Published: 15 July 2019
...Xiao Sun; Xiuli Feng; Dandan Zheng; Ang Li; Chunyan Li; Siying Li; Zhongxi Zhao Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD). CS heightens inflammation, oxidative stress and apoptosis. Ergosterol is the main bioactive ingredient in Cordyceps sinensis ( C...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (9): 1067–1084.
Published: 09 May 2019
... such as hydrogen peroxide (H 2 O 2 ). Mitochondrial protein 18 (Mtp18) is a novel mitochondrial inner membrane protein, shown to involve in the regulation of mitochondrial dynamics. Although Mtp18 is abundant in cardiac muscles, its role in cardiac apoptosis remains elusive. The present study aimed to detect...
Includes: Supplementary data
Articles
Xuhua Yu, Huei Jiunn Seow, Hao Wang, Desiree Anthony, Steven Bozinovski, Lin Lin, Ji-Ming Ye, Ross Vlahos
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (4): 551–564.
Published: 18 February 2019
...) neutrophilia and NE activity in mice. The reduction in BALF neutrophils in CS-exposed mice by matrine was not due to reductions in pro-neutrophil cytokines/chemokines, but rather matrine’s ability to cause apoptosis of neutrophils, which we demonstrated ex vivo . Thus, our data suggest that matrine has anti...
Articles
Ping Chen, De-qiang Xu, Sheng-li Xu, He Xiao, Sheng-hong Wan, Xing-huan Wang, Michael E. DiSanto, Xin-hua Zhang
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (20): 2189–2205.
Published: 19 October 2018
..., and LC 17a/b ) expression was determined via competitive reverse transcriptase PCR. SM myosin heavy chain (MHC), non-muscle (NM) MHC isoforms (NMMHC-A and NMMHC-B), and proteins related to cell apoptosis were further analyzed via Western blotting. Masson’s trichrome staining was applied to tissue...
Includes: Supplementary data
Articles
Ming Zhan, Irtaza Usman, Jingbo Yu, Liemin Ruan, Xueyan Bian, Jun Yang, Shikun Yang, Lin Sun, Yashpal S. Kanwar
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1297–1314.
Published: 26 June 2018
... oxidative stress are both critical for ensuing diabetic tubular cell injury and apoptosis; whether these two processes are interlinked remains unclear. In the present study, we observed changes in mitochondrial morphology and expression of associated proteins in tubules of patients with DN. We demonstrated...
Includes: Supplementary data
Articles
Vanessa Prieto-Vicente, Ana I. Sánchez-Garrido, Víctor Blanco-Gozalo, Miguel Arévalo, Enrique García-Sánchez, Daniel López-Montañés, Yaremi Quiros, Francisco J. López-Hernández, Antonio Rodríguez-Pérez, José M. López-Novoa
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (9): 985–1001.
Published: 23 May 2018
...), inflammatory markers (tumor necrosis factor α (TNF-α), INFγ, IL-17, IL-10, inducible nitric oxide synthase (iNOS)), colon damage, apoptosis (cleaved caspase 3), nuclear factor κB (NFκB) and STAT-3 activation, and bacterial translocation were measured. Compared with mice treated with DSS, mice also treated...
Includes: Supplementary data
Articles
Luciene Cristina Gastalho Campos, João Carlos Ribeiro-Silva, Alessandra Santos Menegon, Valerio Garrone Barauna, Ayumi Aurea Miyakawa, Jose Eduardo Krieger
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (4): 449–459.
Published: 22 February 2018
... apoptosis observed in the wild-type (WT) rat. We then investigated the role of Crp3 in early integrin-mediated signaling apoptosis in isolated jugular SMC. Interestingly, under basal conditions, ceramide treatment failed to induce apoptosis in both WT and Crp3-KO SMC. Under stretch, Crp3 expression...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (13): 1419–1428.
Published: 23 June 2017
...: D. Pellegrino ( [email protected] ) * These authors contributed equally to this work. 27 02 2017 05 05 2017 11 05 2017 11 05 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 apoptosis...
Articles
Dongcheng Feng, Jihong Yao, Guangzhi Wang, Zhenlu Li, Guo Zu, Yang Li, Fuwen Luo, Shili Ning, Wasim Qasim, Zhao Chen, Xiaofeng Tian
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (8): 759–773.
Published: 06 April 2017
...Dongcheng Feng; Jihong Yao; Guangzhi Wang; Zhenlu Li; Guo Zu; Yang Li; Fuwen Luo; Shili Ning; Wasim Qasim; Zhao Chen; Xiaofeng Tian Intestinal epithelial oxidative stress and apoptosis constitute key pathogenic mechanisms underlying intestinal ischemia/reperfusion (I/R) injury. We previously...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (23): 2121–2138.
Published: 20 October 2016
...Guillermo Mazzolini; Jan-Peter Sowa; Ali Canbay The liver is constantly exposed to a host of injurious stimuli. This results in hepatocellular death mainly by apoptosis and necrosis, but also due to autophagy, necroptosis, pyroptosis and in some cases by an intricately balanced combination thereof...
Articles
Yuanna Ling, Guiming Chen, Yi Deng, Huixiong Tang, Long Ling, Xiaoming Zhou, Xudong Song, Pingzhen Yang, Yingfeng Liu, Zhiliang Li, Cong Zhao, Yufei Yang, Xianbao Wang, Masafumi Kitakaze, Yulin Liao, Aihua Chen
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (18): 1641–1653.
Published: 08 August 2016
... on myocardial I/R injury and autophagy. C57BL/6 mice underwent left coronary artery (LCA) occlusion and cultured neonatal rat cardiomyocytes (NRCs) subjected to hypoxia were treated with vehicle or PD during reperfusion or re-oxygenation. We noted that PD enhanced autophagy and decreased apoptosis during I/R...
Includes: Supplementary data
Articles
Md. Abdul Hye Khan, Brian Fish, Geneva Wahl, Amit Sharma, John R. Falck, Mahesh P. Paudyal, John E. Moulder, John D. Imig, Eric P. Cohen
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (8): 587–599.
Published: 08 March 2016
...-A or captopril. We further demonstrated elevated renal parenchymal apoptosis in TBI rats, which was mitigated by EET-A or captopril. Additional studies revealed that captopril or EET-A mitigated renal apoptosis by acting on the p53/Fas/FasL (Fas ligand) apoptotic pathway. The present study demonstrates a novel...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (4): 289–299.
Published: 14 January 2016
... activates differential robust fibrotic, apoptotic and inflammatory responses via ERK1/2 in cardiomyocytes and cardiac fibroblasts inducing DCM and CHF. Blocking the ERK1/2 pathway prevented progression of FasL-induced DCM and CHF by reducing fibrosis, inflammation and apoptosis in the myocardium...
Includes: Supplementary data
Articles
Thomas M. Conlon, Jörg Bartel, Korbinian Ballweg, Stefanie Günter, Cornelia Prehn, Jan Krumsiek, Silke Meiners, Fabian J. Theis, Jerzy Adamski, Oliver Eickelberg, Ali Önder Yildirim
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (4): 273–287.
Published: 14 January 2016
.... In vitro , stimulation of the alveolar epithelial type II (ATII)-like LA4 cell line with L -carnitine diminished apoptosis induced by both PPE and H 2 O 2 . Moreover, PPE-treated mice demonstrated impaired lung function compared with PBS-treated controls (lung compliance; 0.067±0.008 ml/cmH 2 0 compared...
Articles
Valeria Guglielmi, Gaetano Vattemi, Roberto Chignola, Anna Chiarini, Matteo Marini, Ilaria Dal Prà, Marzia Di Chio, Cristiano Chiamulera, Ubaldo Armato, Giuliano Tomelleri
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (3): 167–181.
Published: 17 December 2015
... into the cytosol to activate, along with Apaf-1 (apoptotic protease-activating factor 1), caspase 9 that, in turn, activates effector caspase 3, caspase 6, and caspase 7, suggesting the execution of the intrinsic apoptotic pathway. Whereas active caspase 3 underwent nuclear translocation, AIF (apoptosis-inducing...
Articles
Mark R. Edwards, Pervez Sultan, Ana Gutierrez del Arroyo, John Whittle, Shamir N. Karmali, S. Ramani Moonesinghe, Fares S. Haddad, Michael G. Mythen, Mervyn Singer, Gareth L. Ackland
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (5): 423–437.
Published: 11 June 2015
... apoptosis induced by a range of common stressors. Glucocorticoids, which are ubiquitously elevated for a prolonged period postoperatively, generated increased levels of mitochondrial reactive oxygen species, activated caspase-1 and mature interleukin (IL)-1β in human lymphocytes, suggesting inflammasome...
Includes: Supplementary data
Articles
Xiaoxiong Liu, Nian Wan, Xiao-Jing Zhang, Yichao Zhao, Yan Zhang, Gangying Hu, Fengwei Wan, Rui Zhang, Xueyong Zhu, Hao Xia, Hongliang Li
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (12): 923–936.
Published: 27 March 2015
... decreased MI-induced infarct size, concomitant with an improved cardiac function, leading to an increase in the survival rate. The myocardial apoptosis in the border zone was dramatically reduced by Vinexin-β deficiency, resulting from the altered expression of apoptotic factors. Furthermore, Vinexin-β...
Articles
Liang Shen, Ci Chen, Xuan Wei, Xixian Li, Guangjin Luo, Jingwen Zhang, Jianping Bin, Xiaobo Huang, Shiping Cao, Guofeng Li, Yulin Liao
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (10): 665–678.
Published: 20 February 2015
..., but it remains inconclusive whether this gene promotes or inhibits cell apoptosis. In the present study, we attempted to investigate the role of Ankrd1 on AngII (angiotensin II)- or pressure-overload-induced cardiomyocyte apoptosis. In the failing hearts of mice with pressure overload, the protein expression...
Includes: Supplementary data
Articles
Yi Zhao, Ulf Lützen, Jürgen Fritsch, Maaz Zuhayra, Stefan Schütze, Ulrike M. Steckelings, Chiara Recanti, Pawel Namsoleck, Thomas Unger, Juraj Culman
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (9): 567–578.
Published: 11 February 2015
... in various human and mouse non-tumour cells. We investigated the intracellular distribution of AT 2 receptors including their presence in mitochondria and their role in the induction of apoptosis and cell death in cultured human uterine leiomyosarcoma (SK-UT-1) cells and control human uterine smooth muscle...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (9): 579–592.
Published: 11 February 2015
... a link between modified lipids and vascular smooth muscle remodelling processes, which are critical in this neointima formation. apoptosis chlorinated lipids oxidized phospholipids proliferation restenosis vascular smooth muscle • Abnormal VSMC proliferation and migration contribute...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (9): 527–535.
Published: 27 January 2015
... also has pro-apoptotic, mitogenic and pro-fibrogenic effects, all of which potentially promote active remodelling and expansion of the mesangium. Although mitochondrial dysfunction seems to mediate the aldosterone-induced mesangial apoptosis, the ROS dependent epithelial growth factor receptor (EGFR...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (5): 325–335.
Published: 13 November 2014
... S. The echocardiographical and histopathological data indicated that H 2 S improved left ventricular function and prevented cardiac hypertrophy and myocardial fibrosis in diabetic rats. H 2 S was also found to attenuate hyperglycaemia-induced inflammation, oxidative stress and apoptosis...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (5): 321–323.
Published: 13 November 2014
... an important therapeutic potential of the H 2 S pathway in diabetic cardiomyopathy. Correspondence : Professor Gavin Y. Oudit (email [email protected] ). 20 10 2014 21 10 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 apoptosis diabetic...
Articles
Patricia Prieto, María Teresa Vallejo-Cremades, Gemma Benito, Pilar González-Peramato, Daniel Francés, Noelia Agra, Verónica Terrón, Silvia Gónzalez-Ramos, Carmen Delgado, Mariano Ruiz-Gayo, Ivette Pacheco, Juan P. Velasco-Martín, Javier Regadera, Paloma Martín-Sanz, Eduardo López-Collazo, Lisardo Boscá, María Fernández-Velasco
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (12): 665–677.
Published: 08 August 2014
... with an up-regulation of nuclear factor κB (NF-κB) and increased apoptosis. Heart tissue also exhibited an enhanced expression of pro-inflammatory cytokines. Selective NOD1 activation with C 12 -γ- D -glutamyl- m -diaminopimelic acid (iEDAP) resulted in an increased NF-κB activation and apoptosis...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (8): 519–526.
Published: 30 June 2014
... unclear. A possible role of myocardial apoptosis in the pathogenesis has not been previously examined. We hypothesized that dysregulation of apoptotic signalling participates in cardiac dysfunction in the cirrhotic heart. Therefore, we evaluated apoptotic pathways in the hearts of mice with chronic BDL...
Articles
Vanessa Legry, Derrick M. Van Rooyen, Barbara Lambert, Christine Sempoux, Laurence Poekes, Regina Español-Suñer, Olivier Molendi-Coste, Yves Horsmans, Geoffrey C. Farrell, Isabelle A. Leclercq
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (7): 507–518.
Published: 25 June 2014
... tunicamycin, or conversely with the ER protectant tauroursodeoxycholic acid (TUDCA), on the metabolic and hepatic features. foz/foz mice are obese, glucose intolerant and develop NASH characterized by steatosis, inflammation, ballooned hepatocytes and apoptosis from 6 weeks of HFD feeding...
Includes: Supplementary data
Articles
Zhi Zeng, Liang Shen, Xixian Li, Tao Luo, Xuan Wei, Jingwen Zhang, Shiping Cao, Xiaobo Huang, Yasushi Fukushima, Jianping Bin, Masafumi Kitakaze, Dingli Xu, Yulin Liao
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (7): 435–448.
Published: 17 June 2014
... subjected to transverse aortic constriction (TAC) or sham surgery. The influences of H2R activation or inactivation on mitochondrial function, apoptosis and fibrosis were evaluated in cultured neonatal rat cardiomyocytes and fibroblasts as well as in murine hearts. After 4 weeks, H2R-knockout mice had...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (6): 405–413.
Published: 29 May 2014
... by inducing the PHR (portal hypertensive response) via B 2 R, whereas DABK (des-Arg 9 -BK), a B 1 R agonist, does not elicit the response. During IRI (ischaemia/reperfusion injury), important changes occur in the microcirculation, and cell death by necrosis and apoptosis is involved in poor graft function...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (7): 467–478.
Published: 07 December 2012
... 19 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 apoptosis cannabinoid receptor gene expression insulin secretion mouse islet Data are expressed as means±S.E.M. of four to eight individual experiments. Student's t tests and two-way ANOVA...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (1): 1–15.
Published: 07 September 2012
... (nuclear factor κB) activation, inflammation, apoptosis or necrosis, low-to-moderate levels can enhance the antioxidant response, via Nrf2 (nuclear factor-erythroid 2-related factor 2) activation. However, a clear definition of these concentration thresholds remains to be established. Although a number...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (9): 545–546.
Published: 13 July 2012
...Regje M. E. Blümer; Gregory R. Steinberg TRAIL [TNF (tumour necrosis factor)-related apoptosis-inducing ligand] is in clinical trials for the treatment of cancer. In the present issue of Clinical Science , Bernardi and co-workers report that the administration of TRAIL in mice fed on a high-fat...
Articles
Stella Bernardi, Giorgio Zauli, Christos Tikellis, Riccardo Candido, Bruno Fabris, Paola Secchiero, Mark E. Cooper, Merlin C. Thomas
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (9): 547–555.
Published: 13 July 2012
...Stella Bernardi; Giorgio Zauli; Christos Tikellis; Riccardo Candido; Bruno Fabris; Paola Secchiero; Mark E. Cooper; Merlin C. Thomas TRAIL [TNF (tumour necrosis factor)-related apoptosis-inducing ligand] has recently been shown to ameliorate the natural history of DM (diabetes mellitus). It has...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (7): 417–427.
Published: 07 June 2012
.... The role of magnesium in cancer is also critically examined with regard to mitochondrial function, apoptosis and resistance to treatment. Finally, we bring together the latest experimental evidence indicating that alteration in the expression and/or activity of magnesium channels is a frequent finding...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (8): 315–329.
Published: 24 June 2011
... ). 9 3 2011 28 4 2011 16 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging apoptosis cardiomyocyte cardiovascular disease Aging is often thought of as a progressive disorder that decreases an organism's ability to maintain ‘normostasis...
Articles
António Ascensão, José Lumini-Oliveira, Nuno G. Machado, Rita M. Ferreira, Inês O. Gonçalves, Ana C. Moreira, Franklin Marques, Vilma A. Sardão, Paulo J. Oliveira, José Magalhães
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (1): 37–49.
Published: 17 September 2010
... administration and exercise caused increased cardiac mitochondrial SOD activity. Exercise ameliorated liver mitochondrial complex activities. No alterations were observed in the measured MPTP and apoptosis-related proteins in heart and liver mitochondria. The results demonstrate that acute exercise protects...
Articles
Amalia Forte, Mauro Finicelli, Mario Grossi, Mariano Vicchio, Nicola Alessio, Pasquale Santé, Marisa De Feo, Maurizio Cotrufo, Liberato Berrino, Francesco Rossi, Umberto Galderisi, Marilena Cipollaro
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (7): 473–485.
Published: 12 January 2010
... expression of DNA damage markers and of DNA repair genes, together with the assessment of proliferation and apoptosis indexes. The expression of the oxidative DNA damage marker 7,8-dihydro-8-oxo-2′-deoxyguanosine was increased at 3 and 7 days after arteriotomy, with immunostaining distributed in the injured...
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