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Keywords: arginine
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Articles
Clin Sci (Lond) (2009) 117 (1): 23–30.
Published: 02 June 2009
...Christina C. Kao; Venkata Bandi; Kalpalatha K. Guntupalli; Manhong Wu; Leticia Castillo; Farook Jahoor Arginine has vasodilatory effects, via its conversion by NO synthase into NO, and immunomodulatory actions which play important roles in sepsis. Protein breakdown affects arginine availability...
Articles
Clin Sci (Lond) (2008) 115 (5): 159–166.
Published: 01 August 2008
...Sylwia Osowska; Nathalie Neveux; Samir Nakib; Virginie Lasserre; Luc Cynober; Christophe Moinard Arginine homoeostasis is impaired in short bowel syndrome, but its supplementation in short bowel syndrome patients remains controversial. Recently, we demonstrated the benefits of citrulline...
Articles
Clin Sci (Lond) (2008) 114 (3): 231–241.
Published: 08 January 2008
...Marcel C. G. van de Poll; Sebastiaan J. P. Hanssen; Maaike Berbée; Nicolaas E. P. Deutz; Diethard Monbaliu; Wim A. Buurman; Cornelis H. C. Dejong Arginine is an important substrate in health and disease. It is a commonly held view that arginase-1 release from injured erythrocytes and hepatocytes...
Articles
Clin Sci (Lond) (2007) 112 (10): 527–532.
Published: 12 April 2007
...Yvonne L. J. Vissers; Maarten F. von Meyenfeldt; Yvette C. Luiking; Cornelis H. C. Dejong; Wim A. Buurman; Nicolaas E. P. Deutz We have described recently that cancer patients have low plasma arginine concentrations, even without weight loss being present, suggesting that decreased arginine...
Articles
Clin Sci (Lond) (2006) 111 (6): 389–399.
Published: 14 November 2006
... through a number of pathways. In PTEC exposed to purified albumin, polyamines are required for entry into the cell cycle and are critical for proliferation. Polyamines are synthesized from L -ornithine (itself derived by the action of arginase on L -arginine), and the transport and availability of L...
Articles
Clin Sci (Lond) (2002) 103 (1): 31–41.
Published: 06 June 2002
...Raj C. THURAISINGHAM; Norman B. ROBERTS; Mark WILKES; David I. NEW; A. Claudio MENDES-RIBEIRO; Susan M. DODD; Muhammad M. YAQOOB Results regarding the nitric oxide (NO) system in uraemia are contradictory. l -Arginine, the precursor of NO, is also metabolized by arginase to form ornithine and urea...
Articles
Clin Sci (Lond) (2002) 102 (6): 645–650.
Published: 14 May 2002
...Michael C. READE; Megan F. CLARK; J. Duncan YOUNG; C.A.R. BOYD Increased production of nitric oxide (NO) is thought to be a factor in the pathogenesis of many human diseases - among them the hypotension that often accompanies sepsis. The supply of the cationic amino acid arginine is known...
Articles
Clin Sci (Lond) (2002) 102 (3): 287–295.
Published: 11 February 2002
... the respiratory burst in polymorphonuclear neutrophils (PMNs), but the underlying mechanisms remain unclear. OKG is usually recognized as generating glutamine, arginine and polyamines. The aim of the present study was first to determine the effects of OKG on PMN bactericidal functions (chemotaxis and respiratory...
Articles
Clin Sci (Lond) (1999) 97 (6): 657–669.
Published: 29 October 1999
...Lindsay E. ROBINSON; Françoise I. BUSSIÈRE; Jacques LE BOUCHER; Marie-Chantal FARGES; Luc A. CYNOBER; Catherine J. FIELD; Vickie E. BARACOS Dietary supplementation with glutamine (Gln), arginine (Arg) or ornithine 2-oxoglutarate (α-ketoglutarate; OKG) has attracted recent attention...
Articles
Clin Sci (Lond) (1999) 97 (1): 59–65.
Published: 21 May 1999
...Christophe MOINARD; Béatrice CHAUVEAU; Stéphane WALRAND; Catherine FELGINES; Jacques CHASSAGNE; Florence CALDEFIE; Luc A. CYNOBER; Marie-Paule VASSON The effects of diets supplemented with 6.8 mmol⋅day -1 ⋅kg -1 glutamine, arginine or ornithine 2-oxoglutarate [ornithine α-ketoglutarate (OKG...
Articles
Clin Sci (Lond) (1998) 95 (4): 409–418.
Published: 01 October 1998
...Cornelis H. C. DEJONG; Carlo F. M. WELTERS; Nicolaas E. P. DEUTZ; Erik HEINEMAN; Peter B. SOETERS 1. Arginine can be produced in the kidney from citrulline. An important source of circulating citrulline is the intestinal breakdown of glutamine. Consequently, partial enterectomy leads to decreased...
Articles
Clin Sci (Lond) (1998) 95 (4): 397–407.
Published: 01 October 1998
...Colin MURPHY; Philip NEWSHOLME 1. The intermediates of biochemical cycles are commonly utilized for biosynthetic processes; thus at least one intermediate must be replenished de novo to provide constant flux through the cycle. The utilization of l -arginine for NO synthesis in macrophages may thus...
Articles
Clin Sci (Lond) (1995) 89 (2): 183–190.
Published: 01 August 1995
...R. J. MacAllister; A. L. Calver; J. Collier; C. M. B. Edwards; B. Herreros; S. S. Nussey; P. Vallance 1. The vascular and hormonal effects of l- and d-arginine were compared in healthy subjects and in patients with insulin-dependent diabetes mellitus or untreated essential hypertension. 2. Infusion...
Articles
Clin Sci (Lond) (1991) 81 (5): 695–700.
Published: 01 November 1991
...Alison Calver; Joe Collier; Patrick Vallance 1. l -Arginine is the physiological precursor for the formation of endothelium-derived nitric oxide. The synthesis of nitric oxide is stereospecific: d -arginine is not a substrate for nitric oxide synthase. It is possible that the provision of excess l...
Articles
Clin Sci (Lond) (1991) 80 (2): 161–166.
Published: 01 February 1991
... volunteers before and during blockade of tubular protein reabsorption by intravenous infusion of either l -arginine hydrochloride ( n = 8; 0.5 g h −1 kg −1 body weight) or an equimolar amount of l -lysine hydrochloride ( n = 5; 0.44 g h −1 kg −1 body weight). Glomerular filtration rate was measured...
Articles
Clin Sci (Lond) (1984) 66 (3): 337–342.
Published: 01 March 1984
...]arginine was used in place of the [ 15 N]urea enrichment after a constant infusion of [ 15 N]-glycine. With this approach metabolic pool turnover and protein synthesis were 637.2 ± 73.0 mg of N day −1 kg −1 and 2964.0 ± 409.5 mg of protein day −1 kg −1 respectively. 2. Virtually identical isotopic...
Articles
Clin Sci Mol Med (1974) 46 (6): 715–727.
Published: 01 June 1974
...C. W. Crane; F. A. Jenner; R. J. Pollitt 1. The time-course of urinary excretion of [ 15 N]urea and [ 15 N]argininosuccinate or [ 15 N]arginine after an oral dose of [ 15 N]ammonium lactate has been followed in patients with argininosuccinic aciduria and cystine-lysinuria respectively. The labelled...