... responses. Human mast cells are potent effector cells of the innate immune system, and the triacylglycerol (triglyceride) stores of their cytoplasmic LDs have been shown to contain large amounts of arachidonic acid, the main precursor of pro-inflammatory eicosanoids. In the present review, we discuss...

...Natalie C. Ward; Kevin D. Croft; David Blacker; Graeme J. Hankey; Anne Barden; Trevor A. Mori; Ian B. Puddey; Christopher D. Beer CYP450AAM [arachidonic acid metabolites of the CYP450 (cytochrome P450) enzyme system] have a range of biological functions. CYP450AAM are involved in the pathogenesis...

...Henrik Ortsäter Saturated fatty acids are toxic to pancreatic β-cells. By inducing apoptosis, they contribute to a decrease in β-cell mass, a hallmark of Type 2 diabetes. In the present issue of Clinical Science , Keane and co-workers show that the polyunsaturated fatty acid arachidonic acid...

... fatty acids such as PA (palmitic acid) are detrimental to β-cell function compared with unsaturated fatty acids. In the present study, we describe the effect of the polyunsaturated AA (arachidonic acid) on the function of the clonal pancreatic β-cell line BRIN-BD11 and demonstrate AA-dependent...

... (arachidonic acid) on bone cytokine gene expression has been shown in human osteoblastic cells, OA (oleic acid) and EPA (eicosapentaenoic acid) were ineffective. Since the NO (nitric oxide) system has also been shown to have an important modulatory activity on osteoblasts, osteoclasts and bone metabolism...

... and the Medical Research Society 1996 arachidonic acid Crohn's disease fatty acids phospholipids Clinical Science (1996) 91, 509-512 (Printed in Great Britain) Plasma arachidonic acid-rich phospholipids in Crohn s disease: response to treatment Stephen P. PEREIRA, Theresa B. CASSELL, Jeffrey L...

... of endogenous arachidonic acid by lipoxygenases as judged by the radiolabel associated with hydroxyeicosatetraenoic acids in [ 3 H]arachidonic acid-prelabelled peripheral blood mononuclear cells, whereas the cyclo-oxygenase activity, estimated by the radiolabel associated with thromboxane B 2...

... in these patients is related to a PG precursor fatty acid deficiency, serum levels of linoleic and arachidonic acids and the urinary excretion of PGE 2 , 6-keto-PGF 1α and thromboxane B 2 (TxB 2 ) were measured in 10 normal subjects, 17 non-azotaemic cirrhotic patients with ascites and 10 cirrhotic patients...

...A. M. Van Rij; C. Wade; I. Kirk; C. Thomson; M. F. Robinson 1. Arachidonic acid metabolism through the lipoxygenase pathway in platelets was investigated in 11 patients with low selenium (Se) nutritional status and compared with 14 patients with a normal Se status. 2. Plasma and whole blood Se...

...Sergio Pacheco; Keith Hillier; Colin Smith 1. Colonic mucosa from 19 patients with ulcerative colitis, eight with Crohn's disease and 14 controls were analysed for arachidonic acid (C20:4), linoleic acid (C18:2), oleic acid (C18:1), stearic acid (C18:0) and palmitic acid (C16:0). 2. Gas–liquid...

... plasma and platelets as well as between plasma and platelets indicate that a high linoleic acid content is not associated with an increased arachidonic acid concentration. The results also indicate that the limiting metabolic step in the conversion of linoleic acid into arachidonic acid may be located...

...Carlos P. Vio; Laurie Churchill; Alicia Terragno; John C. McGiff; Norberto A. Terragno 1. The effect of arachidonic acid on kallikrein release was studied in an isolated rat kidney perfused with a modified Krebs-Henseleit solution. 2. Kallikrein activity was measured in both venous and urinary...

... and unilaterally nephrectomized controls of the Sprague—Dawley strain. The responses, measured as a percentage of resting blood pressure, did not differ significantly between the hypertensive rats and the normotensive controls within each strain. 2. The effects of intravenous injections of arachidonic acid were...

...]Phenylethylamine was also metabolized in human lung. 4. Prostaglandin E 2 was inactivated and this inactivation inhibited by bromocresol green and frusemide. 5. About 10% of the radioactivity from infused [ 14 C]arachidonic acid emerged from the lung and a small amount of biological activation occurred. 6. Of [ 14...

...G. J. Dusting; S. Moncada; K. M. Mullane; J. R. Vane 1. The biotransformation of arachidonic acid and prostacyclin in the circulation was studied in anaesthetized dogs, using the blood-bathed organ technique. 2. In passage through the lungs, arachidonate (50–800 μg kg −1 min −1 ) was transformed...