...) with increased arginase activity induce endothelial dysfunction in T2DM, but the implications of RBCs and the role of arginase inhibition in T1DM are unexplored. We aimed to investigate the differences in endothelial function in patients with T1DM and T2DM, with focus on RBCs and arginase. Thirteen patients...

... of this amino acid into ornithine by the intracellular enzyme arginase. The conversion into ornithine caused a progressive depletion of arginine from the culture medium, which ultimately inhibited cell protein synthesis and halted growth. Intracellular arginase activity may be the major factor determining...

...Raj C. THURAISINGHAM; Norman B. ROBERTS; Mark WILKES; David I. NEW; A. Claudio MENDES-RIBEIRO; Susan M. DODD; Muhammad M. YAQOOB Results regarding the nitric oxide (NO) system in uraemia are contradictory. l -Arginine, the precursor of NO, is also metabolized by arginase to form ornithine and urea...